当前位置： SCI文献检索 > EXPERIMENTAL NEUROLOGY期刊下所有文献 > Treatment resistant depression as a failure of brain homeostatic mechanisms: implications for deep brain stimulation.

Treatment resistant depression as a failure of brain homeostatic mechanisms: implications for deep brain stimulation.

Abstract：

:Given the profound negative public health effects of major depressive disorder (MDD), and data suggesting only modest effectiveness of existing psychological and pharmacological treatments for this condition, there has been increasing interest in exploring the antidepressant potential of non-pharmacological, brain-based interventions, such as deep brain stimulation (DBS). The use of the DBS for psychiatric indications follows a decade of data suggesting that DBS is an effective, evidence-based strategy for the treatment of movement disorders such as Parkinson's disease. At the present time there is open-label case series data to suggest that DBS in the subgenual cingulate gyrus, ventral caudate/ventral striatum, and the nucleus accumbens, is associated with antidepressant effects in individuals who fail to respond to conventional treatments for MDD. However a number of unresolved issues about the optimal use of DBS for MDD remain, such as the optimal anatomical placement of the electrodes and the mechanisms of its antidepressant effects. This review summarizes the clinical experience of DBS for treatment resistant depression (TRD). The rationale for the use of DBS for TRD is reviewed in the context of the growing neuroimaging literatures exploring the biomarkers of antidepressant response, and the neural substrates of emotional regulation in both normal and pathological states.

journal_name

Exp Neurol

journal_title

Experimental neurology

authors

Giacobbe P,Mayberg HS,Lozano AM

doi

10.1016/j.expneurol.2009.04.028

subject

Has Abstract

pub_date

2009-09-01 00:00:00

pages

44-52

issue

1

eissn

0014-4886

issn

1090-2430

pii

S0014-4886(09)00178-2

journal_volume

219

pub_type

杂志文章,评审

相关文献

EXPERIMENTAL NEUROLOGY文献大全
  • Boundaries during normal and abnormal brain development: in vivo and in vitro studies of glia and glycoconjugates.

    abstract：:This paper focuses on transient boundaries of glia and glycoconjugates during development of the mouse central nervous system (CNS). Lectin-bound glycoconjugates, glial fibrillary acidic protein, and the J1/tenascin glycoprotein are distributed coextensively within boundaries around developing substructural arrangemen...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/s0014-4886(05)80007-x

    authors： Steindler DA,O'Brien TF,Laywell E,Harrington K,Faissner A,Schachner M

    更新日期：1990-07-01 00:00:00

  • Cerebrospinal fluid pressure during cerebroventricular infusion of angiotensin and vasopressin.

    abstract：:Rationale exists for suspecting that angiotensin (Ang) and arginine vasopressin (AVP) given by the intracerebroventricular (IVT) route can affect cerebrospinal fluid (CSF) pressure. This hypothesis was tested in conscious, unrestrained adult male Sprague-Dawley rats with IVT and left carotid arterial catheters. The ra...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(83)90405-3

    authors： Barbella YR,Keil LC,Wurpel JN,Severs WB

    更新日期：1983-11-01 00:00:00

  • The temporal pattern of stimulation may be important to the mechanism of deep brain stimulation.

    abstract：:Deep brain stimulation (DBS) has emerged as an important and potentially powerful treatment option for the management of carefully selected patients with advanced Parkinson's disease (PD) who are not adequately controlled by standard medication therapy. Though considerable advances have been made, the mechanisms under...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2013.02.001

    authors： Hess CW,Vaillancourt DE,Okun MS

    更新日期：2013-09-01 00:00:00

  • Effect of inhibitory amino acid antagonists on masseteric reflex suppression during active sleep.

    abstract：:We examined the pharmacological basis for the suppression of the masseteric (jaw-closer) reflex which occurs during the behavioral state of active sleep. Accordingly, the masseteric reflex was recorded in intact, unanesthetized, normally respiring cats during naturally occurring states of wakefulness and active sleep....

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(87)90179-8

    authors： Soja PJ,Finch DM,Chase MH

    更新日期：1987-04-01 00:00:00

  • Prevention of hypoxic-ischemic damage with dexamethasone is dependent on age and not influenced by fasting.

    abstract：:Pretreatment with the synthetic glucocorticoid dexamethasone prevents hypoxic-ischemic brain damage in 7-day-old neonatal rats. We presently characterize the response further by examining the effect of varying the age, the glucocorticoid, and the time of injection and by examining whether fasting can influence the res...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(95)90065-9

    authors： Tuor UI,Chumas PD,Del Bigio MR

    更新日期：1995-03-01 00:00:00

  • Acute energy restriction triggers Wallerian degeneration in mouse.

    abstract：:Acute exposure of peripheral axons to the free radical Nitric Oxide (NO) may trigger conduction block and, if prolonged, Wallerian degeneration. It was hypothesized that this neurotoxic effect of NO may be due primarily to energy restriction by inhibition of mitochondrial respiration. We compared the neurotoxic effect...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2008.03.022

    authors： Alvarez S,Moldovan M,Krarup C

    更新日期：2008-07-01 00:00:00

  • Functional regeneration beyond the glial scar.

    abstract：:Astrocytes react to CNS injury by building a dense wall of filamentous processes around the lesion. Stromal cells quickly take up residence in the lesion core and synthesize connective tissue elements that contribute to fibrosis. Oligodendrocyte precursor cells proliferate within the lesion and entrap dystrophic axon ...

    journal_title：Experimental neurology

    pub_type： 杂志文章,评审

    doi：10.1016/j.expneurol.2013.12.024

    authors： Cregg JM,DePaul MA,Filous AR,Lang BT,Tran A,Silver J

    更新日期：2014-03-01 00:00:00

  • Cell adhesion molecule L1 modulates nerve-growth-factor-induced CGRP-IR fiber sprouting.

    abstract：:Overexpression of nerve growth factor (NGF) using adenoviruses (Adts) after spinal cord injury induces extensive regeneration and sprouting of calcitonin-gene-related peptide immunoreactive (CGRP-IR) fibers, whereas overexpression of cell adhesion molecules (CAMs) has no effect on the normal distribution of these fibe...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2006.06.001

    authors： Chaudhry N,de Silva U,Smith GM

    更新日期：2006-11-01 00:00:00

  • Attention-related unit activity in the frontal association cortex during a go/no-go visual discrimination task.

    abstract：:Unit activity related to a go/no-go visual discrimination task was studied in four rhesus monkeys. We recorded 272 task-related cells from frontal cortex in a region extending from the midprincipal sulcus to the central sulcus, and medially to the cingulate sulcus. Units located in anterior regions (dorsolateral prefr...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(87)90213-5

    authors： Pragay EB,Mirsky AF,Nakamura RK

    更新日期：1987-06-01 00:00:00

  • Exosomal shuttled miR-424-5p from ischemic preconditioned microglia mediates cerebral endothelial cell injury through negatively regulation of FGF2/STAT3 pathway.

    abstract：:Exosomes secreted by microglia have been found to play a role in neurovascular unit injury under the ischemic/hypoxic state. However, the modulatory effect of exosomes shuttled miRNAs produced by microglia in endothelial cells remains undefined. Here, an oxygen-glucose deprivation (OGD) model was constructed both in m...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2020.113411

    authors： Xie L,Zhao H,Wang Y,Chen Z

    更新日期：2020-11-01 00:00:00

  • Activated WNK3 induced by intracerebral hemorrhage deteriorates brain injury maybe via WNK3/SPAK/NKCC1 pathway.

    abstract：BACKGROUND:Intracerebral hemorrhage (ICH) is the common brain diseases in middle-aged and elderly people, with high disability and/or mortality rate, and is a serious public health concern. Both WNK3 kinase and the WNK3/SPAK/NKCC1 signaling pathway play an integral role in maintaining normal cell homeostasis. However, ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2020.113386

    authors： Wu D,Lai N,Deng R,Liang T,Pan P,Yuan G,Li X,Li H,Shen H,Wang Z,Chen G

    更新日期：2020-10-01 00:00:00

  • Spinal cord injury and anti-NGF treatment results in changes in CGRP density and distribution in the dorsal horn in the rat.

    abstract：:Spinal cord injury (SCI) results in chronic pain states in which the underlying mechanism is poorly understood. To begin to explore possible mechanisms, calcitonin gene-related peptide (CGRP), a neuropeptide confined to fine primary afferent terminals in laminae I and II in the dorsal horn of the spinal cord and impli...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1997.6608

    authors： Christensen MD,Hulsebosch CE

    更新日期：1997-10-01 00:00:00

  • A decline in glial cell-line-derived neurotrophic factor expression is associated with impaired regeneration after long-term Schwann cell denervation.

    abstract：:In the peripheral nervous system, regeneration of motor and sensory axons into chronically denervated distal nerve segments is impaired compared to regeneration into acutely denervated nerves. In order to find possible causes for this phenomenon we examined the changes in the expression pattern of the glial cell-line-...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.2001.7826

    authors： Höke A,Gordon T,Zochodne DW,Sulaiman OA

    更新日期：2002-01-01 00:00:00

  • AAV2-mediated striatum delivery of human CDNF prevents the deterioration of midbrain dopamine neurons in a 6-hydroxydopamine induced parkinsonian rat model.

    abstract：:Parkinson's disease (PD) is an aging-associated neurodegenerative disorder with progressive pathology involving the loss of midbrain dopaminergic neurons. Neurotrophic factors are promising for PD gene therapy; they are integrally involved in the development of the nigrostriatal system. Cerebral dopamine neurotrophic ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2013.06.002

    authors： Ren X,Zhang T,Gong X,Hu G,Ding W,Wang X

    更新日期：2013-10-01 00:00:00

  • Collagen-GAG substrate enhances the quality of nerve regeneration through collagen tubes up to level of autograft.

    abstract：:Peripheral nerve regeneration was studied across a tubulated 10-mm gap in the rat sciatic nerve using histomorphometry and electrophysiological measurements of A-fiber, B-fiber, and C-fiber peaks of the evoked action potentials. Tubes fabricated from large-pore collagen (max. pore diameter, 22 nm), small-pore collagen...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1998.6955

    authors： Chamberlain LJ,Yannas IV,Hsu HP,Strichartz G,Spector M

    更新日期：1998-12-01 00:00:00

  • Conditional N-WASP knockout in mouse brain implicates actin cytoskeleton regulation in hydrocephalus pathology.

    abstract：:Cerebrospinal fluid (CSF) is produced by the choroid plexus and moved by multi-ciliated ependymal cells through the ventricular system of the vertebrate brain. Defects in the ependymal layer functionality are a common cause of hydrocephalus. N-WASP (Neural-Wiskott Aldrich Syndrome Protein) is a brain-enriched regulato...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2014.01.011

    authors： Jain N,Lim LW,Tan WT,George B,Makeyev E,Thanabalu T

    更新日期：2014-04-01 00:00:00

  • Calcium channel blockers ameliorate disease in a mouse model of multiple sclerosis.

    abstract：:Multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), an animal model of MS, are inflammatory demyelinating diseases of the central nervous system. The inflammatory attacks lead to glial dysfunction and death, axonal damage, and neurological deficits. Numerous studies in rat suggest that extrace...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2004.05.023

    authors： Brand-Schieber E,Werner P

    更新日期：2004-09-01 00:00:00

  • Effect of hyperbaric oxygenation on normal and chronic streptozotocin diabetic peripheral nerves.

    abstract：:Hyperbaric oxygenation is known to affect energy metabolism and endothelial cell structure and function, but its effects on peripheral nerve have not been reported. We investigated whether it would (i) reverse established streptozotocin-induced diabetic neuropathy, a condition in which endoneurial hypoxia exists; (ii)...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(88)90139-2

    authors： Low PA,Schmelzer JD,Ward KK,Curran GL,Poduslo JF

    更新日期：1988-01-01 00:00:00

  • Effects of accumulation of phosphocreatine on utilization and restoration of high-energy phosphates during anoxia and recovery in thin hippocampal slices from the guinea pig.

    abstract：:Effects of accumulation of phosphocreatine (P-creatine) on utilization and restoration of high-energy phosphates during anoxia and recovery were studied using thin hippocampal slices from the guinea pig. Incubation of slices with creatine (5 to 30 mM) increased the content of tissue P-creatine, in a linear fashion, an...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(83)90256-x

    authors： Yoneda K,Arakawa T,Asaoka Y,Fukuoka Y,Kinugasa K,Takimoto K,Okada Y

    更新日期：1983-10-01 00:00:00

  • Neuropeptides and morphological changes in cisplatin-induced dorsal root ganglion neuronopathy.

    abstract：:Dorsal root ganglia (DRG) neuronopathy was induced in rats by chronic treatment (2 mg/kg twice a week for nine injections) with the antineoplastic drug cisplatin. Morphological alterations and changes in peptide [calcitonin gene-related peptide (CGRP), substance P, galanin (Gal), and somatostatin] concentration were s...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1996.0050

    authors： Barajon I,Bersani M,Quartu M,Del Fiacco M,Cavaletti G,Holst JJ,Tredici G

    更新日期：1996-03-01 00:00:00

  • Motor cortical stimulation promotes synaptic plasticity and behavioral improvements following sensorimotor cortex lesions.

    abstract：:Cortical stimulation (CS) as a means to modulate regional activity and excitability in cortex is emerging as a promising approach for facilitating rehabilitative interventions after brain damage, including stroke. In this study, we investigated whether CS-induced functional improvements are linked with synaptic plasti...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2008.01.031

    authors： Adkins DL,Hsu JE,Jones TA

    更新日期：2008-07-01 00:00:00

  • Therapeutic application of gene silencing MMP-9 in a middle cerebral artery occlusion-induced focal ischemia rat model.

    abstract：:RNA interference appears to have a great potential not only as an in vitro target validation, but also as a novel therapeutic strategy based on the highly specific and efficient silencing of a target gene. We hypothesize that MMP-9 siRNA can be effective as an MMP-9 protein inhibitor in a rat focal ischemia model. Mal...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2008.11.007

    authors： Hu Q,Chen C,Yan J,Yang X,Shi X,Zhao J,Lei J,Yang L,Wang K,Chen L,Huang H,Han J,Zhang JH,Zhou C

    更新日期：2009-03-01 00:00:00

  • Controlled release of nerve growth factor enhances sciatic nerve regeneration.

    abstract：:Based on previous studies demonstrating the potential of growth factors to enhance peripheral nerve regeneration, we developed a novel growth factor delivery system to provide sustained delivery of nerve growth factor (NGF). This delivery system uses heparin to immobilize NGF and slow its diffusion from a fibrin matri...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/s0014-4886(03)00258-9

    authors： Lee AC,Yu VM,Lowe JB 3rd,Brenner MJ,Hunter DA,Mackinnon SE,Sakiyama-Elbert SE

    更新日期：2003-11-01 00:00:00

  • Effects of selective spinal cord lesions on hind limb locomotion in birds.

    abstract：:In birds, a variety of subtotal thoracic spinal cord lesions were made to determine the spinal cord pathways essential for avian hind limb locomotion (bipedal walking). The various surgical disruptions included: section of the dorsal half of the cord, a hemisection, section of the dorsal cord and ventromedial funiculi...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(87)90148-8

    authors： Sholomenko GN,Steeves JD

    更新日期：1987-02-01 00:00:00

  • Reduction of postsynaptic inhibition tolerated before seizure initiation: brain stem.

    abstract：:The reduction of GABA-mediated postsynaptic inhibition tolerated before seizure initiation was assessed using the GABA-mediated, disynaptic, inhibitory pathway from the ipsilateral vestibular nerve to trochlear motoneurons in pentobarbital-anesthetized cats. The amplitude of intracellularly recorded IPSPs or the corre...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(83)90284-4

    authors： Tribble GL,Schwindt PC,Crill WE

    更新日期：1983-05-01 00:00:00

  • Adult and embryonic frontal cortex transplants after frontal cortex ablation enhance recovery on a reinforced alternation task.

    abstract：:Damage to the medial frontal cortex in rats results in a learning deficit on a reinforced alternation task. The rate of recovery from this deficit was accelerated by transplantation of either adult or embryonic frontal cortex, provided that a delay was introduced between injury and transplantation. The rates of recove...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(86)90241-4

    authors： Kesslak JP,Brown L,Steichen C,Cotman CW

    更新日期：1986-12-01 00:00:00

  • Quisqualate injection into the nucleus basalis magnocellularis produces seizure-related brain damage that is prevented by MK-801.

    abstract：:Quisqualate (Quis) and other excitotoxins such as ibotenate and N-methyl aspartate, have been used to destroy neurons in the area of the nucleus basalis magnocellularis (NBM) in order to study the relationship between loss of cholinergic neurons in the basal forebrain and various behavioral deficits, including learnin...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1994.1046

    authors： Wozniak DF,Huss J,Olney JW

    更新日期：1994-03-01 00:00:00

  • Mutation of the caspase-3 cleavage site in the astroglial glutamate transporter EAAT2 delays disease progression and extends lifespan in the SOD1-G93A mouse model of ALS.

    abstract：:Downregulation in the astroglial glutamate transporter EAAT2 in amyotrophic lateral sclerosis (ALS) patients and mutant SOD1 mouse models of ALS is believed to contribute to the death of motor neurons by excitotoxicity. We previously reported that caspase-3 cleaves EAAT2 at a unique cleavage consensus site located in ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2017.03.014

    authors： Rosenblum LT,Shamamandri-Markandaiah S,Ghosh B,Foran E,Lepore AC,Pasinelli P,Trotti D

    更新日期：2017-06-01 00:00:00

  • Synergy between chronic corticosterone treatment and cerebral ischemia in producing damage in noncalbindinergic neurons.

    abstract：:Administration of endogenous corticosterone to intact animals induces calbindin-D28k protein in the hippocampal CA1-CA2 subfields. The fact that this effect on calbindin-D28k was shown to be specific for the hippocampus argues for a receptor-mediated effect on gene expression. In addition, chronic pretreatment with co...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1997.6729

    authors： Rami A,Rabié A,Winckler J

    更新日期：1998-02-01 00:00:00

  • The life, death and regenerative ability of immature and mature rat retinal ganglion cells are influenced by their birthdate.

    abstract：:The extensive period of retinal ganglion cell (RGC) neurogenesis in the rat is associated with a protracted sequence of arrival of their axons into central targets such as the superior colliculus (SC) (Dallimore et al., 2002). Using in utero 5-bromo-2'-deoxyrudine (BrdU) injections to label early (embryonic day (E) 15...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2010.07.007

    authors： Dallimore EJ,Park KK,Pollett MA,Taylor JS,Harvey AR

    更新日期：2010-10-01 00:00:00