Is electrical stimulation of the rat incisor an appropriate experimental nociceptive stimulus?

abstract：:Based on their differentiation ability, bone marrow stromal cells (MSCs) are a good source for cell therapy. Using a cynomolgus monkey peripheral nervous system injury model, we examined the safety and efficacy of Schwann cells induced from MSCs as a source for auto-cell transplantation therapy in nerve injury. Serial...

journal_title：Experimental neurology

authors： Wakao S,Hayashi T,Kitada M,Kohama M,Matsue D,Teramoto N,Ose T,Itokazu Y,Koshino K,Watabe H,Iida H,Takamoto T,Tabata Y,Dezawa M

更新日期：2010-06-01 00:00:00

abstract：:The sympathetic innervation of lumbar dorsal root ganglia (DRGs) and the possible presence of spinal cord circuits connecting primary sensory afferents to the sympathetic outflow to DRGs were investigated. We used simultaneous tracing of the sympathetic input to and sensory output from DRGs. Adult male rats received u...

journal_title：Experimental neurology

authors： Hofstetter CP,Card JP,Olson L

更新日期：2005-07-01 00:00:00

abstract：:We have previously demonstrated that systemic administration of testosterone propionate (TP) to adult hamsters accelerates the rate of facial nerve regeneration following crush axotomy of the facial nerve at its exit from the stylomastoid foramen. In this study, we utilized flutamide, a potent nonsteroidal antiandroge...

journal_title：Experimental neurology

authors： Kujawa KA,Tanzer L,Jones KJ

更新日期：1995-06-01 00:00:00

abstract：:A neurochemical target at which cannabinoids interact to have global effects on behavior is brain noradrenergic circuitry. Acute and repeated administration of a cannabinoid receptor synthetic agonist is capable of increasing multiple indices of noradrenergic activity. This includes cannabinoid-induced 1) increases in...

journal_title：Experimental neurology

authors： Reyes BAS,Carvalho AF,Szot P,Kalamarides DJ,Wang Q,Kirby LG,Van Bockstaele EJ

更新日期：2017-06-01 00:00:00

abstract：:The vanilloid receptor TRPV(1) is a key nociceptive molecule located in primary afferent nociceptive neurons in dorsal root ganglia (DRG) for initiating neurogenic inflammation and pain. Our recent study demonstrates that up-regulation of TRPV(1) receptors by intradermal injection of capsaicin is modulated by activati...

journal_title：Experimental neurology

authors： Xu X,Wang P,Zou X,Li D,Fang L,Gong K,Lin Q

更新日期：2010-03-01 00:00:00

abstract：:Angiopoietin-1 (Ang-1) and its naturally occurring antagonist angiopoietin-2 (Ang-2) are novel ligands that regulate tyrosine phosphorylation of the Tie2/Tek receptor on endothelial cells. Proper regulation of Tie2/Tek is absolutely required for normal vascular development, seemingly by regulating vascular remodeling ...

journal_title：Experimental neurology

authors： Zagzag D,Hooper A,Friedlander DR,Chan W,Holash J,Wiegand SJ,Yancopoulos GD,Grumet M

更新日期：1999-10-01 00:00:00

abstract：:Epidermal growth factor responsive (EGFr) neural progenitor (NP) cells have been shown to be a potential alternative tissue source for neural transplantation and for developmental study. We have shown that nonpassaged EGFr NP cells can self-renew for 2 years in neurospheres and can robustly differentiate into glia and...

journal_title：Experimental neurology

authors： Zhou FC,Kelley MR,Chiang YH,Young P

更新日期：2000-07-01 00:00:00

abstract：:Various limbic system structures have been implicated in processing noxious information. One such structure is the anterior cingulate cortex (ACC), a region that is thought to modulate higher order processing of noxious input related to the affective/motivational component of pain. The present experiment examined the ...

journal_title：Experimental neurology

authors： LaGraize SC,Labuda CJ,Rutledge MA,Jackson RL,Fuchs PN

更新日期：2004-07-01 00:00:00

abstract：:Neurons from cerebral neocortex and hippocampus exhibit a striking difference in vulnerability to transient global ischemia. In order to study the contribution of neuronal connections and neuron-glia interactions to this variation in neuronal vulnerability, we used hippocampal and neocortical cultures submitted to var...

journal_title：Experimental neurology

authors： Bernaudin M,Nouvelot A,MacKenzie ET,Petit E

更新日期：1998-03-01 00:00:00

abstract：:One approach to repair of transected nerves is to attempt extrinsic guidance of axons across the gaps. We inserted the proximal and distal stumps of severed mouse sciatic nerves into opposite ends of biodegradable polyester tubes. The nerves and ensheathing tubes were examined after postoperative survival times of as ...

journal_title：Experimental neurology

authors： Henry EW,Chiu TH,Nyilas E,Brushart TM,Dikkes P,Sidman RL

更新日期：1985-12-01 00:00:00

abstract：:Previous studies have demonstrated that neonatal cultures of astrocytes express functional endothelin (ET) receptors. To determine if similar ET receptors are expressed by adult glia we used 125I-ET-1 to examine the expression of ET receptors both in vivo in the normal and transected optic nerves of the rabbit and rat...

journal_title：Experimental neurology

authors： Rogers SD,Demaster E,Catton M,Ghilardi JR,Levin LA,Maggio JE,Mantyh PW

更新日期：1997-05-01 00:00:00

abstract：:Huntington's disease is an autosomal dominant neurogenetic disorder leading to striatal atrophy, characterized by involuntary movements. Voluntary movements also deteriorate, but the neurophysiological mechanisms are less understood. We investigated voluntary movement execution and its neural correlates by means of mo...

journal_title：Experimental neurology

authors： Beste C,Konrad C,Saft C,Ukas T,Andrich J,Pfleiderer B,Hausmann M,Falkenstein M

更新日期：2009-03-01 00:00:00

abstract：:Neuronal apoptosis is a central pathological process in subarachnoid hemorrhage (SAH)-induced early brain injury. Previous studies indicated that ErbB4 (EGFR family member v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4) is essential for normal development and maintenance of the nervous system. In this...

journal_title：Experimental neurology

authors： Yan F,Tan X,Wan W,Dixon BJ,Fan R,Enkhjargal B,Li Q,Zhang J,Chen G,Zhang JH

更新日期：2017-11-01 00:00:00

abstract：:beta-N-methylamino-l-alanine (BMAA) is a non-protein amino acid implicated in the neurodegenerative disease amyotrophic lateral sclerosis/Parkinson-dementia complex (ALS/PDC) on Guam. BMAA has recently been discovered in the brains of Alzheimer's patients in Canada and is produced by various species of cyanobacteria a...

journal_title：Experimental neurology

authors： Liu X,Rush T,Zapata J,Lobner D

更新日期：2009-06-01 00:00:00

abstract：:The conditioned corral preference paradigm was used to assess reinforcing effects of substance P (SP) and its N- and C-terminal fragments injected unilaterally into the region of the nucleus basalis magnocellularis (NBM) in rats. Behavioral testing was carried out in a circular open field, consisting of 4 quadrants eq...

journal_title：Experimental neurology

authors： Hasenöhrl RU,Gerhardt P,Huston JP

更新日期：1992-02-01 00:00:00

abstract：:Osteogenic protein-1 (OP-1), a member of the transforming growth factor-beta (TGF-beta) superfamily, has been demonstrated to stimulate dendrite growth from sympathetic neurons in culture. However, it is not known whether OP-1 affects dendrite growth from central nervous system neurons. Therefore we quantified axon an...

journal_title：Experimental neurology

authors： Le Roux P,Behar S,Higgins D,Charette M

更新日期：1999-11-01 00:00:00

abstract：:Apolipoprotein E (apoE) is known to bind to at least five receptors, including the low-density lipoprotein (LDL) receptor-related protein (LRP), very low density LDL receptor (VLDL-R), LDL-R, apoE receptor 2 (apoER2), and megalin/gp330. In this context, the main objective of the present study was to better understand ...

journal_title：Experimental neurology

authors： Veinbergs I,Van Uden E,Mallory M,Alford M,McGiffert C,DeTeresa R,Orlando R,Masliah E

更新日期：2001-07-01 00:00:00

abstract：:In the neocortex, the effectiveness of potential transplantation therapy for diseases involving neuronal loss may depend upon whether donor neurons can reestablish the precise long-distance projections that form the basis of sensory, motor, and cognitive function. During corticogenesis, the formation of these connecti...

journal_title：Experimental neurology

authors： Hernit-Grant CS,Macklis JD

更新日期：1996-05-01 00:00:00

abstract：:Blood flow in the feline thoracic spinal cord was measured, using a laser-Doppler flowmetry. Rhythmic changes in the spinal cord blood flow were repeatedly observed with a frequency of about three to eight cycles per minute, unrelated to the respiratory or cardiac cycles. These changes were unaffected by hypertension ...

journal_title：Experimental neurology

authors： Mizutani M,Yamamuro T,Shikata J

更新日期：1988-08-01 00:00:00

abstract：:Ca2+ influx through NMDA receptor-gated channels and the subsequent rise in intracellular Ca2+ concentration ([Ca2+]i) have been implicated in cytotoxic processes that lead to irreversible neuronal injury. While many studies have focused on cytosolic Ca2+ homeostasis, much less is known about Ca2+ fluxes in subcellula...

journal_title：Experimental neurology

authors： Peng TI,Jou MJ,Sheu SS,Greenamyre JT

更新日期：1998-01-01 00:00:00

abstract：:Decreases in energy metabolism following traumatic brain injury (TBI) are attributed to impairment of glycolytic flux and oxidative phosphorylation. Glucose utilization post-TBI is decreased while administration of alternative substrates has been shown to be neuroprotective. Changes in energy metabolism following TBI ...

journal_title：Experimental neurology

authors： Greco T,Vespa PM,Prins ML

更新日期：2020-07-01 00:00:00

abstract：:The cellular events in traumatic brain injury (TBI) are complicated, and the factors mediating neurotrophins to protect and repair the injured brain cells are only beginning to be identified. This study examined the effect of dexamethasone (DEX) on neurotrophin-3 (NT-3) expression following TBI. Levels of NT-3 mRNA an...

journal_title：Experimental neurology

authors： Yang JT,Lee TH,Weng HH,Chang CN,Chen WC,Cheng WC,Wu JH

更新日期：2005-04-01 00:00:00

abstract：:The electromyographic (EMG) activity of the gastrocnemius and tibialis anterior muscles was recorded from normal geriatric subjects and from hemiplegic patients subjected to a continuous back-and-forth movement of the platform on which they stood. The platform oscillated at a fixed frequency of 0.5 Hz. Movement amplit...

journal_title：Experimental neurology

authors： Hocherman S,Dickstein R,Hirschbiene A,Pillar T

更新日期：1988-02-01 00:00:00

abstract：:After spinal cord injury at birth, axotomized brainstem-spinal and corticospinal neurons are capable of permanent regenerative axonal growth into and through a fetal spinal cord transplant placed into the site of either a spinal cord hemisection or transection. In contrast, if fetal tissue which is not a normal target...

journal_title：Experimental neurology

authors： Bernstein-Goral H,Diener PS,Bregman BS

更新日期：1997-11-01 00:00:00

abstract：:Grafts of embryonic ventral mesencephalic tissue placed in the striatum of 6-hydroxydopamine-lesioned rats survive, and make and receive connections to and from the host brain. The dopaminergic neurons of the graft can grow processes into the host brain, and thereby alleviate many of the behavioral deficits of this fo...

journal_title：Experimental neurology

authors： Barker RA,Dunnett SB,Faissner A,Fawcett JW

更新日期：1996-09-01 00:00:00

abstract：:Sciatic cryoneurolysis (SCN) is an experimental rat mononeuropathy model that produces neuropathic behavioral sequelae distinct from other neuropathy models. Following SCN, there is limited autotomy peaking in severity and incidence at 7-14 days and delayed but sustained allodynia appearing at about 21 days, with no e...

journal_title：Experimental neurology

authors： Wagner R,DeLeo JA,Heckman HM,Myers RR

更新日期：1995-06-01 00:00:00

abstract：:Lead induces peripheral nerve segmental demyelination in rats. Arsenic and thallium produce a peripheral neuropathy characterized by axonal degeneration in humans. Mercury and thallium appear to damage both the peripheral and the central nervous system. It is not known whether this difference in effect is due to diffe...

journal_title：Experimental neurology

authors： Windebank AJ

更新日期：1986-10-01 00:00:00

abstract：:Exosomes secreted by microglia have been found to play a role in neurovascular unit injury under the ischemic/hypoxic state. However, the modulatory effect of exosomes shuttled miRNAs produced by microglia in endothelial cells remains undefined. Here, an oxygen-glucose deprivation (OGD) model was constructed both in m...

journal_title：Experimental neurology

authors： Xie L,Zhao H,Wang Y,Chen Z

更新日期：2020-11-01 00:00:00

abstract：:Hemiparkinson-hemiatrophy syndrome (HP-HA) is associated with skeletal hemiatrophy and the later development of parkinsonism. It is generally assumed that this phenotype is due to the combination of dysfunction of the basal ganglia (e.g., substantia nigra compacta and/or other related structures), causing parkinsonism...

journal_title：Experimental neurology

authors： Hebb MO,Lang AE,Fletcher PJ,Chambers JW,Lozano AM

更新日期：2002-10-01 00:00:00

abstract：:Thalamocortical spike-and-wave discharges characterize the nonconvulsive absence seizures that occur spontaneously in genetic absence epilepsy rats from Strasbourg (GAERS), a selected strain of Wistar rats. GABA is crucial in the generation of absence seizures. The susceptibility to convulsions induced by threshold do...

journal_title：Experimental neurology

authors： Vergnes M,Boehrer A,Reibel S,Simler S,Marescaux C

更新日期：2000-02-01 00:00:00