当前位置： SCI文献检索 > EXPERIMENTAL NEUROLOGY期刊下所有文献 > Synergy between chronic corticosterone treatment and cerebral ischemia in producing damage in noncalbindinergic neurons.

Synergy between chronic corticosterone treatment and cerebral ischemia in producing damage in noncalbindinergic neurons.

Abstract：

:Administration of endogenous corticosterone to intact animals induces calbindin-D28k protein in the hippocampal CA1-CA2 subfields. The fact that this effect on calbindin-D28k was shown to be specific for the hippocampus argues for a receptor-mediated effect on gene expression. In addition, chronic pretreatment with corticosterone aggravates ischemia-induced neuronal damage in the CA3-CA4 subfields. This effect is similar to that of preischemic hyperglycemia, which also induces postischemic seizures and aggravates brain damage, since corticosterone raises blood glucose level and enhances tissue lactic acidosis during ischemia. The energetically compromising qualities of corticosterone indicates that it is a key factor in hippocampal vulnerability. We assume that the increase of calbindin-D28k expression in the CA1-CA2 subfields in corticosterone-treated animals is an adaptive response to the exogenous stress. The lack of adaptive response in CA3-CA4 neurons endangers them by impairing the ability of these neurons to counteract the deleterious effects of calcium. This finding, supports: (1) the hypothesis that corticosterone treatment, when paired with an ischemic insult, causes a prolonged elevation of neuronal [Ca2+]i, in an energy dependent manner, probably through the reduction of calcium efflux and (2) that neurons which do contain calbindin-D28k are particularly predisposed to ischemic insults. The CA1-CA2 neurons express high amounts of calbindin-D28k under stress conditions because their activity may involve a high rate of calcium buffering.

journal_name

Exp Neurol

journal_title

Experimental neurology

authors

Rami A,Rabié A,Winckler J

doi

10.1006/exnr.1997.6729

subject

Has Abstract

pub_date

1998-02-01 00:00:00

pages

439-46

issue

2

eissn

0014-4886

issn

1090-2430

pii

S0014-4886(97)96729-7

journal_volume

149

pub_type

杂志文章

相关文献

EXPERIMENTAL NEUROLOGY文献大全
  • Effects of compression and ischemia on spinal cord evoked potentials.

    abstract：:Ascending and descending spinal cord potentials were recorded during conduction block produced by compression and ischemia to the spinal cord of cats. Dorsally and ventrally applied compression produced proportional changes in both ascending and descending potentials. Results for induced ischemia were much more variab...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(83)90303-5

    authors： Bennett MH

    更新日期：1983-06-01 00:00:00

  • Suppression of adenosine 2a receptor (A2aR)-mediated adenosine signaling improves disease phenotypes in a mouse model of amyotrophic lateral sclerosis.

    abstract：:Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease in which the majority of upper and lower motor neurons are degenerated. Despite intensive efforts to identify drug targets and develop neuroprotective strategies, effective therapeutics for ALS remains unavailable. The identificatio...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2015.03.004

    authors： Ng SK,Higashimori H,Tolman M,Yang Y

    更新日期：2015-05-01 00:00:00

  • Aberrant trajectory of ascending dopaminergic pathway in mice lacking Nkx2.1.

    abstract：:In the embryonic brain, the transcription factor Nkx2.1 is localized in the medial ganglionic eminence and the ventromedial part of the hypothalamus. In the present study, we examined the development of mesencephalic dopamine (DA) neuron system in mice lacking Nkx2.1. In normal mice, tyrosine hydroxylase-immunoreactiv...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/s0014-4886(03)00030-x

    authors： Kawano H,Horie M,Honma S,Kawamura K,Takeuchi K,Kimura S

    更新日期：2003-07-01 00:00:00

  • Attenuation of acute mitochondrial dysfunction after traumatic brain injury in mice by NIM811, a non-immunosuppressive cyclosporin A analog.

    abstract：:Following traumatic brain injury (TBI), mitochondrial function becomes compromised. Mitochondrial dysfunction is characterized by intra-mitochondrial Ca(2+) accumulation, induction of oxidative damage, and mitochondrial permeability transition (mPT). Experimental studies show that cyclosporin A (CsA) inhibits mPT. How...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2007.09.025

    authors： Mbye LH,Singh IN,Sullivan PG,Springer JE,Hall ED

    更新日期：2008-01-01 00:00:00

  • Local calcium-dependent mechanisms determine whether a cut axonal end assembles a retarded endbulb or competent growth cone.

    abstract：:The transformation of a cut axonal end into a growth cone (GC), after axotomy, is a critical event in the cascade leading to regeneration. In an earlier series of studies we analyzed the cellular cascades that transform a cut axonal end into a competent GC. We found that axotomy of cultured Aplysia neurons leads to a ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2009.05.004

    authors： Kamber D,Erez H,Spira ME

    更新日期：2009-09-01 00:00:00

  • The role of growth factors as a therapeutic approach to demyelinating disease.

    abstract：:A variety of growth factors are being explored as therapeutic agents relevant to the axonal and oligodendroglial deficits that occur as a result of demyelinating lesions such as are evident in Multiple Sclerosis (MS). This review focuses on five such proteins that are present in the lesion site and impact oligodendroc...

    journal_title：Experimental neurology

    pub_type： 杂志文章,评审

    doi：10.1016/j.expneurol.2016.02.023

    authors： Huang Y,Dreyfus CF

    更新日期：2016-09-01 00:00:00

  • Rac1-regulated dendritic spine remodeling contributes to neuropathic pain after peripheral nerve injury.

    abstract：:Although prior studies have implicated maladaptive remodeling of dendritic spines on wide-dynamic range dorsal horn neurons as a contributor to pain after spinal cord injury, there have been no studies on dendritic spines after peripheral nerve injury. To determine whether dendritic spine remodeling contributes to neu...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2011.08.028

    authors： Tan AM,Chang YW,Zhao P,Hains BC,Waxman SG

    更新日期：2011-12-01 00:00:00

  • Theophylline treatment improves mitochondrial function after upper cervical spinal cord hemisection.

    abstract：:The importance of mitochondria in spinal cord injury has mainly been attributed to their participation in apoptosis at the site of injury. But another aspect of mitochondrial function is the generation of more than 90% of cellular energy in the form of ATP, mediated by the oxidative phosphorylation (OxPhos) process. C...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2010.01.020

    authors： Hüttemann M,Nantwi KD,Lee I,Liu J,Mohiuddin S,Petrov T

    更新日期：2010-06-01 00:00:00

  • Gene expression profiling in a mouse model of Dravet syndrome.

    abstract：:Dravet syndrome is a severe, early-onset epileptic encephalopathy frequently resulting from de novo mutations of SCN1A. Mice with heterozygous deletion of Scn1a (Scn1a+/-) model many features of Dravet syndrome, including spontaneous seizures and premature lethality. Scn1a+/- mice exhibit variable phenotype penetrance...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2018.10.010

    authors： Hawkins NA,Calhoun JD,Huffman AM,Kearney JA

    更新日期：2019-01-01 00:00:00

  • State-dependent slow outlasting activities following neocortical kindling in cats.

    abstract：:Some forms of electrographic seizures are generated at the level of the cortical network. Neocortical kindling exhibits a resistance to produce generalized convulsive seizures, and therefore, it was rather difficult to use it to study the cortical epileptogenesis. Here, using supra-threshold cortical kindling, we repo...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2008.02.010

    authors： Nita DA,Cissé Y,Timofeev I

    更新日期：2008-06-01 00:00:00

  • The angiotensin converting enzyme inhibitor captopril protects nigrostriatal dopamine neurons in animal models of parkinsonism.

    abstract：:Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by a prominent loss of nigrostriatal dopamine (DA) neurons with an accompanying neuroinflammation. The peptide angiotensin II (AngII) plays a role in oxidative-stress induced disorders and is thought to mediate its detrimental actions v...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2013.10.014

    authors： Sonsalla PK,Coleman C,Wong LY,Harris SL,Richardson JR,Gadad BS,Li W,German DC

    更新日期：2013-12-01 00:00:00

  • Evidence that oxidative stress is associated with the pathophysiology of inherited hydrocephalus in the H-Tx rat model.

    abstract：:Oxidative stress can contribute to many neurological disease processes. Because many events known to involve oxidative stress (infection, hemorrhage, brain trauma) are accompanied by hydrocephalus, the present study sought to evaluate the relationship between oxidative stress and the progression of hydrocephalus. Assa...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1998.6969

    authors： Socci DJ,Bjugstad KB,Jones HC,Pattisapu JV,Arendash GW

    更新日期：1999-01-01 00:00:00

  • Experimental traumatic brain injury results in estrous cycle disruption, neurobehavioral deficits, and impaired GSK3β/β-catenin signaling in female rats.

    abstract：:An estimated 2.8 million traumatic brain injuries (TBI) occur within the United States each year. Approximately 40% of new TBI cases are female, however few studies have investigated the effects of TBI on female subjects. In addition to typical neurobehavioral sequelae observed after TBI, such as poor cognition, impai...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2019.01.017

    authors： Fortress AM,Avcu P,Wagner AK,Dixon CE,Pang KCH

    更新日期：2019-05-01 00:00:00

  • Excitation of visual cortex neurons by local intracortical microstimulation.

    abstract：:The threshold current required for the excitation of visual cortex neurons in the vicinity (approximately 1 mm) of an intracortical stimulating electrode was measured as a function of the stimulus pulse duration in the anesthetized cat. For cortical neurons with latencies of activation from 0.4 to 3.4 ms and for stimu...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(83)90270-4

    authors： Ronner SF,Lee BG

    更新日期：1983-08-01 00:00:00

  • The effects of passive exercise therapy initiated prior to or after the development of hyperreflexia following spinal transection.

    abstract：:Hyperreflexia develops after spinal cord injury (SCI) in the human and in the spinal cord transected animal, and can be measured by the loss of low frequency-dependent depression of the H-reflex. Previous studies demonstrated normalization of low frequency-dependent depression of the H-reflex using passive exercise wh...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2008.07.002

    authors： Yates CC,Charlesworth A,Reese NB,Skinner RD,Garcia-Rill E

    更新日期：2008-10-01 00:00:00

  • Unilateral accumbal dopamine depletion affects decision-making in a side-specific manner.

    abstract：:Mechanisms underlying affective and cognitive deficits in Parkinson's disease (PD) remain less studied than motor symptoms. Nucleus accumbens (NAc) is affected in PD and due to its well-known involvement in motivation is an interesting target in this context. Furthermore, PD is frequently asymmetrical, with side-speci...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2020.113221

    authors： Cunha AM,Teixeira FG,Guimarães MR,Esteves M,Pereira-Mendes J,Soares AR,Almeida A,Sousa N,Salgado AJ,Leite-Almeida H

    更新日期：2020-05-01 00:00:00

  • Neurotrophic properties of olfactory ensheathing glia.

    abstract：:Olfactory ensheathing cells (OEC) constitute a specialized population of glia that accompany primary olfactory axons and have been reported to facilitate axonal regeneration after spinal cord injury in vivo. In the present report we describe OEC neurotrophic factor expression and neurotrophic properties of OECs in vit...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/s0014-4886(02)00058-4

    authors： Lipson AC,Widenfalk J,Lindqvist E,Ebendal T,Olson L

    更新日期：2003-04-01 00:00:00

  • Apolipoprotein E epsilon4 allele has no effect on age at onset or duration of disease in cases of frontotemporal dementia with pick- or microvacuolar-type histology.

    abstract：:Frontotemporal dementia (FTD) is the second most common cause of presenile dementia. Here we have investigated the frequency of the epsilon4 allele of the Apolipoprotein (APOE) gene in FTD and in other non-Alzheimer forms of dementia related to FTD such as Motor Neurone disease dementia, semantic dementia, progressive...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.2000.7387

    authors： Pickering-Brown SM,Owen F,Isaacs A,Snowden J,Varma A,Neary D,Furlong R,Daniel SE,Cairns NJ,Mann DM

    更新日期：2000-06-01 00:00:00

  • Cerebrospinal fluid pressure and resistance to absorption during development in normal and hydrocephalic mutant mice.

    abstract：:Hydrocephalic mutant mice and matched siblings at different ages were used to measure the pressure and the resistance to drainage of the cerebrospinal fluid (CSF) from the lateral ventricles and from the cisterna magna with glass micropipets. The resting CSF pressure in normal mice increased between 1 to 2 and 4 to 8 ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(85)90049-4

    authors： Jones HC

    更新日期：1985-10-01 00:00:00

  • Nonpermissive nature of fish optic nerves to axonal growth is due to presence of myelin-associated growth inhibitors.

    abstract：:Fish optic nerve sections were recently shown to be nonpermissive to growth of adult retinal axons. In addition, fish optic nerve myelin was found to inhibit growth of adult retinal axons and this inhibition was neutralized by IN-1 antibodies (known to block rat myelin-associated inhibitors). In this study we examined...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1994.1221

    authors： Sivron T,Schwartz M

    更新日期：1994-12-01 00:00:00

  • Acute intermittent hypoxia induced phrenic long-term facilitation despite increased SOD1 expression in a rat model of ALS.

    abstract：:Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease characterized by motor neuron death. Since most ALS patients succumb to ventilatory failure from loss of respiratory motor neurons, any effective ALS treatment must preserve and/or restore breathing capacity. In rats over-expressi...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2015.08.011

    authors： Nichols NL,Satriotomo I,Harrigan DJ,Mitchell GS

    更新日期：2015-11-01 00:00:00

  • Transplanted human glial-restricted progenitors can rescue the survival of dysmyelinated mice independent of the production of mature, compact myelin.

    abstract：:The therapeutic effect of glial progenitor transplantation in diseases of dysmyelination is currently attributed to the formation of new myelin. Using magnetic resonance imaging (MRI), we show that the therapeutic outcome in dysmyelinated shiverer mice is dependent on the extent of cell migration but not the presence ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2017.02.005

    authors： Lyczek A,Arnold A,Zhang J,Campanelli JT,Janowski M,Bulte JW,Walczak P

    更新日期：2017-05-01 00:00:00

  • Motoneurons of the rat sciatic nerve.

    abstract：:The sciatic nerve of the rat is a commonly used model for studies on nerve injury, regeneration, and recovery of function. To interpret the changes that occur in a neuron population subsequent to peripheral nerve injury, and to compare different repair procedures, it is essential to have a complete and accurate unders...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(86)90161-5

    authors： Swett JE,Wikholm RP,Blanks RH,Swett AL,Conley LC

    更新日期：1986-07-01 00:00:00

  • Spectral analysis for electroencephalograms: mathematical determination of neurophysiological relationships from records of limited duration.

    abstract：:Spectral analysis is a mathematical method which contains and generalizes frequency analysis. The form of spectral analysis most applicable to EEG is tutorially presented, using both algebraic formulae and four simplified illustrative examples. The examples are each converted into an autocorrelogram and auto-spectrogr...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(63)90042-6

    authors： Walter DO

    更新日期：1963-08-01 00:00:00

  • Activation of transcription factor c-jun in dorsal root ganglia induces VIP and NPY upregulation and contributes to the pathogenesis of neuropathic pain.

    abstract：:Vasoactive intestinal peptide (VIP) and neuropeptide Y (NPY) in dorsal root ganglia (DRGs) are known to be upregulated and to contribute to the mechanisms of neuropathic pain following peripheral nerve injury. Moreover, transcription factor c-Jun regulates the expressions of both VIP and NPY in cultured DRG neurons. T...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2006.09.020

    authors： Son SJ,Lee KM,Jeon SM,Park ES,Park KM,Cho HJ

    更新日期：2007-03-01 00:00:00

  • Traumatic brain injuries during development disrupt dopaminergic signaling.

    abstract：:Traumatic brain injuries (TBI) sustained during peri-adolescent development produce lasting neuro-behavioral changes that render individuals at an increased risk for developing substance abuse disorders. Experimental and clinical evidence of a prolonged period of hypodopaminergia after TBI have been well documented, b...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2017.08.003

    authors： Karelina K,Gaier KR,Weil ZM

    更新日期：2017-11-01 00:00:00

  • Inverse temporal relationship between rate of neurite outgrowth and neurotransmitter function in rat superior cervical ganglion in vitro.

    abstract：:Explanation of the embryonic rat superior cervical ganglion initiated a retrograde response in noradrenergic neurons. By the 4th day of explanation, tyrosine hydroxylase activity per cell decreased to 62% of the day 0 control value. The rate of neurite outgrowth during the same period increased by 66%. By the 6th day ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(85)90058-5

    authors： Cannella MS,Ross RA

    更新日期：1985-10-01 00:00:00

  • Exposure to prenatal carbon monoxide and postnatal hyperthermia: short and long-term effects on neurochemicals and neuroglia in the developing brain.

    abstract：:The effects of prenatal exposure to carbon monoxide (CO), a major component of cigarette smoke, was studied alone or in combination with postnatal hyperthermia, on the structural and neurochemical development of the postnatal brain at 1 and 8 weeks. Pregnant guinea pigs (n = 11) were exposed to 200 p.p.m CO for 10 h/d...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1999.7272

    authors： Tolcos M,Mallard C,McGregor H,Walker D,Rees S

    更新日期：2000-04-01 00:00:00

  • Effects of leukemia inhibitory factor on galanin expression and on axonal growth in adult dorsal root ganglion neurons in vitro.

    abstract：:Synthesis of leukemia inhibitory factor (LIF) is increased in lesioned peripheral nerves and it is thought that this may cause increased expression of galanin (GAL) in axotomized dorsal root ganglia (DRG) neurons and also to promote axonal regeneration. We therefore compared effects of LIF and nerve growth factor (NGF...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.2001.7667

    authors： Oztürk G,Tonge DA

    更新日期：2001-06-01 00:00:00

  • The antidepressant sertraline improves the phenotype, promotes neurogenesis and increases BDNF levels in the R6/2 Huntington's disease mouse model.

    abstract：:Huntington's disease (HD) is an inherited progressive neurodegenerative disorder characterized by progressive movement, psychiatric and cognitive disturbances. Previous studies have indicated that HD pathogenesis may be mediated in part by loss of brain derived neurotrophic factor (BDNF). Antidepressants selectively b...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2007.10.015

    authors： Peng Q,Masuda N,Jiang M,Li Q,Zhao M,Ross CA,Duan W

    更新日期：2008-03-01 00:00:00