Abstract：
:The effects of neonatal 6-hydroxydopamine (6-OHDA) treatment on the projection of locus coeruleus (LC) neurons to the dorsal part of the lateral geniculate nucleus (dLGN) were examined using histofluorescence and electrophysiological methods. Histofluorescence studies confirmed the previous results of Gustafson and Moore (1987, Dev. Brain Res. 37: 143-155) that catecholamine fibers in the cerebral cortex almost completely disappeared whereas the density of catecholamine fibers in the dLGN increased in the 6-OHDA-treated rats. To quantify the density of the LC projections, we assessed the percentage of LC neurons activated antidromically (projection index, P-index) from the cortex and dLGN. In the 6-OHDA-treated rats, the P-indices for the frontal and visual cortex were greatly reduced, whereas those for the dLGN were increased to twice the control values. In the control rats, about 50% of the LC neurons exhibited antidromic latencies from the dLGN of more than 50 ms, whereas all latencies obtained in the 6-OHDA-treated rats were shorter than 50 ms. These results suggest two types of axonal regeneration of LC neurons: (i) LC neurons projecting to the cerebral cortex lose their distal axonal arborization in the cortex and project alternatively to more proximal sites in the dLGN with regenerating axons; (ii) LC axons projecting to the dLGN with a long trajectory are lost, and regeneration occurs with axons of a shorter trajectory.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Aoki F,Nakamura Sdoi
10.1016/0014-4886(91)90128-ysubject
Has Abstractpub_date
1991-06-01 00:00:00pages
284-91issue
3eissn
0014-4886issn
1090-2430journal_volume
112pub_type
杂志文章abstract：:In monkeys, unilateral intracarotid infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces a useful model of hemiparkinsonism. To evaluate MPTP-induced neurochemical changes in vivo, brain microdialysis was employed to measure extracellular levels of dopamine and its metabolites in the neostriatum of...
journal_title：Experimental neurology
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pub_type： 杂志文章
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journal_title：Experimental neurology
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journal_title：Experimental neurology
pub_type： 杂志文章
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journal_title：Experimental neurology
pub_type： 杂志文章
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journal_title：Experimental neurology
pub_type： 杂志文章
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journal_title：Experimental neurology
pub_type： 杂志文章,评审
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更新日期：2013-06-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2000.7606
更新日期：2001-04-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1016/j.expneurol.2012.05.007
更新日期：2012-08-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2006.12.006
更新日期：2007-04-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2005.03.004
更新日期：2005-08-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
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更新日期：1991-05-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
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journal_title：Experimental neurology
pub_type： 杂志文章
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journal_title：Experimental neurology
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journal_title：Experimental neurology
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更新日期：2014-04-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2003.09.007
更新日期：2004-01-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
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更新日期：2007-03-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1006/exnr.1996.6396
更新日期：1997-03-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(86)90076-2
更新日期：1986-02-01 00:00:00
abstract：:Multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), an animal model of MS, are inflammatory demyelinating diseases of the central nervous system. The inflammatory attacks lead to glial dysfunction and death, axonal damage, and neurological deficits. Numerous studies in rat suggest that extrace...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2004.05.023
更新日期：2004-09-01 00:00:00
