Enhanced functional recovery after proximal nerve root injury by vector-mediated gene transfer.

abstract：:The precise mechanisms underlying the efficacy of intravenous immunoglobulin (IVIg) in autoimmune neurological disorders including Guillain-Barré syndrome (GBS) are not known. Anti-ganglioside antibodies have been reported to be pathogenic in some variants of GBS, and we have developed passive transfer animal models t...

journal_title：Experimental neurology

authors： Zhang G,Massaad CA,Gao T,Pillai L,Bogdanova N,Ghauri S,Sheikh KA

更新日期：2016-08-01 00:00:00

abstract：:Whereas quite a number of previous reports have shown that the developing brain is vulnerable to protein deprivation, the mature CNS is usually considered resistant to this condition. To explore this assumption the present experimental model was built on groups of 2-month-old rats fed with a low-protein diet (8% casei...

journal_title：Experimental neurology

authors： Paula-Barbosa MM,Andrade JP,Castedo JL,Azevedo FP,Camões I,Volk B,Tavares MA

更新日期：1989-02-01 00:00:00

abstract：:Unit activity related to a go/no-go visual discrimination task was studied in four rhesus monkeys. We recorded 272 task-related cells from frontal cortex in a region extending from the midprincipal sulcus to the central sulcus, and medially to the cingulate sulcus. Units located in anterior regions (dorsolateral prefr...

journal_title：Experimental neurology

authors： Pragay EB,Mirsky AF,Nakamura RK

更新日期：1987-06-01 00:00:00

abstract：:The effect of sinusoidal magnetic field stimulation on regeneration of the rat sciatic nerve was studied. Rats were exposed, after crush lesioning of the nerve, between a pair of Helmholtz coils to a 50 Hz magnetic field of 0.2 mT or 0.4 mT, respectively. Regeneration of the sciatic nerve was measured by the "pinch te...

journal_title：Experimental neurology

authors： Rusovan A,Kanje M

更新日期：1991-06-01 00:00:00

abstract：:Bax, a member of the Bcl-2 gene family, is known to promote apoptosis in many cases but to block cell death under certain conditions. To investigate the potential role of Bax in 6-hydroxydopamine (6-OHDA)-induced cell death, we first established and characterized a dopaminergic neuronal cell line (MN9D) stably overexp...

journal_title：Experimental neurology

authors： Oh JH,Choi WS,Kim JE,Seo JW,O'Malley KL,Oh YJ

更新日期：1998-11-01 00:00:00

abstract：:Levodopa or short-acting dopamine (DA) agonist treatment of advanced parkinsonian patients exposes striatal DA receptors to non-physiologic intermittent stimulation that contributes to the development of dyskinesias and other motor complications. To determine whether continuous dopaminergic stimulation can delay or pr...

journal_title：Experimental neurology

authors： Bibbiani F,Costantini LC,Patel R,Chase TN

更新日期：2005-03-01 00:00:00

abstract：:Peripheral nerve regeneration was studied across a tubulated 10-mm gap in the rat sciatic nerve using histomorphometry and electrophysiological measurements of A-fiber, B-fiber, and C-fiber peaks of the evoked action potentials. Tubes fabricated from large-pore collagen (max. pore diameter, 22 nm), small-pore collagen...

journal_title：Experimental neurology

authors： Chamberlain LJ,Yannas IV,Hsu HP,Strichartz G,Spector M

更新日期：1998-12-01 00:00:00

abstract：:We have previously shown that lesions of the sensorimotor cortex induced by either thermocoagulation or aspiration produce different effects on axonal plasticity. We have now investigated whether these methods of lesion also influence the behavioral outcome. The behavioral effects of unilateral and bilateral lesions o...

journal_title：Experimental neurology

authors： Napieralski JA,Banks RJ,Chesselet MF

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:N,N-dimethyltryptamine (DMT) is an endogenous ligand of the Sigma 1 receptor (Sig-1R) with documented in vitro cytoprotective properties against hypoxia. Our aim was to demonstrate the in vivo neuroprotective effect of DMT following ischemia-reperfusion injury in the rat brain. METHODS:Transient...

journal_title：Experimental neurology

authors： Nardai S,László M,Szabó A,Alpár A,Hanics J,Zahola P,Merkely B,Frecska E,Nagy Z

更新日期：2020-05-01 00:00:00

abstract：:Hemiparkinson-hemiatrophy syndrome (HP-HA) is associated with skeletal hemiatrophy and the later development of parkinsonism. It is generally assumed that this phenotype is due to the combination of dysfunction of the basal ganglia (e.g., substantia nigra compacta and/or other related structures), causing parkinsonism...

journal_title：Experimental neurology

authors： Hebb MO,Lang AE,Fletcher PJ,Chambers JW,Lozano AM

更新日期：2002-10-01 00:00:00

abstract：:A significant proportion of neurologic patients suffer electroencephalographic (EEG) seizures in the acute phase following traumatic or ischemic brain injury, including many without overt behavioral manifestations. Although such nonconvulsive seizures may exacerbate neuropathological processes, they have received limi...

journal_title：Experimental neurology

authors： Hartings JA,Williams AJ,Tortella FC

更新日期：2003-02-01 00:00:00

abstract：:Stimulation of peripheral nerves activates corresponding regions in sensorimotor cortex. We have applied functional magnetic resonance imaging (fMRI) techniques to monitor activated brain regions by means of measuring changes of blood oxygenation level-dependent contrast during electric stimulation of the forepaw, hin...

journal_title：Experimental neurology

authors： Spenger C,Josephson A,Klason T,Hoehn M,Schwindt W,Ingvar M,Olson L

更新日期：2000-12-01 00:00:00

abstract：:Previous two-dimensional (2-D) gel electrophoretic studies of proteins secreted by degenerating mammalian peripheral nerves (Ignatius et al., 1986, Proc. Natl. Acad. Sci. USA 83: 1125-1129; Muller et al., 1986, J. Cell Biol. 102: 393-402) detected the up-regulation of two proteins of 67-70 and 34-37 kDa, although they...

journal_title：Experimental neurology

authors： Golding JP,Tonge D

更新日期：2000-03-01 00:00:00

abstract：:A previous study of our group demonstrated that movement performance induced by dopamine agonist drugs in hemiparkinsonian rats unilaterally lesioned with 6-hydroxydopamine (6-OHDA), governs the occurrence of a sensitized motor response to a subsequent dopaminergic challenge (priming model). In the present study, we e...

journal_title：Experimental neurology

authors： Frau L,Morelli M,Simola N

更新日期：2013-09-01 00:00:00

abstract：:Calcium-independent nitric oxide synthase (NOS) activity has been reported in ischemic brains and usually attributed to the inducible isoform, iNOS. Because calcium-independent mechanisms have recently been shown to regulate the constitutive calcium-dependent NOS, we proposed to confirm the presence of iNOS activity i...

journal_title：Experimental neurology

authors： Lerouet D,Jafarian-Tehrani M,Louin G,Palmier B,Bonnefont-Rousselot D,Plotkine M,Margaill I

更新日期：2005-09-01 00:00:00

abstract：:Mitochondrial dysfunction and pathology that contribute to a host of neurodegenerative diseases are deduced from changes in ultrastructure, routinely examined by a host of optical techniques. We adapted the technique of photon correlation spectroscopy (PCS) to evaluate calcium-induced structural alterations in isolate...

journal_title：Experimental neurology

authors： Lifshitz J,Janmey PA,McIntosh TK

更新日期：2006-02-01 00:00:00

abstract：:Ghrelin has been shown to regulate neurogenesis in the hippocampus. The aim of this study was to investigate the possible influence of ghrelin on cell proliferation and neuroblast formation in the subventricular zone (SVZ) and rostral migratory system (RMS) and generation of interneurons in the olfactory bulb (OB). We...

journal_title：Experimental neurology

authors： Li E,Kim Y,Kim S,Sato T,Kojima M,Park S

更新日期：2014-02-01 00:00:00

abstract：:Adult mammalian retinal ganglion cells (RGCs) can regenerate through peripheral nerve (PN) grafts and innervate central nervous system (CNS) targets. Previous studies have demonstrated a basic level of differentiation of such projections. To further assess the specificity and functionality of regenerated CNS connectio...

journal_title：Experimental neurology

authors： Carter DA,Jhaveri S

更新日期：1997-08-01 00:00:00

abstract：:Targeting interhemispheric inhibition using brain stimulation has shown potential for enhancing stroke recovery. Following stroke, increased inhibition originating from the contralesional hemisphere impairs motor activation in ipsilesional areas. We have previously reported that low-intensity electrical theta burst st...

journal_title：Experimental neurology

authors： Boddington LJ,Gray JP,Schulz JM,Reynolds JNJ

更新日期：2020-01-01 00:00:00

abstract：:Traumatic brain injury (TBI) affects millions of individuals every year. Many of these injuries lead to lasting effects, particularly impairments in domains broadly classified as executive functions, such as impulse control and decision-making. While these impairments have been historically associated with frontal bra...

journal_title：Experimental neurology

authors： Ozga-Hess JE,Whirtley C,O'Hearn C,Pechacek K,Vonder Haar C

更新日期：2020-05-01 00:00:00

abstract：:A host protein encoded by the gene specifying the scrapie amyloid precursor affects pathogenesis of the transmissible spongiform encephalopathies: Creutzfeldt-Jakob disease (CJD), Gerstmann-Sträussler-Scheinker's syndrome (GSS), and kuru in man, and scrapie in animals. We found a mutation in this gene of two patients ...

journal_title：Experimental neurology

authors： Goldgaber D,Goldfarb LG,Brown P,Asher DM,Brown WT,Lin S,Teener JW,Feinstone SM,Rubenstein R,Kascsak RJ

更新日期：1989-11-01 00:00:00

abstract：:The review outlines data consistent with the hypothesis that inspiratory drive transmission that generates fetal breathing movements (FBMs) is essential for the developmental plasticity of phrenic motoneurons (PMNs) and diaphragm musculature prior to birth. A systematic examination during the perinatal period demonstr...

journal_title：Experimental neurology

authors： Greer JJ,Martin-Caraballo M

更新日期：2017-01-01 00:00:00

abstract：:Astrocytes react to CNS injury by building a dense wall of filamentous processes around the lesion. Stromal cells quickly take up residence in the lesion core and synthesize connective tissue elements that contribute to fibrosis. Oligodendrocyte precursor cells proliferate within the lesion and entrap dystrophic axon ...

journal_title：Experimental neurology

authors： Cregg JM,DePaul MA,Filous AR,Lang BT,Tran A,Silver J

更新日期：2014-03-01 00:00:00

abstract：:This study of medial gastrocnemius (MG) muscle and motor units (MUs) after spinal cord hemisection and deafferentation (HSDA) in adult cats, asked 1) whether the absence of muscle atrophy and unaltered contractile speed demonstrated previously in HSDA-paralyzed peroneus longus (PerL) muscles, was apparent in the unloa...

journal_title：Experimental neurology

authors： Gordon T,Tyreman N,Harris LR,Rafuse VF

更新日期：2020-05-01 00:00:00

abstract：:This article reviews stem cell-based strategies for spinal cord injury repair, and practical issues concerning their translation to the clinic. Recent progress in the stem cell field includes clinically compliant culture conditions and directed differentiation of both embryonic stem cells and somatic stem cells. We pr...

journal_title：Experimental neurology

authors： Coutts M,Keirstead HS

更新日期：2008-02-01 00:00:00

abstract：:The axonal trajectories of inspiratory bulbospinal neurons were examined after deposition of the anterograde neuronal tracer phaseolus vulgaris leucoagglutinin (PHA-L) into the rostral ventral respiratory group in rats. At the level of the phrenic nucleus, PHA-L-labeled bulbospinal axons crossed the midline of the spi...

journal_title：Experimental neurology

authors： Goshgarian HG,Ellenberger HH,Feldman JL

更新日期：1991-01-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP), vasoactive intestinal peptide (VIP), and their receptors have been localized within the hippocampus but their physiological function on synaptic transmission is still unclear. We investigated the effects of PACAP and VIP on evoked excitatory postsynaptic curr...

journal_title：Experimental neurology

authors： Ciranna L,Cavallaro S

更新日期：2003-12-01 00:00:00

abstract：:Functional neural reconnection is not common after spinal cord transection in the CNS of adult higher vertebrates but has been demonstrated in embryonic avian and neonatal mammalian CNS. Chick brainstem spinal cord preparations from nontransected controls and embryos transected at the cervical level on embryonic days ...

journal_title：Experimental neurology

authors： Sholomenko GN,Delaney KR

更新日期：1998-12-01 00:00:00

abstract：:Adult New Zealand Red (NZR) rabbits were used to determine if the techniques developed in the rat to transplant sheets of photoreceptors could be adapted to larger eyes of the rabbit. Adult donor NZR rabbit retina was cut into small strips, oriented, and drawn up in a small and flat polyethylene tube. By transscleral ...

journal_title：Experimental neurology

authors： Schuschereba ST,Silverman MS

更新日期：1992-01-01 00:00:00

abstract：:Altered activity in one of the output nuclei of the basal ganglia, the internal segment of the globus pallidus, is known to play an important role in the generation of parkinsonism. These inactivation studies tested the hypothesis that altered activity in the second major output nucleus of the basal ganglia, the subst...

journal_title：Experimental neurology

authors： Wichmann T,Kliem MA,DeLong MR

更新日期：2001-02-01 00:00:00