Abstract：
:Functional relations between hippocampal lamellae, the modular units arranged in parallel in the hippocampal formation, were studied in the guinea pig in experiments of evoked field potential analysis. Perforant path volleys, synaptically elicited by stimulation of the dorsal hippocampal commissure, were used to activate the basic three-neuron lamellar circuit: dentate gyrus granule cells-CA3 pyramidal neurons-CA1 pyramidal neurons. After selective activation of the lamellae in the dorsal hippocampal formation, excitatory synaptic effects were observed in fields CA3 and CA1 of the more ventrally situated hippocampal segments. These ventral responses were generated in pyramidal neuron apical dendrites at the termination of the hippocampal longitudinal association fibers, and disappeared after interruption of the longitudinal association pathway. Low-frequency repetitive stimulation, leading to frequency potentiation of both lamellar and ventral responses, was usually required to obtain the appearance and full development of the ventral responses. Responses with the same characteristics as the ventral ones were observed in the dorsal hippocampus after activation of the ventral lamellae. The data indicate that longitudinal association neurons are discharged in the lamellar circuit and that interlamellar impulse volleys are conducted in both dorsoventral and ventrodorsal directions in the hippocampus.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Bartesaghi R,Gessi T,Sperti Ldoi
10.1016/0014-4886(83)90080-8subject
Has Abstractpub_date
1983-12-01 00:00:00pages
550-67issue
3eissn
0014-4886issn
1090-2430journal_volume
82pub_type
杂志文章abstract：:Alcohol intake is one of the important lifestyle factors for the risk of insulin resistance and type 2 diabetes. Acetaldehyde, the major ethanol metabolite which is far more reactive than ethanol, has been postulated to participate in alcohol-induced tissue injury although its direct impact on insulin signaling is unc...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2006.08.002
更新日期：2007-01-01 00:00:00
abstract：:Neuropathic pain is common after traumatic injuries to the cauda equina/conus medullaris and brachial plexus. Clinically, this pain is difficult to treat and its mechanisms are not well understood. Lesions to the ventral roots are common in these injuries, but are rarely considered as potential contributors to pain. W...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2006.11.003
更新日期：2007-03-01 00:00:00
abstract：:We used [2-14C]deoxyglucose as a marker of increased metabolism of the hypoglossal nucleus after transection of its nerve. We studied this metabolism in 3-, 12-, and 24-month-old rats. We found an increase in glucose uptake in the control nucleus of 24-month-old rats which was significant when compared to that of 3-mo...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(90)90012-h
更新日期：1990-04-01 00:00:00
abstract：:Adult mammalian retinal ganglion cells (RGCs) can regenerate through peripheral nerve (PN) grafts and innervate central nervous system (CNS) targets. Previous studies have demonstrated a basic level of differentiation of such projections. To further assess the specificity and functionality of regenerated CNS connectio...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1997.6495
更新日期：1997-08-01 00:00:00
abstract：:Huntington's disease (HD) is an autosomal dominant neurodegenerative disease associated with a CAG trinucleotide repeat expansion in a large gene on chromosome 4. The gene encodes the protein huntingtin with a polyglutamine tract encoded by the CAG repeat at the N-terminus. The number of CAG repeats in HD are signific...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1998.6778
更新日期：1998-04-01 00:00:00
abstract：:The development of the spinal cord represents one of the most complex structure developments of the central nervous system (CNS) as it has to unfold along the longitudinal axis and within segmental cues. There it has to cope with on the one hand connection to the periphery (skeletal muscle, dermomyotome, smooth muscle...
journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1016/j.expneurol.2015.05.018
更新日期：2015-12-01 00:00:00
abstract：:We investigated whether type 2 diabetes mellitus (T2DM), a risk factor of stroke, affects the level of scavenger receptor CD36 and the uptake of its ligand, oxidized LDL (oxLDL); and whether pioglitazone, a drug that enhances CD36, promotes oxLDL uptake. Compared to normoglycemic db/+ mice, adult db/db mice showed a p...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2020.113461
更新日期：2020-12-01 00:00:00
abstract：:One of the major histopathological hallmarks of Alzheimer's disease (AD) is redundant senile plaques mainly composed of beta-amyloid (Abeta) aggregates. Alternative cleavage of the amyloid precursor protein (APP), occurring in both normal and AD subjects, results in the generation and secretion of soluble APP (sAPP) a...
journal_title：Experimental neurology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/s0014-4886(03)00027-x
更新日期：2003-09-01 00:00:00
abstract：:Huntington's disease is an autosomal dominant neurogenetic disorder leading to striatal atrophy, characterized by involuntary movements. Voluntary movements also deteriorate, but the neurophysiological mechanisms are less understood. We investigated voluntary movement execution and its neural correlates by means of mo...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2008.11.018
更新日期：2009-03-01 00:00:00
abstract：:Osteogenic protein-1 (OP-1), a member of the transforming growth factor-beta (TGF-beta) superfamily, has been demonstrated to stimulate dendrite growth from sympathetic neurons in culture. However, it is not known whether OP-1 affects dendrite growth from central nervous system neurons. Therefore we quantified axon an...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1999.7194
更新日期：1999-11-01 00:00:00
abstract：:Russian knapweed is a perennial weed found in many parts of the world, including southern California. Chronic ingestion of this plant by horses has been reported to cause equine nigropallidal encephalomalacia (ENE), which is associated with a movement disorder simulating Parkinson's disease (PD). Repin, a principal in...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1998.6826
更新日期：1998-07-01 00:00:00
abstract：:Ciliary neurotrophic factor (CNTF) and brain-derived neurotrophic factor (BDNF) have been shown both in vitro and in vivo to support the survival and differentiation of developing chick or rat motoneurons. To explore the potential use of these and other neurotrophic factors as therapeutic agents in human motoneuron di...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1994.1198
更新日期：1994-12-01 00:00:00
abstract：:Genetically dystrophic chicks (line 413) were administered 0.3 mg/kg dexamethasone (DEX), a corticosteroid, from 2 to 28 days ex ovo. Diluent-injected dystrophic and normal (line 412) chicks served as controls. The effects of DEX on muscle function were evaluated weekly by the exhaustion score (ES) method. Proton magn...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(88)90096-9
更新日期：1988-11-01 00:00:00
abstract：:Monosialoganglioside GM1 prevents excitatory amino acid (EAA)-related neuronal death in cultured central nervous system (CNS) neurons and reduces the severity of acute brain damage in different experimental models of cerebral ischemia. Using a model of brain damage induced by intracerebroventricular administration of ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(91)90019-9
更新日期：1991-09-01 00:00:00
abstract：:The nontoxic C fragment of tetanus toxin (TC) can transport other proteins from the circulation to central nervous system (CNS) motor neurons. Increased levels of CuZn superoxide dismutase (SOD) are protective in experimental models of stroke and Parkinson's disease, whereas mutations in SOD can cause motor neuron dis...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1997.6490
更新日期：1997-06-01 00:00:00
abstract：:A new method is presented for the quantification of cell viability based on densitometry with computerized image analysis. Neuronal cells were stained with crystal violet and densitometric analysis was performed with an IBAS 2.0 image analyzer (Kontron/ Zeiss), using specially implemented dedicated software which inte...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1997.6647
更新日期：1997-11-01 00:00:00
abstract：:The basis for neuronal dysfunction following inflammatory demyelination of the central nervous system (CNS) remains poorly understood. We characterized the network response to white matter injury in the anterior visual pathway using an experimental model of optic neuritis (ON), as ON is often an early manifestation of...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2017.05.004
更新日期：2017-09-01 00:00:00
abstract：:The review outlines data consistent with the hypothesis that inspiratory drive transmission that generates fetal breathing movements (FBMs) is essential for the developmental plasticity of phrenic motoneurons (PMNs) and diaphragm musculature prior to birth. A systematic examination during the perinatal period demonstr...
journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1016/j.expneurol.2016.05.017
更新日期：2017-01-01 00:00:00
abstract：:In the present study homonymous and heteronymous projections of muscle spindle afferent fibers in the human jaw-closing system were investigated. Stretch reflex responses were elicited with percutaneous displacement stimuli applied to the belly of the anterior superficial divisions of temporalis and masseter muscles. ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(85)90070-6
更新日期：1985-06-01 00:00:00
abstract：:Activation of GABA(A) receptors by GABA causes phasic and tonic conductances in different brain areas. In the ventrobasal (VB) thalamus, tonic inhibition originates from GABA acting on extrasynaptic receptors. Here we show that dopamine (DA), the D2-like agonist quinpirole and the selective D4R agonist PD-168,077 decr...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2013.03.023
更新日期：2013-09-01 00:00:00
abstract：:Traumatic CNS injury triggers a systemic inflammatory response syndrome (SIRS), in which circulating inflammatory cells invade body organs causing local inflammation and tissue damage. We have shown that the SIRS caused by spinal cord injury is greatly reduced by acute intravenous treatment with an antibody against th...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2015.07.003
更新日期：2015-09-01 00:00:00
abstract：:Sleep and behavioral monitoring of young mice is necessary for understating the progress of symptoms in congenital and acquired diseases associated with sleep and movement disorders. In the current study, we have developed a non-invasive sleep monitoring system that identifies wake and sleep patterns of newborn mice u...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2014.08.004
更新日期：2014-11-01 00:00:00
abstract：:The Fmr1 knockout (KO) mouse is characterized by an increased audiogenic seizure (AGS) susceptibility and is considered a good animal model for epilepsy and seizures in the human fragile-X (FRAX) syndrome. Here, we tested the hypothesis that the reintroduction of the FMR1 gene is able to revert the AGS susceptibility ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2006.08.007
更新日期：2007-01-01 00:00:00
abstract：:Intrastriatal injection of excitatory amino acids, particularly quinolinic acid, has been proposed as an animal model of Huntington's disease. Such neurotoxic lesions of caudate-putamen result in marked dopamine type-1 (D1) receptor losses in the injected nuclei as well as in the ipsilateral substantia nigra pars reti...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(90)90033-o
更新日期：1990-11-01 00:00:00
abstract：:The increasing demand on diagnostic assays that are sensitive and specific for pathogenic antibodies, and the interest in identifying new antigens, prompted the development of cell-based assays for the detection of autoantibodies in myasthenia gravis and other autoimmune disorders. Cell-based assays were initially use...
journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1016/j.expneurol.2015.01.011
更新日期：2015-08-01 00:00:00
abstract：:Bombesin/gastrin-releasing peptide (BB/GRP) receptors were characterized in fetal cortex transplants in the rat. Using in vitro autoradiography techniques, the density of (125I-Tyr4)BB grains was low 2 weeks after transplantation but increased 4 weeks after cortex transplantation into the adult rat fourth ventricle. D...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1996.0190
更新日期：1996-11-01 00:00:00
abstract：:Germinal matrix hemorrhage (GMH) is the most common neurological disease of premature newborns. GMH causes neurological sequelae such as cerebral palsy, post-hemorrhagic hydrocephalus, and mental retardation. Despite this, there is no standardized animal model of spontaneous GMH using newborn rats to depict the condit...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2012.04.003
更新日期：2012-07-01 00:00:00
abstract：:The chorda tympani (CT) nerve carries taste information from the anterior tongue to the brain stem. Injury to the chorda tympani may result in loss or distortion of taste information. This study examined changes occurring in the hamster peripheral taste system during recovery from injury. The hamster chorda tympani ne...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1996.0169
更新日期：1996-10-01 00:00:00
abstract：:Spinal cord injury results in cell loss, disruption of neural circuitry and chronic functional impairment. Several different cell types generate progeny in response to injury, which participate in scar formation and remyelination. Work over the last few years has identified neural stem cells and delineated the stem ce...
journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1016/j.expneurol.2013.01.026
更新日期：2014-10-01 00:00:00
abstract：:Fluoxetine is one of the most promising drugs for improving clinical outcome in patients with ischemic stroke. This in vivo study investigated the hypothesis that fluoxetine may affect HIF-1α-Netrin/VEGF cascade, angiogenesis and neuroprotection using a rat model of transient middle cerebral artery occlusion (tMCAO). ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2020.113312
更新日期：2020-07-01 00:00:00
