Transplantation of mesencephalic cell suspension in dopamine-denervated striatum of the rat.I. Effects on spontaneous activity of striatal neurons.

abstract：:The sub-thalamic nucleus (STN) is relevant to the preparation of movement ignition but its role in movement termination is uncertain. Fourteen patients with Parkinson's disease (PD) received local field potentials (LFPs) recording at the left STN on the fourth day after deep brain stimulation surgery. They performed p...

journal_title：Experimental neurology

authors： Hsu YT,Lai HY,Chang YC,Chiou SM,Lu MK,Lin YC,Liu YL,Chen CC,Huang HC,Chien TF,Lin SZ,Chen YY,Tsai CH

更新日期：2012-01-01 00:00:00

abstract：:Global cerebral ischemia depletes brain tissue NAD+, an essential cofactor for mitochondrial and cellular metabolism, leading to bioenergetics failure and cell death. The post-ischemic NAD+ levels can be replenished by the administration of nicotinamide mononucleotide (NMN), which serves as a precursor for NAD+ synthe...

journal_title：Experimental neurology

authors： Klimova N,Fearnow A,Long A,Kristian T

更新日期：2020-03-01 00:00:00

abstract：:The aim of this study was to characterize the microglial and astroglial reactions to degeneration of (a) hippocampal CA1 pyramidal cells and dentate hilar neurons induced by cerebral ischemia and (b) CA3 pyramidal cells and dentate hilar neurons induced by intraventricular injections of kainic acid (KA). The microglia...

journal_title：Experimental neurology

authors： Jørgensen MB,Finsen BR,Jensen MB,Castellano B,Diemer NH,Zimmer J

更新日期：1993-03-01 00:00:00

abstract：:We have previously shown that lesions of the sensorimotor cortex induced by either thermocoagulation or aspiration produce different effects on axonal plasticity. We have now investigated whether these methods of lesion also influence the behavioral outcome. The behavioral effects of unilateral and bilateral lesions o...

journal_title：Experimental neurology

authors： Napieralski JA,Banks RJ,Chesselet MF

更新日期：1998-11-01 00:00:00

abstract：:Autonomic dysreflexia is a condition of episodic hypertension that develops after spinal cord injury (SCI). We previously showed that a two-day anti-inflammatory treatment with an anti-CD11d integrin monoclonal antibody (mAb), soon after SCI in rats, reduced the magnitude of dysreflexia for at least 6 weeks. Effects o...

journal_title：Experimental neurology

authors： Gris D,Marsh DR,Dekaban GA,Weaver LC

更新日期：2005-08-01 00:00:00

abstract：:Following traumatic brain injury (TBI), mitochondrial function becomes compromised. Mitochondrial dysfunction is characterized by intra-mitochondrial Ca(2+) accumulation, induction of oxidative damage, and mitochondrial permeability transition (mPT). Experimental studies show that cyclosporin A (CsA) inhibits mPT. How...

journal_title：Experimental neurology

authors： Mbye LH,Singh IN,Sullivan PG,Springer JE,Hall ED

更新日期：2008-01-01 00:00:00

abstract：:Adenoviral-mediated gene transfer to the caudate nucleus of Macaca mulatta was accomplished using stereotactic injection of two distinct recombinant Ad5 vectors containing the gene for Escherichia coli beta-galactosidase and the cDNA for rat hypoxanthine-guanine phosphoribosylphosphotransferase (HPRT), respectively. M...

journal_title：Experimental neurology

authors： Davidson BL,Doran SE,Shewach DS,Latta JM,Hartman JW,Roessler BJ

更新日期：1994-02-01 00:00:00

abstract：:It is widely accepted that the immune system plays important functional roles in regeneration after injury to the spinal cord. Immune response towards injury involves a complex interplay of immune system cells, such as neutrophils, macrophages and microglia, T- and B-lymphocytes. We investigated the influence of the l...

journal_title：Experimental neurology

authors： Wu B,Matic D,Djogo N,Szpotowicz E,Schachner M,Jakovcevski I

更新日期：2012-10-01 00:00:00

abstract：:The receptiveness of the brain to monocyte infiltration was studied in rats that had been injected intracerebrally with Corynebacterium parvum. At 0-17 days after intracerebral injection and 18 h after intravenous injection of diI-labeled isogenous mononuclear cells, host rats were sacrificed and cells from the vicini...

journal_title：Experimental neurology

authors： Cheng L,Allore RJ,Richardson PM

更新日期：1998-02-01 00:00:00

abstract：:GABAergic dysfunction is implicated in hippocampal deficits of the Ts65Dn mouse model of Down syndrome (DS). Since Ts65Dn mice overexpress G-protein coupled inward-rectifying potassium (GIRK2) containing channels, we sought to evaluate whether increased GABAergic function disrupts the functioning of hippocampal circui...

journal_title：Experimental neurology

authors： Best TK,Cramer NP,Chakrabarti L,Haydar TF,Galdzicki Z

更新日期：2012-02-01 00:00:00

abstract：:The present study demonstrates that the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes significantly greater reductions in striatal dopamine levels in C57/bl mice than in CD-1 mice, thus confirming a greater sensitivity of the C57/bl mice to MPTP. To determine the possible reasons for this diffe...

journal_title：Experimental neurology

authors： Muthane U,Ramsay KA,Jiang H,Jackson-Lewis V,Donaldson D,Fernando S,Ferreira M,Przedborski S

更新日期：1994-04-01 00:00:00

abstract：:Injury of a peripheral nerve not only leads to target denervation, but also induces massive stripping of spinal synapses on axotomized motoneurons, with disruption of spinal circuits. Even when regeneration is successful, unspecific reinnervation and the limited reconnection of the spinal circuits impair functional re...

journal_title：Experimental neurology

authors： Arbat-Plana A,Torres-Espín A,Navarro X,Udina E

更新日期：2015-01-01 00:00:00

abstract：:Exposure of the rodent striatum to quinolinic acid (QA, N-methyl-D-aspartate receptor agonist) induces immediate early gene (IEG; c-fos, c-jun, jun-B, zif/268) expression that may extend 12-24 h after injection. In order to determine the specificity of the prolonged IEG response to the QA injection, the temporal patte...

journal_title：Experimental neurology

authors： Shan Y,Carlock LR,Walker PD

更新日期：1997-04-01 00:00:00

abstract：:Oxaliplatin is first-line chemotherapy for colorectal cancer, but produces dose-limiting neurotoxicity. Acute neurotoxicity following infusion produces symptoms including cold-triggered fasciculations and cramps, with subsequent chronic neuropathy developing at higher cumulative doses. Axonal excitability studies were...

journal_title：Experimental neurology

authors： Park SB,Lin CS,Krishnan AV,Goldstein D,Friedlander ML,Kiernan MC

更新日期：2011-01-01 00:00:00

abstract：:A significant proportion of neurologic patients suffer electroencephalographic (EEG) seizures in the acute phase following traumatic or ischemic brain injury, including many without overt behavioral manifestations. Although such nonconvulsive seizures may exacerbate neuropathological processes, they have received limi...

journal_title：Experimental neurology

authors： Hartings JA,Williams AJ,Tortella FC

更新日期：2003-02-01 00:00:00

abstract：:Systemic administration of the amphetamine derivative p-chloroamphetamine (PCA) causes degeneration of 5-HT axon terminals in rat brain. The present study was designed to determine whether PCA induces neurotoxic effects by a direct action on 5-HT axon terminals. PCA was administered by microinjection directly into the...

journal_title：Experimental neurology

authors： Berger UV,Molliver ME,Grzanna R

更新日期：1990-09-01 00:00:00

abstract：:The presence of the alpha2macroglobulin receptor/low density lipoprotein receptor-related protein (alpha2Mr/LRP) and its ligands alpha2macroglobulin (alpha2M), apoliprotein E, and plasminogen activators was detected in senile plaques of Alzheimer's disease (AD). To explore a possible role of alpha2M in neurodegenerati...

journal_title：Experimental neurology

authors： Fabrizi C,Businaro R,Lauro GM,Starace G,Fumagalli L

更新日期：1999-02-01 00:00:00

abstract：:Administration of endogenous corticosterone to intact animals induces calbindin-D28k protein in the hippocampal CA1-CA2 subfields. The fact that this effect on calbindin-D28k was shown to be specific for the hippocampus argues for a receptor-mediated effect on gene expression. In addition, chronic pretreatment with co...

journal_title：Experimental neurology

authors： Rami A,Rabié A,Winckler J

更新日期：1998-02-01 00:00:00

abstract：:We have previously demonstrated that octanoic (OA) and decanoic acids (DA) inhibit Na+, K+ ATPase activity in synaptic plasma membranes from rat brain. The objective of the present study was to investigate the in vitro effects of the other metabolites that accumulate in tissues of medium-chain acyl-CoA dehydrogenase (...

journal_title：Experimental neurology

authors： de Assis DR,Maria RC,Ferreira GC,Schuck PF,Latini A,Dutra-Filho CS,Wannmacher CM,Wyse AT,Wajner M

更新日期：2006-01-01 00:00:00

abstract：:Human spinal cord injury (SCI) can result in progressive degeneration that may continue for many years and lead to the formation of highly septated cystic cavities. This hallmark feature has been reproduced in experimental models, but neither its pathogenesis nor clinically relevant features have been fully elucidated...

journal_title：Experimental neurology

authors： Radojicic M,Reier PJ,Steward O,Keirstead HS

更新日期：2005-12-01 00:00:00

abstract：:Estrogen has been suggested to be pro-epileptic by reducing GABA synthesis, resulting in increased spine density and a decreased threshold for seizures in the hippocampus, which, once they occur, are characterized by a dramatic spine loss in the affected brain areas. As considerable amounts of estradiol are synthesize...

journal_title：Experimental neurology

authors： Zhou L,Lehan N,Wehrenberg U,Disteldorf E,von Lossow R,Mares U,Jarry H,Rune GM

更新日期：2007-01-01 00:00:00

abstract：:Fish optic nerve sections were recently shown to be nonpermissive to growth of adult retinal axons. In addition, fish optic nerve myelin was found to inhibit growth of adult retinal axons and this inhibition was neutralized by IN-1 antibodies (known to block rat myelin-associated inhibitors). In this study we examined...

journal_title：Experimental neurology

authors： Sivron T,Schwartz M

更新日期：1994-12-01 00:00:00

abstract：:Peripheral nerve regeneration was studied across a tubulated 10-mm gap in the rat sciatic nerve using histomorphometry and electrophysiological measurements of A-fiber, B-fiber, and C-fiber peaks of the evoked action potentials. Tubes fabricated from large-pore collagen (max. pore diameter, 22 nm), small-pore collagen...

journal_title：Experimental neurology

authors： Chamberlain LJ,Yannas IV,Hsu HP,Strichartz G,Spector M

更新日期：1998-12-01 00:00:00

abstract：:Mitochondria play a pivotal role in the cascade of events associated with cell death pathways that are involved with several forms of neurodegeneration. Recent findings show that in the Bax/Bak-dependent pathway of apoptosis, the release of cytochrome c from mitochondria is a consequence of two carefully coordinated e...

journal_title：Experimental neurology

authors： Perkins G,Bossy-Wetzel E,Ellisman MH

更新日期：2009-08-01 00:00:00

abstract：:We have recently shown that tanycytes present in the median eminence (ME) constitute a preferential support for the regeneration of lesioned neurohypophysial oxytocinergic and vasopressinergic axons. However, although tanycytes are particularly abundant in the ME, they are also present along the third ventricle wall. ...

journal_title：Experimental neurology

authors： Chauvet N,Prieto M,Alonso G

更新日期：1998-05-01 00:00:00

abstract：:Following a traumatic brain injury (TBI), the excessive release of interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) is a major cause of cerebral edema, which, in turn, can cause permanent neuronal loss and cognitive deficits in laboratory rats. This study examined the changes in expression of t...

journal_title：Experimental neurology

authors： He J,Evans CO,Hoffman SW,Oyesiku NM,Stein DG

更新日期：2004-10-01 00:00:00

abstract：:This work investigated the extent to which constituent proportions of fast- and slow-twitch muscle units determine whole muscle contractile properties. We employed several self- and cross-reinnervation models using synergistic homogeneous and heterogeneous muscles. By comparing the present data with previously publish...

journal_title：Experimental neurology

authors： Foehring RC,Sypert GW,Munson JB

更新日期：1988-09-01 00:00:00

abstract：:In the intraluminal suture model of middle cerebral artery occlusion (MCAO) in the rat, lesions of the masticator muscles associated with impaired functional outcome occur. We evaluated the role of external carotid artery (ECA) transection. We assessed whether isolated interruption of an arterial or a venous connectio...

journal_title：Experimental neurology

authors： Dittmar MS,Vatankhah B,Fehm NP,Retzl G,Schuierer G,Bogdahn U,Schlachetzki F,Horn M

更新日期：2005-10-01 00:00:00

abstract：:Abnormally associated movements inevitably occur after surgical repair of the facial nerve. The reason for this postparalytic syndrome is poor navigation of regrowing axons. Despite the valuable functional advantage provided by the easily detected movement of vibrissae in rats, the major investigative tools for establ...

journal_title：Experimental neurology

authors： Tomov TL,Guntinas-Lichius O,Grosheva M,Streppel M,Schraermeyer U,Neiss WF,Angelov DN

更新日期：2002-12-01 00:00:00

abstract：:This study uses the saphenous nerve crush model in Thy1-YFP mice and serial transcutaneous imaging to evaluate the rate of nerve regeneration under various FK-506 (tacrolimus) dosing regimens and in the presence of transgenic overexpression of glial cell line-derived neurotrophic factor (GDNF). Thy1-YFP transgenic mic...

journal_title：Experimental neurology

authors： Yan Y,Sun HH,Mackinnon SE,Johnson PJ

更新日期：2011-11-01 00:00:00