Continuous dopaminergic stimulation reduces risk of motor complications in parkinsonian primates.

abstract：:Ascending and descending spinal cord potentials were recorded during conduction block produced by compression and ischemia to the spinal cord of cats. Dorsally and ventrally applied compression produced proportional changes in both ascending and descending potentials. Results for induced ischemia were much more variab...

journal_title：Experimental neurology

authors： Bennett MH

更新日期：1983-06-01 00:00:00

abstract：:Fish optic nerve sections were recently shown to be nonpermissive to growth of adult retinal axons. In addition, fish optic nerve myelin was found to inhibit growth of adult retinal axons and this inhibition was neutralized by IN-1 antibodies (known to block rat myelin-associated inhibitors). In this study we examined...

journal_title：Experimental neurology

authors： Sivron T,Schwartz M

更新日期：1994-12-01 00:00:00

abstract：:The role of microglia and their contribution to the development and maintenance of pain states has emerged as an attractive field of study. Sensitization of central nociceptors and interneurons is thought to be responsible for the symptoms of chronic neuropathic pain states. Microglia interact with these neurons at th...

journal_title：Experimental neurology

authors： Schomberg D,Olson JK

更新日期：2012-04-01 00:00:00

abstract：:Genetically dystrophic chicks (line 413) were administered 0.3 mg/kg dexamethasone (DEX), a corticosteroid, from 2 to 28 days ex ovo. Diluent-injected dystrophic and normal (line 412) chicks served as controls. The effects of DEX on muscle function were evaluated weekly by the exhaustion score (ES) method. Proton magn...

journal_title：Experimental neurology

authors： Misra LK,Entrikin RK

更新日期：1988-11-01 00:00:00

abstract：:With the use of four independent cell markers and Brd-U birthdating we have charted the earliest stages of neuronal differentiation and migration in the developing rat central nervous system, including the cortex, spinal cord, and retina. One of the markers, the monoclonal antibody 2G12, labeled a large subpopulation ...

journal_title：Experimental neurology

authors： Brittis PA,Meiri K,Dent E,Silver J

更新日期：1995-07-01 00:00:00

abstract：:Little is known about the morphological effects of alcoholism on the developing adolescent brain and its consequences into adulthood. We studied here the relationship between two neurotransmitter systems (the serotoninergic and nitrergic) and the astrocytic and neuronal cytoskeleton immediately and long after drinking...

journal_title：Experimental neurology

authors： Evrard SG,Duhalde-Vega M,Tagliaferro P,Mirochnic S,Caltana LR,Brusco A

更新日期：2006-08-01 00:00:00

abstract：:Regeneration in the peripheral nervous system offers unique opportunities and challenges to medicine. Compared to the central nervous system, peripheral axons can and do regenerate resulting in functional recovery, especially if the distance to target is short as in distal limb injuries. However, this regenerative cap...

journal_title：Experimental neurology

authors： Höke A,Brushart T

更新日期：2010-05-01 00:00:00

abstract：:We previously showed that overexpressing the 70-kDa inducible heat shock protein in primary astrocyte cultures and in a rodent stroke model using viral vectors resulted in protection from ischemia and ischemia-like injury. However, viral transfection could potentially provoke a stress response itself; therefore, we ex...

journal_title：Experimental neurology

authors： Lee JE,Yenari MA,Sun GH,Xu L,Emond MR,Cheng D,Steinberg GK,Giffard RG

更新日期：2001-07-01 00:00:00

abstract：:Many neurological and psychiatric disorders exhibit gender disparities, and sex differences in the brain likely explain some of these effects. Recent work in rodents points to a role for epigenetics in the development or maintenance of neural sex differences, although genome-wide studies have so far been lacking. Here...

journal_title：Experimental neurology

authors： Shen EY,Ahern TH,Cheung I,Straubhaar J,Dincer A,Houston I,de Vries GJ,Akbarian S,Forger NG

更新日期：2015-06-01 00:00:00

abstract：:To test the hypothesis that prepubertal exposure of LHRH neurons to a source of catecholamines and neuropeptides accelerates the onset of puberty, we examined the effects of autologous adrenal transplantation into the base of the third ventricle of the brain in juvenile female rhesus monkeys at 11-13 months of age. Th...

journal_title：Experimental neurology

authors： Gore AC,Saitoh Y,Terasawa E

更新日期：1996-08-01 00:00:00

abstract：:The aim of this study was to characterize the microglial and astroglial reactions to degeneration of (a) hippocampal CA1 pyramidal cells and dentate hilar neurons induced by cerebral ischemia and (b) CA3 pyramidal cells and dentate hilar neurons induced by intraventricular injections of kainic acid (KA). The microglia...

journal_title：Experimental neurology

authors： Jørgensen MB,Finsen BR,Jensen MB,Castellano B,Diemer NH,Zimmer J

更新日期：1993-03-01 00:00:00

abstract：:Recently it has been shown that there is impaired cerebral endothelial function in many chronic neurodegenerative disorders including Alzheimer's and Huntington's disease. Such problems have also been reported in Parkinson's disease, in which α-synuclein aggregation is the pathological hallmark. However, little is kno...

journal_title：Experimental neurology

authors： Kuan WL,Bennett N,He X,Skepper JN,Martynyuk N,Wijeyekoon R,Moghe PV,Williams-Gray CH,Barker RA

更新日期：2016-11-01 00:00:00

abstract：:The functional and morphologic consequences of treatment of peripheral nerve lesions with exogenous 3,3',5-triiodo-L-thyronine (T3) are unclear. In this study adult Wistar rats with sciatic nerve crush lesions were treated with 20 micrograms/kg/day of T3. The treated animals gained weight though more slowly than vehic...

journal_title：Experimental neurology

authors： Allpress SJ,Pollock M

更新日期：1986-02-01 00:00:00

abstract：:Our previous studies showed that Insulin-like Growth Factor (IGF)-1 reduced blood brain barrier permeability and decreased infarct volume caused by middle cerebral artery occlusion (MCAo) in middle aged female rats. Similarly, cultures of primary brain microvessel endothelial cells from middle-aged female rats and exp...

journal_title：Experimental neurology

authors： Bake S,Okoreeh A,Khosravian H,Sohrabji F

更新日期：2019-01-01 00:00:00

abstract：:Successful clinical application of fMRI tasks requires reliable knowledge about the brain structures mapped by the task. With memory fMRI, diverging evidence exists concerning the location of major signal sources as well as hippocampal contributions. To clarify these issues, we investigated a frequently applied memory...

journal_title：Experimental neurology

authors： Beisteiner R,Drabeck K,Foki T,Geissler A,Gartus A,Lehner-Baumgartner E,Baumgartner C

更新日期：2008-09-01 00:00:00

abstract：:Eph tyrosine kinase receptors and their ligands, the ephrins, play a key role in the establishment of retinotectal topography during development. Tectal up-regulation of ephrin-A2 in goldfish, coincident with the reestablishment of a retinotectal map, suggests a similar role during optic nerve regeneration. Here we re...

journal_title：Experimental neurology

authors： King CE,Wallace A,Rodger J,Bartlett C,Beazley LD,Dunlop SA

更新日期：2003-10-01 00:00:00

abstract：:A sample of 504 single neurons isolated in three curvilinear arrays of 10 closely spaced tracks in primary somatosensory and in pericruciate sensorimotor cortex was studied in two awake, restrained domestic cats. Modality sensitivity and receptive field size and location were assessed for each neuron, along with respo...

journal_title：Experimental neurology

authors： Slimp JC,Towe AL

更新日期：1990-01-01 00:00:00

abstract：:The response of the developing brain to traumatic injury is different from the response of the mature, adult brain. There are critical developmental trajectories in the young brain, whereby injury can lead to long term functional abnormalities. Emerging preclinical and clinical literature supports the presence of sign...

journal_title：Experimental neurology

authors： Arambula SE,Reinl EL,El Demerdash N,McCarthy MM,Robertson CL

更新日期：2019-07-01 00:00:00

abstract：:One of the sexual dimorphic differences in adult rodents is neural proliferation. Here we demonstrate that physiological hormone stages can modulate this proliferation in the adult forebrain. Female mice, both pregnant and synchronized in oestrus, exhibited higher proliferating cell percentages than males in both the ...

journal_title：Experimental neurology

authors： Díaz D,Valero J,Airado C,Baltanás FC,Weruaga E,Alonso JR

更新日期：2009-04-01 00:00:00

abstract：:Electroconvulsive therapy (ECT) is one of the most effective treatments in cases of severe and treatment resistant major depression. 60-80% of patients respond to ECT, but the procedure is demanding and robust prediction of ECT responses would be of great clinical value. Predictions based on neuroimaging data have rec...

journal_title：Experimental neurology

authors： Gärtner M,Ghisu E,Herrera-Melendez AL,Koslowski M,Aust S,Asbach P,Otte C,Regen F,Heuser I,Borgwardt K,Grimm S,Bajbouj M

更新日期：2021-01-01 00:00:00

abstract：:Hypobaric hypoxia has been implicated with neural degeneration and memory loss. Though there has been considerable knowledge on the role of the p75(NTR) in triggering apoptosis, the occurrence of a similar mechanism in hypoxic stress still remains to be explored. We, in the present study, have tried to explore the rol...

journal_title：Experimental neurology

authors： Hota SK,Barhwal K,Singh SB,Ilavazhagan G

更新日期：2008-07-01 00:00:00

abstract：:Caspases are cysteine proteases involved in apoptotic cell death, and pharmacological caspase inhibition has been demonstrated to prevent neuronal cell death in certain experimental paradigms. In this study, the role of caspase-1 and -3 in the death of dopaminergic neurons derived from the E14 rat ventral mesencephalo...

journal_title：Experimental neurology

authors： Hurelbrink CB,Armstrong RJ,Luheshi LM,Dunnett SB,Rosser AE,Barker RA

更新日期：2001-09-01 00:00:00

abstract：:Recent in vitro studies have shown that the periventricular subependymal zone (SEZ) of the rodent brain is capable of de novo generation of neurons and glia. There is less information available on neurogenesis in the adult human brain, and no study has shown the clonal generation of neurons and glia from in vitro-gene...

journal_title：Experimental neurology

authors： Kukekov VG,Laywell ED,Suslov O,Davies K,Scheffler B,Thomas LB,O'Brien TF,Kusakabe M,Steindler DA

更新日期：1999-04-01 00:00:00

abstract：:Vasoactive intestinal peptide (VIP) is one of the neuropeptides showing the strongest up-regulation in the nociceptive pathway after peripheral nerve injury and has been proposed to support neuropathic pain. Nevertheless, the story may be more complicated considering the known suppressive effects of the peptide on the...

journal_title：Experimental neurology

authors： Gallo A,Leerink M,Michot B,Ahmed E,Forget P,Mouraux A,Hermans E,Deumens R

更新日期：2017-07-01 00:00:00

abstract：:Granule cell (GC) neurogenesis increases following seizures, and some newborn GCs develop in abnormal locations within the hilus. These ectopic GCs (EGCs) display robust spontaneous and evoked excitatory activity. However, the pattern of afferent input they receive has not been fully defined. This study used electron ...

journal_title：Experimental neurology

authors： Pierce JP,Melton J,Punsoni M,McCloskey DP,Scharfman HE

更新日期：2005-12-01 00:00:00

abstract：:Activation of the visual system with a moving black and white geometric pattern resulted in dense patches or columns of 2-deoxyglucose label in primate extrastriate visual cortex. The three-dimensional reconstruction of these metabolic columns showed that they were arranged in irregularly shaped slabs which extended i...

journal_title：Experimental neurology

authors： Herdman SJ,Hand CL,Hand PJ

更新日期：1984-08-01 00:00:00

abstract：:A complex propriospinal network is synaptically coupled to phrenic and intercostal motoneurons, and this makes it difficult to predict how gray matter intraspinal microstimulation (ISMS) will recruit respiratory motor units. We therefore mapped the cervical and high thoracic gray matter at locations which ISMS activat...

journal_title：Experimental neurology

authors： Sunshine MD,Ganji CN,Reier PJ,Fuller DD,Moritz CT

更新日期：2018-04-01 00:00:00

abstract：:Exosomes secreted by microglia have been found to play a role in neurovascular unit injury under the ischemic/hypoxic state. However, the modulatory effect of exosomes shuttled miRNAs produced by microglia in endothelial cells remains undefined. Here, an oxygen-glucose deprivation (OGD) model was constructed both in m...

journal_title：Experimental neurology

authors： Xie L,Zhao H,Wang Y,Chen Z

更新日期：2020-11-01 00:00:00

abstract：:Adenoviral-mediated gene transfer to the caudate nucleus of Macaca mulatta was accomplished using stereotactic injection of two distinct recombinant Ad5 vectors containing the gene for Escherichia coli beta-galactosidase and the cDNA for rat hypoxanthine-guanine phosphoribosylphosphotransferase (HPRT), respectively. M...

journal_title：Experimental neurology

authors： Davidson BL,Doran SE,Shewach DS,Latta JM,Hartman JW,Roessler BJ

更新日期：1994-02-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by cognitive decline and deposition of beta-amyloid (Abeta) plaques in cortex and hippocampus. A transgenic mouse AD model (Tg2576) that overexpresses a mutant form of human Abeta precursor protein exhibits age-related cognitive deficits, Abeta plaque deposition, and oxidative...

journal_title：Experimental neurology

authors： Stackman RW,Eckenstein F,Frei B,Kulhanek D,Nowlin J,Quinn JF

更新日期：2003-11-01 00:00:00