Abstract：
:Polymerized collagen rolls enclosing Schwann cells (SCs) raised in culture were grafted into cystic cavities formed after lesioning the thoracic spinal cord of adult rats. Axons were already present within the graft by 14 days after implantation and both ensheathed and myelinated axons were numerous by 28 days. This axonal ingrowth was maintained over longer survival periods. The axons within the graft always appeared related to Schwann cells. Acellular collagen rolls did not show axonal ingrowth. These Schwann cell-collagen implants resemble peripheral nerve grafts in their ability to induce axonal regeneration into the graft.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Paino CL,Bunge MBdoi
10.1016/0014-4886(91)90043-csubject
Has Abstractpub_date
1991-11-01 00:00:00pages
254-7issue
2eissn
0014-4886issn
1090-2430pii
0014-4886(91)90043-Cjournal_volume
114pub_type
杂志文章abstract：:Recent work has indicated that photobiomodulation (PBM) may beneficially alter the pathological status of several neurological disorders, although the mechanism currently remains unclear. The current study was designed to investigate the beneficial effect of PBM on behavioral deficits and neurogenesis in a photothromb...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2017.10.013
更新日期：2018-01-01 00:00:00
abstract：:Altered activity in one of the output nuclei of the basal ganglia, the internal segment of the globus pallidus, is known to play an important role in the generation of parkinsonism. These inactivation studies tested the hypothesis that altered activity in the second major output nucleus of the basal ganglia, the subst...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2000.7572
更新日期：2001-02-01 00:00:00
abstract：:Synemin (Syn) is an intermediate filament (IF) protein. To gain insight into a morphogenetic role of Syn, we have studied its expression patterns in the developing human retina and lens and compared it with those of other IF proteins. In addition, we have tested Syn expression in fetuses (23 and 28 weeks) affected by ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/s0014-4886(03)00240-1
更新日期：2003-10-01 00:00:00
abstract：:The present study evaluated the growth potential and differentiation of human fetal spinal cord (FSC) tissue in the injured adult rat spinal cord under different lesion and grafting conditions. Donor tissue at 6-9 weeks of gestational age was obtained through elective abortions and transplanted either immediately into...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1997.6703
更新日期：1997-12-01 00:00:00
abstract：:Myelinated axons efficiently transmit information over long distances. The apposed myelin sheath confers favorable electrical properties, but restricts access of the axon to its extracellular milieu. Therefore, axonal metabolic support may require specific axo-myelinic communication. Here we explored activity-dependen...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2015.10.006
更新日期：2016-02-01 00:00:00
abstract：:Ischemic stroke (IS) is one of the most common cerebrovascular diseases worldwide. The aberrant expression of BCL6 has been previously implicated in the pathogenesis of IS. Meanwhile, miR-31 is known as a target of BCL6, and has also been suggested to diminish cell damage by suppressing the PKD1 expression. Expanding ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2020.113528
更新日期：2021-01-01 00:00:00
abstract：:Twenty-one-day-old Wistar rats were fed a diet containing 0.6% cuprizone for 2 weeks. Studies carried out after withdrawal of cuprizone showed histological evidences of marked demyelination in the corpus callosum. Biochemical studies of isolated myelin showed a marked decrease in myelin proteins, phospholipids, and ga...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2005.12.027
更新日期：2006-04-01 00:00:00
abstract：:The influence that the amygdala may exert on the development of hippocampal kindling was investigated using three different approaches: (i) after uni- or bilateral amygdalectomy by thermocoagulation, (ii) after prestimulation of the amygdala until the appearance of masticatory movements, and (iii) after increasing the...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(83)90416-8
更新日期：1983-11-01 00:00:00
abstract：:Recent in vitro studies have shown that the periventricular subependymal zone (SEZ) of the rodent brain is capable of de novo generation of neurons and glia. There is less information available on neurogenesis in the adult human brain, and no study has shown the clonal generation of neurons and glia from in vitro-gene...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1999.7028
更新日期：1999-04-01 00:00:00
abstract：:Mitochondrial dysfunction and pathology that contribute to a host of neurodegenerative diseases are deduced from changes in ultrastructure, routinely examined by a host of optical techniques. We adapted the technique of photon correlation spectroscopy (PCS) to evaluate calcium-induced structural alterations in isolate...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2005.10.002
更新日期：2006-02-01 00:00:00
abstract：:Multiple cellular and molecular interactions are required for the differentiation and development of central neurons. For example, neural activity may modulate trophic function. In the developing cerebellum, establishment of functional excitatory synaptic connections coincides with the expression of NGF and its recept...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1993.1018
更新日期：1993-02-01 00:00:00
abstract：:Forebrain-bisected cats underwent kindling at primary and secondary amygdala sites. The behavioral effect of amygdala kindling was then examined according to the extent of the surgical lesion in the forebrain commissures. Bisection of the corpus callosum with or without lesion of the hippocampal commissure modified bo...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(87)90083-5
更新日期：1987-10-01 00:00:00
abstract：:Regeneration in the peripheral nervous system offers unique opportunities and challenges to medicine. Compared to the central nervous system, peripheral axons can and do regenerate resulting in functional recovery, especially if the distance to target is short as in distal limb injuries. However, this regenerative cap...
journal_title：Experimental neurology
pub_type： 社论
doi：10.1016/j.expneurol.2009.12.001
更新日期：2010-05-01 00:00:00
abstract：:Electromyograms from the flexor and extensor muscles of normal human elbows were simultaneously recorded during maximal-effort isokinetic movement at 15 degrees/s over the joint's full range of motion. The antagonist electromyogram was normalized with respect to its electromyogram when acting as agonist at maximal eff...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(88)90032-5
更新日期：1988-06-01 00:00:00
abstract：:For the past 15 years, patients with Parkinson's disease have participated in clinical trials evaluating the efficacy of intrastriatal dopamine transplants. Principally, two donor tissues have been employed, the chromaffin cells of the adrenal medulla and fetal ventral mesencephalon. The clinical response following ea...
journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1006/exnr.1996.6386
更新日期：1997-03-01 00:00:00
abstract：:Adaptive responses in glutamate and opioid receptor systems in limbic circuits are emerging as a critical component of the neural plasticity induced by chronic use of abused substances. The present commentary reviews findings from neuroanatomical studies, with superior spatial resolution, that support a cellular basis...
journal_title：Experimental neurology
pub_type： 评论,杂志文章
doi：10.1016/j.expneurol.2011.03.016
更新日期：2011-06-01 00:00:00
abstract：:Urethane-induced cortical slow wave activity (SWA) spreads into the basal ganglia in dopamine (DA)-depleted rat models of Parkinson's disease (PD). During physiological sleep, SWA is powerfully expressed at the beginning of night and progressively reduced during sleep-time reflecting the sleep need. However, its under...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2017.12.004
更新日期：2018-03-01 00:00:00
abstract：:Following a traumatic brain injury (TBI), the excessive release of interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) is a major cause of cerebral edema, which, in turn, can cause permanent neuronal loss and cognitive deficits in laboratory rats. This study examined the changes in expression of t...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2004.06.008
更新日期：2004-10-01 00:00:00
abstract：:Stimulation of peripheral nerves activates corresponding regions in sensorimotor cortex. We have applied functional magnetic resonance imaging (fMRI) techniques to monitor activated brain regions by means of measuring changes of blood oxygenation level-dependent contrast during electric stimulation of the forepaw, hin...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2000.7524
更新日期：2000-12-01 00:00:00
abstract：:Olfactory ensheathing cells (OECs) are unique glia that support axon outgrowth in the olfactory system, and when used as cellular therapy after spinal cord injury, improve recovery and axon regeneration. Here we assessed the effects of combining OEC transplantation with another promising therapy, epidural electrical s...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2018.07.015
更新日期：2018-11-01 00:00:00
abstract：:Neurogenesis continues in various regions of the central nervous system (CNS) throughout life. As the mitogen basic fibroblast growth factor (bFGF) can proliferate neuronal precursors of CNS neurons in culture, and is also upregulated within adult dorsal root ganglia following axotomy, it is possible that the postnata...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2001.7761
更新日期：2001-11-01 00:00:00
abstract：:After spinal cord injury at birth, axotomized brainstem-spinal and corticospinal neurons are capable of permanent regenerative axonal growth into and through a fetal spinal cord transplant placed into the site of either a spinal cord hemisection or transection. In contrast, if fetal tissue which is not a normal target...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1997.6632
更新日期：1997-11-01 00:00:00
abstract：:Whereas quite a number of previous reports have shown that the developing brain is vulnerable to protein deprivation, the mature CNS is usually considered resistant to this condition. To explore this assumption the present experimental model was built on groups of 2-month-old rats fed with a low-protein diet (8% casei...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(89)90081-2
更新日期：1989-02-01 00:00:00
abstract：:A complex propriospinal network is synaptically coupled to phrenic and intercostal motoneurons, and this makes it difficult to predict how gray matter intraspinal microstimulation (ISMS) will recruit respiratory motor units. We therefore mapped the cervical and high thoracic gray matter at locations which ISMS activat...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2017.12.014
更新日期：2018-04-01 00:00:00
abstract：:Most neurons in the dorsal neostriatum die 1 day after 30 min of cerebral ischemia. Dopamine may play a role in the pathogenesis of neuronal injury in neostriatum following ischemia. It has been shown that the number of surviving neurons in the right neostriatum dramatically increased following ischemia after lesions ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1999.7074
更新日期：1999-07-01 00:00:00
abstract：:The basis for neuronal dysfunction following inflammatory demyelination of the central nervous system (CNS) remains poorly understood. We characterized the network response to white matter injury in the anterior visual pathway using an experimental model of optic neuritis (ON), as ON is often an early manifestation of...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2017.05.004
更新日期：2017-09-01 00:00:00
abstract：:Unit activity related to a go/no-go visual discrimination task was studied in four rhesus monkeys. We recorded 272 task-related cells from frontal cortex in a region extending from the midprincipal sulcus to the central sulcus, and medially to the cingulate sulcus. Units located in anterior regions (dorsolateral prefr...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(87)90213-5
更新日期：1987-06-01 00:00:00
abstract：:Thalamocortical spike-and-wave discharges characterize the nonconvulsive absence seizures that occur spontaneously in genetic absence epilepsy rats from Strasbourg (GAERS), a selected strain of Wistar rats. GABA is crucial in the generation of absence seizures. The susceptibility to convulsions induced by threshold do...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1999.7302
更新日期：2000-02-01 00:00:00
abstract：:The present study was carried out to determine if augmentation of phrenic nerve activity during the crossed phrenic phenomenon temporally coincides with the morphological changes in the phrenic nucleus that we have observed in previous studies. This investigation consisted of two experiments in spinal cord hemisected ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(91)90012-2
更新日期：1991-02-01 00:00:00
abstract：:Grafting fetal striatal cells into the brain of Huntington's disease (HD) patients has raised certain expectations in the past decade as an effective cell-based-therapy for this devastating condition. We argue that the first requirement for successful transplantation is defining the window of plasticity for the striat...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2014.04.021
更新日期：2014-07-01 00:00:00
