Abstract：
:The effects of sex differences and hormonal factors on the locomotor alterations following intrastriatal injections of quinolinic acid (QA) and the ability of fetal striatal transplants to reverse those effects were examined. Male, female, or ovariectomized female rats received bilateral injections of 150 nmol QA or vehicle into the striatum. Using a multidimensional analysis of spontaneous nocturnal locomotor behavior, a significant increase in locomotion was observed in female but not male or ovariectomized female rats. The increases in activity observed in the lesioned females were attenuated at 6 and 10 weeks following transplantation of rat fetal (E17) striatal tissue into the lesioned striata. Transplanted striatal tissue had no effect on locomotion in male or ovariectomized female rats. Cytochrome oxidase histochemistry revealed that QA produced a marked loss of metabolic activity in regions exhibiting cell loss. Within these areas there was a marked loss of striatal neurons including those reactive for NADPH diaphorase. Despite the sex-related differences in QA-induced locomotion, there were no apparent differences in the extent of striatal pathology or survival of the grafts in any of the groups receiving QA. These experiments demonstrate a sex-dependent dissociation between the behavioral and neurobiological consequences of QA and suggest that sex and hormonal variables play an important role in the locomotor changes following excitotoxic-induced striatal damage.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Emerich DF,Zubricki EM,Shipley MT,Norman AB,Sanberg PRdoi
10.1016/0014-4886(91)90105-lsubject
Has Abstractpub_date
1991-03-01 00:00:00pages
369-78issue
3eissn
0014-4886issn
1090-2430journal_volume
111pub_type
杂志文章abstract：:Chondroitin sulfate proteoglycans (CSPGs), extracellular matrix molecules that increase dramatically following a variety of CNS injuries or diseases, have long been known for their potent capacity to curtail cell migrations as well as axon regeneration and sprouting. The inhibition can be conferred through binding to ...
journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1016/j.expneurol.2020.113276
更新日期：2020-06-01 00:00:00
abstract：:Silent strokes occur more frequently than classic strokes; however, symptoms may go unreported in spite of lasting tissue damage. A silent stroke may indicate elevated susceptibility to recurrent stroke, which may eventually result in apparent and lasting impairments. Here we investigated if multiple silent strokes to...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2012.05.007
更新日期：2012-08-01 00:00:00
abstract：:MK-801, a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, was tested for anticonvulsant effects in rats using two seizure models, coadministration of lithium and pilocarpine and administration of a high dose of pilocarpine alone. Three major results are reported. First, pretreatment with MK-801 produce...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(89)90091-5
更新日期：1989-11-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2013.03.021
更新日期：2013-09-01 00:00:00
abstract：:Activation of GABA(A) receptors by GABA causes phasic and tonic conductances in different brain areas. In the ventrobasal (VB) thalamus, tonic inhibition originates from GABA acting on extrasynaptic receptors. Here we show that dopamine (DA), the D2-like agonist quinpirole and the selective D4R agonist PD-168,077 decr...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2013.03.023
更新日期：2013-09-01 00:00:00
abstract：:Pretreatment with the synthetic glucocorticoid dexamethasone prevents hypoxic-ischemic brain damage in 7-day-old neonatal rats. We presently characterize the response further by examining the effect of varying the age, the glucocorticoid, and the time of injection and by examining whether fasting can influence the res...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(95)90065-9
更新日期：1995-03-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2012.01.020
更新日期：2012-04-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2001.7826
更新日期：2002-01-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1997.6608
更新日期：1997-10-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2003.12.012
更新日期：2004-05-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2017.12.010
更新日期：2018-04-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1997.6470
更新日期：1997-06-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(89)90040-x
更新日期：1989-06-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2007.10.015
更新日期：2008-03-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2000.7606
更新日期：2001-04-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(83)90229-7
更新日期：1983-02-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1016/j.expneurol.2016.04.019
更新日期：2016-10-01 00:00:00
abstract：:CNS damage often results in demyelination of spared axons due to oligodendroglial cell death and dysfunction near the injury site. Although new oligodendroglia are generated following CNS injury and disease, the process of remyelination is typically incomplete resulting in long-term functional deficits. Chondroitin su...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2013.04.003
更新日期：2013-09-01 00:00:00
abstract：:Experimental autoimmune neuritis (EAN) is an animal model of the human disease Guillain-Barré syndrome. In this autoimmune inflammatory disease, CD4(+) T cells mediate demyelination in the peripheral nervous system (PNS). Infiltrating macrophages and T cells as well as cytokines like interferon (IFN)-gamma are intimat...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2001.7662
更新日期：2001-06-01 00:00:00
abstract：:The release of reactive oxygen species (ROS) by neutrophils, which infiltrate the region of damage following spinal cord injury (SCI), was investigated to determine if such release is significant following spinal cord injury. The relationship of extracellular levels of hydroxyl radicals and hydrogen peroxide obtained ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2004.05.046
更新日期：2004-12-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(87)90148-8
更新日期：1987-02-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2014.09.004
更新日期：2015-01-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2007.09.025
更新日期：2008-01-01 00:00:00
abstract：:There is a consensus that active sleep (AS; i.e., REM sleep) is produced by cholinergic projections from the pedunculopontine tegmental nuclei (PPT) that activate AS-on neurons in the nucleus pontis oralis (NPO) that are components of the AS-Generator. However, there is a growing body of evidence indicating that other...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2012.08.001
更新日期：2012-11-01 00:00:00
abstract：:Pituitary adenylate cyclase activating polypeptide (PACAP) has neuroprotective effects against ischemia, even when given by intravenous (iv) administration 24 h after stroke. Transport of PACAP across the blood-brain barrier (BBB) by peptide transport system (PTS)-6 underlies its effectiveness after iv administration....
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2004.09.013
更新日期：2005-01-01 00:00:00
abstract：:Dementia and parkinsonism are late-onset symptoms associated with repetitive head injury, as documented in multiple contact-sport athletes. Clinical symptomatology is the likely phenotype of chronic degeneration and circuit disruption in the substantia nigra (SN). To investigate the initiating neuropathology, we hypot...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2011.12.003
更新日期：2012-03-01 00:00:00
abstract：:The long-term effects of partial denervation on the muscle fiber cross-sectional area, degree of axonal sprouting, and end-plate morphology were examined 1, 3, 6, 9, and 12 months postsurgery in rat plantaris muscle. After 1 month of partial denervation, mean cross-sectional areas of type I and type II myofibers were ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(92)90004-a
更新日期：1992-06-01 00:00:00
abstract：:Increasing evidence indicates that the cytokines, tumor necrosis factor (TNF), interleukin-1, and/or interferon-gamma, may play a crucial role in the pathogenesis of multiple sclerosis. Several reports demonstrated that inhibition of TNF is highly protective in experimental allergic encephalomyelitis (EAE) when sensit...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(95)90044-6
更新日期：1995-02-01 00:00:00
abstract：:A central role for noradrenergic dysregulation in the pathophysiology of post-traumatic stress disorder (PTSD) is increasingly suggested by both clinical and basic neuroscience research. Here, we integrate recent findings from clinical and animal research with the earlier literature. We first review the evidence for n...
journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1016/j.expneurol.2016.05.014
更新日期：2016-10-01 00:00:00
abstract：:In mammals, free d-aspartate (D-Asp) is abundant in the embryonic brain, while levels remain very low during adulthood as a result of the postnatal expression and activity of the catabolizing enzyme d-aspartate oxidase (DDO). Previous studies have shown that long-lasting exposure to nonphysiological, higher D-Asp conc...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2019.02.014
更新日期：2019-07-01 00:00:00
