Autoradiographic measurement of relative changes in ornithine decarboxylase in axotomized superior cervical ganglion neurons.

abstract：:The purpose of this study was to assess the respiratory and tonic activity of the abdominal muscles and the postinspiratory activity of the diaphragm (stage 1 expiration) in rats during sleep while they breathed air, hypercapnic, and hypoxic gas mixtures. ECoG and neck EMG recordings enabled the differentiation to be ...

journal_title：Experimental neurology

authors： Sherrey JH,Pollard MJ,Megirian D

更新日期：1988-07-01 00:00:00

abstract：:Global cerebral ischemia depletes brain tissue NAD+, an essential cofactor for mitochondrial and cellular metabolism, leading to bioenergetics failure and cell death. The post-ischemic NAD+ levels can be replenished by the administration of nicotinamide mononucleotide (NMN), which serves as a precursor for NAD+ synthe...

journal_title：Experimental neurology

authors： Klimova N,Fearnow A,Long A,Kristian T

更新日期：2020-03-01 00:00:00

abstract：:The cascade of events leading to post-traumatic epilepsy (PTE) after traumatic brain injury (TBI) remains unclear. Altered inhibition in the hippocampal formation and dentate gyrus is a hallmark of several neurological disorders, including TBI and PTE. Inhibitory synaptic signaling in the hippocampus is predominately ...

journal_title：Experimental neurology

authors： Butler CR,Boychuk JA,Smith BN

更新日期：2016-06-01 00:00:00

abstract：:Pluripotent neural stem cells (NSCs) have been used as replacement cells in a variety of neurological disease models. Among the many different NSCs that have been used to date, most robust results have been obtained with the immortalized neural stem cell line (C17.2) isolated from postnatal cerebellum. However, it is ...

journal_title：Experimental neurology

authors： Mi R,Luo Y,Cai J,Limke TL,Rao MS,Höke A

更新日期：2005-08-01 00:00:00

abstract：:There is compelling evidence that excessive exposure to manganese (Mn) produces neurotoxicity, especially in the basal ganglia, resulting in a dystonic Parkinsonian disorder. Several experimental or clinical observations suggest that Mn neurotoxicity could involve impairment of energy metabolism. We examined the neuro...

journal_title：Experimental neurology

authors： Brouillet EP,Shinobu L,McGarvey U,Hochberg F,Beal MF

更新日期：1993-03-01 00:00:00

abstract：:Given the profound negative public health effects of major depressive disorder (MDD), and data suggesting only modest effectiveness of existing psychological and pharmacological treatments for this condition, there has been increasing interest in exploring the antidepressant potential of non-pharmacological, brain-bas...

journal_title：Experimental neurology

authors： Giacobbe P,Mayberg HS,Lozano AM

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:N,N-dimethyltryptamine (DMT) is an endogenous ligand of the Sigma 1 receptor (Sig-1R) with documented in vitro cytoprotective properties against hypoxia. Our aim was to demonstrate the in vivo neuroprotective effect of DMT following ischemia-reperfusion injury in the rat brain. METHODS:Transient...

journal_title：Experimental neurology

authors： Nardai S,László M,Szabó A,Alpár A,Hanics J,Zahola P,Merkely B,Frecska E,Nagy Z

更新日期：2020-05-01 00:00:00

abstract：:Fibroblast Growth Factors (FGFs) and their receptors (FGFRs) are widely expressed in the mature nervous system and are thought to mediate plasticity and repair. We report the generation of transgenic mice that can be induced to express a dominant-negative FGFR (dnFGFR) in select neuronal populations. We show that a mo...

journal_title：Experimental neurology

authors： Eckenstein FP,McGovern T,Kern D,Deignan J

更新日期：2006-04-01 00:00:00

abstract：:Local application of exogenous agents with neurotrophic properties enhances the regenerative capacity of injured neurons, especially following reconstructions of long nerve gaps and delayed nerve repairs. Recent advances in biomaterials and biomedical engineering have provided options for the sustained and controlled ...

journal_title：Experimental neurology

authors： Tajdaran K,Chan K,Gordon T,Borschel GH

更新日期：2019-09-01 00:00:00

abstract：:Among the comorbidities observed in epilepsy patients depression is the most frequent one. Likewise, depression by itself is accompanied by an increased risk to develop epilepsy. Both epilepsy and depression are characterized by a high incidence of pharmacoresistance, which might be based on overactivity of multidrug ...

journal_title：Experimental neurology

authors： Klein S,Bankstahl JP,Löscher W,Bankstahl M

更新日期：2015-01-01 00:00:00

abstract：:Diffuse and neuritic plaques are sites of accumulation of beta-amyloid peptides (A beta) in the brains of Alzheimer's disease (AD) patients. Although amyloid fibrils are formed from A beta, the contribution of other plaque-associated proteins and peptides to the pathogenesis of AD amyloidosis is unknown. To pursue thi...

journal_title：Experimental neurology

authors： Schmidt ML,DiDario AG,Otvos L Jr,Hoshi N,Kant JA,Lee VM,Trojanowski JQ

更新日期：1994-12-01 00:00:00

abstract：:The tendency of a rat to approach the wall of an open-field and to travel along the perimeter of the field (termed as "peritaxis" or "wall-facing") is affected by unilateral removal of the vibrissae. Peritaxis is lateralized by hemivibrissotomy. The finding that the dopamine agonist apomorphine reversed the direction ...

journal_title：Experimental neurology

authors： Steiner H,Bonatz AE,Huston JP,Schwarting R

更新日期：1988-03-01 00:00:00

abstract：:Chronic dopamine depletion produces neurochemical changes within the striatum as well as enhanced behavioral and metabolic responses to dopamine agonists. Changes in striatal neuropeptides have been consistently described, including increased expression of preproenkephalin mRNA and decreased expression of preprotachyk...

journal_title：Experimental neurology

authors： Harrison MB,Kumar S,Hubbard CA,Trugman JM

更新日期：2001-02-01 00:00:00

abstract：:Laser Doppler flowmetry was utilized to examine blood flow in sciatic nerves of barbiturate-anesthetized and of unanesthetized decerebrate rats, in response to hypotension induced by graded exsanguination or by graded clamping of the descending aorta. Continuous laser Doppler flowmetry signals decreased linearly with ...

journal_title：Experimental neurology

authors： Sundqvist T,Oberg PA,Rapoport SI

更新日期：1985-10-01 00:00:00

abstract：:We investigated the involvement of central nervous system nicotinic-acetylcholine receptors in the secretory activity of the hypothalamic-hypophyseal-adrenal axis. Antiacetylcholine receptor antibodies derived from rabbits immunized with purified Torpedo-acetylcholine receptor or from myasthenia gravis patients were i...

journal_title：Experimental neurology

authors： Brenner T,Mizrachi R,Bodoff M,Weidenfeld J

更新日期：1986-12-01 00:00:00

abstract：:Synemin (Syn) is an intermediate filament (IF) protein. To gain insight into a morphogenetic role of Syn, we have studied its expression patterns in the developing human retina and lens and compared it with those of other IF proteins. In addition, we have tested Syn expression in fetuses (23 and 28 weeks) affected by ...

journal_title：Experimental neurology

authors： Tawk M,Titeux M,Fallet C,Li Z,Daumas-Duport C,Cavalcante LA,Paulin D,Moura-Neto V

更新日期：2003-10-01 00:00:00

abstract：:The long-term effects of partial denervation on the muscle fiber cross-sectional area, degree of axonal sprouting, and end-plate morphology were examined 1, 3, 6, 9, and 12 months postsurgery in rat plantaris muscle. After 1 month of partial denervation, mean cross-sectional areas of type I and type II myofibers were ...

journal_title：Experimental neurology

authors： Pachter BR,Eberstein A

更新日期：1992-06-01 00:00:00

abstract：:Experimental tumors of the central nervous system were investigated with antibodies to quinolinate to assess the cellular distribution of this endogenous neurotoxin. In advanced F98 and RG-2 glioblastomas and E367 neuroblastomas in the striatum of rats, variable numbers of quinolinate immunoreactive cells were observe...

journal_title：Experimental neurology

authors： Moffett JR,Els T,Espey MG,Walter SA,Streit WJ,Namboodiri MA

更新日期：1997-04-01 00:00:00

abstract：:Breathing is a vital homeostatic behavior and must be precisely regulated throughout life. Clinical conditions commonly associated with inflammation, undermine respiratory function may involve plasticity in respiratory control circuits to compensate and maintain adequate ventilation. Alternatively, other clinical cond...

journal_title：Experimental neurology

authors： Hocker AD,Stokes JA,Powell FL,Huxtable AG

更新日期：2017-01-01 00:00:00

abstract：:Male white mice were exposed to electroshock and then injected intravenously with 5-[3H]uridine immediately after the shock. After 5, 30, or 60 min or 6, 12, or 24 h, the mice were killed, microautoradiographs were prepared, and grains were counted in the cortex, hippocampus, and basal ganglia. The results of the grai...

journal_title：Experimental neurology

authors： Pakkenberg H,Pakkenberg B,Fog R

更新日期：1985-07-01 00:00:00

abstract：:The ability of insulin like growth factor 1 (IGF-1) to prevent the pathophysiology associated with amyotrophic lateral sclerosis (ALS) is currently being explored with animal models and in clinical trials with patients. Several studies have reported positive effects of IGF-1 in reducing motor neuron death, delaying th...

journal_title：Experimental neurology

authors： Messi ML,Clark HM,Prevette DM,Oppenheim RW,Delbono O

更新日期：2007-09-01 00:00:00

abstract：:The aim of the present study is to determine whether the expansion and mobilization of circulating bone marrow (BM) stem cells by in vivo treatment with granulocyte-colony stimulating factor (G-CSF) and stem cell factor (SCF) increase the amount of BM-derived neuronal cells in mouse brain. The presence of BM-derived c...

journal_title：Experimental neurology

authors： Corti S,Locatelli F,Strazzer S,Salani S,Del Bo R,Soligo D,Bossolasco P,Bresolin N,Scarlato G,Comi GP

更新日期：2002-10-01 00:00:00

abstract：:Oscillatory activity has been well-studied in many structures within cortico-basal ganglia circuits, but it is not well understood within the pedunculopontine nucleus (PPN), which was recently introduced as a potential target for the treatment of gait and postural impairments in advanced stages of Parkinson's disease ...

journal_title：Experimental neurology

authors： Li M,Zhou M,Wen P,Wang Q,Yang Y,Xiao H,Xie Z,Li X,Wang N,Wang J,Luo F,Chang J,Zhang W

更新日期：2016-08-01 00:00:00

abstract：:The loss or injury of neurons associated with oxidative and nitrosative redox stress plays an important role in the onset of various neurodegenerative diseases. Specifically, nitric oxide (NO), can affect neuronal survival through a process called S-nitrosylation, by which the NO group undergoes a redox reaction with ...

journal_title：Experimental neurology

authors： Nakamura T,Cho DH,Lipton SA

更新日期：2012-11-01 00:00:00

abstract：:We have previously demonstrated that systemic administration of testosterone propionate (TP) to adult hamsters accelerates the rate of facial nerve regeneration following crush axotomy of the facial nerve at its exit from the stylomastoid foramen. In this study, we utilized flutamide, a potent nonsteroidal antiandroge...

journal_title：Experimental neurology

authors： Kujawa KA,Tanzer L,Jones KJ

更新日期：1995-06-01 00:00:00

abstract：:Parkinson's Disease (PD) and Extrapyramidal Syndrome (EPS) are movement disorders that result from degeneration of the dopaminergic input to the striatum and chronic inhibition of striatal dopamine D(2) receptors by antipsychotics, respectively. Adenosine A(2A) receptors are selectively localized in the basal ganglia,...

journal_title：Experimental neurology

authors： Hodgson RA,Bedard PJ,Varty GB,Kazdoba TM,Di Paolo T,Grzelak ME,Pond AJ,Hadjtahar A,Belanger N,Gregoire L,Dare A,Neustadt BR,Stamford AW,Hunter JC

更新日期：2010-10-01 00:00:00

abstract：:Intracranial collaterals provide residual blood flow to penumbral tissue in acute ischemic stroke and contribute to infarct size variability in humans. In the present study, hemodynamic monitoring of the borderzone territory between the leptomeningeal branches of middle cerebral artery and anterior cerebral artery was...

journal_title：Experimental neurology

authors： Riva M,Pappadà GB,Papadakis M,Cuccione E,Carone D,Menendez VR,Sganzerla EP,Beretta S

更新日期：2012-02-01 00:00:00

abstract：:Huntington's disease (HD) is a progressive neurodegenerative disorder characterized by chorea, psychiatric disturbances, and dementia. It is caused by a polyglutamine repeat expansion in the huntingtin protein. The striatum is a major site of neuronal loss in HD, but the mechanisms underlying the neurodegenerative pro...

journal_title：Experimental neurology

authors： Duan W,Guo Z,Mattson MP

更新日期：2000-09-01 00:00:00

abstract：:The abuse of pharmaceutical drugs and the inadequate ingestion of nutrients constitute external factors that can alter brain development, both individually and in combination. We used cortical spreading depression (CSD) as a neurophysiological parameter to investigate the combined effects of the antipyretic/analgesic/...

journal_title：Experimental neurology

authors： do Amaral AP,Barbosa MS,de Souza VC,Ramos IL,Guedes RC

更新日期：2009-10-01 00:00:00

abstract：:Astrocytes are relatively resistant to injury compared to neurons and oligodendrocytes. Here, we report transient region-specific loss of astrocytes in mice early after pilocarpine-induced status epilepticus (SE). In the dentate hilus, immunoreactivity for glial acidic fibrillary protein (GFAP) was decreased, and the ...

journal_title：Experimental neurology

authors： Borges K,McDermott D,Irier H,Smith Y,Dingledine R

更新日期：2006-10-01 00:00:00