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Repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex and cortical excitability in patients with major depressive disorder.

Abstract：

:Repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex is a relatively non-invasive technique with putative therapeutic effects in major depression. However, the exact neurophysiological basis of these effects needs further clarification. Therefore, we studied the impact of ten daily sessions of left, dorsolateral prefrontal rTMS on motor cortical excitability, as revealed by transcranial magnetic stimulation-elicited motor-evoked potentials in 30 patients. As compared to the non-responders, responders (33%) showed changes in parameters pointing towards a reduced cortical excitability. These results suggest that repetitive transcranial magnetic stimulation of the dorsolateral, prefrontal cortex may have inhibitory effects on motor cortical neuronal excitability in patients with major depressive disorder. Furthermore, measurement of motor cortical excitability may be a useful tool for investigating and monitoring inhibitory brain effects of antidepressant stimulation techniques like rTMS.

journal_name

Exp Neurol

journal_title

Experimental neurology

authors

Bajbouj M,Brakemeier EL,Schubert F,Lang UE,Neu P,Schindowski C,Danker-Hopfe H

doi

10.1016/j.expneurol.2005.08.008

keywords:

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

332-8

issue

2

eissn

0014-4886

issn

1090-2430

pii

S0014-4886(05)00283-9

journal_volume

196

pub_type

临床试验,杂志文章

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