当前位置： SCI文献检索 > EXPERIMENTAL NEUROLOGY期刊下所有文献 > Dopaminergic modulation of tonic but not phasic GABAA-receptor-mediated current in the ventrobasal thalamus of Wistar and GAERS rats.

Dopaminergic modulation of tonic but not phasic GABAA-receptor-mediated current in the ventrobasal thalamus of Wistar and GAERS rats.

Abstract：

:Activation of GABA(A) receptors by GABA causes phasic and tonic conductances in different brain areas. In the ventrobasal (VB) thalamus, tonic inhibition originates from GABA acting on extrasynaptic receptors. Here we show that dopamine (DA), the D2-like agonist quinpirole and the selective D4R agonist PD-168,077 decrease the magnitude of the tonic GABA(A) current while D1-like agonist SKF39383 lacks any significant effects in VB neurons of Wistar rats. On the other hand, DA and D1/D2 receptor activation does not alter phasic GABA(A) conductance. As we previously reported that an increased tonic GABA(A) current in VB neurons is critical for absence seizure generation, we also investigated whether D2-D4 receptor activation is capable of normalizing this aberrant conductance in genetic absence epilepsy rats from Strasbourg (GAERS). Quinpirole and PD-168,077 selectively reduces tonic GABA(A) current as in normal rats. Therefore, it is conceivable that some DA anti-absence effects occur via modulation of tonic GABA(A) current in the VB.

journal_name

Exp Neurol

journal_title

Experimental neurology

authors

Yagüe JG,Cavaccini A,Errington AC,Crunelli V,Di Giovanni G

doi

10.1016/j.expneurol.2013.03.023

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

1-7

eissn

0014-4886

issn

1090-2430

pii

S0014-4886(13)00116-7

journal_volume

247

pub_type

杂志文章

相关文献

EXPERIMENTAL NEUROLOGY文献大全
  • Desmoplakin is involved in organization of an adhesion complex in peripheral nerve regeneration after injury.

    abstract：:Peripheral nerves have the unique capability to regenerate after injury. Insights into regeneration of peripheral nerves after injury may have implications for neurodegenerative diseases of the nervous system. In this study, we analyzed the expression and function of desmoplakin in peripheral nerve regeneration. Desmo...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2014.12.005

    authors： Gess B,Röhr D,Lange E,Halfter H,Young P

    更新日期：2015-02-01 00:00:00

  • The L-amino acid carrier inhibitor 2-aminobicyclo[2.2.1]heptane-2-carboxylic acid (BCH) reduces L-dopa-elicited responses in dopaminergic neurons of the substantia nigra pars compacta.

    abstract：:It is not yet clear how L-dopa, that is the most effective drug for the treatment of Parkinson's disease, enters into the dopaminergic neurons to be transformed into dopamine. It is suggested that L-dopa is mainly transported into cells by a group of L-amino acid carriers named "System L". Since these carriers are sel...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2008.04.005

    authors： Sebastianelli L,Ledonne A,Marrone MC,Bernardi G,Mercuri NB

    更新日期：2008-07-01 00:00:00

  • Alternative substrate metabolism depends on cerebral metabolic state following traumatic brain injury.

    abstract：:Decreases in energy metabolism following traumatic brain injury (TBI) are attributed to impairment of glycolytic flux and oxidative phosphorylation. Glucose utilization post-TBI is decreased while administration of alternative substrates has been shown to be neuroprotective. Changes in energy metabolism following TBI ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2020.113289

    authors： Greco T,Vespa PM,Prins ML

    更新日期：2020-07-01 00:00:00

  • Improved outcome after spinal cord compression injury in mice treated with docosahexaenoic acid.

    abstract：:In this study we have characterised the locomotor recovery, and temporal profile of cell loss, in a novel thoracic compression spinal cord injury (SCI) in the mouse. We have also shown that treatment with docosahexaenoic acid (DHA) is neuroprotective in this model of SCI, strengthening the growing literature demonstra...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2012.09.015

    authors： Lim SN,Huang W,Hall JC,Michael-Titus AT,Priestley JV

    更新日期：2013-01-01 00:00:00

  • Discharge from total populations of Ia and II afferent fibers in the cat's deefferented medial gastrocnemius muscle during static stretch.

    abstract：:Estimates were made of the changing volumes of discharge arising from the total populations of Ia and II spindle afferent fibers in the cat's deefferented medial gastrocnemius as the muscle was extended stepwise over its excursion range. The estimates were based on values reported elsewhere for (i) the incidence of ac...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(83)90017-1

    authors： Botterman BR,Eldred E

    更新日期：1983-04-01 00:00:00

  • Calcium channel blockers ameliorate disease in a mouse model of multiple sclerosis.

    abstract：:Multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), an animal model of MS, are inflammatory demyelinating diseases of the central nervous system. The inflammatory attacks lead to glial dysfunction and death, axonal damage, and neurological deficits. Numerous studies in rat suggest that extrace...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2004.05.023

    authors： Brand-Schieber E,Werner P

    更新日期：2004-09-01 00:00:00

  • Repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex and cortical excitability in patients with major depressive disorder.

    abstract：:Repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex is a relatively non-invasive technique with putative therapeutic effects in major depression. However, the exact neurophysiological basis of these effects needs further clarification. Therefore, we studied the impact of ten daily...

    journal_title：Experimental neurology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.expneurol.2005.08.008

    authors： Bajbouj M,Brakemeier EL,Schubert F,Lang UE,Neu P,Schindowski C,Danker-Hopfe H

    更新日期：2005-12-01 00:00:00

  • Muscle fiber transformation in capsaicin-treated rats.

    abstract：:Rats were injected with capsaicin or solvent on the 2nd day of life. Nine weeks later both animal groups were further subdivided: one was untreated and the other group underwent surgery consisting in either (a) removal of one sternohyoid superior muscle or (b) a sham operation. The sternohyoid superior muscles were re...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(85)90124-4

    authors： Müntener M

    更新日期：1985-04-01 00:00:00

  • Differential abundance of glutamate transporter subtypes in amyotrophic lateral sclerosis (ALS)-vulnerable versus ALS-resistant brain stem motor cell groups.

    abstract：:Previous studies have suggested that defective high-affinity glutamate uptake, due mainly to a major loss of the astroglial-specific GLT-1 glutamate transporter, underlies the selective motoneuron degeneration observed in sporadic ALS (24, 28). If a defect in glutamate transport underlies the pathogenesis of sporadic ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1996.0198

    authors： Medina L,Figueredo-Cardenas G,Rothstein JD,Reiner A

    更新日期：1996-12-01 00:00:00

  • β band stability over time correlates with Parkinsonian rigidity and bradykinesia.

    abstract：:Abnormal oscillatory activity in the basal ganglia is increasingly implicated in the pathophysiology of Parkinson's disease. Such activity is recorded in patients in the form of oscillations in the local field potential (LFP) picked up in the subthalamic nucleus. Previous studies have focused on correlations between f...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2012.04.024

    authors： Little S,Pogosyan A,Kuhn AA,Brown P

    更新日期：2012-08-01 00:00:00

  • Recovery of chorda tympani nerve function following injury.

    abstract：:The chorda tympani (CT) nerve carries taste information from the anterior tongue to the brain stem. Injury to the chorda tympani may result in loss or distortion of taste information. This study examined changes occurring in the hamster peripheral taste system during recovery from injury. The hamster chorda tympani ne...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1996.0169

    authors： Cain P,Frank ME,Barry MA

    更新日期：1996-10-01 00:00:00

  • The effects of aluminum chloride on the rate of secretion of the cerebrospinal fluid.

    abstract：:The claim that AlCl3 could produce 100% inhibition of cerebrospinal fluid secretion was investigated using ventriculocisternal perfusion in the rabbit, and it was shown that a large part of this inhibition was an artefact due to a pH sensitivity of Blue Dextran, used as an indiffusible marker, caused by AlCl3. Thus th...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(87)90253-6

    authors： Zlokovic BV,Davson H,Preston JE,Segal MB

    更新日期：1987-11-01 00:00:00

  • Pioglitazone activates paraoxonase-2 in the brain: A novel neuroprotective mechanism.

    abstract：:Paraoxonase-2 regulates reactive oxygen species production in mitochondria. Stimulating its expression has therapeutic potential for diseases where oxidative stress plays a significant role in the pathology. Evidence suggests that the anti-diabetic drug pioglitazone may provide neuroprotection in Parkinson's disease, ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2020.113234

    authors： Blackburn JK,Curry DW,Thomsen AN,Roth RH,Elsworth JD

    更新日期：2020-05-01 00:00:00

  • Effect of repeated versus single electroconvulsive seizures on adrenergic-mediated phosphatidylinositol hydrolysis in rat neocortex.

    abstract：:Adrenergic-stimulated phosphatidylinositol (PI) hydrolysis was measured in cortical slices obtained from adult rats following electroconvulsive seizures (ECS). One group of animals received ECS daily for 15 days and a second group received a single ECS. Rats were then sacrificed at intervals of 15 min, 60 min, 4 h, an...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(89)90121-0

    authors： Dubeau F,Sherwin AL

    更新日期：1989-08-01 00:00:00

  • Functional and electrophysiological changes after graded traumatic spinal cord injury in adult rat.

    abstract：:A graded contusion spinal cord injury (SCI) was created in the adult rat spinal cord using the Infinite Horizons (IH) impactor to study the correlation between injury severity and anatomical, behavioral, and electrophysiological outcomes. Adult Fisher rats were equally divided into five groups and received contusion i...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2004.08.026

    authors： Cao Q,Zhang YP,Iannotti C,DeVries WH,Xu XM,Shields CB,Whittemore SR

    更新日期：2005-02-01 00:00:00

  • Postural development in rats.

    abstract：:Mammals adopt a limited number of postures during their day-to-day activities. These stereotyped skeletal configurations are functionally adequate and limit the number of degrees of freedom to be controlled by the central nervous system. The temporal pattern of emergence of these configurations in altricial mammals is...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2006.05.018

    authors： Lelard T,Jamon M,Gasc JP,Vidal PP

    更新日期：2006-11-01 00:00:00

  • Redox regulation of protein misfolding, mitochondrial dysfunction, synaptic damage, and cell death in neurodegenerative diseases.

    abstract：:The loss or injury of neurons associated with oxidative and nitrosative redox stress plays an important role in the onset of various neurodegenerative diseases. Specifically, nitric oxide (NO), can affect neuronal survival through a process called S-nitrosylation, by which the NO group undergoes a redox reaction with ...

    journal_title：Experimental neurology

    pub_type： 杂志文章,评审

    doi：10.1016/j.expneurol.2012.06.032

    authors： Nakamura T,Cho DH,Lipton SA

    更新日期：2012-11-01 00:00:00

  • Targeting deficiencies in mitochondrial respiratory complex I and functional uncoupling exerts anti-seizure effects in a genetic model of temporal lobe epilepsy and in a model of acute temporal lobe seizures.

    abstract：:Mitochondria actively participate in neurotransmission by providing energy (ATP) and maintaining normative concentrations of reactive oxygen species (ROS) in both presynaptic and postsynaptic elements. In human and animal epilepsies, ATP-producing respiratory rates driven by mitochondrial respiratory complex (MRC) I a...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2013.11.005

    authors： Simeone KA,Matthews SA,Samson KK,Simeone TA

    更新日期：2014-01-01 00:00:00

  • Dysfunctional hippocampal inhibition in the Ts65Dn mouse model of Down syndrome.

    abstract：:GABAergic dysfunction is implicated in hippocampal deficits of the Ts65Dn mouse model of Down syndrome (DS). Since Ts65Dn mice overexpress G-protein coupled inward-rectifying potassium (GIRK2) containing channels, we sought to evaluate whether increased GABAergic function disrupts the functioning of hippocampal circui...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2011.11.033

    authors： Best TK,Cramer NP,Chakrabarti L,Haydar TF,Galdzicki Z

    更新日期：2012-02-01 00:00:00

  • Theophylline treatment improves mitochondrial function after upper cervical spinal cord hemisection.

    abstract：:The importance of mitochondria in spinal cord injury has mainly been attributed to their participation in apoptosis at the site of injury. But another aspect of mitochondrial function is the generation of more than 90% of cellular energy in the form of ATP, mediated by the oxidative phosphorylation (OxPhos) process. C...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2010.01.020

    authors： Hüttemann M,Nantwi KD,Lee I,Liu J,Mohiuddin S,Petrov T

    更新日期：2010-06-01 00:00:00

  • MK-801 does not attenuate immediate-early gene expression following an amygdala afterdischarge.

    abstract：:It has been suggested that the increased transient expression of immediate-early gene transcription factors seen in nerve cells following an afterdischarge may initiate longer lasting or permanent changes in gene expression which underly the development of kindling. Since the development of kindling is sensitive to ph...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1994.1137

    authors： Hughes P,Singleton K,Dragunow M

    更新日期：1994-08-01 00:00:00

  • Mutations in familial Creutzfeldt-Jakob disease and Gerstmann-Sträussler-Scheinker's syndrome.

    abstract：:A host protein encoded by the gene specifying the scrapie amyloid precursor affects pathogenesis of the transmissible spongiform encephalopathies: Creutzfeldt-Jakob disease (CJD), Gerstmann-Sträussler-Scheinker's syndrome (GSS), and kuru in man, and scrapie in animals. We found a mutation in this gene of two patients ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(89)90095-2

    authors： Goldgaber D,Goldfarb LG,Brown P,Asher DM,Brown WT,Lin S,Teener JW,Feinstone SM,Rubenstein R,Kascsak RJ

    更新日期：1989-11-01 00:00:00

  • Transient up-regulation of retinal EphA3 and EphA5, but not ephrin-A2, coincides with re-establishment of a topographic map during optic nerve regeneration in goldfish.

    abstract：:Eph tyrosine kinase receptors and their ligands, the ephrins, play a key role in the establishment of retinotectal topography during development. Tectal up-regulation of ephrin-A2 in goldfish, coincident with the reestablishment of a retinotectal map, suggests a similar role during optic nerve regeneration. Here we re...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/s0014-4886(03)00211-5

    authors： King CE,Wallace A,Rodger J,Bartlett C,Beazley LD,Dunlop SA

    更新日期：2003-10-01 00:00:00

  • The neurotoxicity of amphetamines: bridging drugs of abuse and neurodegenerative disorders.

    abstract：:Amphetamine derivatives are the most commonly abused drugs. These compounds have been known for many years to induce neurotoxicity. However, recent findings have highlighted novel alterations produced by amphetamines in the central nervous system consisting of neuronal inclusions and the involvement of proteins belong...

    journal_title：Experimental neurology

    pub_type： 杂志文章,评审

    doi：10.1016/j.expneurol.2006.02.130

    authors： Iacovelli L,Fulceri F,De Blasi A,Nicoletti F,Ruggieri S,Fornai F

    更新日期：2006-09-01 00:00:00

  • Hippocampal metabolic proteins are modulated in voluntary and treadmill exercise rats.

    abstract：:Systematic protein expression studies in the brain of exercising and sedentary animals have not been carried out so far and it was therefore decided to determine differences in metabolic protein levels in rat hippocampus of sedentary, voluntary and involuntary exercising rats by a proteomic approach. Aged, male Spragu...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2008.03.014

    authors： Kirchner L,Chen WQ,Afjehi-Sadat L,Viidik A,Skalicky M,Höger H,Lubec G

    更新日期：2008-07-01 00:00:00

  • Neurotropism of nerve growth factor for adult rat septal cholinergic axons in vivo.

    abstract：:Nerve growth factor (NGF) can induce sprouting of axotomized adult rat medial septum cholinergic neurons and promote their regeneration into septohippocampal nerve grafts and hippocampal formation. This study investigated the potential neurotropic (chemotactic/attracting) action of NGF in the adult rat cholinergic sep...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1993.1005

    authors： Hagg T,Varon S

    更新日期：1993-01-01 00:00:00

  • Differences in kindling development in seven outbred and inbred rat strains.

    abstract：:The kindling phenomenon, i.e., the progressive development of focal and secondarily generalized seizures upon repeated electrical stimulation of a limbic brain region, occurs in various species, but with marked differences in kindling rate between species and also within the same species. In rats, differences in kindl...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1998.6948

    authors： Löscher W,Cramer S,Ebert U

    更新日期：1998-12-01 00:00:00

  • Kynurenine aminotransferase in the supratentorial dura mater of the rat: effect of stimulation of the trigeminal ganglion.

    abstract：:Electrical stimulation of the trigeminal ganglion has been widely used as a model of nociception, characterizing migraine. This treatment is known to evoke release of neuropeptides and neurotransmitters from nerve fibers of the dura mater. On the basis of immunocytochemical investigations, we found that under normal c...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2003.12.001

    authors： Knyihár-Csillik E,Chadaide Z,Okuno E,Krisztin-Péva B,Toldi J,Varga C,Molnár A,Csillik B,Vécsei L

    更新日期：2004-04-01 00:00:00

  • Transplantation of porcine umbilical cord matrix cells into the rat brain.

    abstract：:Immune rejection of transplanted material is a potential complication of organ donation. In response to tissue transplantation, immune rejection has two components: a host defense directed against the grafted tissue and an immune response from the grafted tissue against the host (graft vs host disease). To treat immun...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/s0014-4886(03)00128-6

    authors： Weiss ML,Mitchell KE,Hix JE,Medicetty S,El-Zarkouny SZ,Grieger D,Troyer DL

    更新日期：2003-08-01 00:00:00

  • Mechanisms of decreased cholinergic arousal in focal seizures: In vivo whole-cell recordings from the pedunculopontine tegmental nucleus.

    abstract：:Focal limbic seizures often impair consciousness/awareness with major negative impact on quality of life. Recent work has shown that limbic seizures depress brainstem arousal systems, including reduced action potential firing in a key node: cholinergic neurons of the pedunculopontine tegmental nucleus (PPT). In vivo w...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2018.11.008

    authors： Andrews JP,Yue Z,Ryu JH,Neske G,McCormick DA,Blumenfeld H

    更新日期：2019-04-01 00:00:00