Audiogenic seizure susceptibility is reduced in fragile X knockout mice after introduction of FMR1 transgenes.

abstract：:Axons are the anatomical link between neuronal cell bodies and their target organs, and thus axonal degeneration is the pathological substrate that underlies neurological dysfunction in a large number of neurological conditions. Recent advances in the field of axonal biology demonstrate that axons possess programs for...

journal_title：Experimental neurology

authors： Fischer-Hayes LR,Brotherton T,Glass JD

更新日期：2013-08-01 00:00:00

abstract：:Systematic protein expression studies in the brain of exercising and sedentary animals have not been carried out so far and it was therefore decided to determine differences in metabolic protein levels in rat hippocampus of sedentary, voluntary and involuntary exercising rats by a proteomic approach. Aged, male Spragu...

journal_title：Experimental neurology

authors： Kirchner L,Chen WQ,Afjehi-Sadat L,Viidik A,Skalicky M,Höger H,Lubec G

更新日期：2008-07-01 00:00:00

abstract：:Experimental tumors of the central nervous system were investigated with antibodies to quinolinate to assess the cellular distribution of this endogenous neurotoxin. In advanced F98 and RG-2 glioblastomas and E367 neuroblastomas in the striatum of rats, variable numbers of quinolinate immunoreactive cells were observe...

journal_title：Experimental neurology

authors： Moffett JR,Els T,Espey MG,Walter SA,Streit WJ,Namboodiri MA

更新日期：1997-04-01 00:00:00

abstract：:The majority of human spinal cord injuries involve gray matter loss from the cervical or lumbar enlargements. However, the deficits that arise from gray matter damage are largely masked by the severe deficits due to associated white matter damage. We have developed a model to examine gray matter-specific deficits and ...

journal_title：Experimental neurology

authors： Magnuson DS,Trinder TC,Zhang YP,Burke D,Morassutti DJ,Shields CB

更新日期：1999-03-01 00:00:00

abstract：:One of the most interesting findings in the field of neurodegeneration in recent years is tfche discovery of a genetic mutation in the C9orf72 gene, the most common mutation found to be causative of sporadic and familial frontotemporal lobar degeneration (FTLD), amyotrophic lateral sclerosis (ALS) and concomitant FTD-...

journal_title：Experimental neurology

authors： Bennion Callister J,Pickering-Brown SM

更新日期：2014-12-01 00:00:00

abstract：:Chronic nerve compression (CNC) injuries induce a robust Schwann cell proliferation in a distinct spatial and temporal pattern, which is accompanied by an increase in the number of small un-myelinated axons in the area of the injury. These findings suggest that this local proliferation of Schwann cells may induce loca...

journal_title：Experimental neurology

authors： Gupta R,Rummler LS,Palispis W,Truong L,Chao T,Rowshan K,Mozaffar T,Steward O

更新日期：2006-08-01 00:00:00

abstract：:Spinal ischemia is a frequent cause of paralysis. Here we explore the biological basis of ischemic preconditioning (IPC), the phenomenon in which a brief period of ischemia can confer protection against subsequent longer and normally injurious ischemia, to identify mediators of endogenous neuroprotection. Using microa...

journal_title：Experimental neurology

authors： Carmel JB,Kakinohana O,Mestril R,Young W,Marsala M,Hart RP

更新日期：2004-01-01 00:00:00

abstract：:Cortical stimulation (CS) as a means to modulate regional activity and excitability in cortex is emerging as a promising approach for facilitating rehabilitative interventions after brain damage, including stroke. In this study, we investigated whether CS-induced functional improvements are linked with synaptic plasti...

journal_title：Experimental neurology

authors： Adkins DL,Hsu JE,Jones TA

更新日期：2008-07-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease in which the majority of upper and lower motor neurons are degenerated. Despite intensive efforts to identify drug targets and develop neuroprotective strategies, effective therapeutics for ALS remains unavailable. The identificatio...

journal_title：Experimental neurology

authors： Ng SK,Higashimori H,Tolman M,Yang Y

更新日期：2015-05-01 00:00:00

abstract：:MK-801, a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, was tested for anticonvulsant effects in rats using two seizure models, coadministration of lithium and pilocarpine and administration of a high dose of pilocarpine alone. Three major results are reported. First, pretreatment with MK-801 produce...

journal_title：Experimental neurology

authors： Ormandy GC,Jope RS,Snead OC 3rd

更新日期：1989-11-01 00:00:00

abstract：:The dependence of movement on visual information was compared for healthy individuals and Stage II-III patients with Parkinson's disease (PD). A time delay (0-1400 ms) was introduced into a visually guided motor tracking task which required the subject to maintain constant index finger position relative to a stationar...

journal_title：Experimental neurology

authors： Beuter A,Milton JG,Labrie C,Glass L,Gauthier S

更新日期：1990-11-01 00:00:00

abstract：:Children who are born preterm are at risk for encephalopathy of prematurity, a leading cause of cerebral palsy, cognitive delay and behavioral disorders. Current interventions are limited and none have been shown to reverse cognitive and behavioral impairments, a primary determinant of poor quality of life for these c...

journal_title：Experimental neurology

authors： Robinson S,Corbett CJ,Winer JL,Chan LAS,Maxwell JR,Anstine CV,Yellowhair TR,Andrews NA,Yang Y,Sillerud LO,Jantzie LL

更新日期：2018-04-01 00:00:00

abstract：:A number of neuron-supporting functions have been ascribed to astrocytes. In this study we found that a proliferation of Purkinje cell dendritic spines, a target site for presynaptic axon terminals, was induced in cytosine arabinoside-treated cerebellar cultures by exposure to astrocyte-conditioned medium. This result...

journal_title：Experimental neurology

authors： Seil FJ,Eckenstein FP,Reier PJ

更新日期：1992-07-01 00:00:00

abstract：:Rats were injected with progressively increasing doses of morphine or meperidine during a period of 3 to 40 days. From this colony of animals individual rats were used at 3- to 4-day intervals for electrophysiologic experiments to analyze the activity of nociceptive neurons in the somesthetic thalamus. After an i.p. i...

journal_title：Experimental neurology

authors： Emmers R

更新日期：1984-01-01 00:00:00

abstract：:Some forms of electrographic seizures are generated at the level of the cortical network. Neocortical kindling exhibits a resistance to produce generalized convulsive seizures, and therefore, it was rather difficult to use it to study the cortical epileptogenesis. Here, using supra-threshold cortical kindling, we repo...

journal_title：Experimental neurology

authors： Nita DA,Cissé Y,Timofeev I

更新日期：2008-06-01 00:00:00

abstract：:l-DOPA therapy in Parkinson's disease often results in side effects such as l-DOPA-induced dyskinesia (LID). Our previous studies demonstrated that defective desensitization of dopamine receptors caused by decreased expression of G protein-coupled receptor kinases (GRKs) plays a role. Overexpression of GRK6, the isofo...

journal_title：Experimental neurology

authors： Ahmed MR,Bychkov E,Kook S,Zurkovsky L,Dalby KN,Gurevich EV

更新日期：2015-04-01 00:00:00

abstract：:Hyperreflexia develops after spinal cord injury (SCI) in the human and in the spinal cord transected animal, and can be measured by the loss of low frequency-dependent depression of the H-reflex. Previous studies demonstrated normalization of low frequency-dependent depression of the H-reflex using passive exercise wh...

journal_title：Experimental neurology

authors： Yates CC,Charlesworth A,Reese NB,Skinner RD,Garcia-Rill E

更新日期：2008-10-01 00:00:00

abstract：:Calcium-independent nitric oxide synthase (NOS) activity has been reported in ischemic brains and usually attributed to the inducible isoform, iNOS. Because calcium-independent mechanisms have recently been shown to regulate the constitutive calcium-dependent NOS, we proposed to confirm the presence of iNOS activity i...

journal_title：Experimental neurology

authors： Lerouet D,Jafarian-Tehrani M,Louin G,Palmier B,Bonnefont-Rousselot D,Plotkine M,Margaill I

更新日期：2005-09-01 00:00:00

abstract：:The ability to differentiate neural stem cells (NSCs) into dopamine neurons is fundamental to their role in cell replacement therapies for neurodegenerative disorders such as Parkinson's disease. We show here that when a clonal line (C17.2) of undifferentiated NSCs is transplanted into the intact or 6-hydroxydopamine-...

journal_title：Experimental neurology

authors： Yang M,Stull ND,Berk MA,Snyder EY,Iacovitti L

更新日期：2002-09-01 00:00:00

abstract：:The dendritic organization of the phrenic nucleus as a whole was studied after injections of the B-subunit of cholera toxin conjugated to horseradish peroxidase were made into the diaphragm of adult rats. Transverse, sagittal, and horizontal sections through the phrenic nucleus (C3-C5) were incubated according to a mo...

journal_title：Experimental neurology

authors： Furicchia JV,Goshgarian HG

更新日期：1987-06-01 00:00:00

abstract：:After spinal cord injury, proteoglycans with growth-inhibitory glycosaminoglycan (GAG-) side chains in scar tissue limit spontaneous axonal sprouting/regeneration. Interventions that reduce scar-related inhibition facilitate an axonal growth response and possibly plasticity-based spinal cord repair. Xylosyltransferase...

journal_title：Experimental neurology

authors： Oudega M,Chao OY,Avison DL,Bronson RT,Buchser WJ,Hurtado A,Grimpe B

更新日期：2012-09-01 00:00:00

abstract：:Cordotomy-denervation interactions were studied on contractile and myofibrillar properties of slow (soleus) and fast (extensor digitorum longus) muscles of the rat. The spinal cord was transected midthoracically in neonatal (2-day-old) animals. Two months after birth, a unilateral transection of the sciatic nerve was ...

journal_title：Experimental neurology

authors： Midrio M,Danieli Betto D,Betto R,Noventa D,Antico F

更新日期：1988-04-01 00:00:00

abstract：:Subcortical deafferentation of the rat hippocampus has been suggested to offer a model for developing limbic epilepsy. In the present study, the long-term effect of fimbria-fornix lesioning on the density and distribution of hippocampal N-methyl-D-aspartate (NMDA)-sensitive L-[3H]glutamate binding was studied using qu...

journal_title：Experimental neurology

authors： Lahtinen H,Korhonen E,Castrén E,Miettinen R,Ylinen A,Riekkinen PJ Sr

更新日期：1993-06-01 00:00:00

abstract：:An electron microscopic investigation of neuromuscular synapses of the tensor fasciae latae muscle in juvenile mice was carried out to determine the relationship between the presynaptic (nerve terminal) and postsynaptic (end-plate plaque) elements during the major phase of postnatal growth. In the first month of life ...

journal_title：Experimental neurology

authors： Habgood MD,Hopkins WG

更新日期：1987-05-01 00:00:00

abstract：:In the embryonic brain, the transcription factor Nkx2.1 is localized in the medial ganglionic eminence and the ventromedial part of the hypothalamus. In the present study, we examined the development of mesencephalic dopamine (DA) neuron system in mice lacking Nkx2.1. In normal mice, tyrosine hydroxylase-immunoreactiv...

journal_title：Experimental neurology

authors： Kawano H,Horie M,Honma S,Kawamura K,Takeuchi K,Kimura S

更新日期：2003-07-01 00:00:00

abstract：:A previous study of our group demonstrated that movement performance induced by dopamine agonist drugs in hemiparkinsonian rats unilaterally lesioned with 6-hydroxydopamine (6-OHDA), governs the occurrence of a sensitized motor response to a subsequent dopaminergic challenge (priming model). In the present study, we e...

journal_title：Experimental neurology

authors： Frau L,Morelli M,Simola N

更新日期：2013-09-01 00:00:00

abstract：:Neural progenitor cells (NPCs) grafted to sites of spinal cord injury (SCI) extend numerous axons over long distances and form new synaptic connections with host neurons. In the present study we examined the myelination of axons emerging from NPC grafts. Rat embryonic day 14 (E14) multipotent NPCs constitutively expre...

journal_title：Experimental neurology

authors： Hunt M,Lu P,Tuszynski MH

更新日期：2017-10-01 00:00:00

abstract：:Spinal cord injury results in cell loss, disruption of neural circuitry and chronic functional impairment. Several different cell types generate progeny in response to injury, which participate in scar formation and remyelination. Work over the last few years has identified neural stem cells and delineated the stem ce...

journal_title：Experimental neurology

authors： Sabelström H,Stenudd M,Frisén J

更新日期：2014-10-01 00:00:00

abstract：:Paclitaxel is an effective chemotherapeutic agent that, despite its common use, often causes peripheral sensory neuropathy. In neurons, paclitaxel binds to and stabilizes microtubules, and through unknown mechanisms, bundles microtubules and disrupts their organization. Because microtubules serve as tracks on which a ...

journal_title：Experimental neurology

authors： Bober BG,Gutierrez E,Plaxe S,Groisman A,Shah SB

更新日期：2015-09-01 00:00:00

abstract：:Axonal injury close to cell bodies of motoneurons induces the death of the vast majority of affected cells. Neurotrophic factors, such as brain derived neurotrophic factor (BDNF) and glial cell derived neurotrophic factor (GDNF), delivered close to the damaged motor pool in a non-regulated manner induce good survival ...

journal_title：Experimental neurology

authors： Pajenda G,Hercher D,Márton G,Pajer K,Feichtinger GA,Maléth J,Redl H,Nógrádi A

更新日期：2014-11-01 00:00:00