Abstract：
:Blood flow in the feline thoracic spinal cord was measured, using a laser-Doppler flowmetry. Rhythmic changes in the spinal cord blood flow were repeatedly observed with a frequency of about three to eight cycles per minute, unrelated to the respiratory or cardiac cycles. These changes were unaffected by hypertension induced by angiotensin II, but disappeared when systemic blood pressure was lowered by trimethaphan or when hypercapnia was induced. CO2 responsiveness of the blood flow and postocclusive reactive hyperemia were also examined, in both the normal and injured spinal cord. CO2 responsiveness was lost 1 h after a 500 gm/cm injury without rhythmic changes, but was partially regained 2 days later, at which time rhythmic changes were frequently observed. Postocclusive hyperemia apparently diminished 1 h after a 500 gm/cm injury, but reappeared 2 days later. Vasomotion in the normal and injured spinal cord is discussed.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Mizutani M,Yamamuro T,Shikata Jdoi
10.1016/0014-4886(88)90009-xsubject
Has Abstractpub_date
1988-08-01 00:00:00pages
256-66issue
2eissn
0014-4886issn
1090-2430pii
0014-4886(88)90009-Xjournal_volume
101pub_type
杂志文章abstract：:Previous studies have shown that the herpes simplex virus type 2 protein kinase ICP10 PK activates the Ras/MEK/MAPK pathway in nonneuronal cells. Here we report that ectopically expressed ICP10 PK has anti-apoptotic activity in various paradigms of neuronal cell death. Neuronally differentiated PC12 cells and primary ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2001.7849
更新日期：2002-03-01 00:00:00
abstract：:It is controversial whether levodopa (L-DOPA) therapy in the early stages of Parkinson's disease (PD) predisposes to later complications. Partial lesions of the substantia nigra (SN) in rat provide a model of the early stages of PD. We have investigated the potential effects of L-DOPA in early PD by analyzing its infl...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1993.1057
更新日期：1993-04-01 00:00:00
abstract：:Parkinson's disease is a neurodegenerative disorder associated with selective loss of the dopaminergic neurons in the substantia nigra. We have previously shown that tetrahydrobiopterin (BH4), the obligatory cofactor for dopamine synthesis, exerts selective toxicity on dopamine-producing cells. In the present study we...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/s0014-4886(03)00054-2
更新日期：2003-06-01 00:00:00
abstract：:Excessive synchronization of neuronal activity at around 20 Hz is a common finding in the basal ganglia of patients with untreated Parkinson's disease (PD). Correlative evidence suggests, but does not prove, that this spontaneous activity may contribute to slowness of movement in this condition. Here we investigate wh...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2007.01.027
更新日期：2007-05-01 00:00:00
abstract：:In mammals, free d-aspartate (D-Asp) is abundant in the embryonic brain, while levels remain very low during adulthood as a result of the postnatal expression and activity of the catabolizing enzyme d-aspartate oxidase (DDO). Previous studies have shown that long-lasting exposure to nonphysiological, higher D-Asp conc...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2019.02.014
更新日期：2019-07-01 00:00:00
abstract：:The vibrissae of rats were shaved from one side of the face daily for 10 days. To see whether or not this treatment had an effect on crossed and uncrossed striatal afferent connections from the midbrain, the tract tracer horseradish peroxidase was applied to the caudate-putamen on day 11. When the tracer was deposited...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(86)90198-6
更新日期：1986-08-01 00:00:00
abstract：:Myelinated axons efficiently transmit information over long distances. The apposed myelin sheath confers favorable electrical properties, but restricts access of the axon to its extracellular milieu. Therefore, axonal metabolic support may require specific axo-myelinic communication. Here we explored activity-dependen...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2015.10.006
更新日期：2016-02-01 00:00:00
abstract：BACKGROUND AND PURPOSE:N,N-dimethyltryptamine (DMT) is an endogenous ligand of the Sigma 1 receptor (Sig-1R) with documented in vitro cytoprotective properties against hypoxia. Our aim was to demonstrate the in vivo neuroprotective effect of DMT following ischemia-reperfusion injury in the rat brain. METHODS:Transient...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2020.113245
更新日期：2020-05-01 00:00:00
abstract：:Both alpha- and beta-adrenergic receptors (ARs) are involved in the facilitation of the monosynaptic jaw-closing reflex in the trigeminal motor nucleus (MoV) caused by norepinephrine (NE). The amplitude of muscle spindle afferent-evoked EPSPs in masseter motor neurons is 65% greater when noradrenergic axons to the mot...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(91)90038-e
更新日期：1991-11-01 00:00:00
abstract：:The precise role of hypothalamic norepinephrine (NE) in the control of vasopressin (AVP) release has remained unclear, due to reports of both inhibitory and excitatory effects of NE and only a few studies with direct hypothalamic manipulations. The present study utilized a chronically implanted swivel brain cannula to...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(90)90042-q
更新日期：1990-12-01 00:00:00
abstract：:The development of reliable biological markers of nigrostriatal degeneration has important implications from both experimental and clinical viewpoints, since such biomarkers could be used for diagnostic and monitoring purposes in models of parkinsonism as well as in Parkinson's disease patients. In this study, levels ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/s0014-4886(03)00140-7
更新日期：2003-09-01 00:00:00
abstract：:Ciliary neurotrophic factor (CNTF) and brain-derived neurotrophic factor (BDNF) have been shown both in vitro and in vivo to support the survival and differentiation of developing chick or rat motoneurons. To explore the potential use of these and other neurotrophic factors as therapeutic agents in human motoneuron di...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1994.1198
更新日期：1994-12-01 00:00:00
abstract：:We investigated whether type 2 diabetes mellitus (T2DM), a risk factor of stroke, affects the level of scavenger receptor CD36 and the uptake of its ligand, oxidized LDL (oxLDL); and whether pioglitazone, a drug that enhances CD36, promotes oxLDL uptake. Compared to normoglycemic db/+ mice, adult db/db mice showed a p...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2020.113461
更新日期：2020-12-01 00:00:00
abstract：:Thyroid hormones and spermidine, a motor neuron trophic polyamine (PA), have been shown to enhance peripheral motor nerve regeneration; however, the mechanism by which these treatment modalities exert their effect is unknown. Similarities in treatment outcome suggest that these molecules may be working via a common me...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2004.05.024
更新日期：2004-09-01 00:00:00
abstract：:A new procedure was developed for ablating the mammillary nuclei in nonhuman primates via direct visual exposure. Using this technique, monkeys receiving lesions of the mammillary nuclei were compared to control animals after surgery to assess the retention of preoperatively acquired visuospatial discriminations and s...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(83)90160-7
更新日期：1983-07-01 00:00:00
abstract：:We examined the response of neuronal nitric oxide synthase (nNOS)-containing CNS neurons in rats exposed to a unilateral hypoxic-ischemic insult at 7 days of age. Animals were sacrificed at several time points after the injury, up to and including 7 days (Postnatal Day 14). Brain regions ipsilateral to the injury (inc...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2000.7606
更新日期：2001-04-01 00:00:00
abstract：:In 3-, 9-, 24-, and 30-month-old male rats (Fischer 344), the nuclear perimeter and the density and diameter of nuclear pore complexes in the granule cells of the dentate fascia were studied. Whereas the nuclear perimeter and the diameter of nuclear pore complexes did not change as a function of age, there was a signi...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(87)90314-1
更新日期：1987-03-01 00:00:00
abstract：:Synemin (Syn) is an intermediate filament (IF) protein. To gain insight into a morphogenetic role of Syn, we have studied its expression patterns in the developing human retina and lens and compared it with those of other IF proteins. In addition, we have tested Syn expression in fetuses (23 and 28 weeks) affected by ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/s0014-4886(03)00240-1
更新日期：2003-10-01 00:00:00
abstract：:Human immunodeficiency virus-associated distal-symmetric neuropathy (HIV-DSP) is the most common neurological complication of HIV infection. The pathophysiology of HIV-DSP is poorly understood and no treatment is available for this entity. The dorsal root ganglia (DRG) are the principal sites of neuronal damage and ar...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2007.06.015
更新日期：2008-03-01 00:00:00
abstract：:In recent years, it has become evident that Parkinson's disease is associated with a self-sustaining cycle of neuroinflammation and neurodegeneration, with dying neurons activating microglia, which, once activated, can release several factors that kill further neurons. One emerging pharmacological target that has the ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2016.06.014
更新日期：2016-09-01 00:00:00
abstract：:Hyperreflexia develops after spinal cord injury (SCI) in the human and in the spinal cord transected animal, and can be measured by the loss of low frequency-dependent depression of the H-reflex. Previous studies demonstrated normalization of low frequency-dependent depression of the H-reflex using passive exercise wh...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2008.07.002
更新日期：2008-10-01 00:00:00
abstract：:Exposure to low doses of gamma irradiation results in the modification of both the antinociceptive properties of morphine and the severity of naloxone-precipitated withdrawal in morphine-dependent rats. To better define the interactions between gamma irradiation and these opiate-mediated phenomena, dose-response studi...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(87)90244-5
更新日期：1987-11-01 00:00:00
abstract：:Polymerized collagen rolls enclosing Schwann cells (SCs) raised in culture were grafted into cystic cavities formed after lesioning the thoracic spinal cord of adult rats. Axons were already present within the graft by 14 days after implantation and both ensheathed and myelinated axons were numerous by 28 days. This a...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(91)90043-c
更新日期：1991-11-01 00:00:00
abstract：:Fluorescence microscopy revealed that the innervation of the vasa nervorum of both cranial and spinal nerve roots in the subarachnoid space in the monkey is adrenergic in nature. The endoneurium of the cranial nerve roots contained free adrenergic nerve fibers which were not related to the vessel wall. ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(87)90275-5
更新日期：1987-12-01 00:00:00
abstract：:The failure of axons to regenerate after spinal cord injury remains one of the greatest challenges facing both medicine and neuroscience, but in the last 20 years there have been tremendous advances in the field of spinal cord injury repair. One of the most important of these has been the identification of inhibitory ...
journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1016/j.expneurol.2007.06.020
更新日期：2008-02-01 00:00:00
abstract：:Antegrade, target-directed axonal regeneration is the explicit goal of nerve repair. However, aberrant and dysfunctional regrowth is commonly observed as well. At the site of surgical nerve coaptation, axonal sprouts encounter fibrotic connective tissue rich in growth-inhibiting chondroitin sulfate proteoglycan that m...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2006.08.004
更新日期：2007-01-01 00:00:00
abstract：:Whereas quite a number of previous reports have shown that the developing brain is vulnerable to protein deprivation, the mature CNS is usually considered resistant to this condition. To explore this assumption the present experimental model was built on groups of 2-month-old rats fed with a low-protein diet (8% casei...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(89)90081-2
更新日期：1989-02-01 00:00:00
abstract：:The effect of olfactory deprivation in the postnatal development of the anterior olfactory nucleus (AON) was studied in 60-day-old rats which underwent unilateral naris closure after birth (postnatal day 1). Volumetric and morphometric analyses of the AON ipsilateral and contralateral to the closed naris were performe...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2001.7760
更新日期：2001-10-01 00:00:00
abstract：:Our primary aim was to determine if there exists a preferential involvement of the fast-twitch or slow-twitch skeletal muscle fibers in the dy2J/dy2J strain of murine dystrophy. The changes in the contractile properties of the slow-twitch soleus (SOL) and the fast-twitch extensor digitorum longus (EDL) muscles of norm...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(83)90297-2
更新日期：1983-05-01 00:00:00
abstract：:Huntington's disease (HD) is an autosomal dominant neurodegenerative disease associated with a CAG trinucleotide repeat expansion in a large gene on chromosome 4. The gene encodes the protein huntingtin with a polyglutamine tract encoded by the CAG repeat at the N-terminus. The number of CAG repeats in HD are signific...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1998.6778
更新日期：1998-04-01 00:00:00
