Abstract:
:Fish optic nerve sections were recently shown to be nonpermissive to growth of adult retinal axons. In addition, fish optic nerve myelin was found to inhibit growth of adult retinal axons and this inhibition was neutralized by IN-1 antibodies (known to block rat myelin-associated inhibitors). In this study we examined whether the growth nonpermissiveness of fish optic nerves which had not been injured prior to their excision results, at least in part, from the presence of myelin-associated growth inhibitors. It was found that preincubation of the sections with IN-1 antibodies, known to recognize and neutralize the myelin-associated growth inhibitors of the rat central nervous system, increases sixfold the number of axons that grow on these sections. This demonstrates that fish myelin-associated growth inhibitors, which are similar to those of rat, are at least partly responsible for the growth nonpermissiveness of normal fish optic nerves.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Sivron T,Schwartz Mdoi
10.1006/exnr.1994.1221subject
Has Abstractpub_date
1994-12-01 00:00:00pages
411-3issue
2eissn
0014-4886issn
1090-2430pii
S0014-4886(84)71221-0journal_volume
130pub_type
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journal_title:Experimental neurology
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journal_title:Experimental neurology
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pub_type: 杂志文章
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journal_title:Experimental neurology
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journal_title:Experimental neurology
pub_type: 杂志文章
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journal_title:Experimental neurology
pub_type: 杂志文章
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更新日期:2015-03-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2012.11.009
更新日期:2013-03-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1996.6406
更新日期:1997-02-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2012.06.013
更新日期:2012-09-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
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更新日期:1983-07-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2007.06.015
更新日期:2008-03-01 00:00:00