Effects of treatment with scopolamine and naloxone, singly and in combination, on amygdala kindling.

abstract：:Peripheral nerves have the unique capability to regenerate after injury. Insights into regeneration of peripheral nerves after injury may have implications for neurodegenerative diseases of the nervous system. In this study, we analyzed the expression and function of desmoplakin in peripheral nerve regeneration. Desmo...

journal_title：Experimental neurology

authors： Gess B,Röhr D,Lange E,Halfter H,Young P

更新日期：2015-02-01 00:00:00

abstract：:One of the major histopathological hallmarks of Alzheimer's disease (AD) is redundant senile plaques mainly composed of beta-amyloid (Abeta) aggregates. Alternative cleavage of the amyloid precursor protein (APP), occurring in both normal and AD subjects, results in the generation and secretion of soluble APP (sAPP) a...

journal_title：Experimental neurology

authors： Olsson A,Höglund K,Sjögren M,Andreasen N,Minthon L,Lannfelt L,Buerger K,Möller HJ,Hampel H,Davidsson P,Blennow K

更新日期：2003-09-01 00:00:00

abstract：:The present study evaluates the temporal relationships between increases in glial fibrillary acidic protein (GFAP) mRNA, GFA protein levels, and GFAP immunostaining in the hippocampus of adult rats following unilateral lesions of the entorhinal cortex (EC). GFAP mRNA levels were assessed at 12 h, 1, 2, 4, 6, 8, 10, 12...

journal_title：Experimental neurology

authors： Steward O,Kelley MS,Torre ER

更新日期：1993-12-01 00:00:00

abstract：:Traumatic brain injuries (TBI) sustained during peri-adolescent development produce lasting neuro-behavioral changes that render individuals at an increased risk for developing substance abuse disorders. Experimental and clinical evidence of a prolonged period of hypodopaminergia after TBI have been well documented, b...

journal_title：Experimental neurology

authors： Karelina K,Gaier KR,Weil ZM

更新日期：2017-11-01 00:00:00

abstract：:Traumatic brain injury (TBI) affects millions of individuals every year. Many of these injuries lead to lasting effects, particularly impairments in domains broadly classified as executive functions, such as impulse control and decision-making. While these impairments have been historically associated with frontal bra...

journal_title：Experimental neurology

authors： Ozga-Hess JE,Whirtley C,O'Hearn C,Pechacek K,Vonder Haar C

更新日期：2020-05-01 00:00:00

abstract：:We recently revealed a unique glycan on the Fc domain of IgG antibodies in ALS patients that mediates antibody-dependent cell cytotoxicity (ADCC). This glycan has a bi-antennary structure that lacks the core fucose and sialic acid residues but contains a bisecting GlcNAc (A2BG2). Little is known, however, about the in...

journal_title：Experimental neurology

authors： Edri-Brami M,Sharoni H,Hayoun D,Skutelsky L,Nemirovsky A,Porgador A,Lichtenstein RG

更新日期：2015-05-01 00:00:00

abstract：:The present study was performed to establish an anatomical context for studies of phrenic motor function in mouse models of central nervous system trauma and disease. Application of cholera toxin β-subunit to the diaphragm of adult C57BL/6 mice revealed a columnar organization of phrenic motoneurons (PhMNs) which exte...

journal_title：Experimental neurology

authors： Qiu K,Lane MA,Lee KZ,Reier PJ,Fuller DD

更新日期：2010-11-01 00:00:00

abstract：:Tuberoinfundibular peptide of 39 residues (TIP39) synthesizing neurons at the caudal border of the thalamus and in the lateral pons project to areas rich in its receptor, the parathyroid hormone 2 receptor (PTH2R). These areas include many involved in processing nociceptive information. Here we examined the potential ...

journal_title：Experimental neurology

authors： Dimitrov EL,Petrus E,Usdin TB

更新日期：2010-11-01 00:00:00

abstract：:While past neuroimaging methods have contributed greatly to our understanding of brain function after traumatic brain injury (TBI), resting state functional MRI (rsfMRI) connectivity methods have more recently provided a far more unbiased approach with which to monitor brain circuitry compared to task-based approaches...

journal_title：Experimental neurology

authors： Harris NG,Verley DR,Gutman BA,Thompson PM,Yeh HJ,Brown JA

更新日期：2016-03-01 00:00:00

abstract：:Proximal axotomy in adult animals results in delayed death of motor neurons. Features characteristic of both necrosis and apoptosis have been described in motor neurons of the spinal cord following proximal avulsion of the ventral roots. We have previously demonstrated that a genomic herpes simplex virus (HSV)-based v...

journal_title：Experimental neurology

authors： Yamada M,Natsume A,Mata M,Oligino T,Goss J,Glorioso J,Fink DJ

更新日期：2001-04-01 00:00:00

abstract：:Myasthenia gravis (MG) with antibodies against the acetylcholine receptor (AChR) is characterized by a chronic, fatigable weakness of voluntary muscles. The production of autoantibodies involves the dysregulation of T cells which provide the environment for the development of autoreactive B cells. The symptoms are cau...

journal_title：Experimental neurology

authors： Losen M,Martinez-Martinez P,Molenaar PC,Lazaridis K,Tzartos S,Brenner T,Duan RS,Luo J,Lindstrom J,Kusner L

更新日期：2015-08-01 00:00:00

abstract：:The afferent pathway involved in initiation of audiogenic seizures in the genetically epilepsy-prone rat was investigated by bilateral microinfusion of the excitant amino acid antagonist 2-amino-7-phosphonoheptanoate into the major brain stem and subcortical nuclei of the auditory system. This antagonist has been show...

journal_title：Experimental neurology

authors： Faingold CL,Millan MH,Boersma CA,Meldrum BS

更新日期：1988-03-01 00:00:00

abstract：:Ethanol withdrawal (ETX) in ethanol-dependent rats results in susceptibility to seizures, including generalized tonic-clonic audiogenic seizures (AGS). The inferior colliculus (IC) is strongly implicated in AGS initiation during ETX, but IC neuronal mechanisms subserving AGS are unclear. The present study examined IC ...

journal_title：Experimental neurology

authors： Faingold CL,Riaz A

更新日期：1995-03-01 00:00:00

abstract：:Abnormal corticostriatal plasticity is a key mechanism of L-DOPA-induced dyskinesia (LID) in Parkinson's disease (PD). Antagonists at glutamatergic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, such as IEM 1460, reduce induction and expression of dyskinesia in rat and non-human primate models ...

journal_title：Experimental neurology

authors： Kobylecki C,Crossman AR,Ravenscroft P

更新日期：2013-09-01 00:00:00

abstract：:Primary spinal cord trauma can initiate a cascade of pathophysiologic events which markedly contribute to the expansion and amplification of the primary insult. The detailed mechanisms of these secondary neurochemical reactions are largely unknown; however, they involve membrane lipid derangements with the release of ...

journal_title：Experimental neurology

authors： Toborek M,Garrido R,Malecki A,Kaiser S,Mattson MP,Hennig B,Young B

更新日期：2000-02-01 00:00:00

abstract：:Sciatic cryoneurolysis (SCN) is an experimental rat mononeuropathy model that produces neuropathic behavioral sequelae distinct from other neuropathy models. Following SCN, there is limited autotomy peaking in severity and incidence at 7-14 days and delayed but sustained allodynia appearing at about 21 days, with no e...

journal_title：Experimental neurology

authors： Wagner R,DeLeo JA,Heckman HM,Myers RR

更新日期：1995-06-01 00:00:00

abstract：:Human recombinant activated factor-VII (rFVIIa) has been used successfully in the treatment of spontaneous intracerebral hemorrhage. In addition, there is increasing interest in its use to treat uncontrolled bleeding of other origins, including trauma. The aim of this study was to evaluate the safety and potential eff...

journal_title：Experimental neurology

authors： Zhang J,Groff RF 4th,Chen XH,Browne KD,Huang J,Schwartz ED,Meaney DF,Johnson VE,Stein SC,Rojkjaer R,Smith DH

更新日期：2008-04-01 00:00:00

abstract：:Chronic administration of cocaine (10 mg/kg, i.p., every 12 h for 10 consecutive days) produced a large decrease in tyrosine hydroxylase-staining axons and terminal boutons in the caudate nucleus in rats when examined 60 days after the final cocaine injection. This effect was quantitated using the Leitz data acquisiti...

journal_title：Experimental neurology

authors： Trulson ME,Babb S,Joe JC,Raese JD

更新日期：1986-12-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) support axon regeneration across artificial nerve bridges but their differentiative capacity and ability to promote nerve regeneration remains unclear. In this study, MSCs isolated from bone marrow of Sprague-Dawley rats were characterized by plastic adherence and pluripotency towards mes...

journal_title：Experimental neurology

authors： Ladak A,Olson J,Tredget EE,Gordon T

更新日期：2011-04-01 00:00:00

abstract：:Exposure of the rodent striatum to quinolinic acid (QA, N-methyl-D-aspartate receptor agonist) induces immediate early gene (IEG; c-fos, c-jun, jun-B, zif/268) expression that may extend 12-24 h after injection. In order to determine the specificity of the prolonged IEG response to the QA injection, the temporal patte...

journal_title：Experimental neurology

authors： Shan Y,Carlock LR,Walker PD

更新日期：1997-04-01 00:00:00

abstract：:Ischemic stroke is a devastating brain injury and an important cause of neurologic disability worldwide and across the lifespan. Despite the physical, social, and economic burdens of this disease there is only a single approved medicine for the treatment of acute stroke, and its use is unfortunately limited to the sma...

journal_title：Experimental neurology

authors： Felling RJ,Song H

更新日期：2015-06-01 00:00:00

abstract：:It is controversial whether levodopa (L-DOPA) therapy in the early stages of Parkinson's disease (PD) predisposes to later complications. Partial lesions of the substantia nigra (SN) in rat provide a model of the early stages of PD. We have investigated the potential effects of L-DOPA in early PD by analyzing its infl...

journal_title：Experimental neurology

authors： Cole DG,Growdon JH,DiFiglia M

更新日期：1993-04-01 00:00:00

abstract：:The loss or injury of neurons associated with oxidative and nitrosative redox stress plays an important role in the onset of various neurodegenerative diseases. Specifically, nitric oxide (NO), can affect neuronal survival through a process called S-nitrosylation, by which the NO group undergoes a redox reaction with ...

journal_title：Experimental neurology

authors： Nakamura T,Cho DH,Lipton SA

更新日期：2012-11-01 00:00:00

abstract：:Although brain pathways activated by sepsis may respond acutely to endotoxin administration, the long-term central response to sepsis is not known. We prepared male rats for hormonal sampling at the circadian nadir (AM) and peak (PM) after cecal ligation and puncture (CLP) or sham surgery. Diurnal variation of cortico...

journal_title：Experimental neurology

authors： Carlson DE,Chiu WC,Fiedler SM,Hoffman GE

更新日期：2007-06-01 00:00:00

abstract：:Cerebral edema is a clinical problem that frequently follows ischemic infarcts. Sulfonylurea receptor 1 (SUR1) is an inducible protein that can form a heteromultimeric complex with aquaporin 4 (AQP4) that mediate the ion/water transport involved in brain tissue swelling. Transcription of the Abcc8 gene coding for SUR1...

journal_title：Experimental neurology

authors： Alquisiras-Burgos I,Ortiz-Plata A,Franco-Pérez J,Millán A,Aguilera P

更新日期：2020-08-01 00:00:00

abstract：:We have previously demonstrated an opioid link in nucleus accumbens (NAc) that mediates antinociception produced by a novel ascending pain modulation pathway. For example, noxious stimulation induces heterosegmental antinociception that is mediated by both mu- and delta-opioid receptors in NAc. However, spinal intrath...

journal_title：Experimental neurology

authors： Gear RW,Levine JD

更新日期：2011-06-01 00:00:00

abstract：:Wistar rats (n = 58) were injected subcutaneously during the lactation period with fluoxetine (5, 10, 20 or 40 mg/kg/day) and cortical spreading depression (SD) was recorded immediately after weaning (25-30 days of life). An additional group (10 mg/kg; n = 8) was SD-recorded at 60-70 days. As compared to the saline-in...

journal_title：Experimental neurology

authors： dos Santos AA,Pinheiro PC,de Lima DS,Ozias MG,de Oliveira MB,Guimarães NX,Guedes RC

更新日期：2006-08-01 00:00:00

abstract：:Paclitaxel is an effective chemotherapeutic agent that, despite its common use, often causes peripheral sensory neuropathy. In neurons, paclitaxel binds to and stabilizes microtubules, and through unknown mechanisms, bundles microtubules and disrupts their organization. Because microtubules serve as tracks on which a ...

journal_title：Experimental neurology

authors： Bober BG,Gutierrez E,Plaxe S,Groisman A,Shah SB

更新日期：2015-09-01 00:00:00

abstract：:Several mutations in transthyretin (TTR) are related to familial amyloidotic polyneuropathy (FAP), a neurodegenerative disorder caused by extracellular deposition of TTR fibrils, particularly in the peripheral nervous system (PNS). TTR is mainly synthesized by the liver and choroid plexus of the brain that contribute ...

journal_title：Experimental neurology

authors： Sousa MM,Saraiva MJ

更新日期：2008-12-01 00:00:00

abstract：:Rats were treated with single subcutaneous injections of the irreversible AChE inhibitors, sarin (90 to 100 micrograms/kg) or soman (55 micrograms/kg), and with chronic doses of the reversible carbamate inhibitor, pyridostigmine. In surviving animals with severe behavioral symptoms, we examined the end-plate regions o...

journal_title：Experimental neurology

authors： Meshul CK,Boyne AF,Deshpande SS,Albuquerque EX

更新日期：1985-07-01 00:00:00