Abstract:
:Five subjects matched the force of a sustained isometric contraction with a contraction of the contralateral muscle. Estimates of the sustained constant forces increased with time despite the direction to disregard the increased effort associated with the fatiguing contraction. These instructions did not produce a noticeable dissociation between effort and achieved force during fatigue as had previously been reported during paresis and tendon vibration.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Jones LAdoi
10.1016/0014-4886(83)90278-9subject
Has Abstractpub_date
1983-08-01 00:00:00pages
497-503issue
2eissn
0014-4886issn
1090-2430pii
0014-4886(83)90278-9journal_volume
81pub_type
杂志文章abstract::Tamoxifen-induced mutagenesis via the so-called CreER(T2) fusion enzyme is a key technology for the inducible gene knockout in the adult murine brain. However, it requires a subchronic transient treatment with high doses of the non-selective estrogen receptor antagonist tamoxifen. It has been shown earlier that acute ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2007.12.012
更新日期:2008-05-01 00:00:00
abstract::Pituitary adenylate cyclase activating polypeptide (PACAP) has neuroprotective effects against ischemia, even when given by intravenous (iv) administration 24 h after stroke. Transport of PACAP across the blood-brain barrier (BBB) by peptide transport system (PTS)-6 underlies its effectiveness after iv administration....
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2004.09.013
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Medial forebrain bundle (MFB) deep brain stimulation (DBS) has anti-depressant effects clinically and in depression models. Currently, therapeutic mechanisms of MFB DBS or how stimulation parameters acutely impact neurotransmitter release, particularly dopamine, are unknown. Experimentally, MFB DBS has been ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2020.113224
更新日期:2020-05-01 00:00:00
abstract::Ghrelin, a 28-amino acid peptide, is an endogenous ligand for the growth hormone secretagogue (GHS) receptor. Our previous data showed that ghrelin could inhibit apoptosis in Parkinson's disease (PD) models both in vitro and in vivo. There is now growing evidence that oxidative stress has a critical role in the etiolo...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2009.11.009
更新日期:2010-03-01 00:00:00
abstract::The sciatic nerve of the rat is a commonly used model for studies on nerve injury, regeneration, and recovery of function. To interpret the changes that occur in a neuron population subsequent to peripheral nerve injury, and to compare different repair procedures, it is essential to have a complete and accurate unders...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(86)90161-5
更新日期:1986-07-01 00:00:00
abstract::A new procedure was developed for ablating the mammillary nuclei in nonhuman primates via direct visual exposure. Using this technique, monkeys receiving lesions of the mammillary nuclei were compared to control animals after surgery to assess the retention of preoperatively acquired visuospatial discriminations and s...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(83)90160-7
更新日期:1983-07-01 00:00:00
abstract::Adult mammalian retinal ganglion cells (RGCs) can regenerate through peripheral nerve (PN) grafts and innervate central nervous system (CNS) targets. Previous studies have demonstrated a basic level of differentiation of such projections. To further assess the specificity and functionality of regenerated CNS connectio...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1997.6495
更新日期:1997-08-01 00:00:00
abstract::The tachykinin neuropeptides acting at NK3 receptors affect mean arterial pressure (MAP) through both neuroendocrine and neural mechanisms. NK3 receptors are found in brainstem nuclei that mediate the baroreflex, but the effects of NK3 receptor stimulation on baroreflex function are unknown. The present study tests th...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2004.12.011
更新日期:2005-05-01 00:00:00
abstract::Mechanisms underlying affective and cognitive deficits in Parkinson's disease (PD) remain less studied than motor symptoms. Nucleus accumbens (NAc) is affected in PD and due to its well-known involvement in motivation is an interesting target in this context. Furthermore, PD is frequently asymmetrical, with side-speci...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2020.113221
更新日期:2020-05-01 00:00:00
abstract::The competence of neurons to regenerate depends on their ability to initiate a program of gene expression supporting growth and on the growth-permissive properties of glial cells in the distal stump of the injured nerve. Most studies on intrinsic molecular mechanisms governing peripheral nerve regeneration have focuss...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1998.6886
更新日期:1998-10-01 00:00:00
abstract::Peripheral neuropathy (PN) is a debilitating and dose-limiting side effect of treatment with the chemotherapeutic agent, paclitaxel. Understanding the effects of paclitaxel on sensory neuronal function and the signaling pathways which mediate these paclitaxel-induced changes in function are critical for the developmen...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2013.12.011
更新日期:2014-03-01 00:00:00
abstract::The pro-inflammatory cytokine tumor necrosis factor-alpha (TNF) is involved in injury-induced peripheral nerve pathology and in the generation of neuropathic pain. Here, we investigated local protein levels of the two known TNF receptors, TNF receptor 1 and 2 (TNFR1, TNFR2), on days 0, 1, 3, 7, 14, and 28 after unilat...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2004.11.002
更新日期:2005-03-01 00:00:00
abstract::The alpha-secretase-derived form of the amyloid precursor protein (sAPPalpha), which is released from neurons in an activity-dependent manner, has been shown to promote long-term survival of hippocampal and cortical neurons in culture and can protect those neurons against excitotoxic and ischemic injury in culture and...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.2002.7920
更新日期:2002-06-01 00:00:00
abstract::A single fourth lumbar dorsal rootlet was transected at the entry point into the spinal cord. The nerve fibres were labelled with biotin dextran injected into the rootlet. An endogenous matrix containing olfactory-ensheathing cells (OECs) labelled with green fluorescent protein was applied to the opposing cut surfaces...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2004.04.021
更新日期:2004-08-01 00:00:00
abstract::The amount of myelination in vivo and in vitro depends on the number of oligodendrocyte progenitors, their differentiation, and on the neuron function. It has been shown that continuous administration of FGF2, a mitotic and neuroprotective factor, allows oligodendrocyte progenitors to proliferate, but prevents them fr...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/s0014-4886(02)00053-5
更新日期:2003-05-01 00:00:00
abstract::Genetic and protein studies have indicated abnormalities in alpha-synuclein in neurodegenerative diseases. However, the developmental localization and cellular role of synuclein isoforms is contentious. We investigated the cellular localization of alpha-, beta-, and gamma-synuclein in developing cultured rat neurons a...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/s0014-4886(03)00108-0
更新日期:2003-07-01 00:00:00
abstract::Mismatches between tissue perfusion-weighted imaging (PWI; an index of blood flow deficit) and cellular diffusion-weighted imaging (DWI; an index of tissue injury) provide information on potentially salvageable penumbra tissue in focal stroke and can identify "treatable" stroke patients. The present pre-clinical studi...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2008.03.011
更新日期:2008-07-01 00:00:00
abstract::In the embryonic brain, the transcription factor Nkx2.1 is localized in the medial ganglionic eminence and the ventromedial part of the hypothalamus. In the present study, we examined the development of mesencephalic dopamine (DA) neuron system in mice lacking Nkx2.1. In normal mice, tyrosine hydroxylase-immunoreactiv...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/s0014-4886(03)00030-x
更新日期:2003-07-01 00:00:00
abstract::Long-term levodopa or dopamine agonist treatment in the MPTP-lesioned primate model of Parkinson's disease elicits dyskinesia, which is phenotypically similar to levodopa-induced dyskinesia in patients with Parkinson's disease. AMPA receptor antagonists have previously been shown to have both anti-parkinsonian and ant...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.2001.7854
更新日期:2002-03-01 00:00:00
abstract::Breathing is a life-sustaining behavior that in mammals is accomplished by activation of dedicated muscles responsible for inspiratory and expiratory forces acting on the lung and chest wall. Motor control is exerted by specialized pools of motoneurons in the medulla and spinal cord innervated by projections from mult...
journal_title:Experimental neurology
pub_type: 杂志文章,评审
doi:10.1016/j.expneurol.2016.09.014
更新日期:2017-01-01 00:00:00
abstract::Noradrenergic input to the rat substantia innominata (SI) was analyzed in this study by immunocytochemical localization of dopamine beta-hydroxylase (DBH), the synthetic enzyme for noradrenaline. DBH immunoreactive (DBH+) axons ramified extensively within the SI and appeared to be contiguous with the DBH+ terminal fie...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/s0014-4886(89)80002-0
更新日期:1989-05-01 00:00:00
abstract::Injection of lysosomal enzyme into cisternal or ventricular cerebrospinal fluid (CSF) has been carried out in 11 lysosomal storage disorder models, with each study demonstrating reductions in primary substrate and secondary neuropathological changes, and several reports of improved neurological function. Whilst acute ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2014.09.008
更新日期:2015-01-01 00:00:00
abstract::This study reevaluated the possibility of using predegenerated nerves as donor nerve allografts for nerve repair and compared the results of functional recovery to those obtained after standard, fresh nerve allograft repair. Twenty donor rats underwent a ligature/ section of the left sciatic nerve 4 weeks before nerve...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1997.6667
更新日期:1997-11-01 00:00:00
abstract::Excitotoxic mechanisms may play a critical role in the pathophysiology of several neurological and psychiatric diseases. Excitatory amino acid receptor antagonists are therefore of great therapeutic interest, but untoward side effects often prevent their clinical use. Targeting the glycine coagonist site of the (NMDA)...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1999.7284
更新日期:2000-05-01 00:00:00
abstract::Spectral analysis is a mathematical method which contains and generalizes frequency analysis. The form of spectral analysis most applicable to EEG is tutorially presented, using both algebraic formulae and four simplified illustrative examples. The examples are each converted into an autocorrelogram and auto-spectrogr...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(63)90042-6
更新日期:1963-08-01 00:00:00
abstract::Physiological/anatomical studies of rat frontal cortex in vitro have distinguished subpopulations of gamma-aminobutyric acid (GABA)-expressing inhibitory interneurons defined by expression of the calcium-binding proteins, parvalbumin (PV) and calbindin (CA). Using a novel 2DG/immunostaining technique to double-label h...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1997.6426
更新日期:1997-05-01 00:00:00
abstract::Cannabis abuse may precipitate the onset of schizophrenia and a dysfunction of the endocannabinoid system may be involved in the pathology of schizophrenia. Nevertheless, only few studies have addressed the neurobiological consequences of cannabis abuse for the development and course of schizophrenia. We measured the ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2007.02.004
更新日期:2007-05-01 00:00:00
abstract::Subcortical deafferentation of the rat hippocampus has been suggested to offer a model for developing limbic epilepsy. In the present study, the long-term effect of fimbria-fornix lesioning on the density and distribution of hippocampal N-methyl-D-aspartate (NMDA)-sensitive L-[3H]glutamate binding was studied using qu...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1993.1086
更新日期:1993-06-01 00:00:00
abstract::Intercostal muscle tendon organs have an inhibitory effect on the medullary neurons driving all inspiratory muscles, and on a subpopulation of medullary bulbospinal expiratory neurons. Results from this study showed that the activity of expiratory related neurons in the region of the retrofacial nucleus (Botzinger com...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90129-4
更新日期:1987-09-01 00:00:00
abstract::Immune rejection of transplanted material is a potential complication of organ donation. In response to tissue transplantation, immune rejection has two components: a host defense directed against the grafted tissue and an immune response from the grafted tissue against the host (graft vs host disease). To treat immun...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/s0014-4886(03)00128-6
更新日期:2003-08-01 00:00:00