Evidence for physiological down-regulation of brain oxidative phosphorylation in Alzheimer's disease.

abstract：:The present study evaluated the growth potential and differentiation of human fetal spinal cord (FSC) tissue in the injured adult rat spinal cord under different lesion and grafting conditions. Donor tissue at 6-9 weeks of gestational age was obtained through elective abortions and transplanted either immediately into...

journal_title：Experimental neurology

authors： Giovanini MA,Reier PJ,Eskin TA,Wirth E,Anderson DK

更新日期：1997-12-01 00:00:00

abstract：:Urotensin-II (U-II) is a cyclic peptide identified recently in many mammalian species including man. U-II and its receptor are expressed in the central nervous system, in the cardiovascular system and in other peripheral tissues. Although this peptide has been reported initially to be a potent vasoconstrictor, increas...

journal_title：Experimental neurology

authors： Chuquet J,Lecrux C,Chatenet D,Leprince J,Chazalviel L,Roussel S,MacKenzie ET,Vaudry H,Touzani O

更新日期：2008-04-01 00:00:00

abstract：:The failure of axons to regenerate after spinal cord injury remains one of the greatest challenges facing both medicine and neuroscience, but in the last 20 years there have been tremendous advances in the field of spinal cord injury repair. One of the most important of these has been the identification of inhibitory ...

journal_title：Experimental neurology

authors： Hannila SS,Filbin MT

更新日期：2008-02-01 00:00:00

abstract：:The aim of this study was to elucidate whether oligodendrocytes die in fiber tracts that are spared by a spinal cord injury but are in close vicinity of inflammatory cells. Adult rat spinal cords were studied histologically 1 day to 2 weeks after a contusion lesion that left the ventral white matter largely intact. Ma...

journal_title：Experimental neurology

authors： Frei E,Klusman I,Schnell L,Schwab ME

更新日期：2000-06-01 00:00:00

abstract：:Human apolipoprotein E (apoE) is a 34.2kDa glycosylated protein with three isoforms (apoE2, apoE3 and apoE4). Experimental autoimmune neuritis (EAN), an animal model for human Guillain-Barré syndrome, is an immune-mediated experimental disorder of the peripheral nervous system (PNS). Increased susceptibility to EAN in...

journal_title：Experimental neurology

authors： Zhang HL,Mao XJ,Zhang XM,Li HF,Zheng XY,Adem A,Mix E,Zhu J

更新日期：2011-08-01 00:00:00

abstract：:We recently reported structural changes in nodes of Ranvier of frog dorsal roots that are associated with activation at 20 or 50 Hz for 15 min. The structural effects co-occur with alterations in the latency, amplitude, and waveform of the compound action potential. The alterations in nodal morphology include formatio...

journal_title：Experimental neurology

authors： Wurtz CC,Ellisman MH

更新日期：1988-07-01 00:00:00

abstract：:The conditioned corral preference paradigm was used to assess reinforcing effects of substance P (SP) and its N- and C-terminal fragments injected unilaterally into the region of the nucleus basalis magnocellularis (NBM) in rats. Behavioral testing was carried out in a circular open field, consisting of 4 quadrants eq...

journal_title：Experimental neurology

authors： Hasenöhrl RU,Gerhardt P,Huston JP

更新日期：1992-02-01 00:00:00

abstract：:Spinal cord injury (SCI) initiates biochemical events that lead to an increase in extracellular excitatory amino acid concentrations, resulting in glutamate receptor-mediated excitotoxic events. These receptors include the three groups of metabotropic glutamate receptors (mGluRs). Group I mGluR activation can initiate...

journal_title：Experimental neurology

authors： Mills CD,Fullwood SD,Hulsebosch CE

更新日期：2001-08-01 00:00:00

abstract：:Adaptive responses in glutamate and opioid receptor systems in limbic circuits are emerging as a critical component of the neural plasticity induced by chronic use of abused substances. The present commentary reviews findings from neuroanatomical studies, with superior spatial resolution, that support a cellular basis...

journal_title：Experimental neurology

authors： Scavone JL,Asan E,Van Bockstaele EJ

更新日期：2011-06-01 00:00:00

abstract：:Sarcoplasmic reticulum (SR) of high purity and functional integrity was isolated from skeletal muscle of normal and ethanol-tolerant rats. Ethanol at low concentrations (0.1 to 0.2 M), added in vitro to isolated SR, resulted in slight inhibition of both calcium loading and calcium-stimulated ATPase rates. Higher conce...

journal_title：Experimental neurology

authors： Mrak RE

更新日期：1983-06-01 00:00:00

abstract：:We investigated the role of the NO/cGMP system in the vasodilatory response to hypercapnia after cortical spreading depression (CSD) in barbiturate anesthetized rats in vivo. Regional cerebral blood flow (rCBF) was measured by laser Doppler flowmetry (LDF). Hypercapnia (arterial pCO2 50-60 mm Hg) increased rCBF by 2.8...

journal_title：Experimental neurology

authors： Scheckenbach KE,Dreier JP,Dirnagl U,Lindauer U

更新日期：2006-12-01 00:00:00

abstract：:Exogenous myelin- or axolemma-enriched fractions were assessed for the ability to inhibit biochemical and morphological expressions of reactive gliosis in rat optic nerve. Elvax pellets containing exogenous myelin, axolemma, whole-brain homogenate, liver, or red cell extracts or no homogenate were inserted into a dura...

journal_title：Experimental neurology

authors： Politis MJ

更新日期：1988-05-01 00:00:00

abstract：:The axonal trajectories of inspiratory bulbospinal neurons were examined after deposition of the anterograde neuronal tracer phaseolus vulgaris leucoagglutinin (PHA-L) into the rostral ventral respiratory group in rats. At the level of the phrenic nucleus, PHA-L-labeled bulbospinal axons crossed the midline of the spi...

journal_title：Experimental neurology

authors： Goshgarian HG,Ellenberger HH,Feldman JL

更新日期：1991-01-01 00:00:00

abstract：:Synemin (Syn) is an intermediate filament (IF) protein. To gain insight into a morphogenetic role of Syn, we have studied its expression patterns in the developing human retina and lens and compared it with those of other IF proteins. In addition, we have tested Syn expression in fetuses (23 and 28 weeks) affected by ...

journal_title：Experimental neurology

authors： Tawk M,Titeux M,Fallet C,Li Z,Daumas-Duport C,Cavalcante LA,Paulin D,Moura-Neto V

更新日期：2003-10-01 00:00:00

abstract：:The contribution of chondroitin sulfate proteoglycan (CSPG) in the suppression of axonal growth in rat spinal cord has been examined by means of an in vitro bioassay in which regenerating neurons are grown on tissue section substrata. Dissociated embryonic chick dorsal root ganglionic neurons were grown on normal and ...

journal_title：Experimental neurology

authors： Zuo J,Neubauer D,Dyess K,Ferguson TA,Muir D

更新日期：1998-12-01 00:00:00

abstract：:Sympathetic axons have been shown to invade the rat hippocampal formation after lesions of the septohippocampal (cholinergic) projection. To test the generality of this type of transmitter-specific sprouting within the central nervous system, lesions were placed within the horizontal limb of the diagonal band in order...

journal_title：Experimental neurology

authors： Gibby WA,Crutcher KA

更新日期：1984-05-01 00:00:00

abstract：:In this study, we show that removal of entorhinal cortex (ERC) afferents to hippocampus reduces levels of presenilin 1 (PS1) in the dentate gyrus of APPswe/PS1DeltaE9 transgenic (Tg) mice. PS1 immunoreactivity on the deafferented dentate gyrus decreases by approximately 25% and 50%, 2 and 4 weeks post-lesion compared ...

journal_title：Experimental neurology

authors： Sheng JG,Price DL,Koliatsos VE

更新日期：2003-12-01 00:00:00

abstract：:Huntingtin is a cytoplasmic protein that is found in neurons and somatic cells. In patients with Huntington's disease (HD), the NH2-terminal region of huntingtin has an expanded polyglutamine tract. An abnormal protein interaction by mutant huntingtin has been proposed as a mechanism for HD pathogenesis. Huntingtin as...

journal_title：Experimental neurology

authors： Velier J,Kim M,Schwarz C,Kim TW,Sapp E,Chase K,Aronin N,DiFiglia M

更新日期：1998-07-01 00:00:00

abstract：:The vanilloid receptor TRPV(1) is a key nociceptive molecule located in primary afferent nociceptive neurons in dorsal root ganglia (DRG) for initiating neurogenic inflammation and pain. Our recent study demonstrates that up-regulation of TRPV(1) receptors by intradermal injection of capsaicin is modulated by activati...

journal_title：Experimental neurology

authors： Xu X,Wang P,Zou X,Li D,Fang L,Gong K,Lin Q

更新日期：2010-03-01 00:00:00

abstract：:The sympathetic innervation of lumbar dorsal root ganglia (DRGs) and the possible presence of spinal cord circuits connecting primary sensory afferents to the sympathetic outflow to DRGs were investigated. We used simultaneous tracing of the sympathetic input to and sensory output from DRGs. Adult male rats received u...

journal_title：Experimental neurology

authors： Hofstetter CP,Card JP,Olson L

更新日期：2005-07-01 00:00:00

abstract：:Traumatic brain injuries (TBI) sustained during peri-adolescent development produce lasting neuro-behavioral changes that render individuals at an increased risk for developing substance abuse disorders. Experimental and clinical evidence of a prolonged period of hypodopaminergia after TBI have been well documented, b...

journal_title：Experimental neurology

authors： Karelina K,Gaier KR,Weil ZM

更新日期：2017-11-01 00:00:00

abstract：:The effects of neonatal 6-hydroxydopamine (6-OHDA) treatment on the projection of locus coeruleus (LC) neurons to the dorsal part of the lateral geniculate nucleus (dLGN) were examined using histofluorescence and electrophysiological methods. Histofluorescence studies confirmed the previous results of Gustafson and Mo...

journal_title：Experimental neurology

authors： Aoki F,Nakamura S

更新日期：1991-06-01 00:00:00

abstract：:The sciatic nerve of the rat is a commonly used model for studies on nerve injury, regeneration, and recovery of function. To interpret the changes that occur in a neuron population subsequent to peripheral nerve injury, and to compare different repair procedures, it is essential to have a complete and accurate unders...

journal_title：Experimental neurology

authors： Swett JE,Wikholm RP,Blanks RH,Swett AL,Conley LC

更新日期：1986-07-01 00:00:00

abstract：:The loss or injury of neurons associated with oxidative and nitrosative redox stress plays an important role in the onset of various neurodegenerative diseases. Specifically, nitric oxide (NO), can affect neuronal survival through a process called S-nitrosylation, by which the NO group undergoes a redox reaction with ...

journal_title：Experimental neurology

authors： Nakamura T,Cho DH,Lipton SA

更新日期：2012-11-01 00:00:00

abstract：:One approach to repair of transected nerves is to attempt extrinsic guidance of axons across the gaps. We inserted the proximal and distal stumps of severed mouse sciatic nerves into opposite ends of biodegradable polyester tubes. The nerves and ensheathing tubes were examined after postoperative survival times of as ...

journal_title：Experimental neurology

authors： Henry EW,Chiu TH,Nyilas E,Brushart TM,Dikkes P,Sidman RL

更新日期：1985-12-01 00:00:00

abstract：:The Alzheimer's disease-related peptide beta(1-40) amyloid self-associates to form fibrils exhibiting a morphology characteristic of amyloidogenic proteins. The mechanism of this fibrillization process has yet to be fully elucidated. In this study we have immobilized the beta(1-40) amyloid to flat gold surfaces using ...

journal_title：Experimental neurology

authors： Blackley HK,Patel N,Davies MC,Roberts CJ,Tendler SJ,Wilkinson MJ,Williams PM

更新日期：1999-08-01 00:00:00

abstract：:Previous studies have suggested that defective high-affinity glutamate uptake, due mainly to a major loss of the astroglial-specific GLT-1 glutamate transporter, underlies the selective motoneuron degeneration observed in sporadic ALS (24, 28). If a defect in glutamate transport underlies the pathogenesis of sporadic ...

journal_title：Experimental neurology

authors： Medina L,Figueredo-Cardenas G,Rothstein JD,Reiner A

更新日期：1996-12-01 00:00:00

abstract：:Stress is a common environmental factor associated with depressive illness and the amygdala is thought to be integral for this association. For example, repeated stress impairs amygdalar neuroplasticity in rodents and these defects parallel amygdalar deficits in depressive illness patients. Because the excitatory neur...

journal_title：Experimental neurology

authors： Piroli GG,Reznikov LR,Grillo CA,Hagar JM,Fadel JR,Reagan LP

更新日期：2013-03-01 00:00:00

abstract：:Although aluminum (Al) contributes to a variety of cognitive dysfunctions and mental diseases, the underlying mechanisms of Al interactions with the nervous system are still unknown. We have studied the action of Al on synaptic transmission and long-term potentiation (LTP) by performing electrophysiological recordings...

journal_title：Experimental neurology

authors： Platt B,Carpenter DO,Büsselberg D,Reymann KG,Riedel G

更新日期：1995-07-01 00:00:00

abstract：:The functional and morphologic consequences of treatment of peripheral nerve lesions with exogenous 3,3',5-triiodo-L-thyronine (T3) are unclear. In this study adult Wistar rats with sciatic nerve crush lesions were treated with 20 micrograms/kg/day of T3. The treated animals gained weight though more slowly than vehic...

journal_title：Experimental neurology

authors： Allpress SJ,Pollock M

更新日期：1986-02-01 00:00:00