Ablations of the mammillary nuclei in monkeys: effects on postoperative memory.

Abstract:

:A new procedure was developed for ablating the mammillary nuclei in nonhuman primates via direct visual exposure. Using this technique, monkeys receiving lesions of the mammillary nuclei were compared to control animals after surgery to assess the retention of preoperatively acquired visuospatial discriminations and subsequent postoperative ability to attain a demanding spatial memory task. Although the lesions proved to be accurate and complete, no changes in gross behavior or deficits in preoperatively acquired visual and spatial behaviors were noted. The monkeys with mammillary body lesions were, however, impaired in their ability to acquire postoperatively the demanding spatial memory task. These findings are consistent with previous investigations suggesting that the mammillary bodies are involved in the acquisition of spatial discriminations and skills.

journal_name

Exp Neurol

journal_title

Experimental neurology

authors

Holmes EJ,Jacobson S,Stein BM,Butters N

doi

10.1016/0014-4886(83)90160-7

subject

Has Abstract

pub_date

1983-07-01 00:00:00

pages

97-113

issue

1

eissn

0014-4886

issn

1090-2430

pii

0014-4886(83)90160-7

journal_volume

81

pub_type

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