Mossy fibers are the primary source of afferent input to ectopic granule cells that are born after pilocarpine-induced seizures.

abstract：:Intracerebral transplants of ventral mesencephalic (VM) tissue have been well characterized. VM grafts contain numerous tyrosine hydroxylase immunoreactive neurons which send axons into the host brain. Transplanted neurons in VM grafts develop normally in that they contain tyrosine hydroxylase and GAP43. An overlooked...

journal_title：Experimental neurology

authors： Mahalik TJ,Hahn WE,Clayton GH,Owens GP

更新日期：1994-09-01 00:00:00

abstract：:Neural stem cell (NSC) transplantation provides a new approach for the repair of damage to the central nervous system (CNS), including that resulting from cerebral infarction and spinal cord injury (SCI). In the past, there were no reputable means of converting non-neural somatic cells into neural cells. This status w...

journal_title：Experimental neurology

authors： Matsui T,Akamatsu W,Nakamura M,Okano H

更新日期：2014-10-01 00:00:00

abstract：:Genetically dystrophic chicks (line 413) were administered 0.3 mg/kg dexamethasone (DEX), a corticosteroid, from 2 to 28 days ex ovo. Diluent-injected dystrophic and normal (line 412) chicks served as controls. The effects of DEX on muscle function were evaluated weekly by the exhaustion score (ES) method. Proton magn...

journal_title：Experimental neurology

authors： Misra LK,Entrikin RK

更新日期：1988-11-01 00:00:00

abstract：:The release of reactive oxygen species (ROS) by neutrophils, which infiltrate the region of damage following spinal cord injury (SCI), was investigated to determine if such release is significant following spinal cord injury. The relationship of extracellular levels of hydroxyl radicals and hydrogen peroxide obtained ...

journal_title：Experimental neurology

authors： de Castro R Jr,Hughes MG,Xu GY,Clifton C,Calingasan NY,Gelman BB,McAdoo DJ

更新日期：2004-12-01 00:00:00

abstract：:We examined the response of neuronal nitric oxide synthase (nNOS)-containing CNS neurons in rats exposed to a unilateral hypoxic-ischemic insult at 7 days of age. Animals were sacrificed at several time points after the injury, up to and including 7 days (Postnatal Day 14). Brain regions ipsilateral to the injury (inc...

journal_title：Experimental neurology

authors： Ishida A,Ishiwa S,Trescher WH,Nakajima W,Lange MS,Blue ME,Johnston MV

更新日期：2001-04-01 00:00:00

abstract：:Caloric restriction (CR) is a daily reduction of total caloric intake without a decrease in micronutrients or disproportionate reduction of any one dietary component. CR can increase lifespan reliably in a wide range of species and appears to counteract some aspects of the aging process throughout the body. The effect...

journal_title：Experimental neurology

authors： Adams MM,Shi L,Linville MC,Forbes ME,Long AB,Bennett C,Newton IG,Carter CS,Sonntag WE,Riddle DR,Brunso-Bechtold JK

更新日期：2008-05-01 00:00:00

abstract：:Contusive spinal cord injury (SCI) results in the formation of a chronic lesion cavity surrounded by a rim of spared fibers. Tissue bridges containing axons extend from the spared rim into the cavity dividing it into chambers. Whether descending axons can grow into these trabeculae or whether fibers within the trabecu...

journal_title：Experimental neurology

authors： Hill CE,Beattie MS,Bresnahan JC

更新日期：2001-09-01 00:00:00

abstract：:A central role for noradrenergic dysregulation in the pathophysiology of post-traumatic stress disorder (PTSD) is increasingly suggested by both clinical and basic neuroscience research. Here, we integrate recent findings from clinical and animal research with the earlier literature. We first review the evidence for n...

journal_title：Experimental neurology

authors： Hendrickson RC,Raskind MA

更新日期：2016-10-01 00:00:00

abstract：:A new mutant, peroneal muscular atrophy (pma) mouse in CF#1 strain has an autosomal recessively inherited equinovarus (club foot deformity) of the hind legs because of the absence of the common peroneal nerve branch of the sciatic nerve. We found the peroneal muscles were hypoplastic with histochemical and electron mi...

journal_title：Experimental neurology

authors： Nonaka I,Kikuchi A,Suzuki T,Esaki K

更新日期：1986-03-01 00:00:00

abstract：:A significant proportion of neurologic patients suffer electroencephalographic (EEG) seizures in the acute phase following traumatic or ischemic brain injury, including many without overt behavioral manifestations. Although such nonconvulsive seizures may exacerbate neuropathological processes, they have received limi...

journal_title：Experimental neurology

authors： Hartings JA,Williams AJ,Tortella FC

更新日期：2003-02-01 00:00:00

abstract：:After spinal cord injury at birth, axotomized brainstem-spinal and corticospinal neurons are capable of permanent regenerative axonal growth into and through a fetal spinal cord transplant placed into the site of either a spinal cord hemisection or transection. In contrast, if fetal tissue which is not a normal target...

journal_title：Experimental neurology

authors： Bernstein-Goral H,Diener PS,Bregman BS

更新日期：1997-11-01 00:00:00

abstract：:Apnea of prematurity (AoP) is associated with severe and repeated episodes of arterial oxygen desaturation (intermittent hypoxia - IH), which in turn increases the number of apneas. So far, there is no data addressing whether IH leads to sex-specific respiratory consequences, neither if drugs targeting AoP are more ef...

journal_title：Experimental neurology

authors： Laouafa S,Iturri P,Arias-Reyes C,Marcouiller F,Gonzales M,Joseph V,Bairam A,Soliz J

更新日期：2019-10-01 00:00:00

abstract：:The development of the corpus callosum (CC) was examined in BALB/cCF mice in relation to the effects of a 32-h period of maternal fasting. The treatment was imposed on days 15 and 16 during gestation, which immediately precedes the time when the initial callosal axons cross the midline. The BALB/c strain was used beca...

journal_title：Experimental neurology

authors： Wainwright P,Gagnon M

更新日期：1984-07-01 00:00:00

abstract：:We investigated whether administration of neurotrophin-3 (NT-3) and NMDA-2D-expressing units, found previously to enhance transmission in neonatal rat spinal cord, strengthens synaptic connections in the injured neonatal cord. We employed electrophysiological methods to evaluate the strength of synaptic transmission t...

journal_title：Experimental neurology

authors： Arvanian VL,Bowers WJ,Anderson A,Horner PJ,Federoff HJ,Mendell LM

更新日期：2006-02-01 00:00:00

abstract：:Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for nigrostriatal dopaminergic, central cholinergic, and motoneurons. GDNF also prevents the neuronal loss in experimental animal models for Parkinson's disease (PD). We have now investigated the GDNF gene for possible mutations in a group ...

journal_title：Experimental neurology

authors： Wartiovaara K,Hytönen M,Vuori M,Paulin L,Rinne J,Sariola H

更新日期：1998-08-01 00:00:00

abstract：:The recently discovered endocannabinoid system (ECS), which includes endocannabinoids and the proteins that metabolize and bind them, has been implicated in multiple regulatory functions both in health and disease. Several studies have suggested that ECS is centrally and peripherally involved in the processing of pain...

journal_title：Experimental neurology

authors： Greco R,Gasperi V,Maccarrone M,Tassorelli C

更新日期：2010-07-01 00:00:00

abstract：:The behavioral effects of augmenting dopamine D1 receptor expression in the brain were investigated in mice incorporating additional copies of the mouse D1 receptor gene. Two transgenic lines showed increases in brain D1 receptor binding sites, which were greatest in extrastriatal regions. The full D1 agonist SKF 8129...

journal_title：Experimental neurology

authors： Dracheva S,Xu M,Kelley KA,Haroutunian V,Holstein GR,Haun S,Silverstein JH,Sealfon SC

更新日期：1999-05-01 00:00:00

abstract：:This study examines the effects of high K+ concentration on the growth and development of mesencephalic cells and their glutamate vulnerability. Mesencephalic cell cultures obtained from Wistar rat embryos on the 14th gestational day were maintained for 14 days in medium with either normal (4.2 mM) or elevated (24.2 m...

journal_title：Experimental neurology

authors： Andreeva N,Ungethum U,Heldt J,Marschhausen G,Altmann T,Andersson K,Gross J

更新日期：1996-02-01 00:00:00

abstract：:Youth is a strong predictor of functional recovery after peripheral nerve repair, while adulthood is commonly associated with poor outcome. Identification of the factors responsible for this difference could form the basis for strategies to improve regeneration in adults. Preferential reinnervation of motor pathways b...

journal_title：Experimental neurology

authors： Le TB,Aszmann O,Chen YG,Royall RM,Brushart TM

更新日期：2001-01-01 00:00:00

abstract：:Calcium-independent nitric oxide synthase (NOS) activity has been reported in ischemic brains and usually attributed to the inducible isoform, iNOS. Because calcium-independent mechanisms have recently been shown to regulate the constitutive calcium-dependent NOS, we proposed to confirm the presence of iNOS activity i...

journal_title：Experimental neurology

authors： Lerouet D,Jafarian-Tehrani M,Louin G,Palmier B,Bonnefont-Rousselot D,Plotkine M,Margaill I

更新日期：2005-09-01 00:00:00

abstract：:The postischemic time course of amyloid protein precursor (APP), beta-amyloid protein (beta-AP), and apolipoprotein E (APO-E) immunoreactivity were examined in comparison to neuronal necrosis in the selectively vulnerable hippocampal CA1 region of gerbils subjected to 10 min of bilateral carotid occlusion-induced fore...

journal_title：Experimental neurology

authors： Hall ED,Oostveen JA,Dunn E,Carter DB

更新日期：1995-09-01 00:00:00

abstract：:The psychopathological impact of emotional stress on a specific individual varies markedly: while most escape the development of post-traumatic stress disorder and/or major depression, a select group of individuals demonstrate a vulnerability to succumb to these conditions. The past decade has witnessed an explosion i...

journal_title：Experimental neurology

authors： Krishnan V

更新日期：2014-11-01 00:00:00

abstract：:Seizures were induced in immature 18-day-old rats by i.p. administration of homocysteine (11 mmol/kg) and the effects of selected antagonists of NMDA receptors [MK-801 (0.5 mg/kg), AP7 (0.33 mmol/kg), CGP 40116 (10 mg/kg)] and non-NMDA receptors [GDEE (4 mmol/kg), NBQX (two doses, 30 mg/kg each)] were studied. The eff...

journal_title：Experimental neurology

authors： Folbergrová J

更新日期：1997-06-01 00:00:00

abstract：:Intracellular proteinaceous inclusions are well-documented hallmarks of the fatal motor neuron disorder amyotrophic lateral sclerosis (ALS). The pathological significance of these inclusions remains unknown. Peripherin, a type III intermediate filament protein, is upregulated in ALS and identified as a component withi...

journal_title：Experimental neurology

authors： McLean JR,Smith GA,Rocha EM,Osborn TM,Dib S,Hayes MA,Beagan JA,Brown TB,Lawson TF,Hallett PJ,Robertson J,Isacson O

更新日期：2014-11-01 00:00:00

abstract：:Tuberoinfundibular peptide of 39 residues (TIP39) synthesizing neurons at the caudal border of the thalamus and in the lateral pons project to areas rich in its receptor, the parathyroid hormone 2 receptor (PTH2R). These areas include many involved in processing nociceptive information. Here we examined the potential ...

journal_title：Experimental neurology

authors： Dimitrov EL,Petrus E,Usdin TB

更新日期：2010-11-01 00:00:00

abstract：:Ubiquitin (Ub) C-terminal hydrolase L1 (UCHL1) is a multifunctional protein that is expressed in neurons throughout brain at high levels. UCHL1 deletion is associated with axonal degeneration, progressive sensory motor ataxia, and premature death in mice. UCHL1 has been hypothesized to play a role in the pathogenesis ...

journal_title：Experimental neurology

authors： Mi Z,Liu H,Rose ME,Ma X,Reay DP,Ma J,Henchir J,Dixon CE,Graham SH

更新日期：2021-02-01 00:00:00

abstract：:Dopaminergic loss is known to be one of the major hallmarks of Parkinson disease (PD). In addition to its function as a neurotransmitter, dopamine plays significant roles in developmental and adult neurogenesis. Both dopaminergic deafferentation and stimulation modulate proliferation in the subventricular zone (SVZ)/o...

journal_title：Experimental neurology

authors： Winner B,Geyer M,Couillard-Despres S,Aigner R,Bogdahn U,Aigner L,Kuhn G,Winkler J

更新日期：2006-01-01 00:00:00

abstract：:Blood flow in the feline thoracic spinal cord was measured, using a laser-Doppler flowmetry. Rhythmic changes in the spinal cord blood flow were repeatedly observed with a frequency of about three to eight cycles per minute, unrelated to the respiratory or cardiac cycles. These changes were unaffected by hypertension ...

journal_title：Experimental neurology

authors： Mizutani M,Yamamuro T,Shikata J

更新日期：1988-08-01 00:00:00

abstract：:Altered activity in one of the output nuclei of the basal ganglia, the internal segment of the globus pallidus, is known to play an important role in the generation of parkinsonism. These inactivation studies tested the hypothesis that altered activity in the second major output nucleus of the basal ganglia, the subst...

journal_title：Experimental neurology

authors： Wichmann T,Kliem MA,DeLong MR

更新日期：2001-02-01 00:00:00

abstract：:Microfilaments (MFs) play an important role in wound healing and other regenerative events. The purpose of this study was to characterize changes in the distribution of MFs in traumatized auditory epithelia and compare these changes between avian (regenerating) and mammalian (nonregenerating) ears. Chicks and guinea p...

journal_title：Experimental neurology

authors： Raphael Y,Altschuler RA

更新日期：1992-01-01 00:00:00