Abstract：
:We investigated whether type 2 diabetes mellitus (T2DM), a risk factor of stroke, affects the level of scavenger receptor CD36 and the uptake of its ligand, oxidized LDL (oxLDL); and whether pioglitazone, a drug that enhances CD36, promotes oxLDL uptake. Compared to normoglycemic db/+ mice, adult db/db mice showed a pronounced reduction in surface CD36 expression on myeloid cells from the blood, brain, and bone marrow as detected by flow cytometry, which correlated with elevated plasma soluble-CD36 as determined by ELISA. Increased CD36 expression was found in brain macrophages and microglia of both genotypes 7 days after ischemic stroke. In juvenile db/db mice, prior to obesity and hyperglycemia, only a mild reduction of surface CD36 was found in blood neutrophils, while all other myeloid cells showed no difference relative to the db/+ strain. In vivo, oral pioglitazone treatment for four weeks increased CD36 levels on myeloid cells in db/db mice. In vitro, uptake of oxLDL by bone marrow derived macrophages (BMDMs) of db/db mice was reduced relative to db/+ mice in normal glucose medium. OxLDL uptake inversely correlated with glucose levels in the medium in db/+ BMDMs. Furthermore, pioglitazone restored oxLDL uptake by BMDMs from db/db mice cultured in high glucose. Our data suggest that T2DM is associated with reduced CD36 on adult myeloid cells, and pioglitazone enhances CD36 expression in db/db cells. T2DM or high glucose reduces oxLDL uptake while pioglitazone enhances oxLDL uptake. Our findings provide new insight into the mechanism by which pioglitazone may be beneficial in the treatment of insulin resistance.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Kanoke A,Nishijima Y,Ljungberg M,Omodaka S,Yang SY,Wong S,Rabiller G,Tominaga T,Hsieh CL,Liu Jdoi
10.1016/j.expneurol.2020.113461subject
Has Abstractpub_date
2020-12-01 00:00:00pages
113461eissn
0014-4886issn
1090-2430pii
S0014-4886(20)30292-2journal_volume
334pub_type
杂志文章abstract：:The review outlines data consistent with the hypothesis that inspiratory drive transmission that generates fetal breathing movements (FBMs) is essential for the developmental plasticity of phrenic motoneurons (PMNs) and diaphragm musculature prior to birth. A systematic examination during the perinatal period demonstr...
journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1016/j.expneurol.2016.05.017
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abstract：:Sciatic cryoneurolysis (SCN) is an experimental rat mononeuropathy model that produces neuropathic behavioral sequelae distinct from other neuropathy models. Following SCN, there is limited autotomy peaking in severity and incidence at 7-14 days and delayed but sustained allodynia appearing at about 21 days, with no e...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1995.1028
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abstract：:The beta-amyloid precursor protein (betaAPP) is found in skeletal muscle localized to the base of the postsynaptic folds of the neuromuscular junction; yet here, as well as in neurons, its function remains enigmatic. Here we report that the motor nerve-derived trophic factor neuregulin-1 (NRG1) regulates both steady-s...
journal_title：Experimental neurology
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doi：10.1016/s0014-4886(03)00031-1
更新日期：2003-06-01 00:00:00
abstract：:The long-term effects of partial denervation on the muscle fiber cross-sectional area, degree of axonal sprouting, and end-plate morphology were examined 1, 3, 6, 9, and 12 months postsurgery in rat plantaris muscle. After 1 month of partial denervation, mean cross-sectional areas of type I and type II myofibers were ...
journal_title：Experimental neurology
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doi：10.1016/0014-4886(92)90004-a
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2018.10.010
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abstract：:Infection with human immunodeficiency virus-1 (HIV-1) is associated with dysfunctions of the central nervous system (CNS). HIV-1 induces its effects on the CNS by a variety of mechanisms, including by shedding the neurotoxic viral proteins such as gp120 and Tat. Both HIV-1 and gp120 have been shown to cross the blood-...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2004.11.019
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abstract：:The blood-brain barrier function and the vasomotor response in rat microcirculation was studied using a closed cranial window technique and an intravital fluorescence microscope with an attempt to reduce both the light intensity and the amount of 2% Na(+)-fluorescein to as little as possible. The light intensities in ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(92)90133-b
更新日期：1992-09-01 00:00:00
abstract：:Parkinson's disease (PD) is characterized by the polymerization of wild-type (WT) or mutant alpha-synuclein (AS) into aggregates and fibrils, which are observed as Lewy bodies (LBs) and Lewy neurites (LNs) in PD patients. However, inability to demonstrate aggregation in many cell culture systems is a major drawback fo...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2005.10.019
更新日期：2006-02-01 00:00:00
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journal_title：Experimental neurology
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doi：10.1016/j.expneurol.2020.113505
更新日期：2021-01-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2014.04.019
更新日期：2014-07-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2000.7576
更新日期：2001-03-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(86)90190-1
更新日期：1986-08-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2007.02.004
更新日期：2007-05-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2005.08.007
更新日期：2005-12-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(89)90048-4
更新日期：1989-03-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2005.11.029
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2004.09.013
更新日期：2005-01-01 00:00:00
abstract：:Reactive synaptogenesis and terminal proliferation are known to occur in the dentate gyrus of the rat hippocampus following removal of specific afferents. In the present study we have examined the relation of synaptophysin immunoreactivity to the immunohistochemical staining pattern of GAP-43, a putative marker of neu...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(91)90169-d
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2016.05.007
更新日期：2016-08-01 00:00:00
abstract：:In this study, the effects of testosterone propionate (TP) on recovery from facial paralysis following crush axotomy of the facial nerve in male hamsters were examined. In the first experiment, TP (5 mg/ml sesame oil; 0.1 ml) was injected subcutaneously and on alternate days in one-half of the animals subjected to cru...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(89)90174-x
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journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1006/exnr.1996.0180
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journal_title：Experimental neurology
pub_type： 杂志文章
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更新日期：1987-11-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(83)90251-0
更新日期：1983-10-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2012.04.006
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/s0014-4886(02)00058-4
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2015.03.004
更新日期：2015-05-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(83)90080-8
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2013.12.004
更新日期：2014-03-01 00:00:00
abstract：:Osteogenic protein-1 (OP-1), a member of the transforming growth factor-beta (TGF-beta) superfamily, has been demonstrated to stimulate dendrite growth from sympathetic neurons in culture. However, it is not known whether OP-1 affects dendrite growth from central nervous system neurons. Therefore we quantified axon an...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1999.7194
更新日期：1999-11-01 00:00:00
abstract：:Increased vascular permeability causing vasogenic brain edema is characteristic for many acute neurological diseases such as stroke, brain trauma, and meningitis. Src family kinases, especially c-Src, play an important role in regulating blood-brain barrier permeability in response to VEGF, but also mediate leukocyte ...
journal_title：Experimental neurology
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doi：10.1016/j.expneurol.2006.08.003
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