Abstract:
:The tachykinin neuropeptides acting at NK3 receptors affect mean arterial pressure (MAP) through both neuroendocrine and neural mechanisms. NK3 receptors are found in brainstem nuclei that mediate the baroreflex, but the effects of NK3 receptor stimulation on baroreflex function are unknown. The present study tests the effects of intraventricular injections of senktide, a selective NK3 receptor agonist, on the sensitivity of the baroreflex in three stains of rats: Charles River Laboratory, Long-Evans, and Brattleboro rats, which lack the ability to synthesize vasopressin. Rats with lateral ventricle cannulas were administered injections of isotonic saline, 100 ng, or 200 ng senktide, and 5 min later arterial baroreceptor-heart rate (HR) function was examined by constructing full-range blood pressure-HR curves using alternating doses (5-20 microg kg min) of phenylephrine and nitroprusside to raise and decrease blood pressure approximately 50 mm Hg over a period of 1 min, respectively. Intraventricular injections of 200 ng senktide had no significant effect on baseline MAP, but significantly decreased the gain of the baroreflex in all three rat strains whereas the 100 ng dose had no effect on the baroreflex. These results show that NK3 receptor stimulation modulates the baroreflex that is independent of any action of vasopressin.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Flynn FWdoi
10.1016/j.expneurol.2004.12.011keywords:
subject
Has Abstractpub_date
2005-05-01 00:00:00pages
118-24issue
1eissn
0014-4886issn
1090-2430pii
S0014-4886(04)00496-0journal_volume
193pub_type
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journal_title:Experimental neurology
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doi:10.1016/0014-4886(83)90229-7
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pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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journal_title:Experimental neurology
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journal_title:Experimental neurology
pub_type: 杂志文章
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journal_title:Experimental neurology
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更新日期:2007-09-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
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journal_title:Experimental neurology
pub_type: 杂志文章
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更新日期:1995-03-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
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journal_title:Experimental neurology
pub_type: 杂志文章
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journal_title:Experimental neurology
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pub_type: 评论,杂志文章,评审
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pub_type: 杂志文章
doi:10.1016/0014-4886(95)90065-9
更新日期:1995-03-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2017.02.005
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(91)90118-v
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1998.6951
更新日期:1998-12-01 00:00:00
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journal_title:Experimental neurology
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journal_title:Experimental neurology
pub_type: 杂志文章
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更新日期:2012-05-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90098-7
更新日期:1987-08-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
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更新日期:1988-08-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
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更新日期:2005-01-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2014.10.009
更新日期:2015-01-01 00:00:00
abstract::Secondary degeneration is a form of 'bystander' damage that can affect neural tissue both nearby and remote from an initial injury. Partial optic nerve transection is an excellent model in which to unequivocally differentiate events occurring during secondary degeneration from those resulting from primary CNS injury. ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2008.11.026
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