当前位置： SCI文献检索 > EXPERIMENTAL NEUROLOGY期刊下所有文献 > At-level neuropathic pain is induced by lumbosacral ventral root avulsion injury and ameliorated by root reimplantation into the spinal cord.

At-level neuropathic pain is induced by lumbosacral ventral root avulsion injury and ameliorated by root reimplantation into the spinal cord.

Abstract：

:Neuropathic pain is common after traumatic injuries to the cauda equina/conus medullaris and brachial plexus. Clinically, this pain is difficult to treat and its mechanisms are not well understood. Lesions to the ventral roots are common in these injuries, but are rarely considered as potential contributors to pain. We examined whether a unilateral L6-S1 ventral root avulsion (VRA) injury in adult female rats might elicit pain within the dermatome projecting to the adjacent, uninjured L5 spinal segment. Additionally, a subset of subjects had the avulsed L6-S1 ventral roots reimplanted (VRA+Imp) into the lateral funiculus post-avulsion to determine whether this neural repair strategy elicits or ameliorates pain. Behavioral tests for mechanical allodynia and hyperalgesia were performed weekly over 7 weeks post-injury at the hindpaw plantar surface. Allodynia developed early and persisted post-VRA, whereas VRA+Imp rats exhibited allodynia only at 1 week post-operatively. Hyperalgesia was not observed at any time in any experimental group. Quantitative immunohistochemistry showed increased levels of inflammatory markers in laminae III-V and in the dorsal funiculus of the L5 spinal cord of VRA, but not VRA+Imp rats, specific to areas that receive projections from mechanoreceptive, but not nociceptive, primary afferents. These data suggest that sustained at-level neuropathic pain can develop following a pure motor lesion, whereas the pain may be ameliorated by acute root reimplantation. We believe that our findings are of translational research interest, as root implantation surgery is emerging as a potentially useful strategy for the repair of cauda equina/conus medullaris injuries.

journal_name

Exp Neurol

journal_title

Experimental neurology

authors

Bigbee AJ,Hoang TX,Havton LA

doi

10.1016/j.expneurol.2006.11.003

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

273-82

issue

1

eissn

0014-4886

issn

1090-2430

pii

S0014-4886(06)00611-X

journal_volume

204

pub_type

杂志文章

相关文献

EXPERIMENTAL NEUROLOGY文献大全
  • Cortical and striatal neuronal cultures of the same embryonic origin show intrinsic differences in glutamate receptor expression and vulnerability to excitotoxicity.

    abstract：:Cortical and striatal cultures were prepared from the same embryonic rat brains and maintained in identical culture conditions. In this way, the intrinsic, genetically imprinted differences determine the responses of cortical and striatal neurons in comparative studies. Cortical and striatal neurons differed in their ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.2000.7576

    authors： Kovács AD,Cebers G,Cebere A,Moreira T,Liljequist S

    更新日期：2001-03-01 00:00:00

  • Broadening the definition of brain insulin resistance in aging and Alzheimer's disease.

    abstract：:It has been >20 years since studies first revealed that the brain is insulin sensitive, highlighted by the expression of insulin receptors in neurons and glia, the presence of circulating brain insulin, and even localized insulin production. Following these discoveries, evidence of decreased brain insulin receptor num...

    journal_title：Experimental neurology

    pub_type： 杂志文章,评审

    doi：10.1016/j.expneurol.2018.12.007

    authors： Frazier HN,Ghoweri AO,Anderson KL,Lin RL,Porter NM,Thibault O

    更新日期：2019-03-01 00:00:00

  • Antisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in rats.

    abstract：:Patients with neuropathic pain frequently experience hypersensitivity to cold stimulation. However, the underlying mechanisms of this enhanced sensitivity to cold are not well understood. After partial nerve injury, the transient receptor potential ion channel TRPV1 increases in the intact small dorsal root ganglion (...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2006.01.031

    authors： Katsura H,Obata K,Mizushima T,Yamanaka H,Kobayashi K,Dai Y,Fukuoka T,Tokunaga A,Sakagami M,Noguchi K

    更新日期：2006-07-01 00:00:00

  • Site specificity of adrenalectomy-induced brain growth.

    abstract：:Infant, juvenile, and adult brain growth is modulated by corticosterone. This study was designed to determine whether such modulation is confined to certain specific brain areas, and if the pattern of growth revealed is consistent across strains of rats. Young female Sprague-Dawley-derived rats were either adrenalecto...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(88)90229-4

    authors： Thomas TL,Devenport LD

    更新日期：1988-12-01 00:00:00

  • Increased quantal size in transmission at slow but not fast neuromuscular synapses of apolipoprotein E deficient mice.

    abstract：:Uncertainties from the literature concerning the role of apolipoprotein E (apoE) in central cholinergic function prompted us to investigate what effect apoE may have on transmission at the neuromuscular junction. Both spontaneous and evoked release were measured in isolated extensor digitorum longus (edl) and soleus m...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2003.10.006

    authors： Everett AW,Ernst EJ

    更新日期：2004-02-01 00:00:00

  • Autoradiographic measurement of relative changes in ornithine decarboxylase in axotomized superior cervical ganglion neurons.

    abstract：:An autoradiographic method is described for detecting changes in ornithine decarboxylase in axotomized superior cervical ganglion neurons of rats using [3H]difluoromethylornithine. An increase in binding to neurons was seen at 12 h and 1 day after crushing the postganglionic nerves. Binding returned to control values ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(86)90097-x

    authors： Wells MR

    更新日期：1986-05-01 00:00:00

  • Diffusion tensor imaging to assess axonal regeneration in peripheral nerves.

    abstract：:Development of outcome measures to assess ongoing nerve regeneration in the living animal that can be translated to human can provide extremely useful tools for monitoring the effects of therapeutic interventions to promote nerve regeneration. Diffusion tensor imaging (DTI), a magnetic resonance based technique, provi...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2009.10.012

    authors： Lehmann HC,Zhang J,Mori S,Sheikh KA

    更新日期：2010-05-01 00:00:00

  • Celecoxib reverts oxaliplatin-induced neuropathic pain through inhibiting PI3K/Akt2 pathway in the mouse dorsal root ganglion.

    abstract：:Oxaliplatin (OXA) is the common and extremely potent anti-advanced colorectal cancer chemotherapeutic. Accumulating evidence reveals that OXA evokes mechanical and cold hypersensitivity. However, the mechanism underlying these bothersome and dose-limiting adverse effects is poorly understood. It is well known that cyc...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2015.11.001

    authors： Jiang SP,Zhang ZD,Kang LM,Wang QH,Zhang L,Chen HP

    更新日期：2016-01-01 00:00:00

  • Neuroprotection by estradiol: a role of aromatase against spine synapse loss after blockade of GABA(A) receptors.

    abstract：:Estrogen has been suggested to be pro-epileptic by reducing GABA synthesis, resulting in increased spine density and a decreased threshold for seizures in the hippocampus, which, once they occur, are characterized by a dramatic spine loss in the affected brain areas. As considerable amounts of estradiol are synthesize...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2006.07.020

    authors： Zhou L,Lehan N,Wehrenberg U,Disteldorf E,von Lossow R,Mares U,Jarry H,Rune GM

    更新日期：2007-01-01 00:00:00

  • Optogenetic exploration and modulation of pain processing.

    abstract：:Intractable pain is the single most common cause of disability, affecting more than 20% of the population world-wide. There is accordingly a global effort to decipher how changes in nociceptive processing in the peripheral and central nervous systems contribute to the onset and maintenance of chronic pain. The past se...

    journal_title：Experimental neurology

    pub_type： 杂志文章,评审

    doi：10.1016/j.expneurol.2018.05.003

    authors： Xie YF,Wang J,Bonin RP

    更新日期：2018-08-01 00:00:00

  • Progesterone and allopregnanolone reduce inflammatory cytokines after traumatic brain injury.

    abstract：:Following a traumatic brain injury (TBI), the excessive release of interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) is a major cause of cerebral edema, which, in turn, can cause permanent neuronal loss and cognitive deficits in laboratory rats. This study examined the changes in expression of t...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2004.06.008

    authors： He J,Evans CO,Hoffman SW,Oyesiku NM,Stein DG

    更新日期：2004-10-01 00:00:00

  • In situ produced 7-chlorokynurenate provides protection against quinolinate- and malonate-induced neurotoxicity in the rat striatum.

    abstract：:Excitotoxic mechanisms may play a critical role in the pathophysiology of several neurological and psychiatric diseases. Excitatory amino acid receptor antagonists are therefore of great therapeutic interest, but untoward side effects often prevent their clinical use. Targeting the glycine coagonist site of the (NMDA)...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1999.7284

    authors： Guidetti P,Wu HQ,Schwarcz R

    更新日期：2000-05-01 00:00:00

  • Postural responses of normal geriatric and hemiplegic patients to a continuing perturbation.

    abstract：:The electromyographic (EMG) activity of the gastrocnemius and tibialis anterior muscles was recorded from normal geriatric subjects and from hemiplegic patients subjected to a continuous back-and-forth movement of the platform on which they stood. The platform oscillated at a fixed frequency of 0.5 Hz. Movement amplit...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(88)90156-2

    authors： Hocherman S,Dickstein R,Hirschbiene A,Pillar T

    更新日期：1988-02-01 00:00:00

  • Prenatal exposure to alcohol alters short-term plasticity in hippocampus.

    abstract：:Paired-pulse potentiation was studied in the CA1 region of rats exposed prenatally to alcohol. Pregnant rats were fed a liquid diet containing 35% ethanol-derived calories on days 3 to 21 of gestation. Control animals were fed liquid diets without ethanol. When the pups of both groups were 40 to 60 days old, hippocamp...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(86)90203-7

    authors： Hablitz JJ

    更新日期：1986-08-01 00:00:00

  • Reactive synaptogenesis assessed by synaptophysin immunoreactivity is associated with GAP-43 in the dentate gyrus of the adult rat.

    abstract：:Reactive synaptogenesis and terminal proliferation are known to occur in the dentate gyrus of the rat hippocampus following removal of specific afferents. In the present study we have examined the relation of synaptophysin immunoreactivity to the immunohistochemical staining pattern of GAP-43, a putative marker of neu...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(91)90169-d

    authors： Masliah E,Fagan AM,Terry RD,DeTeresa R,Mallory M,Gage FH

    更新日期：1991-08-01 00:00:00

  • Advances in nonhuman primate models of autism: Integrating neuroscience and behavior.

    abstract：:Given the prevalence and societal impact of autism spectrum disorders (ASD), there is an urgent need to develop innovative preventative strategies and treatments to reduce the alarming number of cases and improve core symptoms for afflicted individuals. Translational efforts between clinical and preclinical research a...

    journal_title：Experimental neurology

    pub_type： 杂志文章,评审

    doi：10.1016/j.expneurol.2017.07.021

    authors： Bauman MD,Schumann CM

    更新日期：2018-01-01 00:00:00

  • Neuroprotection and neurorestoration as experimental therapeutics for Parkinson's disease.

    abstract：:Disease-modifying treatments remain an unmet medical need in Parkinson's disease (PD). Such treatments can be operationally defined as interventions that slow down the clinical evolution to advanced disease milestones. A treatment may achieve this outcome by either inhibiting primary neurodegenerative events ("neuropr...

    journal_title：Experimental neurology

    pub_type： 杂志文章,评审

    doi：10.1016/j.expneurol.2017.10.001

    authors： Francardo V,Schmitz Y,Sulzer D,Cenci MA

    更新日期：2017-12-01 00:00:00

  • Thalamic kindling: electrical stimulation of the lateral geniculate nucleus produces photosensitive grand mal seizures.

    abstract：:Kindling is traditionally viewed as a chronic, focal epilepsy model which consistently induces complex partial seizures from limbic structures in animals. This study revealed that primary or exceedingly rapid secondary generalized seizures could also be kindled when stimulation was applied to the lateral geniculate nu...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(84)90063-3

    authors： Shouse MN,Ryan W

    更新日期：1984-10-01 00:00:00

  • The protective effects of β-lactam antibiotics in motor neuron disorders.

    abstract：:In the June issue of Experimental Neurology, Nizzardo and colleagues demonstrate that the beta-lactam antibiotic ceftriaxone is neuroprotective in a mouse model of spinal muscular atrophy. Here I review their main findings and the relevance to previous and future work on motor neuron disorders and for developing thera...

    journal_title：Experimental neurology

    pub_type： 评论,杂志文章,评审

    doi：10.1016/j.expneurol.2011.06.002

    authors： Hedlund E

    更新日期：2011-09-01 00:00:00

  • Early microfilament reorganization in injured auditory epithelia.

    abstract：:Microfilaments (MFs) play an important role in wound healing and other regenerative events. The purpose of this study was to characterize changes in the distribution of MFs in traumatized auditory epithelia and compare these changes between avian (regenerating) and mammalian (nonregenerating) ears. Chicks and guinea p...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(92)90217-e

    authors： Raphael Y,Altschuler RA

    更新日期：1992-01-01 00:00:00

  • Combined delivery of neurotrophin-3 and NMDA receptors 2D subunit strengthens synaptic transmission in contused and staggered double hemisected spinal cord of neonatal rat.

    abstract：:We investigated whether administration of neurotrophin-3 (NT-3) and NMDA-2D-expressing units, found previously to enhance transmission in neonatal rat spinal cord, strengthens synaptic connections in the injured neonatal cord. We employed electrophysiological methods to evaluate the strength of synaptic transmission t...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2005.10.008

    authors： Arvanian VL,Bowers WJ,Anderson A,Horner PJ,Federoff HJ,Mendell LM

    更新日期：2006-02-01 00:00:00

  • Effect of L-carnitine on nucleic acid status of aged rat brain.

    abstract：:The accumulation of damage to DNA plays a significant role in the etiology of the aging process. The importance of nutrition in delaying the aging process is well recognized. L-carnitine is a quaternary ammonium compound heterogeneously distributed in the brain. In the present study the effect of L-carnitine on DNA da...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2004.09.009

    authors： Juliet PA,Joyee AG,Jayaraman G,Mohankumar MN,Panneerselvam C

    更新日期：2005-01-01 00:00:00

  • Repin-induced neurotoxicity in rodents.

    abstract：:Russian knapweed is a perennial weed found in many parts of the world, including southern California. Chronic ingestion of this plant by horses has been reported to cause equine nigropallidal encephalomalacia (ENE), which is associated with a movement disorder simulating Parkinson's disease (PD). Repin, a principal in...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1998.6826

    authors： Robles M,Choi BH,Han B,Santa Cruz K,Kim RC

    更新日期：1998-07-01 00:00:00

  • Macrophage colony stimulating factor (M-CSF) exacerbates ALS disease in a mouse model through altered responses of microglia expressing mutant superoxide dismutase.

    abstract：:Macrophage colony stimulating factor (M-CSF) is a cytokine that regulates the survival, proliferation and maturation of microglial cells. Administration of M-CSF can promote neuronal survival in various models of central nervous system (CNS) injury. Here, in an attempt to induce a neuroprotective microglial cell pheno...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2009.08.021

    authors： Gowing G,Lalancette-Hébert M,Audet JN,Dequen F,Julien JP

    更新日期：2009-12-01 00:00:00

  • Effects of tractotomy on nociceptive reactions induced by tooth pulp stimulation in the rat.

    abstract：:The effects of a trigeminal tractotomy on nociceptive reactions induced by electrical stimulation of an inferior incisor were studied in freely moving rats. Behavioral tests were based on the observation of three reactions: jaw opening reflex, face scratching with forepaws, and head rotation toward the stimulated side...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(89)90147-7

    authors： Dallel R,Clavelou P,Woda A

    更新日期：1989-10-01 00:00:00

  • Mutation of the caspase-3 cleavage site in the astroglial glutamate transporter EAAT2 delays disease progression and extends lifespan in the SOD1-G93A mouse model of ALS.

    abstract：:Downregulation in the astroglial glutamate transporter EAAT2 in amyotrophic lateral sclerosis (ALS) patients and mutant SOD1 mouse models of ALS is believed to contribute to the death of motor neurons by excitotoxicity. We previously reported that caspase-3 cleaves EAAT2 at a unique cleavage consensus site located in ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2017.03.014

    authors： Rosenblum LT,Shamamandri-Markandaiah S,Ghosh B,Foran E,Lepore AC,Pasinelli P,Trotti D

    更新日期：2017-06-01 00:00:00

  • Functional neuromuscular stimulation to improve severe hand dysfunction after stroke: does inhibitory rTMS enhance therapeutic efficiency?

    abstract：BACKGROUND:Novel strategies to improve hand function after stroke are needed. Electromyography-triggered functional neuromuscular stimulation (EMG-FNMS) and repetitive transcranial magnetic stimulation (rTMS) are promising techniques to facilitate recovery of sensory-motor hand dysfunction after stroke. OBJECTIVE:To i...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2011.04.010

    authors： Theilig S,Podubecka J,Bösl K,Wiederer R,Nowak DA

    更新日期：2011-07-01 00:00:00

  • Expression of c-Jun protein in degenerating retinal ganglion cells after optic nerve lesion in the rat.

    abstract：:Axonal lesions to the optic nerve (ON) induce c-Jun expression in retinal ganglion cells (RGCs) of the rat in vivo. Detailed investigations using retrograde tracers, and double labeling studies for c-Jun and regeneration-associated factors, such as the growth-associated protein GAP-43, have suggested that this upregul...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1997.6585

    authors： Isenmann S,Bähr M

    更新日期：1997-09-01 00:00:00

  • Photobiomodulation therapy promotes neurogenesis by improving post-stroke local microenvironment and stimulating neuroprogenitor cells.

    abstract：:Recent work has indicated that photobiomodulation (PBM) may beneficially alter the pathological status of several neurological disorders, although the mechanism currently remains unclear. The current study was designed to investigate the beneficial effect of PBM on behavioral deficits and neurogenesis in a photothromb...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2017.10.013

    authors： Yang L,Tucker D,Dong Y,Wu C,Lu Y,Li Y,Zhang J,Liu TC,Zhang Q

    更新日期：2018-01-01 00:00:00

  • Neuronal cell loss accompanies the brain tissue response to chronically implanted silicon microelectrode arrays.

    abstract：:Implantable silicon microelectrode array technology is a useful technique for obtaining high-density, high-spatial resolution sampling of neuronal activity within the brain and holds promise for a wide range of neuroprosthetic applications. One of the limitations of the current technology is inconsistent performance i...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2005.04.020

    authors： Biran R,Martin DC,Tresco PA

    更新日期：2005-09-01 00:00:00