Neurotrophic properties of olfactory ensheathing glia.

abstract：:Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system, in which the myelin sheath has been considered to be the primary target for many years. However, an increasing number of reports have focused on neurodegenerative aspects of the disease pathogenesis. Recent studies i...

journal_title：Experimental neurology

authors： Herz J,Zipp F,Siffrin V

更新日期：2010-09-01 00:00:00

abstract：:Axonal injury is present in essentially all clinically significant cases of traumatic brain injury (TBI). While no effective treatment has been identified to date, experimental TBI models have shown promising axonal protection using immunosuppressants FK506 and Cyclosporine-A, with treatment benefits attributed to cal...

journal_title：Experimental neurology

authors： Reeves TM,Trimmer PA,Colley BS,Phillips LL

更新日期：2016-09-01 00:00:00

abstract：:Spinal axons in the larval sea lamprey regenerate following a complete spinal transection. It is not known whether regenerating growth cones require contact with cellular elements or whether the basement membrane and collagenous meninx primitiva which surround the spinal cord are sufficient for neurite out-growth. To ...

journal_title：Experimental neurology

authors： Lurie DI,Selzer ME

更新日期：1991-04-01 00:00:00

abstract：:Genetic and protein studies have indicated abnormalities in alpha-synuclein in neurodegenerative diseases. However, the developmental localization and cellular role of synuclein isoforms is contentious. We investigated the cellular localization of alpha-, beta-, and gamma-synuclein in developing cultured rat neurons a...

journal_title：Experimental neurology

authors： Quilty MC,Gai WP,Pountney DL,West AK,Vickers JC

更新日期：2003-07-01 00:00:00

abstract：:Functional neural reconnection is not common after spinal cord transection in the CNS of adult higher vertebrates but has been demonstrated in embryonic avian and neonatal mammalian CNS. Chick brainstem spinal cord preparations from nontransected controls and embryos transected at the cervical level on embryonic days ...

journal_title：Experimental neurology

authors： Sholomenko GN,Delaney KR

更新日期：1998-12-01 00:00:00

abstract：:Traumatic brain injuries (TBI) sustained during peri-adolescent development produce lasting neuro-behavioral changes that render individuals at an increased risk for developing substance abuse disorders. Experimental and clinical evidence of a prolonged period of hypodopaminergia after TBI have been well documented, b...

journal_title：Experimental neurology

authors： Karelina K,Gaier KR,Weil ZM

更新日期：2017-11-01 00:00:00

abstract：:Cats were kindled in the amygdala. After completion of kindling, their EEG was monitored almost continuously by a computer system which allowed the detection of spontaneous seizures and the quantification of interictal spikes. The relationships between seizures triggered by stimulation, spontaneous seizures, and inter...

journal_title：Experimental neurology

authors： Gotman J

更新日期：1984-05-01 00:00:00

abstract：:The alpha-secretase-derived form of the amyloid precursor protein (sAPPalpha), which is released from neurons in an activity-dependent manner, has been shown to promote long-term survival of hippocampal and cortical neurons in culture and can protect those neurons against excitotoxic and ischemic injury in culture and...

journal_title：Experimental neurology

authors： Cheng G,Yu Z,Zhou D,Mattson MP

更新日期：2002-06-01 00:00:00

abstract：:Cannabis abuse may precipitate the onset of schizophrenia and a dysfunction of the endocannabinoid system may be involved in the pathology of schizophrenia. Nevertheless, only few studies have addressed the neurobiological consequences of cannabis abuse for the development and course of schizophrenia. We measured the ...

journal_title：Experimental neurology

authors： Rentzsch J,Penzhorn A,Kernbichler K,Plöckl D,Gómez-Carrillo de Castro A,Gallinat J,Jockers-Scherübl MC

更新日期：2007-05-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) patients treated with nucleoside reverse transcriptase inhibitors (NRTIs), have been known to develop neuropathic pain. While there has been a major shift away from some neurotoxic NRTIs in current antiretroviral therapy, a large number of HIV patients alive today have previously rec...

journal_title：Experimental neurology

authors： Iida T,Yi H,Liu S,Huang W,Kanda H,Lubarsky DA,Hao S

更新日期：2016-07-01 00:00:00

abstract：:Peripheral inflammation induces sensitization of nociceptive spinal cord neurons. Both spinal tumor necrosis factor (TNF) and neuronal membrane insertion of Ca2+ permeable AMPA receptor (AMPAr) contribute to spinal sensitization and resultant pain behavior, molecular mechanisms connecting these two events have not bee...

journal_title：Experimental neurology

authors： Wigerblad G,Huie JR,Yin HZ,Leinders M,Pritchard RA,Koehrn FJ,Xiao WH,Bennett GJ,Huganir RL,Ferguson AR,Weiss JH,Svensson CI,Sorkin LS

更新日期：2017-07-01 00:00:00

abstract：:The long-term effects of partial denervation on the muscle fiber cross-sectional area, degree of axonal sprouting, and end-plate morphology were examined 1, 3, 6, 9, and 12 months postsurgery in rat plantaris muscle. After 1 month of partial denervation, mean cross-sectional areas of type I and type II myofibers were ...

journal_title：Experimental neurology

authors： Pachter BR,Eberstein A

更新日期：1992-06-01 00:00:00

abstract：:Previous studies have demonstrated that neonatal cultures of astrocytes express functional endothelin (ET) receptors. To determine if similar ET receptors are expressed by adult glia we used 125I-ET-1 to examine the expression of ET receptors both in vivo in the normal and transected optic nerves of the rabbit and rat...

journal_title：Experimental neurology

authors： Rogers SD,Demaster E,Catton M,Ghilardi JR,Levin LA,Maggio JE,Mantyh PW

更新日期：1997-05-01 00:00:00

abstract：:Scopolamine and naloxone were administered singly and in combination to different groups of rats undergoing electrical kindling of the amygdala. Scopolamine significantly reduced the maximal seizure stage attained during 15 drug sessions and increased the total number of afterdischarges required to kindle a generalize...

journal_title：Experimental neurology

authors： Cain DP,McKitrick DJ,Desborough KA

更新日期：1987-04-01 00:00:00

abstract：:Nerve growth factor (NGF) is well known to be involved in the development, survival, and maintenance of sympathetic and neural crest-derived sensory neurons in the peripheral nervous system. Over the last 10-15 years, however, the role of NGF as a necessary trophic substrate for magnocellular cholinergic neurons in th...

journal_title：Experimental neurology

authors： Springer JE

更新日期：1988-12-01 00:00:00

abstract：:Peripheral nerve regeneration was studied across a tubulated 10-mm gap in the rat sciatic nerve using histomorphometry and electrophysiological measurements of A-fiber, B-fiber, and C-fiber peaks of the evoked action potentials. Tubes fabricated from large-pore collagen (max. pore diameter, 22 nm), small-pore collagen...

journal_title：Experimental neurology

authors： Chamberlain LJ,Yannas IV,Hsu HP,Strichartz G,Spector M

更新日期：1998-12-01 00:00:00

abstract：:Chemotherapy-related cognitive deficits are a major neurological problem, but the underlying mechanisms are unclear. The death of neural stem/precursor cell (NSC) by cisplatin has been reported as a potential cause, but this requires high doses of chemotherapeutic agents. Cisplatin is frequently used in modern oncolog...

journal_title：Experimental neurology

authors： Andres AL,Gong X,Di K,Bota DA

更新日期：2014-05-01 00:00:00

abstract：:Regeneration of axons in the peripheral nervous system is enhanced by the removal of glycosaminoglycan side chains (GAGs) of chondroitin sulfate proteoglycans. However, some axons regenerate poorly despite such treatment, suggesting the existence of additional inhibitors. We compared the effects of enzymatic removal o...

journal_title：Experimental neurology

authors： Groves ML,McKeon R,Werner E,Nagarsheth M,Meador W,English AW

更新日期：2005-10-01 00:00:00

abstract：:Infusions of an excitant amino acid, N-methyl-D-aspartate (NMDA) into the inferior colliculus (IC) render normal rats susceptible to audiogenic seizures (AGS) and/or spontaneous audiogenic-like seizures without tonic components. The excess excitant amino acid in the IC and the anticonvulsant effects of NMDA antagonist...

journal_title：Experimental neurology

authors： Browning RA,Wang C,Faingold CL

更新日期：1991-05-01 00:00:00

abstract：:Outcome following stroke is difficult to measure because the behavioral response to infarction is variable. We hypothesized that cognitive function, such as spatial learning, may be a reproducible and sensitive outcome variable. We developed an animal model of multifocal cerebral ischemia in order to study the effects...

journal_title：Experimental neurology

authors： Lyden PD,Zivin JA,Chabolla DR,Jacobs MA,Gage FH

更新日期：1992-05-01 00:00:00

abstract：:The loss or injury of neurons associated with oxidative and nitrosative redox stress plays an important role in the onset of various neurodegenerative diseases. Specifically, nitric oxide (NO), can affect neuronal survival through a process called S-nitrosylation, by which the NO group undergoes a redox reaction with ...

journal_title：Experimental neurology

authors： Nakamura T,Cho DH,Lipton SA

更新日期：2012-11-01 00:00:00

abstract：:In this study we evaluate the expression of all members of the class 3 semaphorins and their receptor components following complete transection and contusion lesions of the adult rat spinal cord. Following both types of lesions the expression of all class 3 semaphorins is induced in fibroblast in the neural scar. The ...

journal_title：Experimental neurology

authors： De Winter F,Oudega M,Lankhorst AJ,Hamers FP,Blits B,Ruitenberg MJ,Pasterkamp RJ,Gispen WH,Verhaagen J

更新日期：2002-05-01 00:00:00

abstract：:A new method is presented for the quantification of cell viability based on densitometry with computerized image analysis. Neuronal cells were stained with crystal violet and densitometric analysis was performed with an IBAS 2.0 image analyzer (Kontron/ Zeiss), using specially implemented dedicated software which inte...

journal_title：Experimental neurology

authors： Andreoni G,Angeretti N,Lucca E,Forloni G

更新日期：1997-11-01 00:00:00

abstract：:We have investigated the formation of DNA adducts and oxidative base damage produced by copper sulfate activation of dopamine and 6-hydroxydopamine. In the presence of 10 microM copper sulfate both 100 microM dopamine and 100 microM 6-hydroxydopamine formed three similar DNA adducts with relative adduct levels of 8.36...

journal_title：Experimental neurology

authors： Lévay G,Ye Q,Bodell WJ

更新日期：1997-08-01 00:00:00

abstract：:The present study was carried out to determine if augmentation of phrenic nerve activity during the crossed phrenic phenomenon temporally coincides with the morphological changes in the phrenic nucleus that we have observed in previous studies. This investigation consisted of two experiments in spinal cord hemisected ...

journal_title：Experimental neurology

authors： O'Hara TE Jr,Goshgarian HG

更新日期：1991-02-01 00:00:00

abstract：:Graft-induced dyskinesia has emerged as a problematic side effect after transplantation of fetal dopamine cells into the striatum of patients with Parkinson's disease. These adverse effects of dystonic and choreatiform hyperkinesias that persisted even after withdrawal of L-DOPA medication are not yet fully understood...

journal_title：Experimental neurology

authors： García J,Carlsson T,Döbrössy M,Nikkhah G,Winkler C

更新日期：2011-12-01 00:00:00

abstract：:The present experiments focused on the morphological interaction between serotonergic (5-HT) and noradrenergic (NA) axons during regeneration following partial axonal denervation in the cerebral cortex in adult rats. The denervation paradigm used employed two neurotoxins, one for 5-HT and one for NA axons, infused tog...

journal_title：Experimental neurology

authors： Liu Y,Ishida Y,Shinoda K,Nakamura S

更新日期：2003-11-01 00:00:00

abstract：:Olfactory ensheathing cells (OECs) are unique glia that support axon outgrowth in the olfactory system, and when used as cellular therapy after spinal cord injury, improve recovery and axon regeneration. Here we assessed the effects of combining OEC transplantation with another promising therapy, epidural electrical s...

journal_title：Experimental neurology

authors： Thornton MA,Mehta MD,Morad TT,Ingraham KL,Khankan RR,Griffis KG,Yeung AK,Zhong H,Roy RR,Edgerton VR,Phelps PE

更新日期：2018-11-01 00:00:00

abstract：:Parkinson's disease (PD) is associated with complex compensatory changes in the functional and neurochemical anatomy of the basal ganglia resulting from striatal dopamine deficiency. Available evidence suggests that glutamatergic corticostriatal pathway becomes overactive following nigrostriatal dopaminergic denervati...

journal_title：Experimental neurology

authors： Betarbet R,Poisik O,Sherer TB,Greenamyre JT

更新日期：2004-05-01 00:00:00

abstract：:Functional relations between hippocampal lamellae, the modular units arranged in parallel in the hippocampal formation, were studied in the guinea pig in experiments of evoked field potential analysis. Perforant path volleys, synaptically elicited by stimulation of the dorsal hippocampal commissure, were used to activ...

journal_title：Experimental neurology

authors： Bartesaghi R,Gessi T,Sperti L

更新日期：1983-12-01 00:00:00