Stem cells for the treatment of spinal cord injury.

abstract：:Using an approach that combines gene therapy with aromatic l-amino acid decarboxylase (AADC) gene and a pro-drug (l-dopa), dopamine, the neurotransmitter involved in Parkinson's disease, can be synthesized and regulated. Striatal neurons infected with the AADC gene by an adeno-associated viral vector can convert perip...

journal_title：Experimental neurology

authors： Bankiewicz KS,Eberling JL,Kohutnicka M,Jagust W,Pivirotto P,Bringas J,Cunningham J,Budinger TF,Harvey-White J

更新日期：2000-07-01 00:00:00

abstract：:The effects of intranigral iron injection on dopamine (DA) release and content in the caudate putamen (CPu) and their relationship to DA-related behavioral response were investigated in rats. Different concentrations of FeCl(3) (10, 20, and 40 microg) and saline were injected separately into the left substantia nigra....

journal_title：Experimental neurology

authors： Junxia X,Hong J,Wenfang C,Ming Q

更新日期：2003-08-01 00:00:00

abstract：:Grafts of neonatal striatal tissue were placed into the striata of adult rats. When challenged immediately with intrastriatal injections of either kainic or quinolinic acid, excitotoxic damage was prevented. Thirty days later these same graft recipients received another injection of excitotoxin. The intrastriatal graf...

journal_title：Experimental neurology

authors： Tulipan N,Luo SQ,Allen GS,Whetsell WO

更新日期：1988-12-01 00:00:00

abstract：:The kindling phenomenon, i.e., the progressive development of focal and secondarily generalized seizures upon repeated electrical stimulation of a limbic brain region, occurs in various species, but with marked differences in kindling rate between species and also within the same species. In rats, differences in kindl...

journal_title：Experimental neurology

authors： Löscher W,Cramer S,Ebert U

更新日期：1998-12-01 00:00:00

abstract：:c-fos expression in response to noxious mechanical stimulation of the peripheral receptive field was used to study the somatotopic representation of the oral mucous membrane and trigeminal cutaneous receptive fields in the trigeminal subnucleus caudalis and the cervical spinal dorsal horn. Fos-neurons (neurons with c-...

journal_title：Experimental neurology

authors： Sugimoto T,Hara T,Shirai H,Abe T,Ichikawa H,Sato T

更新日期：1994-10-01 00:00:00

abstract：:Although zinc is essential for the activity of numerous biological systems, and zinc deficiency has been associated with various pathologies, this metal can also exert direct neurotoxic action. In primary cultures of rat cerebellar granule neurons, a brief, 15- to 30-min exposure to zinc (100-500 microM) resulted in c...

journal_title：Experimental neurology

authors： Manev H,Kharlamov E,Uz T,Mason RP,Cagnoli CM

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:Medial forebrain bundle (MFB) deep brain stimulation (DBS) has anti-depressant effects clinically and in depression models. Currently, therapeutic mechanisms of MFB DBS or how stimulation parameters acutely impact neurotransmitter release, particularly dopamine, are unknown. Experimentally, MFB DBS has been ...

journal_title：Experimental neurology

authors： Ashouri Vajari D,Ramanathan C,Tong Y,Stieglitz T,Coenen VA,Döbrössy MD

更新日期：2020-05-01 00:00:00

abstract：:Paraoxonase-2 regulates reactive oxygen species production in mitochondria. Stimulating its expression has therapeutic potential for diseases where oxidative stress plays a significant role in the pathology. Evidence suggests that the anti-diabetic drug pioglitazone may provide neuroprotection in Parkinson's disease, ...

journal_title：Experimental neurology

authors： Blackburn JK,Curry DW,Thomsen AN,Roth RH,Elsworth JD

更新日期：2020-05-01 00:00:00

abstract：:Disease-modifying treatments remain an unmet medical need in Parkinson's disease (PD). Such treatments can be operationally defined as interventions that slow down the clinical evolution to advanced disease milestones. A treatment may achieve this outcome by either inhibiting primary neurodegenerative events ("neuropr...

journal_title：Experimental neurology

authors： Francardo V,Schmitz Y,Sulzer D,Cenci MA

更新日期：2017-12-01 00:00:00

abstract：:A number of neuron-supporting functions have been ascribed to astrocytes. In this study we found that a proliferation of Purkinje cell dendritic spines, a target site for presynaptic axon terminals, was induced in cytosine arabinoside-treated cerebellar cultures by exposure to astrocyte-conditioned medium. This result...

journal_title：Experimental neurology

authors： Seil FJ,Eckenstein FP,Reier PJ

更新日期：1992-07-01 00:00:00

abstract：AIMS/HYPOTHESIS:Dorsal root ganglia (DRG) sensory neurons cultured from 3 to 5 month streptozotocin (STZ)-induced diabetic rats exhibit structural and biochemical changes seen in peripheral nerve fibers in vivo, including axonal swellings, oxidative damage, reduced axonal sprouting, and decreased NF-κB activity. NF-κB ...

journal_title：Experimental neurology

authors： Saleh A,Schapansky J,Smith DR,Young N,Odero GL,Aulston B,Fernyhough P,Glazner GW

更新日期：2013-03-01 00:00:00

abstract：:Recent studies have shown that hemorrhagic injury in the preterm cerebellum leads to long-term neurological sequelae, such as motor, affective, and cognitive dysfunction. How cerebellar hemorrhage (CBH) affects the development and function of the cerebellum is largely unknown. Our study focuses on developing a mouse m...

journal_title：Experimental neurology

authors： Yoo JY,Mak GK,Goldowitz D

更新日期：2014-02-01 00:00:00

abstract：:Among endogenous adaptive systems to hypoxia, neuroglobin, a recently discovered heme protein, was suggested as a novel oxygen-dependent neuroprotectant. We aimed to characterize i) maturational age-related regulation of neuroglobin in the developing mouse brain under normoxic and hypoxic conditions, and ii) the role ...

journal_title：Experimental neurology

authors： Hümmler N,Schneider C,Giessl A,Bauer R,Walkinshaw G,Gassmann M,Rascher W,Trollmann R

更新日期：2012-07-01 00:00:00

abstract：:The vibrissae of rats were shaved from one side of the face daily for 10 days. To see whether or not this treatment had an effect on crossed and uncrossed striatal afferent connections from the midbrain, the tract tracer horseradish peroxidase was applied to the caudate-putamen on day 11. When the tracer was deposited...

journal_title：Experimental neurology

authors： Huston JP,Morgan S,Lange KW,Steiner H

更新日期：1986-08-01 00:00:00

abstract：:Neurons from cerebral neocortex and hippocampus exhibit a striking difference in vulnerability to transient global ischemia. In order to study the contribution of neuronal connections and neuron-glia interactions to this variation in neuronal vulnerability, we used hippocampal and neocortical cultures submitted to var...

journal_title：Experimental neurology

authors： Bernaudin M,Nouvelot A,MacKenzie ET,Petit E

更新日期：1998-03-01 00:00:00

abstract：:Axonal injury is present in essentially all clinically significant cases of traumatic brain injury (TBI). While no effective treatment has been identified to date, experimental TBI models have shown promising axonal protection using immunosuppressants FK506 and Cyclosporine-A, with treatment benefits attributed to cal...

journal_title：Experimental neurology

authors： Reeves TM,Trimmer PA,Colley BS,Phillips LL

更新日期：2016-09-01 00:00:00

abstract：:Exposure of the rodent striatum to quinolinic acid (QA, N-methyl-D-aspartate receptor agonist) induces immediate early gene (IEG; c-fos, c-jun, jun-B, zif/268) expression that may extend 12-24 h after injection. In order to determine the specificity of the prolonged IEG response to the QA injection, the temporal patte...

journal_title：Experimental neurology

authors： Shan Y,Carlock LR,Walker PD

更新日期：1997-04-01 00:00:00

abstract：:Antegrade, target-directed axonal regeneration is the explicit goal of nerve repair. However, aberrant and dysfunctional regrowth is commonly observed as well. At the site of surgical nerve coaptation, axonal sprouts encounter fibrotic connective tissue rich in growth-inhibiting chondroitin sulfate proteoglycan that m...

journal_title：Experimental neurology

authors： Graham JB,Neubauer D,Xue QS,Muir D

更新日期：2007-01-01 00:00:00

abstract：:Caloric restriction (CR) is a daily reduction of total caloric intake without a decrease in micronutrients or disproportionate reduction of any one dietary component. CR can increase lifespan reliably in a wide range of species and appears to counteract some aspects of the aging process throughout the body. The effect...

journal_title：Experimental neurology

authors： Adams MM,Shi L,Linville MC,Forbes ME,Long AB,Bennett C,Newton IG,Carter CS,Sonntag WE,Riddle DR,Brunso-Bechtold JK

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:N,N-dimethyltryptamine (DMT) is an endogenous ligand of the Sigma 1 receptor (Sig-1R) with documented in vitro cytoprotective properties against hypoxia. Our aim was to demonstrate the in vivo neuroprotective effect of DMT following ischemia-reperfusion injury in the rat brain. METHODS:Transient...

journal_title：Experimental neurology

authors： Nardai S,László M,Szabó A,Alpár A,Hanics J,Zahola P,Merkely B,Frecska E,Nagy Z

更新日期：2020-05-01 00:00:00

abstract：:The effects of aspirin or 5-hydroxytryptamine (5-HT)-related drugs on the dental pain induced by electrical stimulation of tooth pulp afferent fibers were assessed in conscious monkeys. The electrical current required for producing jaw opening is referred to as the pain threshold. Both systemic (25 to 75 mg/kg, i.p.) ...

journal_title：Experimental neurology

authors： Shyu KW,Lin MT,Wu TC

更新日期：1984-04-01 00:00:00

abstract：:It is not yet clear how L-dopa, that is the most effective drug for the treatment of Parkinson's disease, enters into the dopaminergic neurons to be transformed into dopamine. It is suggested that L-dopa is mainly transported into cells by a group of L-amino acid carriers named "System L". Since these carriers are sel...

journal_title：Experimental neurology

authors： Sebastianelli L,Ledonne A,Marrone MC,Bernardi G,Mercuri NB

更新日期：2008-07-01 00:00:00

abstract：:Parkinson's Disease (PD) and Extrapyramidal Syndrome (EPS) are movement disorders that result from degeneration of the dopaminergic input to the striatum and chronic inhibition of striatal dopamine D(2) receptors by antipsychotics, respectively. Adenosine A(2A) receptors are selectively localized in the basal ganglia,...

journal_title：Experimental neurology

authors： Hodgson RA,Bedard PJ,Varty GB,Kazdoba TM,Di Paolo T,Grzelak ME,Pond AJ,Hadjtahar A,Belanger N,Gregoire L,Dare A,Neustadt BR,Stamford AW,Hunter JC

更新日期：2010-10-01 00:00:00

abstract：:Scopolamine and naloxone were administered singly and in combination to different groups of rats undergoing electrical kindling of the amygdala. Scopolamine significantly reduced the maximal seizure stage attained during 15 drug sessions and increased the total number of afterdischarges required to kindle a generalize...

journal_title：Experimental neurology

authors： Cain DP,McKitrick DJ,Desborough KA

更新日期：1987-04-01 00:00:00

abstract：:Blood flow in the feline thoracic spinal cord was measured, using a laser-Doppler flowmetry. Rhythmic changes in the spinal cord blood flow were repeatedly observed with a frequency of about three to eight cycles per minute, unrelated to the respiratory or cardiac cycles. These changes were unaffected by hypertension ...

journal_title：Experimental neurology

authors： Mizutani M,Yamamuro T,Shikata J

更新日期：1988-08-01 00:00:00

abstract：:The neuronal basis for neurological deficits in infantile hydrocephalus is poorly understood. Changes in the dendritic architecture of pyramidal cells of the auditory cortex have been measured at 21 days after birth in H-Tx rats. Tissue was prepared by the rapid Golgi method from hydrocephalic and control litter-mates...

journal_title：Experimental neurology

authors： Harris NG,McAllister JP 2nd,Conaughty JM,Jones HC

更新日期：1996-10-01 00:00:00

abstract：:Twelve neurons in the median preoptic nucleus were antidromically activated by electrical stimulation of the hypothalamic paraventricular nucleus in the rat. Electrical stimulation of the subfornical organ produced excitation (N = 7) or inhibition (N = 4) of the activity of these identified units. The activity of all ...

journal_title：Experimental neurology

authors： Tanaka J,Kaba H,Saito H,Seto K

更新日期：1986-09-01 00:00:00

abstract：:The roles of inflammation and degeneration as well as of gray matter abnormalities in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) are controversial. We analyzed the pathological manifestations in two EAE models, the chronic oligodendrocyte glycoprotein (MOG)-induced ver...

journal_title：Experimental neurology

authors： Aharoni R,Sasson E,Blumenfeld-Katzir T,Eilam R,Sela M,Assaf Y,Arnon R

更新日期：2013-02-01 00:00:00

abstract：:The present study was carried out to determine if augmentation of phrenic nerve activity during the crossed phrenic phenomenon temporally coincides with the morphological changes in the phrenic nucleus that we have observed in previous studies. This investigation consisted of two experiments in spinal cord hemisected ...

journal_title：Experimental neurology

authors： O'Hara TE Jr,Goshgarian HG

更新日期：1991-02-01 00:00:00

abstract：:The effect of proximal nerve crush on regeneration after unrepaired nerve transection was studied in feline cutaneous nerves. Delays between the initial transection and the subsequent nerve crush varied between 0 (immediate crush) and 13 months. A survival time of 6 to 12 months after the crush was allowed for regener...

journal_title：Experimental neurology

authors： Koerber HR,Horch KW

更新日期：1985-05-01 00:00:00