Abstract：
:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by selective motor neuron degeneration in the motor cortex, brainstem and spinal cord. It is generally accepted that ALS is caused by death of motor neurons, however the exact temporal cascade of degenerative processes is not yet completely known. To identify the early pathological changes in spinal cord of G93A-SOD1 ALS mice we performed a comprehensive longitudinal analysis employing diffusion-tensor magnetic resonance imaging alongside histology and electron microscopy, in parallel with peripheral nerve histology. We showed the gradient of degeneration appearance in spinal cord white and gray matter, starting earliest in the ventral white matter, due to a cascade of pathological events including axon dysfunction and mitochondrial changes. Notably, we found that even the main sensory regions are affected by the neurodegenerative process at symptomatic disease phase. Overall our results attest the applicability of DTI in determining disease progression in ALS mice. These findings suggest that DTI could be potentially adapted in humans to aid the assessment of ALS progression and eventually the evaluation of treatment efficacy.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Marcuzzo S,Bonanno S,Figini M,Scotti A,Zucca I,Minati L,Riva N,Domi T,Fossaghi A,Quattrini A,Galbardi B,D'Alessandro S,Bruzzone MG,García-Verdugo JM,Moreno-Manzano V,Mantegazza R,Bernasconi Pdoi
10.1016/j.expneurol.2017.03.018subject
Has Abstractpub_date
2017-07-01 00:00:00pages
43-52eissn
0014-4886issn
1090-2430pii
S0014-4886(17)30078-Xjournal_volume
293pub_type
杂志文章abstract：:Adrenergic-stimulated phosphatidylinositol (PI) hydrolysis was measured in cortical slices obtained from adult rats following electroconvulsive seizures (ECS). One group of animals received ECS daily for 15 days and a second group received a single ECS. Rats were then sacrificed at intervals of 15 min, 60 min, 4 h, an...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(89)90121-0
更新日期：1989-08-01 00:00:00
abstract：:GABAergic dysfunction is implicated in hippocampal deficits of the Ts65Dn mouse model of Down syndrome (DS). Since Ts65Dn mice overexpress G-protein coupled inward-rectifying potassium (GIRK2) containing channels, we sought to evaluate whether increased GABAergic function disrupts the functioning of hippocampal circui...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2011.11.033
更新日期：2012-02-01 00:00:00
abstract：:The beta-Amyloid peptide (A beta) is hypothesized to mediate the neurodegeneration seen in Alzheimer's disease. Recently, we proposed a new hypothesis to explain the toxicity of A beta based on the free-radical generating capacity of A beta. We have recently demonstrated using electron paramagnetic resonance (EPR) spe...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(95)90041-1
更新日期：1995-02-01 00:00:00
abstract：:Neural progenitor cells (NPCs) grafted to sites of spinal cord injury (SCI) extend numerous axons over long distances and form new synaptic connections with host neurons. In the present study we examined the myelination of axons emerging from NPC grafts. Rat embryonic day 14 (E14) multipotent NPCs constitutively expre...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2017.07.005
更新日期：2017-10-01 00:00:00
abstract：:Decreases in energy metabolism following traumatic brain injury (TBI) are attributed to impairment of glycolytic flux and oxidative phosphorylation. Glucose utilization post-TBI is decreased while administration of alternative substrates has been shown to be neuroprotective. Changes in energy metabolism following TBI ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2020.113289
更新日期：2020-07-01 00:00:00
abstract：:Convection-enhanced delivery has recently entered the clinic and represents a promising new therapeutic option in the field of neurodegenerative diseases and treatment of brain tumors. Understanding of the principles governing delivery and flow of macromolecules within the CNS is still poorly understood and requires m...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2005.07.009
更新日期：2005-11-01 00:00:00
abstract：:Nerve growth factor (NGF) can induce sprouting of axotomized adult rat medial septum cholinergic neurons and promote their regeneration into septohippocampal nerve grafts and hippocampal formation. This study investigated the potential neurotropic (chemotactic/attracting) action of NGF in the adult rat cholinergic sep...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1993.1005
更新日期：1993-01-01 00:00:00
abstract：:Multiple system atrophy (MSA) is a rare neurodegenerative disease of undetermined cause manifesting with progressive autonomic failure (AF), cerebellar ataxia and parkinsonism due to neuronal loss in multiple brain areas associated with (oligodendro)glial cytoplasmic alpha-synuclein (alpha SYN) inclusions (GCIs). Usin...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2010.05.008
更新日期：2010-08-01 00:00:00
abstract：:One of the primary hallmarks of glutamate excitotoxicity is degradation of the neuronal cytoskeleton. Using a tissue culture approach, we have investigated the relationship between excitotoxicity and cytoskeletal degradation within axons, with particular reference to the axon specific neurofilament proteins. Neurofila...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2005.01.005
更新日期：2005-06-01 00:00:00
abstract：:Excitotoxic mechanisms may play a critical role in the pathophysiology of several neurological and psychiatric diseases. Excitatory amino acid receptor antagonists are therefore of great therapeutic interest, but untoward side effects often prevent their clinical use. Targeting the glycine coagonist site of the (NMDA)...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1999.7284
更新日期：2000-05-01 00:00:00
abstract：:Bilateral lesions of the ventromedial nucleus of the hypothalamus (VMN) significantly attentuated lordosis behavior in the female rat. The degree of this deficit was significantly correlated with the amount of damage to the VMN. There was no improvement in lordosis performance even after an extended recovery period. ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(83)90035-3
更新日期：1983-03-01 00:00:00
abstract：:The pro-inflammatory cytokine tumor necrosis factor-alpha (TNF) is involved in injury-induced peripheral nerve pathology and in the generation of neuropathic pain. Here, we investigated local protein levels of the two known TNF receptors, TNF receptor 1 and 2 (TNFR1, TNFR2), on days 0, 1, 3, 7, 14, and 28 after unilat...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2004.11.002
更新日期：2005-03-01 00:00:00
abstract：:Inflammation plays a central role in the development of numerous disorders of the central nervous system (CNS) such as multiple sclerosis (MS). For a long time it was assumed that recruitment of macrophages into the CNS and breakdown of the blood-brain barrier (BBB) are closely linked. In the present study we challeng...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2009.08.027
更新日期：2009-11-01 00:00:00
abstract：:The question of whether or not the development of dystrophic muscles is similar to that of normal muscles, prior to the manifestations of the symptoms of the disease, is investigated here. The developmental change in the activity of succinate dehydrogenase was therefore measured in individual fibers of prospectively d...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(87)90020-3
更新日期：1987-01-01 00:00:00
abstract：:Regeneration of axons in the peripheral nervous system is enhanced by the removal of glycosaminoglycan side chains (GAGs) of chondroitin sulfate proteoglycans. However, some axons regenerate poorly despite such treatment, suggesting the existence of additional inhibitors. We compared the effects of enzymatic removal o...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2005.04.007
更新日期：2005-10-01 00:00:00
abstract：:Five subjects matched the force of a sustained isometric contraction with a contraction of the contralateral muscle. Estimates of the sustained constant forces increased with time despite the direction to disregard the increased effort associated with the fatiguing contraction. These instructions did not produce a not...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(83)90278-9
更新日期：1983-08-01 00:00:00
abstract：:It has been reported that the severe cerebral edema produced in experimental animals by Clostridium perfringens (Cl p) type D epsilon toxin can be prevented by prior treatment with its precursor prototoxin due to competitive binding to endothelial cells (ECs) at the blood-brain barrier (BBB). In this study we investig...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2001.7652
更新日期：2001-05-01 00:00:00
abstract：:The possible pain inhibitory effects of periaqueductal gray (PAG) stimulation were investigated in cats anesthetized with Nembutal and immobilized with Flaxedil. Unitary responses evoked by electrical stimulation of the upper canine dentine and by cutaneous facial noxious and nonnoxious stimuli were recorded extracell...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(83)90155-3
更新日期：1983-07-01 00:00:00
abstract：:Parkinson's Disease (PD) is the most common neurodegenerative movement disorder. Autosomal-recessive mutations in the mitochondrial protein kinase PINK1 (PTEN-induced kinase 1) account for 1-2% of the hereditary early-onset cases. To study the mechanisms underlying disease development, we generated Pink1-deficient mic...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2012.01.002
更新日期：2012-05-01 00:00:00
abstract：:We report on a 41-year old woman with prolonged comatose unresponsiveness following traumatic head injury. Structural MRI showed bilateral midbrain damage and ventriculomegalia. Functional MRI revealed robust cortical responses to visual, auditory and tactile stimulation. Speech stimuli moreover consistently elicited ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2008.08.007
更新日期：2008-12-01 00:00:00
abstract：:The effect of sinusoidal magnetic field stimulation on regeneration of the rat sciatic nerve was studied. Rats were exposed, after crush lesioning of the nerve, between a pair of Helmholtz coils to a 50 Hz magnetic field of 0.2 mT or 0.4 mT, respectively. Regeneration of the sciatic nerve was measured by the "pinch te...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(91)90132-v
更新日期：1991-06-01 00:00:00
abstract：:RNA interference appears to have a great potential not only as an in vitro target validation, but also as a novel therapeutic strategy based on the highly specific and efficient silencing of a target gene. We hypothesize that MMP-9 siRNA can be effective as an MMP-9 protein inhibitor in a rat focal ischemia model. Mal...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2008.11.007
更新日期：2009-03-01 00:00:00
abstract：:Activation of GABA(A) receptors by GABA causes phasic and tonic conductances in different brain areas. In the ventrobasal (VB) thalamus, tonic inhibition originates from GABA acting on extrasynaptic receptors. Here we show that dopamine (DA), the D2-like agonist quinpirole and the selective D4R agonist PD-168,077 decr...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2013.03.023
更新日期：2013-09-01 00:00:00
abstract：:Studies of the effects of lesions of the parietal cortex suggest that this region plays a critical role in visuomotor guidance, whereas experiments on the effects of disconnecting this region from visual input have been inconsistent in supporting this hypothesis. In the present experiment, monkeys with a unilateral oc...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(83)90161-9
更新日期：1983-07-01 00:00:00
abstract：:The cellular events in traumatic brain injury (TBI) are complicated, and the factors mediating neurotrophins to protect and repair the injured brain cells are only beginning to be identified. This study examined the effect of dexamethasone (DEX) on neurotrophin-3 (NT-3) expression following TBI. Levels of NT-3 mRNA an...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2004.12.023
更新日期：2005-04-01 00:00:00
abstract：:Nerve growth factor (NGF) is well known to be involved in the development, survival, and maintenance of sympathetic and neural crest-derived sensory neurons in the peripheral nervous system. Over the last 10-15 years, however, the role of NGF as a necessary trophic substrate for magnocellular cholinergic neurons in th...
journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1016/0014-4886(88)90231-2
更新日期：1988-12-01 00:00:00
abstract：:It has been >20 years since studies first revealed that the brain is insulin sensitive, highlighted by the expression of insulin receptors in neurons and glia, the presence of circulating brain insulin, and even localized insulin production. Following these discoveries, evidence of decreased brain insulin receptor num...
journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1016/j.expneurol.2018.12.007
更新日期：2019-03-01 00:00:00
abstract：:Extracellular unit activity from 29 neurons in the preoptic area was recorded together with the cortical EEG in encéphale isolé cats. A majority (55%) of neurons showed alterations in their firing rates during transient changes in the EEG. Among them, a majority (62.5%) showed an increased firing rate during synchroni...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(83)90328-x
更新日期：1983-09-01 00:00:00
abstract：:Ascending and descending spinal cord potentials were recorded during conduction block produced by compression and ischemia to the spinal cord of cats. Dorsally and ventrally applied compression produced proportional changes in both ascending and descending potentials. Results for induced ischemia were much more variab...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(83)90303-5
更新日期：1983-06-01 00:00:00
abstract：:Regeneration in the peripheral nervous system offers unique opportunities and challenges to medicine. Compared to the central nervous system, peripheral axons can and do regenerate resulting in functional recovery, especially if the distance to target is short as in distal limb injuries. However, this regenerative cap...
journal_title：Experimental neurology
pub_type： 社论
doi：10.1016/j.expneurol.2009.12.001
更新日期：2010-05-01 00:00:00
