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Abnormal neuronal growth in the little (lit) cerebrum.

Abstract：

:Mice genetically deficient in growth hormone were compared with normal littermates for evidence of altered neuronal development. In the lit/lit motor cortex, area 6 of Caviness, cell number, stratification of neurons, and the proportionate layer widths were identical to those of the controls (lit/+). Examined by the Golgi-Cox method modified by Ramon-Moliner, however, the pyramidal neuron was found to have short primary dendrites with sparse branchings. This result was confirmed in sections stained for neuron-specific enolase. Therefore, we conclude that growth hormone has an independent action on neuronal development.

journal_name

Exp Neurol

journal_title

Experimental neurology

authors

Noguchi T,Sugisaki T

doi

10.1016/0014-4886(85)90284-5

subject

Has Abstract

pub_date

1985-07-01 00:00:00

pages

274-8

issue

1

eissn

0014-4886

issn

1090-2430

pii

0014-4886(85)90284-5

journal_volume

89

pub_type

杂志文章

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