Abstract:
:The cellular events in traumatic brain injury (TBI) are complicated, and the factors mediating neurotrophins to protect and repair the injured brain cells are only beginning to be identified. This study examined the effect of dexamethasone (DEX) on neurotrophin-3 (NT-3) expression following TBI. Levels of NT-3 mRNA and protein in rat hippocampus were measured using in situ hybridization and immunohistochemistry, respectively. After TBI, the NT-3 mRNA expression was down-regulated during the first 24 h. DEX reversed the post-traumatic reduction of NT-3 mRNA expression at 2, 4, 6, and 12 h in the hippocampus, and also decreased the cell death in hippocampal hilum and supraventricular cerebral cortex after 7 days. The NT-3 protein levels generally corresponded to the mRNA levels in the hippocampal region. DEX enhanced the NT-3 expression after TBI, indicating that post-traumatic neuroprotection in the hippocampus is at least partially mediated by NT-3 and thus can be modulated by DEX treatment.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Yang JT,Lee TH,Weng HH,Chang CN,Chen WC,Cheng WC,Wu JHdoi
10.1016/j.expneurol.2004.12.023keywords:
subject
Has Abstractpub_date
2005-04-01 00:00:00pages
437-43issue
2eissn
0014-4886issn
1090-2430pii
S0014-4886(05)00002-6journal_volume
192pub_type
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