当前位置： SCI文献检索 > EXPERIMENTAL NEUROLOGY期刊下所有文献 > Attenuation of acute mitochondrial dysfunction after traumatic brain injury in mice by NIM811, a non-immunosuppressive cyclosporin A analog.

Attenuation of acute mitochondrial dysfunction after traumatic brain injury in mice by NIM811, a non-immunosuppressive cyclosporin A analog.

Abstract：

:Following traumatic brain injury (TBI), mitochondrial function becomes compromised. Mitochondrial dysfunction is characterized by intra-mitochondrial Ca(2+) accumulation, induction of oxidative damage, and mitochondrial permeability transition (mPT). Experimental studies show that cyclosporin A (CsA) inhibits mPT. However, CsA also inhibits calcineurin. In the present study, we conducted a dose-response analysis of NIM811, a non-calcineurin inhibitory CsA analog, on mitochondrial dysfunction following TBI in mice, and compared the effects of the optimal dose of NIM811 (10 mg/kg i.p.) against an optimized dose of CsA (20 mg/kg i.p.). Male CF-1 mice were subjected to severe TBI utilizing the controlled cortical impact model. Mitochondrial respiration was assessed from animals treated with either NIM811, CsA, or vehicle 15 min post-injury. The respiratory control ratio (RCR) of mitochondria from vehicle-treated animals was significantly (p<0.01) lower at 3 or 12 h post-TBI, relative to shams. Treatment of animals with either NIM811 or CsA significantly (p<0.03) attenuated this reduction. Consistent with this finding, both NIM811 and CsA significantly reduced lipid peroxidative and protein nitrative damage to mitochondria at 12 h post-TBI. These results showing the ability of NIM811 to fully duplicate the mitochondrial protective efficacy of CsA supports the conclusion that inhibition of the mPT may be sufficient to explain CsA's protective effects.

journal_name

Exp Neurol

journal_title

Experimental neurology

authors

Mbye LH,Singh IN,Sullivan PG,Springer JE,Hall ED

doi

10.1016/j.expneurol.2007.09.025

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

243-53

issue

1

eissn

0014-4886

issn

1090-2430

pii

S0014-4886(07)00369-X

journal_volume

209

pub_type

杂志文章

相关文献

EXPERIMENTAL NEUROLOGY文献大全
  • Myelination of axons emerging from neural progenitor grafts after spinal cord injury.

    abstract：:Neural progenitor cells (NPCs) grafted to sites of spinal cord injury (SCI) extend numerous axons over long distances and form new synaptic connections with host neurons. In the present study we examined the myelination of axons emerging from NPC grafts. Rat embryonic day 14 (E14) multipotent NPCs constitutively expre...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2017.07.005

    authors： Hunt M,Lu P,Tuszynski MH

    更新日期：2017-10-01 00:00:00

  • Phenytoin, tetrodotoxin, and acetylcholine release.

    abstract：:To determine if phenytoin reduces depolarization-linked acetylcholine release from synaptosomes solely by interacting with Na+, the effect of phenytoin (100 to 200 microM) and/or tetrodotoxin (1 microM) on ACh release was assayed in synaptosomes depolarized with either KCl 56 mM or veratridine 10 microM. Phenytoin red...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(86)90255-4

    authors： Pincus JH,Kiss A

    更新日期：1986-12-01 00:00:00

  • Effect of norepinephrine depletion on audiogenic-like seizures elicited by microinfusion of an excitant amino acid into the inferior colliculus of normal rats.

    abstract：:Infusions of an excitant amino acid, N-methyl-D-aspartate (NMDA) into the inferior colliculus (IC) render normal rats susceptible to audiogenic seizures (AGS) and/or spontaneous audiogenic-like seizures without tonic components. The excess excitant amino acid in the IC and the anticonvulsant effects of NMDA antagonist...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(91)90070-s

    authors： Browning RA,Wang C,Faingold CL

    更新日期：1991-05-01 00:00:00

  • Excitant amino acids and audiogenic seizures in the genetically epilepsy-prone rat. I. Afferent seizure initiation pathway.

    abstract：:The afferent pathway involved in initiation of audiogenic seizures in the genetically epilepsy-prone rat was investigated by bilateral microinfusion of the excitant amino acid antagonist 2-amino-7-phosphonoheptanoate into the major brain stem and subcortical nuclei of the auditory system. This antagonist has been show...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(88)90184-7

    authors： Faingold CL,Millan MH,Boersma CA,Meldrum BS

    更新日期：1988-03-01 00:00:00

  • The temporal pattern of stimulation may be important to the mechanism of deep brain stimulation.

    abstract：:Deep brain stimulation (DBS) has emerged as an important and potentially powerful treatment option for the management of carefully selected patients with advanced Parkinson's disease (PD) who are not adequately controlled by standard medication therapy. Though considerable advances have been made, the mechanisms under...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2013.02.001

    authors： Hess CW,Vaillancourt DE,Okun MS

    更新日期：2013-09-01 00:00:00

  • Hyperbaric oxygen therapy: can it prevent irradiation-induced necrosis?

    abstract：:Radiosurgery is an important non-invasive procedure for the treatment of tumors and vascular malformations. However, in addition to killing target tissues, cranial irradiation induces damage to adjacent healthy tissues leading to neurological deterioration in both pediatric and adult patients, which is poorly understo...

    journal_title：Experimental neurology

    pub_type： 杂志文章,评审

    doi：10.1016/j.expneurol.2012.03.011

    authors： Kuffler DP

    更新日期：2012-06-01 00:00:00

  • The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan, and versican are differentially regulated following spinal cord injury.

    abstract：:Chondroitin sulfate proteoglycans (CSPGs) are extracellular matrix (ECM) molecules that are widely expressed throughout the developing and adult CNS. In vitro studies demonstrate their potential to restrict neurite outgrowth, and it is believed that CSPGs also inhibit axonal regeneration after CNS injury in vivo. Prev...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/s0014-4886(03)00087-6

    authors： Jones LL,Margolis RU,Tuszynski MH

    更新日期：2003-08-01 00:00:00

  • Distribution of serotonin 2A and 2C receptor mRNA expression in the cervical ventral horn and phrenic motoneurons following spinal cord hemisection.

    abstract：:Cervical spinal cord injury leads to a disruption of bulbospinal innervation from medullary respiratory centers to phrenic motoneurons. Animal models utilizing cervical hemisection result in inhibition of ipsilateral phrenic nerve activity, leading to paralysis of the hemidiaphragm. We have previously demonstrated a r...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.2001.7682

    authors： Basura GJ,Zhou SY,Walker PD,Goshgarian HG

    更新日期：2001-06-01 00:00:00

  • Site specificity of adrenalectomy-induced brain growth.

    abstract：:Infant, juvenile, and adult brain growth is modulated by corticosterone. This study was designed to determine whether such modulation is confined to certain specific brain areas, and if the pattern of growth revealed is consistent across strains of rats. Young female Sprague-Dawley-derived rats were either adrenalecto...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(88)90229-4

    authors： Thomas TL,Devenport LD

    更新日期：1988-12-01 00:00:00

  • Myelinated axons fail to develop properly in a genetically authentic mouse model of Charcot-Marie-Tooth disease type 2E.

    abstract：:We have analyzed a mouse model of Charcot-Marie-Tooth disease 2E (CMT2E) harboring a heterozygous p.Asn98Ser (p.N98S) Nefl mutation, whose human counterpart results in a severe, early-onset neuropathy. Behavioral, electrophysiological, and pathological analyses were done on separate cohorts of NeflN98S/+ mutant mice a...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2018.06.010

    authors： Lancaster E,Li J,Hanania T,Liem R,Scheideler MA,Scherer SS

    更新日期：2018-10-01 00:00:00

  • Calcium transport and fluorescence polarization of 1,6-diphenyl-1, 3,5-hexatriene in sarcoplasmic reticulum from normal and ethanol-tolerant rats.

    abstract：:Sarcoplasmic reticulum (SR) of high purity and functional integrity was isolated from skeletal muscle of normal and ethanol-tolerant rats. Ethanol at low concentrations (0.1 to 0.2 M), added in vitro to isolated SR, resulted in slight inhibition of both calcium loading and calcium-stimulated ATPase rates. Higher conce...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(83)90308-4

    authors： Mrak RE

    更新日期：1983-06-01 00:00:00

  • Regulation by interleukin-1beta of formation of a line of delimiting astrocytes following prenatal trauma to the brain of the mouse.

    abstract：:The regulation of perinatal glia limitans (GL) reformation by interleukin-1beta (IL-1beta) following prenatal neural trauma in the mouse was studied in lesioned fetal mice by immunocytochemistry and computer-assisted image analysis for presence and distribution of astrocytes and IL-1beta immunoreactivity (ir). Astrocy...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1997.6470

    authors： Scripter JL,Ko J,Kow K,Arimura A,Ide CF

    更新日期：1997-06-01 00:00:00

  • Light and confocal microscopic studies of evolutionary changes in neurofilament proteins following cortical impact injury in the rat.

    abstract：:Previous studies have shown that traumatic brain injury (TBI) produces progressive degradation of cytoskeletal proteins including neurofilaments (e.g., neurofilament 68 [NF68] and neurofilament 200 [NF200]) within the first 24 h after injury. Thus, we employed immunofluorescence (light and confocal microscopy) to stud...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1999.7244

    authors： Posmantur RM,Newcomb JK,Kampfl A,Hayes RL

    更新日期：2000-01-01 00:00:00

  • The protective effects of β-lactam antibiotics in motor neuron disorders.

    abstract：:In the June issue of Experimental Neurology, Nizzardo and colleagues demonstrate that the beta-lactam antibiotic ceftriaxone is neuroprotective in a mouse model of spinal muscular atrophy. Here I review their main findings and the relevance to previous and future work on motor neuron disorders and for developing thera...

    journal_title：Experimental neurology

    pub_type： 评论,杂志文章,评审

    doi：10.1016/j.expneurol.2011.06.002

    authors： Hedlund E

    更新日期：2011-09-01 00:00:00

  • Wild-type and mutant huntingtins function in vesicle trafficking in the secretory and endocytic pathways.

    abstract：:Huntingtin is a cytoplasmic protein that is found in neurons and somatic cells. In patients with Huntington's disease (HD), the NH2-terminal region of huntingtin has an expanded polyglutamine tract. An abnormal protein interaction by mutant huntingtin has been proposed as a mechanism for HD pathogenesis. Huntingtin as...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1998.6832

    authors： Velier J,Kim M,Schwarz C,Kim TW,Sapp E,Chase K,Aronin N,DiFiglia M

    更新日期：1998-07-01 00:00:00

  • Overlapping and additive effects of neurotrophins and CNTF on cultured human spinal cord neurons.

    abstract：:Ciliary neurotrophic factor (CNTF) and brain-derived neurotrophic factor (BDNF) have been shown both in vitro and in vivo to support the survival and differentiation of developing chick or rat motoneurons. To explore the potential use of these and other neurotrophic factors as therapeutic agents in human motoneuron di...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1994.1198

    authors： Kato AC,Lindsay RM

    更新日期：1994-12-01 00:00:00

  • Increased rate of peripheral nerve regeneration using bioresorbable nerve guides and a laminin-containing gel.

    abstract：:The sciatic nerve of adult mice was transected and proximal and distal nerve stumps were sutured into a nontoxic bioresorbable nerve guide. Nerve guide lumens were either empty or filled with a gel containing 80% laminin and additional extracellular matrix components. Two weeks later cells in the L3 through L5 dorsal ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(85)90087-1

    authors： Madison R,da Silva CF,Dikkes P,Chiu TH,Sidman RL

    更新日期：1985-06-01 00:00:00

  • In vivo microdialysis studies on somatodendritic dopamine release in the rat substantia nigra: effects of unilateral 6-OHDA lesions and GDNF.

    abstract：:Dopamine (DA) release and metabolism within the substantia nigra (SN) were studied in normal rats, rats with unilateral 6-hydroxydopamine (6-OHDA) lesions, and 6-OHDA-lesioned rats treated with glial cells line-derived neurotrophic factor (GDNF). Animals with > 99% DA depletions, as determined by apomorphine-induced c...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1997.6571

    authors： Hoffman AF,van Horne CG,Eken S,Hoffer BJ,Gerhardt GA

    更新日期：1997-09-01 00:00:00

  • Herpes simplex virus vector-mediated expression of Bcl-2 protects spinal motor neurons from degeneration following root avulsion.

    abstract：:Proximal axotomy in adult animals results in delayed death of motor neurons. Features characteristic of both necrosis and apoptosis have been described in motor neurons of the spinal cord following proximal avulsion of the ventral roots. We have previously demonstrated that a genomic herpes simplex virus (HSV)-based v...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.2000.7597

    authors： Yamada M,Natsume A,Mata M,Oligino T,Goss J,Glorioso J,Fink DJ

    更新日期：2001-04-01 00:00:00

  • Vitamin D deficiency increases blood-brain barrier dysfunction after ischemic stroke in male rats.

    abstract：:Because vitamin D hormone deficiency (VDHdef) can worsen severity and outcome for ischemic stroke, we examined the role of VDH in maintaining blood-brain-barrier (BBB integrity) in a rat model of stroke. In most types of stroke, the BBB is markedly compromised, potentially leading to a cascade of injury processes and ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2018.11.005

    authors： Sayeed I,Turan N,Stein DG,Wali B

    更新日期：2019-02-01 00:00:00

  • OP-1 enhances dendritic growth from cerebral cortical neurons in vitro.

    abstract：:Osteogenic protein-1 (OP-1), a member of the transforming growth factor-beta (TGF-beta) superfamily, has been demonstrated to stimulate dendrite growth from sympathetic neurons in culture. However, it is not known whether OP-1 affects dendrite growth from central nervous system neurons. Therefore we quantified axon an...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1999.7194

    authors： Le Roux P,Behar S,Higgins D,Charette M

    更新日期：1999-11-01 00:00:00

  • Apolipoprotein E epsilon4 allele has no effect on age at onset or duration of disease in cases of frontotemporal dementia with pick- or microvacuolar-type histology.

    abstract：:Frontotemporal dementia (FTD) is the second most common cause of presenile dementia. Here we have investigated the frequency of the epsilon4 allele of the Apolipoprotein (APOE) gene in FTD and in other non-Alzheimer forms of dementia related to FTD such as Motor Neurone disease dementia, semantic dementia, progressive...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.2000.7387

    authors： Pickering-Brown SM,Owen F,Isaacs A,Snowden J,Varma A,Neary D,Furlong R,Daniel SE,Cairns NJ,Mann DM

    更新日期：2000-06-01 00:00:00

  • Misreaching in monkeys after combined unilateral occipital lobectomy and splenial transection.

    abstract：:Studies of the effects of lesions of the parietal cortex suggest that this region plays a critical role in visuomotor guidance, whereas experiments on the effects of disconnecting this region from visual input have been inconsistent in supporting this hypothesis. In the present experiment, monkeys with a unilateral oc...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(83)90161-9

    authors： Jason GW

    更新日期：1983-07-01 00:00:00

  • Developmental regulation of BDNF and NT-3 expression by quinolinic acid in the striatum and its main connections.

    abstract：:Interactions between neurotrophic factors and neurotransmitters participate in the formation and maintenance of appropriate connections, as well as in neurodegenerative processes. Here we have measured changes in the developmental expression pattern of BDNF and NT-3 in the striatum, cortex, and substantia nigra induce...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.2000.7451

    authors： Checa N,Canals JM,Alberch J

    更新日期：2000-09-01 00:00:00

  • Spinal CPEB-mtROS-CBP signaling pathway contributes to perineural HIV gp120 with ddC-related neuropathic pain in rats.

    abstract：:Human immunodeficiency virus (HIV) patients treated with nucleoside reverse transcriptase inhibitors (NRTIs), have been known to develop neuropathic pain. While there has been a major shift away from some neurotoxic NRTIs in current antiretroviral therapy, a large number of HIV patients alive today have previously rec...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2016.04.012

    authors： Iida T,Yi H,Liu S,Huang W,Kanda H,Lubarsky DA,Hao S

    更新日期：2016-07-01 00:00:00

  • Acute intermittent hypoxia boosts spinal plasticity in humans with tetraplegia.

    abstract：:Paired corticospinal-motoneuronal stimulation (PCMS) elicits spinal synaptic plasticity in humans with chronic incomplete cervical spinal cord injury (SCI). Here, we examined whether PCMS-induced plasticity could be potentiated by acute intermittent hypoxia (AIH), a treatment also known to induce spinal synaptic plast...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2020.113483

    authors： Christiansen L,Chen B,Lei Y,Urbin MA,Richardson MSA,Oudega M,Sandhu M,Rymer WZ,Trumbower RD,Mitchell GS,Perez MA

    更新日期：2021-01-01 00:00:00

  • Reciprocal pre- and postsynaptic actions of cocaine at a central noradrenergic synapse.

    abstract：:Single-unit microelectrode studies were conducted to test the effects of systemic cocaine HCl on spontaneously firing single noradrenergic locus ceruleus (presynaptic) and cerebellar Purkinje (postsynaptic) neurons in rats in vivo. The spontaneous neuronal activity of all locus ceruleus neurons was inhibited by cocain...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(87)90261-5

    authors： Pitts DK,Marwah J

    更新日期：1987-12-01 00:00:00

  • Postural responses of normal geriatric and hemiplegic patients to a continuing perturbation.

    abstract：:The electromyographic (EMG) activity of the gastrocnemius and tibialis anterior muscles was recorded from normal geriatric subjects and from hemiplegic patients subjected to a continuous back-and-forth movement of the platform on which they stood. The platform oscillated at a fixed frequency of 0.5 Hz. Movement amplit...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(88)90156-2

    authors： Hocherman S,Dickstein R,Hirschbiene A,Pillar T

    更新日期：1988-02-01 00:00:00

  • Improved regeneration after spinal cord injury in mice lacking functional T- and B-lymphocytes.

    abstract：:It is widely accepted that the immune system plays important functional roles in regeneration after injury to the spinal cord. Immune response towards injury involves a complex interplay of immune system cells, such as neutrophils, macrophages and microglia, T- and B-lymphocytes. We investigated the influence of the l...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2012.07.016

    authors： Wu B,Matic D,Djogo N,Szpotowicz E,Schachner M,Jakovcevski I

    更新日期：2012-10-01 00:00:00

  • Adenosine and propentofylline inhibit the proliferation of cultured microglial cells.

    abstract：:Propentofylline is a xanthine derivative that has been known to protec t neurons against ischemia-induced damage. To assess its neuroprotective mechanisms, we examined the effect of propentofylline on microglial proliferation that is thought to play an important role in neuronal damage. We determined the proliferation...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1996.0035

    authors： Si QS,Nakamura Y,Schubert P,Rudolphi K,Kataoka K

    更新日期：1996-02-01 00:00:00