Changes in the nuclear pore complexes of the dentate granule cells in aged rats.

abstract：:The effects of N-methyl-d-aspartate (NMDA) and non-NMDA receptor antagonists were compared on audiogenic seizures in the rats neonatally exposed to propylthiouracil (PTU). The rats treated with 0.02% PTU through mother's milk during days 0-19 after delivery showed a high incidence of audiogenic seizures consisting of ...

journal_title：Experimental neurology

authors： Higashiyama A,Ishida N,Nishimura T,Yasuda S,Kuroda Y,McEwen BS,Kato N

更新日期：1998-09-01 00:00:00

abstract：:Following a traumatic brain injury (TBI), the excessive release of interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) is a major cause of cerebral edema, which, in turn, can cause permanent neuronal loss and cognitive deficits in laboratory rats. This study examined the changes in expression of t...

journal_title：Experimental neurology

authors： He J,Evans CO,Hoffman SW,Oyesiku NM,Stein DG

更新日期：2004-10-01 00:00:00

abstract：:Zebrafish is an excellent model to study central nervous system (CNS) axonal degeneration and regeneration since we can observe these processes in vivo and in real time in transparent larvae. Previous studies have shown that Mauthner cell (M-cell) axon regenerates poorly after mechanical spinal cord injury. Inconsiste...

journal_title：Experimental neurology

authors： Hu BB,Chen M,Huang RC,Huang YB,Xu Y,Yin W,Li L,Hu B

更新日期：2018-02-01 00:00:00

abstract：:The effect of corporal hypothermia on regional blood flow in peripheral nerve is unknown. We compared blood flow in resting sciatic nerves of anesthetized, normothermic rats with that of rats whose rectal temperatures had been acutely lowered to 28 to 30 degrees C. Peripheral nerve regional blood flow in normothermic ...

journal_title：Experimental neurology

authors： Sugimoto H,Monafo WW,Shimazaki S

更新日期：1987-08-01 00:00:00

abstract：:Muscle disuse-induced changes in the cholinergic system of sciatic nerve, slow-twitch soleus (SOL), and fast-twitch extensor digitorum longus (EDL) muscles were studied in rats. Rats with hind limbs suspended for 2 to 3 weeks showed marked elevation in the activity of choline acetyltransferase in sciatic nerve (38%), ...

journal_title：Experimental neurology

authors： Gupta RC,Misulis KE,Dettbarn WD

更新日期：1985-09-01 00:00:00

abstract：:Caspases are cysteine proteases involved in apoptotic cell death, and pharmacological caspase inhibition has been demonstrated to prevent neuronal cell death in certain experimental paradigms. In this study, the role of caspase-1 and -3 in the death of dopaminergic neurons derived from the E14 rat ventral mesencephalo...

journal_title：Experimental neurology

authors： Hurelbrink CB,Armstrong RJ,Luheshi LM,Dunnett SB,Rosser AE,Barker RA

更新日期：2001-09-01 00:00:00

abstract：:An inherited deficiency of β-galactosylceramidase (GALC) causes the lysosomal storage disease globoid cell leukodystrophy (GLD). The disease is characterized by the accumulation of the cytotoxic metabolite psychosine (galactosylsphingosine), causing rapid degeneration of myelinating cells. Most patients suffer from th...

journal_title：Experimental neurology

authors： Matthes F,Andersson C,Stein A,Eistrup C,Fogh J,Gieselmann V,Wenger DA,Matzner U

更新日期：2015-09-01 00:00:00

abstract：:The role of nerve growth factor (NGF) was examined in the neural repair of adult rabbit facial nerves using an in vivo preparation. A 35-microliters nerve growth chamber was created by suturing the proximal and distal ends of a transected facial nerve (superior buccal branch) into a silicone tube. A gap of 8 mm in the...

journal_title：Experimental neurology

authors： Chen YS,Wang-Bennett LT,Coker NJ

更新日期：1989-01-01 00:00:00

abstract：:Total, Mg2+-, Na+,K+-, and Ca2+-ATPase activities were studied in fresh brain membrane preparations from adult epileptic (El) mice and nonepileptic C57BL/6J (B6) mice. The El mice have an inherited type of temporal lobe epilepsy. No significant differences were observed between the El and B6 mice for any of the ATPase...

journal_title：Experimental neurology

authors： Palayoor ST,Seyfried TN

更新日期：1988-03-01 00:00:00

abstract：:Electromyograms from the flexor and extensor muscles of normal human elbows were simultaneously recorded during maximal-effort isokinetic movement at 15 degrees/s over the joint's full range of motion. The antagonist electromyogram was normalized with respect to its electromyogram when acting as agonist at maximal eff...

journal_title：Experimental neurology

authors： Solomonow M,Baratta R,Zhou BH,D'Ambrosia R

更新日期：1988-06-01 00:00:00

abstract：:Multiple cellular and molecular interactions are required for the differentiation and development of central neurons. For example, neural activity may modulate trophic function. In the developing cerebellum, establishment of functional excitatory synaptic connections coincides with the expression of NGF and its recept...

journal_title：Experimental neurology

authors： Cohen-Cory S,Elliott RC,Dreyfus CF,Black IB

更新日期：1993-02-01 00:00:00

abstract：:Among the comorbidities observed in epilepsy patients depression is the most frequent one. Likewise, depression by itself is accompanied by an increased risk to develop epilepsy. Both epilepsy and depression are characterized by a high incidence of pharmacoresistance, which might be based on overactivity of multidrug ...

journal_title：Experimental neurology

authors： Klein S,Bankstahl JP,Löscher W,Bankstahl M

更新日期：2015-01-01 00:00:00

abstract：:The astrocyte-endothelial cell interaction is crucial for normal brain homeostasis and blood-brain barrier (BBB) disruption in pathological conditions. However, the mechanism by which astrocytes control BBB integrity, especially after traumatic brain injury (TBI), remains unclear. Here, we present evidence that astroc...

journal_title：Experimental neurology

authors： Rui Q,Ni H,Lin X,Zhu X,Li D,Liu H,Chen G

更新日期：2019-12-01 00:00:00

abstract：:It is controversial whether levodopa (L-DOPA) therapy in the early stages of Parkinson's disease (PD) predisposes to later complications. Partial lesions of the substantia nigra (SN) in rat provide a model of the early stages of PD. We have investigated the potential effects of L-DOPA in early PD by analyzing its infl...

journal_title：Experimental neurology

authors： Cole DG,Growdon JH,DiFiglia M

更新日期：1993-04-01 00:00:00

abstract：:We recently revealed a unique glycan on the Fc domain of IgG antibodies in ALS patients that mediates antibody-dependent cell cytotoxicity (ADCC). This glycan has a bi-antennary structure that lacks the core fucose and sialic acid residues but contains a bisecting GlcNAc (A2BG2). Little is known, however, about the in...

journal_title：Experimental neurology

authors： Edri-Brami M,Sharoni H,Hayoun D,Skutelsky L,Nemirovsky A,Porgador A,Lichtenstein RG

更新日期：2015-05-01 00:00:00

abstract：:Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by a progressive and extensive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) and their terminals in the striatum, which results in debilitating movement disorders. This devastating disease affects over 1 m...

journal_title：Experimental neurology

authors： Glavaski-Joksimovic A,Bohn MC

更新日期：2013-09-01 00:00:00

abstract：:It is widely accepted that the immune system plays important functional roles in regeneration after injury to the spinal cord. Immune response towards injury involves a complex interplay of immune system cells, such as neutrophils, macrophages and microglia, T- and B-lymphocytes. We investigated the influence of the l...

journal_title：Experimental neurology

authors： Wu B,Matic D,Djogo N,Szpotowicz E,Schachner M,Jakovcevski I

更新日期：2012-10-01 00:00:00

abstract：:Adult cats were subjected to subarachnoid hemorrhage by three repeated intracisternal injections of autogenous nonheparinized blood (2 ml/injection) at weekly intervals. Histological studies (light and electron microscope) were made of the basilar artery and the middle cerebral arteries of all animals. In the subarach...

journal_title：Experimental neurology

authors： Clower BR,Kapp JP,Moore NA,Smith RR,Haining JL

更新日期：1986-11-01 00:00:00

abstract：:The major neutral and acidic cerebellar lipids were studied in audiogenic seizure (AGS)-resistant C57BL/6 (B6) and AGS-susceptible DBA/2J (D2) mice. These cerebellar lipids were also studied in the D2.B6- Iasb congenic mice and in the B6D2F1 hybrids that are mostly AGS resistant. Except for the Iasb gene, which inhibi...

journal_title：Experimental neurology

authors： Seyfried TN,Bernard D,Mayeda F,Macala L,Yu RK

更新日期：1984-06-01 00:00:00

abstract：:Stress and glucocorticoids exacerbate pain via undefined mechanisms. Macrophage migration inhibitory factor (MIF) is a constitutively expressed protein that is secreted to maintain immune function when glucocorticoids are elevated by trauma or stress. Here we show that MIF is essential for the development of neuropath...

journal_title：Experimental neurology

authors： Alexander JK,Cox GM,Tian JB,Zha AM,Wei P,Kigerl KA,Reddy MK,Dagia NM,Sielecki T,Zhu MX,Satoskar AR,McTigue DM,Whitacre CC,Popovich PG

更新日期：2012-08-01 00:00:00

abstract：:The sympathetic innervation of lumbar dorsal root ganglia (DRGs) and the possible presence of spinal cord circuits connecting primary sensory afferents to the sympathetic outflow to DRGs were investigated. We used simultaneous tracing of the sympathetic input to and sensory output from DRGs. Adult male rats received u...

journal_title：Experimental neurology

authors： Hofstetter CP,Card JP,Olson L

更新日期：2005-07-01 00:00:00

abstract：:Scopolamine and naloxone were administered singly and in combination to different groups of rats undergoing electrical kindling of the amygdala. Scopolamine significantly reduced the maximal seizure stage attained during 15 drug sessions and increased the total number of afterdischarges required to kindle a generalize...

journal_title：Experimental neurology

authors： Cain DP,McKitrick DJ,Desborough KA

更新日期：1987-04-01 00:00:00

abstract：:We investigated whether administration of neurotrophin-3 (NT-3) and NMDA-2D-expressing units, found previously to enhance transmission in neonatal rat spinal cord, strengthens synaptic connections in the injured neonatal cord. We employed electrophysiological methods to evaluate the strength of synaptic transmission t...

journal_title：Experimental neurology

authors： Arvanian VL,Bowers WJ,Anderson A,Horner PJ,Federoff HJ,Mendell LM

更新日期：2006-02-01 00:00:00

abstract：:Cerebral ischemia caused by loss of blood supply to the brain during cardiac arrest or stroke are major causes of death and disability. Biological sex is an important factor in predicting vulnerability of the brain to an ischemic insult, with males being at higher risk for cardio-cerebrovascular events than females of...

journal_title：Experimental neurology

authors： Quillinan N,Deng G,Grewal H,Herson PS

更新日期：2014-09-01 00:00:00

abstract：:Altered activity in one of the output nuclei of the basal ganglia, the internal segment of the globus pallidus, is known to play an important role in the generation of parkinsonism. These inactivation studies tested the hypothesis that altered activity in the second major output nucleus of the basal ganglia, the subst...

journal_title：Experimental neurology

authors： Wichmann T,Kliem MA,DeLong MR

更新日期：2001-02-01 00:00:00

abstract：:We evaluated the effects of allogeneic bone marrow stromal cell treatment of stroke on functional outcome, glial-axonal architecture, and immune reaction. Female Wistar rats were subjected to 2 h of middle cerebral artery occlusion. Rats were injected intravenously with PBS, male allogeneic ACI--or syngeneic Wistar--b...

journal_title：Experimental neurology

authors： Li Y,McIntosh K,Chen J,Zhang C,Gao Q,Borneman J,Raginski K,Mitchell J,Shen L,Zhang J,Lu D,Chopp M

更新日期：2006-04-01 00:00:00

abstract：:Acute exposure of peripheral axons to the free radical Nitric Oxide (NO) may trigger conduction block and, if prolonged, Wallerian degeneration. It was hypothesized that this neurotoxic effect of NO may be due primarily to energy restriction by inhibition of mitochondrial respiration. We compared the neurotoxic effect...

journal_title：Experimental neurology

authors： Alvarez S,Moldovan M,Krarup C

更新日期：2008-07-01 00:00:00

abstract：:Intercostal muscle tendon organs have an inhibitory effect on the medullary neurons driving all inspiratory muscles, and on a subpopulation of medullary bulbospinal expiratory neurons. Results from this study showed that the activity of expiratory related neurons in the region of the retrofacial nucleus (Botzinger com...

journal_title：Experimental neurology

authors： Shannon R,Lindsey BG

更新日期：1987-09-01 00:00:00

abstract：:The effects of sex differences and hormonal factors on the locomotor alterations following intrastriatal injections of quinolinic acid (QA) and the ability of fetal striatal transplants to reverse those effects were examined. Male, female, or ovariectomized female rats received bilateral injections of 150 nmol QA or v...

journal_title：Experimental neurology

authors： Emerich DF,Zubricki EM,Shipley MT,Norman AB,Sanberg PR

更新日期：1991-03-01 00:00:00

abstract：:Effects of accumulation of phosphocreatine (P-creatine) on utilization and restoration of high-energy phosphates during anoxia and recovery were studied using thin hippocampal slices from the guinea pig. Incubation of slices with creatine (5 to 30 mM) increased the content of tissue P-creatine, in a linear fashion, an...

journal_title：Experimental neurology

authors： Yoneda K,Arakawa T,Asaoka Y,Fukuoka Y,Kinugasa K,Takimoto K,Okada Y

更新日期：1983-10-01 00:00:00