Transplantation of mesencephalic cell suspension in dopamine-denervated striatum of the rat.I. Effects on spontaneous activity of striatal neurons.

abstract：:The age-dependent effects of sympathetic superior cervical ganglionectomy on smooth muscle alpha-adrenoceptor contractile responses were investigated in Müller's muscle in the superior eyelid of the Sprague-Dawley rat. Ganglionectomies in juvenile (32 days) and adult (70 days) rats produced sustained sympathetic dener...

journal_title：Experimental neurology

authors： Smith PG

更新日期：1986-01-01 00:00:00

abstract：:This study characterizes the impact of increasing-intensity treadmill exercise (iTR) on noradrenergic (NE) and serotonergic (5HT) modulation of neuropathic pain. Following sciatic nerve transection and repair (SNTR) rats developed significant mechanical and thermal hyperalgesia that was partially prevented by iTR perf...

journal_title：Experimental neurology

authors： Lopez-Alvarez VM,Puigdomenech M,Navarro X,Cobianchi S

更新日期：2018-01-01 00:00:00

abstract：:By combining neurochemical measurement of norepinephrine (NE) with double-label immunocytochemistry for tyrosine hydroxylase-positive (TH+) noradrenergic nerves and specific lymphoid markers, we have examined the developmental compartmentation of noradrenergic nerves in the rat spleen. TH+ nerve fibers were present in...

journal_title：Experimental neurology

authors： Ackerman KD,Felten SY,Dijkstra CD,Livnat S,Felten DL

更新日期：1989-03-01 00:00:00

abstract：:Increased vascular permeability causing vasogenic brain edema is characteristic for many acute neurological diseases such as stroke, brain trauma, and meningitis. Src family kinases, especially c-Src, play an important role in regulating blood-brain barrier permeability in response to VEGF, but also mediate leukocyte ...

journal_title：Experimental neurology

authors： Paul R,Angele B,Popp B,Klein M,Riedel E,Pfister HW,Koedel U

更新日期：2007-01-01 00:00:00

abstract：:Huntington's disease (HD) is a progressive neurodegenerative disorder characterized by chorea, psychiatric disturbances, and dementia. It is caused by a polyglutamine repeat expansion in the huntingtin protein. The striatum is a major site of neuronal loss in HD, but the mechanisms underlying the neurodegenerative pro...

journal_title：Experimental neurology

authors： Duan W,Guo Z,Mattson MP

更新日期：2000-09-01 00:00:00

abstract：:Peripheral nerve grafts (PNG) into the rat spinal cord support axon regeneration after acute or chronic injury, with synaptic reconnection across the lesion site and some level of behavioral recovery. Here, we grafted a peripheral nerve into the injured spinal cord of cats as a preclinical treatment approach to promot...

journal_title：Experimental neurology

authors： Côté MP,Hanna A,Lemay MA,Ollivier-Lanvin K,Santi L,Miller K,Monaghan R,Houlé JD

更新日期：2010-09-01 00:00:00

abstract：:Polymerized collagen rolls enclosing Schwann cells (SCs) raised in culture were grafted into cystic cavities formed after lesioning the thoracic spinal cord of adult rats. Axons were already present within the graft by 14 days after implantation and both ensheathed and myelinated axons were numerous by 28 days. This a...

journal_title：Experimental neurology

authors： Paino CL,Bunge MB

更新日期：1991-11-01 00:00:00

abstract：:The strength of contractures, produced by 15 to 146 mM [K]0 (as L-glutamate), was measured in isolated small bundles of muscle fibers from the fast-twitch extensor digitorum longus and from the slow-twitch soleus of normal and dystrophic (C57 BL/6J dy2J/dy2J) mice. The analysis of the relation between the maximal ampl...

journal_title：Experimental neurology

authors： Noireaud J,Léoty C

更新日期：1985-03-01 00:00:00

abstract：:Pluripotent neural stem cells (NSCs) have been used as replacement cells in a variety of neurological disease models. Among the many different NSCs that have been used to date, most robust results have been obtained with the immortalized neural stem cell line (C17.2) isolated from postnatal cerebellum. However, it is ...

journal_title：Experimental neurology

authors： Mi R,Luo Y,Cai J,Limke TL,Rao MS,Höke A

更新日期：2005-08-01 00:00:00

abstract：:Hyperbaric oxygen preconditioning (HBO-PC) has been demonstrated to attenuate hemorrhagic transformation (HT) after middle cerebral artery occlusion (MCAO) in hyperglycemic rats. However, the mechanisms remain to be illustrated. Recently, HBO-PC has been shown to activate peroxisome proliferator-activated receptor-gam...

journal_title：Experimental neurology

authors： Bian H,Hu Q,Liang X,Chen D,Li B,Tang J,Zhang JH

更新日期：2015-03-01 00:00:00

abstract：:It is widely accepted that the immune system plays important functional roles in regeneration after injury to the spinal cord. Immune response towards injury involves a complex interplay of immune system cells, such as neutrophils, macrophages and microglia, T- and B-lymphocytes. We investigated the influence of the l...

journal_title：Experimental neurology

authors： Wu B,Matic D,Djogo N,Szpotowicz E,Schachner M,Jakovcevski I

更新日期：2012-10-01 00:00:00

abstract：:This paper reports that endolymphatic hydrops causes a significant reduction of retrogradely labeled cell bodies of the ipsilateral trigeminal ganglion following application of horseradish peroxidase in the cochlea. We previously showed that the trigeminal ganglion is a source of primary sensory innervation to the coc...

journal_title：Experimental neurology

authors： Vass Z,Shore SE,Nuttall AL,Miller JM

更新日期：1998-06-01 00:00:00

abstract：:Mesiotemporal lobe Epilepsy (MTLE), the most frequent form of focal epilepsy, is often drug-resistant. Enriching the epileptic focus with GABA-releasing engineered cells has been proposed as a strategy to prevent seizures. However, ex vivo data from animal models and MTLE patients suggest that, due to changes in chlor...

journal_title：Experimental neurology

authors： Stamboulian-Platel S,Legendre A,Chabrol T,Platel JC,Pernot F,Duveau V,Roucard C,Baudry M,Depaulis A

更新日期：2016-10-01 00:00:00

abstract：:Diffuse axonal injury is thought to be the basis of the functional impairments stemming from mild traumatic brain injury. To examine how axons are damaged by traumatic events, such as motor vehicle accidents, falls, sports activities, or explosive blasts, we have taken advantage of the spinal cord with its extensive w...

journal_title：Experimental neurology

authors： del Mar N,von Buttlar X,Yu AS,Guley NH,Reiner A,Honig MG

更新日期：2015-09-01 00:00:00

abstract：:Among the comorbidities observed in epilepsy patients depression is the most frequent one. Likewise, depression by itself is accompanied by an increased risk to develop epilepsy. Both epilepsy and depression are characterized by a high incidence of pharmacoresistance, which might be based on overactivity of multidrug ...

journal_title：Experimental neurology

authors： Klein S,Bankstahl JP,Löscher W,Bankstahl M

更新日期：2015-01-01 00:00:00

abstract：:Infection with human immunodeficiency virus-1 (HIV-1) is associated with dysfunctions of the central nervous system (CNS). HIV-1 induces its effects on the CNS by a variety of mechanisms, including by shedding the neurotoxic viral proteins such as gp120 and Tat. Both HIV-1 and gp120 have been shown to cross the blood-...

journal_title：Experimental neurology

authors： Banks WA,Robinson SM,Nath A

更新日期：2005-05-01 00:00:00

abstract：:Heme oxygenase-1 is a cellular stress protein expressed in brain and other tissues in response to oxidative challenge and other noxious stimuli. In the present study, immunohistochemistry was used to assess HO-1 expression in various postmortem human brain specimens derived from PD and control subjects. In the substan...

journal_title：Experimental neurology

authors： Schipper HM,Liberman A,Stopa EG

更新日期：1998-03-01 00:00:00

abstract：:Overt behavioral symptoms of Parkinson's disease (PD) do not occur until over 80% of the striatal dopamine content has been lost. Diagnosis of the disorder relies on identifying clinical symptoms including akinesia, resting tremor, and rigidity. In retrospect, behavioral deficits are observed several years prior to di...

journal_title：Experimental neurology

authors： Tillerson JL,Caudle WM,Reverón ME,Miller GW

更新日期：2002-11-01 00:00:00

abstract：:Alpha-synuclein (alphaSN) is implicated in Parkinson's disease (PD) and is the major component of Lewy bodies (LBs). Although alphaSN is mainly expressed in neuronal cells and exists as a cytoplasmic protein, it has been found in body fluids including cerebrospinal fluid and blood. This study explored plasma alphaSN a...

journal_title：Experimental neurology

authors： Li QX,Mok SS,Laughton KM,McLean CA,Cappai R,Masters CL,Culvenor JG,Horne MK

更新日期：2007-04-01 00:00:00

abstract：:It has been >20 years since studies first revealed that the brain is insulin sensitive, highlighted by the expression of insulin receptors in neurons and glia, the presence of circulating brain insulin, and even localized insulin production. Following these discoveries, evidence of decreased brain insulin receptor num...

journal_title：Experimental neurology

authors： Frazier HN,Ghoweri AO,Anderson KL,Lin RL,Porter NM,Thibault O

更新日期：2019-03-01 00:00:00

abstract：:Ca2+ influx through NMDA receptor-gated channels and the subsequent rise in intracellular Ca2+ concentration ([Ca2+]i) have been implicated in cytotoxic processes that lead to irreversible neuronal injury. While many studies have focused on cytosolic Ca2+ homeostasis, much less is known about Ca2+ fluxes in subcellula...

journal_title：Experimental neurology

authors： Peng TI,Jou MJ,Sheu SS,Greenamyre JT

更新日期：1998-01-01 00:00:00

abstract：:Peripheral nerve regeneration following injury occurs spontaneously, but many of the processes require metabolic energy. The mechanism of energy supply to axons has not previously been determined. In the central nervous system, monocarboxylate transporter 1 (MCT1), expressed in oligodendroglia, is critical for supplyi...

journal_title：Experimental neurology

authors： Morrison BM,Tsingalia A,Vidensky S,Lee Y,Jin L,Farah MH,Lengacher S,Magistretti PJ,Pellerin L,Rothstein JD

更新日期：2015-01-01 00:00:00

abstract：:Adult neurogenesis is modulated by growth factors, physical conditions, and other alterations in the physical microenvironment. We studied the effects of focal ischemia on neurogenesis in the subventricular zone (SVZ), olfactory bulb (OB), and hippocampal dentate gyrus (DG) (known to be persistent neurogenic regions) ...

journal_title：Experimental neurology

authors： Koketsu D,Furuichi Y,Maeda M,Matsuoka N,Miyamoto Y,Hisatsune T

更新日期：2006-05-01 00:00:00

abstract：:We have analyzed the effects of environmental enrichment (EE) in a seizure-prone mouse model in which the genetic disruption of the presynaptic protein Bassoon leads to structural and functional alterations in the hippocampus and causes early spontaneous seizures mimicking human neurodevelopmental disorders. One-month...

journal_title：Experimental neurology

authors： Morelli E,Ghiglieri V,Pendolino V,Bagetta V,Pignataro A,Fejtova A,Costa C,Ammassari-Teule M,Gundelfinger ED,Picconi B,Calabresi P

更新日期：2014-11-01 00:00:00

abstract：:The binding of agonists and antagonists to beta-adrenergic receptors in brain tissue obtained postmortem in nonalcoholic controls and matched intoxicated and sober alcoholics was measured to assess the state of the receptors and their coupling to adenylate cyclase. Binding of antagonist, iodocyanopindolol, to cerebral...

journal_title：Experimental neurology

authors： Valverius P,Borg S,Valverius MR,Hoffman PL,Tabakoff B

更新日期：1989-09-01 00:00:00

abstract：:Ascending and descending spinal cord potentials were recorded during conduction block produced by compression and ischemia to the spinal cord of cats. Dorsally and ventrally applied compression produced proportional changes in both ascending and descending potentials. Results for induced ischemia were much more variab...

journal_title：Experimental neurology

authors： Bennett MH

更新日期：1983-06-01 00:00:00

abstract：RATIONALE:Neurofibromatosis type 1 (NF1) is associated with higher rates of epilepsy compared to the general population. Some NF1 patients with epilepsy do not have intracranial lesions, suggesting the genetic mutation itself may contribute to higher rates of epilepsy in these patients. We have recently demonstrated in...

journal_title：Experimental neurology

authors： Sabetghadam A,Wu C,Liu J,Zhang L,Reid AY

更新日期：2020-09-01 00:00:00

abstract：:In chronically implanted rats, we examined the respiratory EMG activity of the two parts of the diaphragm, costal and crural, during sleep and wakefulness. Their activity was compared and contrasted with that of the EMG activity of the cricothyroid muscle. Whether in wakefulness, while grooming and drinking, or in non...

journal_title：Experimental neurology

authors： Pollard MJ,Megirian D,Sherrey JH

更新日期：1985-10-01 00:00:00

abstract：:The ability of striatal embryonic grafts to promote functional recovery on complex behavioral tasks depends on various factors, including the amount of striatal-like tissue within the grafts and the duration of post-graft training. However, how the innate paw bias of animals is affected by experience, or influences re...

journal_title：Experimental neurology

authors： Döbrössy MD,Dunnett SB

更新日期：2006-06-01 00:00:00

abstract：:When antibodies specific to fast-twitch, slow-twitch, and slow-tonic myosins were used to stain the clasp muscle, m. sternoradialis, of Xenopus laevis, three predominant fiber types were identified in both males and females. Three fiber types can also be distinguished by the diameters and conduction velocities of thei...

journal_title：Experimental neurology

authors： Rubinstein NA,Erulkar SD,Schneider GT

更新日期：1983-11-01 00:00:00