Abstract：
:An electron microscopic investigation of neuromuscular synapses of the tensor fasciae latae muscle in juvenile mice was carried out to determine the relationship between the presynaptic (nerve terminal) and postsynaptic (end-plate plaque) elements during the major phase of postnatal growth. In the first month of life growth of the synapse was accompanied by a decrease in the size of pre- and postsynaptic elements in cross section. A decrease in the fraction of the width of end-plate plaque opposed by nerve terminal was also observed to age 2 months, and in older animal some end-plate plaques were completely unopposed by nerve terminal. This implies that end plates grow at a faster rate than nerve terminals and suggests that the availability of uninnervated, differentiated end plate permits or promotes nerve terminal growth.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Habgood MD,Hopkins WGdoi
10.1016/0014-4886(87)90065-3subject
Has Abstractpub_date
1987-05-01 00:00:00pages
474-8issue
2eissn
0014-4886issn
1090-2430pii
0014-4886(87)90065-3journal_volume
96pub_type
杂志文章abstract：:Activity-dependent alteration in synaptic efficacy is referred to as synaptic plasticity and is the believed hallmark of any learning process. Here we employed a recently validated complex maze for spatial training and investigated the impact of repeated and extensive training on basal synaptic transmission of the hip...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2006.08.025
更新日期：2007-02-01 00:00:00
abstract：:Methylmalonic acidemia is an inherited metabolic disorder that leads to brain damage associated to the accumulation of methylmalonic acid (MMA) and impairment of energy metabolism. We demonstrate here that treatment with diazoxide, an agonist of mitochondrial ATP-sensitive K(+) channels (mitoK(ATP)), can prevent death...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2006.04.004
更新日期：2006-09-01 00:00:00
abstract：:The claim that AlCl3 could produce 100% inhibition of cerebrospinal fluid secretion was investigated using ventriculocisternal perfusion in the rabbit, and it was shown that a large part of this inhibition was an artefact due to a pH sensitivity of Blue Dextran, used as an indiffusible marker, caused by AlCl3. Thus th...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(87)90253-6
更新日期：1987-11-01 00:00:00
abstract：:Urinary bladder and urethral sphincter responses evoked by bladder distention, ventral root stimulation, or microstimulation of S2 segment of the sacral spinal cord were investigated under alpha-chloralose anesthesia in cats with an intact spinal cord and in chronic spinal cord injured (SCI) cats 6-8 weeks after spina...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2004.07.001
更新日期：2004-11-01 00:00:00
abstract：:The hph-1 mice have defective tetrahydrobiopterin biosynthesis and share many neurochemical similarities with l-dopa-responsive dystonia (DRD) in humans. In both, there are deficiencies in GTP cyclohydrolase I and low brain levels of dopamine (DA). Striatal tyrosine hydroxylase (TH) levels are decreased while the numb...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2004.08.022
更新日期：2004-12-01 00:00:00
abstract：:Damage to the fimbria-fornix, and separately to the perforant path, leads to distinct and dramatic time-dependent increases in glial fibrillary acidic protein immunoreactivity (GFAP-IR) in specific areas of the hippocampal formation. Specifically, fimbria-fornix lesions resulted in an increase in the GFAP-IR in the py...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(88)90073-8
更新日期：1988-10-01 00:00:00
abstract：:In order to test the functional implication of herpes simplex virus (HSV) vector-mediated gene transfer after axonal injury, we injected replication-incompetent HSV vectors coding for the anti-apoptotic peptide Bcl-2 and the glial cell-derived neurotrophic factor (GDNF), separately or in combination into ventral spina...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/S0014-4886(03)00334-0
更新日期：2003-12-01 00:00:00
abstract：:Levodopa or short-acting dopamine (DA) agonist treatment of advanced parkinsonian patients exposes striatal DA receptors to non-physiologic intermittent stimulation that contributes to the development of dyskinesias and other motor complications. To determine whether continuous dopaminergic stimulation can delay or pr...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2004.11.013
更新日期：2005-03-01 00:00:00
abstract：:With the consideration of the multifactorial etiology of diabetic peripheral neuropathy, an ideal drug or drug combination should target at least several key pathogenetic mechanisms. The flavonoid baicalein (5,6,7-trihydroxyflavone) has been reported to counteract sorbitol accumulation, activation of 12/15-lipoxygenas...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2011.04.002
更新日期：2011-07-01 00:00:00
abstract：:Excessive synchronization of basal ganglia neuronal activity at ~20 Hz is characteristic of patients with untreated Parkinson's disease (PD). Correlative evidence suggests that this activity may contribute to bradykinesia. Attempts to demonstrate causality through stimulation imposed synchronization at 20 Hz in the re...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2011.05.018
更新日期：2011-09-01 00:00:00
abstract：:A novel model of status epilepticus based on the kindling model of epilepsy is described. The model involves the administration of a small dose of pilocarpine (20 mg/kg) to rats that have been previously kindled. Stimulation of these pretreated rats produces seizures which continue uninterrupted for approximately 4 h ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(86)90274-8
更新日期：1986-10-01 00:00:00
abstract：:In order to study the ocular dominance and responsiveness of cells in the deafferented visual cortex, the geniculate and the callosal inputs were interrupted in adult cats by either simultaneous (OTCCX) or separate surgical transection of the optic tract (OTX) and the posterior corpus callosum (CCX). Unit recording wa...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(88)90174-4
更新日期：1988-03-01 00:00:00
abstract：:Stress is a common environmental factor associated with depressive illness and the amygdala is thought to be integral for this association. For example, repeated stress impairs amygdalar neuroplasticity in rodents and these defects parallel amygdalar deficits in depressive illness patients. Because the excitatory neur...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2012.12.005
更新日期：2013-03-01 00:00:00
abstract：:RNA interference appears to have a great potential not only as an in vitro target validation, but also as a novel therapeutic strategy based on the highly specific and efficient silencing of a target gene. We hypothesize that MMP-9 siRNA can be effective as an MMP-9 protein inhibitor in a rat focal ischemia model. Mal...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2008.11.007
更新日期：2009-03-01 00:00:00
abstract：:Increasing evidence indicates that the cytokines, tumor necrosis factor (TNF), interleukin-1, and/or interferon-gamma, may play a crucial role in the pathogenesis of multiple sclerosis. Several reports demonstrated that inhibition of TNF is highly protective in experimental allergic encephalomyelitis (EAE) when sensit...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(95)90044-6
更新日期：1995-02-01 00:00:00
abstract：:Caloric restriction (CR) is a daily reduction of total caloric intake without a decrease in micronutrients or disproportionate reduction of any one dietary component. CR can increase lifespan reliably in a wide range of species and appears to counteract some aspects of the aging process throughout the body. The effect...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2008.01.016
更新日期：2008-05-01 00:00:00
abstract：:Huntington's disease (HD) is an inherited progressive neurodegenerative disorder characterized by progressive movement, psychiatric and cognitive disturbances. Previous studies have indicated that HD pathogenesis may be mediated in part by loss of brain derived neurotrophic factor (BDNF). Antidepressants selectively b...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2007.10.015
更新日期：2008-03-01 00:00:00
abstract：:The possible pain inhibitory effects of periaqueductal gray (PAG) stimulation were investigated in cats anesthetized with Nembutal and immobilized with Flaxedil. Unitary responses evoked by electrical stimulation of the upper canine dentine and by cutaneous facial noxious and nonnoxious stimuli were recorded extracell...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(83)90155-3
更新日期：1983-07-01 00:00:00
abstract：:Male white mice were exposed to electroshock and then injected intravenously with 5-[3H]uridine immediately after the shock. After 5, 30, or 60 min or 6, 12, or 24 h, the mice were killed, microautoradiographs were prepared, and grains were counted in the cortex, hippocampus, and basal ganglia. The results of the grai...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(85)90269-9
更新日期：1985-07-01 00:00:00
abstract：:Chronic dopamine depletion produces neurochemical changes within the striatum as well as enhanced behavioral and metabolic responses to dopamine agonists. Changes in striatal neuropeptides have been consistently described, including increased expression of preproenkephalin mRNA and decreased expression of preprotachyk...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2000.7555
更新日期：2001-02-01 00:00:00
abstract：:This study characterizes the impact of increasing-intensity treadmill exercise (iTR) on noradrenergic (NE) and serotonergic (5HT) modulation of neuropathic pain. Following sciatic nerve transection and repair (SNTR) rats developed significant mechanical and thermal hyperalgesia that was partially prevented by iTR perf...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2017.10.007
更新日期：2018-01-01 00:00:00
abstract：:We have previously demonstrated that octanoic (OA) and decanoic acids (DA) inhibit Na+, K+ ATPase activity in synaptic plasma membranes from rat brain. The objective of the present study was to investigate the in vitro effects of the other metabolites that accumulate in tissues of medium-chain acyl-CoA dehydrogenase (...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2005.09.002
更新日期：2006-01-01 00:00:00
abstract：:Diffuse noxious inhibitory controls (DNIC) are very powerful long-lasting descending inhibitory controls which are pivotal in modulating the activity of spinal and trigeminal nociceptive neurons. DNIC are subserved by a loop involving supraspinal structures such as the lateral parabrachial nucleus and the subnucleus r...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2014.03.006
更新日期：2014-06-01 00:00:00
abstract：:The inferior colliculus was selected as a brain stem site for study of neural grafting and identification of calcium binding proteins. Unilateral ablation sites of eight midbrain inferior colliculus in adult Long-Evans rats were implanted with E17-18 caudal tectum. After 2 to 9 months animals were sacrificed and secti...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(92)90238-l
更新日期：1992-01-01 00:00:00
abstract：:Embryonic substantia nigra grafts partially reinnervate the dopamine-denervated corpus striatum when implanted adjacent to that structure. This reinnervation is generally limited to a small portion of the denervated striatum and does not completely compensate for the behavioral effects of a 6-hydroxydopamine lesion of...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(87)90151-8
更新日期：1987-02-01 00:00:00
abstract：:HIV-associated neurocognitive disorders (HAND) continue to persist despite effective control of viral replication. Although the mechanisms underlying HAND are poorly understood, recent attention has focused on altered neuronal population activity as a correlate of impaired cognition. However, while alterations in neur...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2019.113077
更新日期：2020-01-01 00:00:00
abstract：:The development and maturation of sensory systems depends on the correct pattern of connections which occurs during a critical period when axonal elimination and synaptic plasticity are involved in the formation of topographical maps. Among the mechanisms involved in synaptic stabilization, essential fatty acids (EFAs...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2011.12.032
更新日期：2012-03-01 00:00:00
abstract：:Functional neural reconnection is not common after spinal cord transection in the CNS of adult higher vertebrates but has been demonstrated in embryonic avian and neonatal mammalian CNS. Chick brainstem spinal cord preparations from nontransected controls and embryos transected at the cervical level on embryonic days ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1998.6944
更新日期：1998-12-01 00:00:00
abstract：:Potassium and caffeine contractures of isolated small bundles (100 to 200 micron diameter) of muscle fibers isolated from the diaphragm of normal and dystrophic (C57BL/6J dy2J/dy2J) mice were compared. In diaphragms of pathologic mice (3 to 5 months old) the resting potential, the characteristics of the twitch, and so...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(84)90126-2
更新日期：1984-03-01 00:00:00
abstract：:Given the profound negative public health effects of major depressive disorder (MDD), and data suggesting only modest effectiveness of existing psychological and pharmacological treatments for this condition, there has been increasing interest in exploring the antidepressant potential of non-pharmacological, brain-bas...
journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1016/j.expneurol.2009.04.028
更新日期：2009-09-01 00:00:00
