Electrophysiologic identification of preganglionic neurons in rat dorsal motor nucleus and analysis of vagus afferent projections.

abstract：:The antiretroviral toxic neuropathy, a distal sensory polyneuropathy associated with antiretroviral treatment, is a frequently occurring neurological complication during treatment of patients with AIDS and often leads to discontinuation of antiretroviral therapy. The mechanisms by which antiretroviral drugs contribute...

journal_title：Experimental neurology

authors： Sanna MD,Peroni D,Quattrone A,Ghelardini C,Galeotti N

更新日期：2015-05-01 00:00:00

abstract：:Ibuprofen is commonly used as an anti-inflammatory analgesic drug, although it is not amongst the first-line treatments for neuropathic pain. Its main effects are mediated by non-specific inhibition of COX enzymes, but it also exerts some COX-independent effects, such as the inhibition of RhoA signaling and the modula...

journal_title：Experimental neurology

authors： Redondo-Castro E,Navarro X

更新日期：2014-02-01 00:00:00

abstract：:Axons are the anatomical link between neuronal cell bodies and their target organs, and thus axonal degeneration is the pathological substrate that underlies neurological dysfunction in a large number of neurological conditions. Recent advances in the field of axonal biology demonstrate that axons possess programs for...

journal_title：Experimental neurology

authors： Fischer-Hayes LR,Brotherton T,Glass JD

更新日期：2013-08-01 00:00:00

abstract：:Local field potential recordings made from the basal ganglia of patients undergoing deep brain stimulation have suggested that frequency specific activity is involved in determining the rate of force development and the peak force at the outset of a movement. However, the extent to which the basal ganglia might be inv...

journal_title：Experimental neurology

authors： Tan H,Pogosyan A,Anzak A,Foltynie T,Limousin P,Zrinzo L,Ashkan K,Bogdanovic M,Green AL,Aziz T,Brown P

更新日期：2013-02-01 00:00:00

abstract：:Periodic changes in ovarian steroid levels during fertility cycles affect learning both in humans and in rats in parallel with electrophysiological and morphological fluctuations in selective neuronal populations. In particular, during the estrous cycle of the female rat, hippocampal CA1 region undergoes cyclic modifi...

journal_title：Experimental neurology

authors： Crispino M,Stone DJ,Wei M,Anderson CP,Tocco G,Finch CE,Baudry M

更新日期：1999-10-01 00:00:00

abstract：:The antinociceptive properties of a new synthetic dipeptide (N-hexanoyl-5-hydroxytryptophyl-5-hydroxytryptophan amide, or 5-HTP-DP-hex) were studied in rats by an electrophysiological method. After an i.p. injection of alpha-chloralose and urethane, the animals were prepared for stereotaxic approach to the nucleus ven...

journal_title：Experimental neurology

authors： Emmers R,Tamir H,Wilchek M

更新日期：1987-06-01 00:00:00

abstract：:Exogenous myelin- or axolemma-enriched fractions were assessed for the ability to inhibit biochemical and morphological expressions of reactive gliosis in rat optic nerve. Elvax pellets containing exogenous myelin, axolemma, whole-brain homogenate, liver, or red cell extracts or no homogenate were inserted into a dura...

journal_title：Experimental neurology

authors： Politis MJ

更新日期：1988-05-01 00:00:00

abstract：:We investigated the role of the NO/cGMP system in the vasodilatory response to hypercapnia after cortical spreading depression (CSD) in barbiturate anesthetized rats in vivo. Regional cerebral blood flow (rCBF) was measured by laser Doppler flowmetry (LDF). Hypercapnia (arterial pCO2 50-60 mm Hg) increased rCBF by 2.8...

journal_title：Experimental neurology

authors： Scheckenbach KE,Dreier JP,Dirnagl U,Lindauer U

更新日期：2006-12-01 00:00:00

abstract：:The competence of neurons to regenerate depends on their ability to initiate a program of gene expression supporting growth and on the growth-permissive properties of glial cells in the distal stump of the injured nerve. Most studies on intrinsic molecular mechanisms governing peripheral nerve regeneration have focuss...

journal_title：Experimental neurology

authors： Pasterkamp RJ,Giger RJ,Verhaagen J

更新日期：1998-10-01 00:00:00

abstract：:Repeatedly it was reported that a short ischemic episode may ameliorate biochemical and morphological impairment upon succeeding severe ischemia. We investigated whether the pattern of respiratory enzyme activity (RA), adenine nucleotides, and membrane potential in hippocampal slices following low-dose in vivo (20 mg/...

journal_title：Experimental neurology

authors： Riepe MW,Niemi WN,Megow D,Ludolph AC,Carpenter DO

更新日期：1996-03-01 00:00:00

abstract：:Ciliary neurotrophic factor (CNTF) and brain-derived neurotrophic factor (BDNF) have been shown both in vitro and in vivo to support the survival and differentiation of developing chick or rat motoneurons. To explore the potential use of these and other neurotrophic factors as therapeutic agents in human motoneuron di...

journal_title：Experimental neurology

authors： Kato AC,Lindsay RM

更新日期：1994-12-01 00:00:00

abstract：:The aim of this study was to compare the physiological properties of single neurons in the glabrous (G) and heterogeneous (H) subdivisions of primary somatosensory digit 3 cortex of adult raccoons. Extracellular recordings were obtained from 50 G neurons whose receptive fields (RFs) were confined to the glabrous skin ...

journal_title：Experimental neurology

authors： Doetsch GS,Stoney SD Jr,Hauge DH

更新日期：1992-02-01 00:00:00

abstract：:The longitudinal distributions of both phrenic and medial gastrocnemius motoneurons were quantitatively studied in the cat spinal cord. Both populations of motoneurons were retrogradely labeled by applying horseradish peroxidase (HRP) to the cut central ends of the appropriate peripheral nerves. The longitudinal posit...

journal_title：Experimental neurology

authors： Berger AJ,Cameron WE,Averill DB,Kramis RC,Binder MD

更新日期：1984-12-01 00:00:00

abstract：:Exogenously added gangliosides enhance sprouting, neurite outgrowth, and other neuronal activities; this effect may be initiated when a ganglioside binds to a membrane protein or when a ganglioside intercalates into the plasma membrane. To test whether binding to membrane proteins is sufficient for ganglioside-mediate...

journal_title：Experimental neurology

authors： Riggott MJ,Matthew WD

更新日期：1997-05-01 00:00:00

abstract：:Based on previous studies demonstrating the potential of growth factors to enhance peripheral nerve regeneration, we developed a novel growth factor delivery system to provide sustained delivery of nerve growth factor (NGF). This delivery system uses heparin to immobilize NGF and slow its diffusion from a fibrin matri...

journal_title：Experimental neurology

authors： Lee AC,Yu VM,Lowe JB 3rd,Brenner MJ,Hunter DA,Mackinnon SE,Sakiyama-Elbert SE

更新日期：2003-11-01 00:00:00

abstract：:Wnt5b, a member of Wnt family, plays multiple roles in tumor progression and metastasis. However, whether Wnt5b contributes to the sensitization of dorsal root ganglia (DRG) neurons and pathogenesis of bone cancer pain still remains unclear. Here, we found that the protein expression of Wnt5b and its atypical tyrosine...

journal_title：Experimental neurology

authors： He JJ,Wang X,Liang C,Yao X,Zhang ZS,Yang RH,Fang D

更新日期：2020-12-01 00:00:00

abstract：:The neural substrate underlying the aversive effects induced by ethanol abstinence is still unclear. One candidate for such effects is the dorsal periaqueductal gray (dPAG), a core structure of the brain aversion system. The main aim of this study is to examine the role of the dPAG as a possible locus of the aversive ...

journal_title：Experimental neurology

authors： Cabral A,Isoardi N,Salum C,Macedo CE,Nobre MJ,Molina VA,Brandão ML

更新日期：2006-07-01 00:00:00

abstract：:Dopaminergic (DAergic) hypofunction in the medial prefrontal cortex (mPFC) has been implicated in the negative and cognitive symptoms of schizophrenia and is regulated by serotonergic (5-HTergic) neurons in the dorsal raphe nucleus (DRN). The lateral habenula (LHb) is a key element in controlling DRN 5-HT neurons. We ...

journal_title：Experimental neurology

authors： Li J,Yang S,Liu X,Han Y,Li Y,Feng J,Zhao H

更新日期：2019-08-01 00:00:00

abstract：:Intrastriatal injection of excitatory amino acids, particularly quinolinic acid, has been proposed as an animal model of Huntington's disease. Such neurotoxic lesions of caudate-putamen result in marked dopamine type-1 (D1) receptor losses in the injected nuclei as well as in the ipsilateral substantia nigra pars reti...

journal_title：Experimental neurology

authors： Filloux F,Wagster MV,Folstein S,Price DL,Hedreen JC,Dawson TM,Wamsley JK

更新日期：1990-11-01 00:00:00

abstract：:Total, Mg2+-, Na+,K+-, and Ca2+-ATPase activities were studied in fresh brain membrane preparations from adult epileptic (El) mice and nonepileptic C57BL/6J (B6) mice. The El mice have an inherited type of temporal lobe epilepsy. No significant differences were observed between the El and B6 mice for any of the ATPase...

journal_title：Experimental neurology

authors： Palayoor ST,Seyfried TN

更新日期：1988-03-01 00:00:00

abstract：:In this study, we show that removal of entorhinal cortex (ERC) afferents to hippocampus reduces levels of presenilin 1 (PS1) in the dentate gyrus of APPswe/PS1DeltaE9 transgenic (Tg) mice. PS1 immunoreactivity on the deafferented dentate gyrus decreases by approximately 25% and 50%, 2 and 4 weeks post-lesion compared ...

journal_title：Experimental neurology

authors： Sheng JG,Price DL,Koliatsos VE

更新日期：2003-12-01 00:00:00

abstract：:The effect of corporal hypothermia on regional blood flow in peripheral nerve is unknown. We compared blood flow in resting sciatic nerves of anesthetized, normothermic rats with that of rats whose rectal temperatures had been acutely lowered to 28 to 30 degrees C. Peripheral nerve regional blood flow in normothermic ...

journal_title：Experimental neurology

authors： Sugimoto H,Monafo WW,Shimazaki S

更新日期：1987-08-01 00:00:00

abstract：:Neonatal hypoxia ischemia (HI) is the main cause of newborn mortality and morbidity. Preclinical studies have shown that the immature rat brain is more resilient to HI injury, suggesting innate mechanisms of neuroprotection. During neonatal period brain metabolism experience changes that might greatly affect the outco...

journal_title：Experimental neurology

authors： Odorcyk FK,Duran-Carabali LE,Rocha DS,Sanches EF,Martini AP,Venturin GT,Greggio S,da Costa JC,Kucharski LC,Zimmer ER,Netto CA

更新日期：2020-08-01 00:00:00

abstract：:Idiopathic inflammatory myopathies (IIMs), comprising of polymyositis, dermatomyositis, and inclusion-body myositis, are characterized by muscle weakness and various types of inflammatory changes in muscle cells. They also show non-inflammatory changes, including perifascicular atrophy, mitochondrial changes, and amyl...

journal_title：Experimental neurology

authors： Nozaki K,Das A,Ray SK,Banik NL

更新日期：2010-10-01 00:00:00

abstract：:Dementia and parkinsonism are late-onset symptoms associated with repetitive head injury, as documented in multiple contact-sport athletes. Clinical symptomatology is the likely phenotype of chronic degeneration and circuit disruption in the substantia nigra (SN). To investigate the initiating neuropathology, we hypot...

journal_title：Experimental neurology

authors： van Bregt DR,Thomas TC,Hinzman JM,Cao T,Liu M,Bing G,Gerhardt GA,Pauly JR,Lifshitz J

更新日期：2012-03-01 00:00:00

abstract：:Mitochondrial dysfunction and pathology that contribute to a host of neurodegenerative diseases are deduced from changes in ultrastructure, routinely examined by a host of optical techniques. We adapted the technique of photon correlation spectroscopy (PCS) to evaluate calcium-induced structural alterations in isolate...

journal_title：Experimental neurology

authors： Lifshitz J,Janmey PA,McIntosh TK

更新日期：2006-02-01 00:00:00

abstract：:An important issue in stem cell biology relates to mechanisms of cellular plasticity. Specifically, could any observed multipotency of, e.g., adult stem cells arise from true transdifferentiation or as a result of cell-cell fusion? We studied this issue using a culture paradigm of astrocyte monolayers and multipotent ...

journal_title：Experimental neurology

authors： Chen KA,Laywell ED,Marshall G,Walton N,Zheng T,Steindler DA

更新日期：2006-03-01 00:00:00

abstract：:Both alpha- and beta-adrenergic receptors (ARs) are involved in the facilitation of the monosynaptic jaw-closing reflex in the trigeminal motor nucleus (MoV) caused by norepinephrine (NE). The amplitude of muscle spindle afferent-evoked EPSPs in masseter motor neurons is 65% greater when noradrenergic axons to the mot...

journal_title：Experimental neurology

authors： Shao YP,Sutin J

更新日期：1991-11-01 00:00:00

abstract：:Youth is a strong predictor of functional recovery after peripheral nerve repair, while adulthood is commonly associated with poor outcome. Identification of the factors responsible for this difference could form the basis for strategies to improve regeneration in adults. Preferential reinnervation of motor pathways b...

journal_title：Experimental neurology

authors： Le TB,Aszmann O,Chen YG,Royall RM,Brushart TM

更新日期：2001-01-01 00:00:00

abstract：:Pericytes are a major component of cerebrovasculature playing a key role in maintaining cerebrovascular homeostasis. These cells have also been suggested to regulate brain metabolism of amyloid-β (Aβ), disturbances of which are believed to contribute to the pathogenesis of Alzheimer's disease (AD). To examine the effe...

journal_title：Experimental neurology

authors： Tachibana M,Yamazaki Y,Liu CC,Bu G,Kanekiyo T

更新日期：2018-02-01 00:00:00