Bladder and urethral sphincter responses evoked by microstimulation of S2 sacral spinal cord in spinal cord intact and chronic spinal cord injured cats.

abstract：:Although axons lose some of their intrinsic capacity for growth after their developmental period, some axons retain the potential for regrowth after injury. When provided with a growth-promoting substrate such as a peripheral nerve graft (PNG), severed axons regenerate into and through the graft; however, they stop wh...

journal_title：Experimental neurology

authors： Tom VJ,Sandrow-Feinberg HR,Miller K,Domitrovich C,Bouyer J,Zhukareva V,Klaw MC,Lemay MA,Houlé JD

更新日期：2013-01-01 00:00:00

abstract：:Peripheral nerve grafts (PNG) into the rat spinal cord support axon regeneration after acute or chronic injury, with synaptic reconnection across the lesion site and some level of behavioral recovery. Here, we grafted a peripheral nerve into the injured spinal cord of cats as a preclinical treatment approach to promot...

journal_title：Experimental neurology

authors： Côté MP,Hanna A,Lemay MA,Ollivier-Lanvin K,Santi L,Miller K,Monaghan R,Houlé JD

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:The pathogenesis of pain in irritable bowel syndrome (IBS) is poorly understood and treatment remains difficult. We have previously reported that TTX-resistant (TTX-R) sodium channels in colon-specific dorsal root ganglion (DRG) neurons were sensitized and the expression of the endogenous hydrogen sulfide pr...

journal_title：Experimental neurology

authors： Hu S,Xu W,Miao X,Gao Y,Zhu L,Zhou Y,Xiao Y,Xu GY

更新日期：2013-10-01 00:00:00

abstract：:These studies have examined the extent to which intrastriatal grafts of embryonic mesencephalic neurons induce recovery of normal discharge patterns in striatal neurons of rats after a unilateral 6-hydroxydopamine (6-OHDA) lesion of the nigrostriatal dopamine (DA) pathway. Lesioned rats were tested for rotational beha...

journal_title：Experimental neurology

authors： Di Loreto S,Florio T,Capozzo A,Napolitano A,Adorno D,Scarnati E

更新日期：1996-04-01 00:00:00

abstract：:The electromyographic (EMG) activity of the gastrocnemius and tibialis anterior muscles was recorded from normal geriatric subjects and from hemiplegic patients subjected to a continuous back-and-forth movement of the platform on which they stood. The platform oscillated at a fixed frequency of 0.5 Hz. Movement amplit...

journal_title：Experimental neurology

authors： Hocherman S,Dickstein R,Hirschbiene A,Pillar T

更新日期：1988-02-01 00:00:00

abstract：:AMPA receptors (AMPARs) are responsible for fast excitatory neurotransmission, and their prolonged activation can result in the generation and spread of epileptic seizures. At early stages of postnatal development, the majority of AMPARs are permeable to both Na(+) and Ca(2+) ions. This permeability, which increases n...

journal_title：Experimental neurology

authors： Szczurowska E,Ergang P,Kubová H,Druga R,Salaj M,Mareš P

更新日期：2016-09-01 00:00:00

abstract：:We recently revealed a unique glycan on the Fc domain of IgG antibodies in ALS patients that mediates antibody-dependent cell cytotoxicity (ADCC). This glycan has a bi-antennary structure that lacks the core fucose and sialic acid residues but contains a bisecting GlcNAc (A2BG2). Little is known, however, about the in...

journal_title：Experimental neurology

authors： Edri-Brami M,Sharoni H,Hayoun D,Skutelsky L,Nemirovsky A,Porgador A,Lichtenstein RG

更新日期：2015-05-01 00:00:00

abstract：:One of the most interesting findings in the field of neurodegeneration in recent years is tfche discovery of a genetic mutation in the C9orf72 gene, the most common mutation found to be causative of sporadic and familial frontotemporal lobar degeneration (FTLD), amyotrophic lateral sclerosis (ALS) and concomitant FTD-...

journal_title：Experimental neurology

authors： Bennion Callister J,Pickering-Brown SM

更新日期：2014-12-01 00:00:00

abstract：:Dopaminergic (DAergic) hypofunction in the medial prefrontal cortex (mPFC) has been implicated in the negative and cognitive symptoms of schizophrenia and is regulated by serotonergic (5-HTergic) neurons in the dorsal raphe nucleus (DRN). The lateral habenula (LHb) is a key element in controlling DRN 5-HT neurons. We ...

journal_title：Experimental neurology

authors： Li J,Yang S,Liu X,Han Y,Li Y,Feng J,Zhao H

更新日期：2019-08-01 00:00:00

abstract：:Convection-enhanced delivery has recently entered the clinic and represents a promising new therapeutic option in the field of neurodegenerative diseases and treatment of brain tumors. Understanding of the principles governing delivery and flow of macromolecules within the CNS is still poorly understood and requires m...

journal_title：Experimental neurology

authors： Krauze MT,Saito R,Noble C,Bringas J,Forsayeth J,McKnight TR,Park J,Bankiewicz KS

更新日期：2005-11-01 00:00:00

abstract：:Rats were injected with progressively increasing doses of morphine or meperidine during a period of 3 to 40 days. From this colony of animals individual rats were used at 3- to 4-day intervals for electrophysiologic experiments to analyze the activity of nociceptive neurons in the somesthetic thalamus. After an i.p. i...

journal_title：Experimental neurology

authors： Emmers R

更新日期：1984-01-01 00:00:00

abstract：:The effects of sex differences and hormonal factors on the locomotor alterations following intrastriatal injections of quinolinic acid (QA) and the ability of fetal striatal transplants to reverse those effects were examined. Male, female, or ovariectomized female rats received bilateral injections of 150 nmol QA or v...

journal_title：Experimental neurology

authors： Emerich DF,Zubricki EM,Shipley MT,Norman AB,Sanberg PR

更新日期：1991-03-01 00:00:00

abstract：:Parkinson's disease is a neurodegenerative disorder associated with selective loss of the dopaminergic neurons in the substantia nigra. We have previously shown that tetrahydrobiopterin (BH4), the obligatory cofactor for dopamine synthesis, exerts selective toxicity on dopamine-producing cells. In the present study we...

journal_title：Experimental neurology

authors： Choi HJ,Kim SW,Lee SY,Moon YW,Hwang O

更新日期：2003-06-01 00:00:00

abstract：:We investigated whether administration of neurotrophin-3 (NT-3) and NMDA-2D-expressing units, found previously to enhance transmission in neonatal rat spinal cord, strengthens synaptic connections in the injured neonatal cord. We employed electrophysiological methods to evaluate the strength of synaptic transmission t...

journal_title：Experimental neurology

authors： Arvanian VL,Bowers WJ,Anderson A,Horner PJ,Federoff HJ,Mendell LM

更新日期：2006-02-01 00:00:00

abstract：:Patients with neuropathic pain frequently experience hypersensitivity to cold stimulation. However, the underlying mechanisms of this enhanced sensitivity to cold are not well understood. After partial nerve injury, the transient receptor potential ion channel TRPV1 increases in the intact small dorsal root ganglion (...

journal_title：Experimental neurology

authors： Katsura H,Obata K,Mizushima T,Yamanaka H,Kobayashi K,Dai Y,Fukuoka T,Tokunaga A,Sakagami M,Noguchi K

更新日期：2006-07-01 00:00:00

abstract：:Stroke is a devastating neurological disease with no satisfactory therapies to preserve long-term neurological function, perhaps due to the sole emphasis on neuronal survival in most preclinical studies. Recent studies have revealed the importance of protecting multiple cell types in the injured brain, such as oligode...

journal_title：Experimental neurology

authors： Zhang W,Wang H,Zhang H,Leak RK,Shi Y,Hu X,Gao Y,Chen J

更新日期：2015-10-01 00:00:00

abstract：:Cholinergic neurons in the basal forebrain magnocellular complex (BFMC) respond to nerve growth factor (NGF) during development and in adult life, and it has been suggested that the administration of NGF might ameliorate some of the abnormalities that occur in neurological disorders associated with degeneration of thi...

journal_title：Experimental neurology

authors： Koliatsos VE,Applegate MD,Knüsel B,Junard EO,Burton LE,Mobley WC,Hefti FF,Price DL

更新日期：1991-05-01 00:00:00

abstract：:We have previously found that fetal cortex taken from 16- to 18-day-old donors survives grafting to the infarcted cortex 5-7 days after middle cerebral artery occlusion. The present study was undertaken to examine the effect on graft survival of varying the age of the fetal donor tissue and the time between vessel occ...

journal_title：Experimental neurology

authors： Grabowski M,Johansson BB,Brundin P

更新日期：1994-05-01 00:00:00

abstract：:No current therapy for Parkinson disease has been shown to slow or reverse the progressive course of the disease. As a departure from traditional treatments, gene therapy approaches provide a new hope for realizing this long-sought goal; but before they can be widely employed for use in patients, they must first be su...

journal_title：Experimental neurology

authors： Lewis TB,Standaert DG

更新日期：2008-01-01 00:00:00

abstract：:Deep brain stimulation (DBS) has emerged as an important and potentially powerful treatment option for the management of carefully selected patients with advanced Parkinson's disease (PD) who are not adequately controlled by standard medication therapy. Though considerable advances have been made, the mechanisms under...

journal_title：Experimental neurology

authors： Hess CW,Vaillancourt DE,Okun MS

更新日期：2013-09-01 00:00:00

abstract：:One of the major histopathological hallmarks of Alzheimer's disease (AD) is redundant senile plaques mainly composed of beta-amyloid (Abeta) aggregates. Alternative cleavage of the amyloid precursor protein (APP), occurring in both normal and AD subjects, results in the generation and secretion of soluble APP (sAPP) a...

journal_title：Experimental neurology

authors： Olsson A,Höglund K,Sjögren M,Andreasen N,Minthon L,Lannfelt L,Buerger K,Möller HJ,Hampel H,Davidsson P,Blennow K

更新日期：2003-09-01 00:00:00

abstract：:Fluorescence microscopy revealed that the innervation of the vasa nervorum of both cranial and spinal nerve roots in the subarachnoid space in the monkey is adrenergic in nature. The endoneurium of the cranial nerve roots contained free adrenergic nerve fibers which were not related to the vessel wall. ...

journal_title：Experimental neurology

authors： Hara H,Kobayashi S

更新日期：1987-12-01 00:00:00

abstract：:Peroxiredoxin-2 (PRX-2) is known to be released from erythrocytes and induce brain damage after intracerebral hemorrhage (ICH); lipocalin-2 (LCN-2) is involved in neuroinflammation following ICH. This study examined the role of LCN-2 in PRX-2 induced brain injury and involved three parts. In the first part, adult male...

journal_title：Experimental neurology

authors： Zhang J,Novakovic N,Hua Y,Keep RF,Xi G

更新日期：2021-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Dorsal root ganglia (DRG) sensory neurons cultured from 3 to 5 month streptozotocin (STZ)-induced diabetic rats exhibit structural and biochemical changes seen in peripheral nerve fibers in vivo, including axonal swellings, oxidative damage, reduced axonal sprouting, and decreased NF-κB activity. NF-κB ...

journal_title：Experimental neurology

authors： Saleh A,Schapansky J,Smith DR,Young N,Odero GL,Aulston B,Fernyhough P,Glazner GW

更新日期：2013-03-01 00:00:00

abstract：:The distribution and relative intrafascicular contribution of myelin fibers derived from spinal segments L-4 to L-6 were analyzed in adult rat sciatic nerve and its main branches, using 200-kDa neurofilament subunit immunodetection in previously injured nerve sections in the L-4 or L-5 spinal branch or both. These bra...

journal_title：Experimental neurology

authors： Montoya G JV,Ariza J,Sutachán JJ,Hurtado H

更新日期：2002-02-01 00:00:00

abstract：:Repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex is a relatively non-invasive technique with putative therapeutic effects in major depression. However, the exact neurophysiological basis of these effects needs further clarification. Therefore, we studied the impact of ten daily...

journal_title：Experimental neurology

authors： Bajbouj M,Brakemeier EL,Schubert F,Lang UE,Neu P,Schindowski C,Danker-Hopfe H

更新日期：2005-12-01 00:00:00

abstract：:To determine if phenytoin reduces depolarization-linked acetylcholine release from synaptosomes solely by interacting with Na+, the effect of phenytoin (100 to 200 microM) and/or tetrodotoxin (1 microM) on ACh release was assayed in synaptosomes depolarized with either KCl 56 mM or veratridine 10 microM. Phenytoin red...

journal_title：Experimental neurology

authors： Pincus JH,Kiss A

更新日期：1986-12-01 00:00:00

abstract：:Serial diffusion tensor imaging scans were collected at baseline and 1 year follow-up to investigate the neurodegenerative profile of white matter (WM) in seven individuals with the Huntington's Disease (HD) gene mutation and seven control subjects matched on age and gender. In the HD subjects, but not controls, a sig...

journal_title：Experimental neurology

authors： Weaver KE,Richards TL,Liang O,Laurino MY,Samii A,Aylward EH

更新日期：2009-04-01 00:00:00

abstract：:As part of a wider investigation on brain structure and function in young rats with inherited hydrocephalus, this study was undertaken to develop a technique to monitor, and quantify, progressive changes in ventricle and cortical dimensions in hydrocephalic rats in vivo. Magnetic resonance images were obtained with a ...

journal_title：Experimental neurology

authors： Harris NG,Jones HC,Williams SC

更新日期：1992-10-01 00:00:00

abstract：:We have analyzed a mouse model of Charcot-Marie-Tooth disease 2E (CMT2E) harboring a heterozygous p.Asn98Ser (p.N98S) Nefl mutation, whose human counterpart results in a severe, early-onset neuropathy. Behavioral, electrophysiological, and pathological analyses were done on separate cohorts of NeflN98S/+ mutant mice a...

journal_title：Experimental neurology

authors： Lancaster E,Li J,Hanania T,Liem R,Scheideler MA,Scherer SS

更新日期：2018-10-01 00:00:00