Abstract：
:A sample of 504 single neurons isolated in three curvilinear arrays of 10 closely spaced tracks in primary somatosensory and in pericruciate sensorimotor cortex was studied in two awake, restrained domestic cats. Modality sensitivity and receptive field size and location were assessed for each neuron, along with response adaptation rate and state of arousal at the time of recording. Reconstruction of the spatial distribution of these response properties failed to show any simple organization, beyond general somatotopy. The spatial distribution of modality sensitivities was quantitatively tested in relation to a strict columnar model and to a random model; the data could not be clearly distinguished from the random model, in any of the three recording arrays. Observations made on two or more neurons isolated simultaneously at the same recording site revealed that few shared both modality and receptive field (RF) in common. Among the simultaneously recorded neurons, five-ninths showed disparate modality sensitivities and two-thirds showed limited or no RF overlap. Many pairs of neurons showing the same modality sensitivity showed limited or no RF overlap, and many pairs showing partial or complete RF overlap showed disparate modality sensitivities. Hence, the data failed to support any model of cerebral organization that features local, bounded regions within which all neuron response properties are the same and, in particular, the model of columnar organization. On the other hand, models that feature intermingled local clusters of neurons (a cluster consists of neurons that share the same response properties) are not excluded by the data.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Slimp JC,Towe ALdoi
10.1016/0014-4886(90)90065-zsubject
Has Abstractpub_date
1990-01-01 00:00:00pages
78-96issue
1eissn
0014-4886issn
1090-2430pii
0014-4886(90)90065-Zjournal_volume
107pub_type
杂志文章abstract：:Caspases are cysteine proteases involved in apoptotic cell death, and pharmacological caspase inhibition has been demonstrated to prevent neuronal cell death in certain experimental paradigms. In this study, the role of caspase-1 and -3 in the death of dopaminergic neurons derived from the E14 rat ventral mesencephalo...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2001.7749
更新日期：2001-09-01 00:00:00
abstract：:Mitochondrial dysfunction and pathology that contribute to a host of neurodegenerative diseases are deduced from changes in ultrastructure, routinely examined by a host of optical techniques. We adapted the technique of photon correlation spectroscopy (PCS) to evaluate calcium-induced structural alterations in isolate...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2005.10.002
更新日期：2006-02-01 00:00:00
abstract：:The effects of N-methyl-d-aspartate (NMDA) and non-NMDA receptor antagonists were compared on audiogenic seizures in the rats neonatally exposed to propylthiouracil (PTU). The rats treated with 0.02% PTU through mother's milk during days 0-19 after delivery showed a high incidence of audiogenic seizures consisting of ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1998.6871
更新日期：1998-09-01 00:00:00
abstract：:After spinal cord injury (SCI), apoptosis of neurons and oligodendrocytes is associated with axonal degeneration and loss of neurological function. Recent data have suggested a potential role for FAS death receptor-mediated apoptosis in the pathophysiology of SCI. In this study, we examined the effect of FAS deficienc...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2005.08.020
更新日期：2005-12-01 00:00:00
abstract：:Cereport (RMP-7) enhances delivery of chemotherapeutics into brain tumors by increasing the permeability of the glioma vasculature (i.e. , the blood-brain tumor barrier; BBTB). Its effect on brain tumors has consistently been more robust than that on normal brain. The present experiments tested the hypothesis that the...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1999.7247
更新日期：2000-01-01 00:00:00
abstract：:Parkinson's Disease (PD) and Extrapyramidal Syndrome (EPS) are movement disorders that result from degeneration of the dopaminergic input to the striatum and chronic inhibition of striatal dopamine D(2) receptors by antipsychotics, respectively. Adenosine A(2A) receptors are selectively localized in the basal ganglia,...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2010.07.011
更新日期：2010-10-01 00:00:00
abstract：:Axons of the CNS do normally not regenerate after injury, in contrast to axons of the PNS. This is due to a different microenvironment at the site of the lesion as well as a particular intrinsic program of axonal regrowth. Although transplantation of peripheral nerve tissue bridges is perhaps the most successful appro...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1999.7204
更新日期：1999-11-01 00:00:00
abstract：:The regional, cellular, and subcellular localization of phosphorylated p38 MAPK (pp38) was examined by immunocytochemistry, immuofluorescent multiple labeling, and immunoblotting of extracts as well as immunoprecipitates of human postmortem tissue from control and Alzheimer's disease (AD) cases at different Braak stag...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/s0014-4886(03)00180-8
更新日期：2003-10-01 00:00:00
abstract：:Children who are born preterm are at risk for encephalopathy of prematurity, a leading cause of cerebral palsy, cognitive delay and behavioral disorders. Current interventions are limited and none have been shown to reverse cognitive and behavioral impairments, a primary determinant of poor quality of life for these c...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2017.12.010
更新日期：2018-04-01 00:00:00
abstract：:Nitric oxide may be a key mediator of excitotoxic neuronal injury in the central nervous system. In the present experiments we found that S-methylthiocitrulline, a relatively selective neuronal nitric oxide synthase (NOS) inhibitor, produced significant neuroprotection against striatal lesions produced by malonate, an...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1996.6406
更新日期：1997-02-01 00:00:00
abstract：:The Alzheimer's disease-related peptide beta(1-40) amyloid self-associates to form fibrils exhibiting a morphology characteristic of amyloidogenic proteins. The mechanism of this fibrillization process has yet to be fully elucidated. In this study we have immobilized the beta(1-40) amyloid to flat gold surfaces using ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1999.7114
更新日期：1999-08-01 00:00:00
abstract：:Abnormally associated movements inevitably occur after surgical repair of the facial nerve. The reason for this postparalytic syndrome is poor navigation of regrowing axons. Despite the valuable functional advantage provided by the easily detected movement of vibrissae in rats, the major investigative tools for establ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2002.8040
更新日期：2002-12-01 00:00:00
abstract：:For the past 15 years, patients with Parkinson's disease have participated in clinical trials evaluating the efficacy of intrastriatal dopamine transplants. Principally, two donor tissues have been employed, the chromaffin cells of the adrenal medulla and fetal ventral mesencephalon. The clinical response following ea...
journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1006/exnr.1996.6386
更新日期：1997-03-01 00:00:00
abstract：:The effects of a very low oral dose of Al on spatial learning and neurogenesis were evaluated in a transgenic mouse (Tg 2576) model of Alzheimer disease. At 5 months of age, wild and Tg 2576 mice received a diet supplemented with Al lactate at 0 and 1 mg/g of diet for 120 days. The experimental groups (n=7-8) were: co...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2008.08.017
更新日期：2008-12-01 00:00:00
abstract：:Rats with precollicular transections leaving the brain stem intact were subjected to electroshock or pentylenetetrazol-induced convulsions. Animals with transections failed to display the face and forelimb clonus (with or without rearing) typically seen in sham-operated rats subjected to pentylenetetrazol- or minimal ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(86)90174-3
更新日期：1986-09-01 00:00:00
abstract：:Serotonergic neurons were recorded in the nucleus centralis superior (NCS) in freely moving cats and were initially identified on-line by their slow and regular spontaneous activity (mean 2.55 +/- 0.21 spikes/s). Discharge rates of NCS serotonergic neurons were highest during active waking (AW) (mean 2.94 +/- 0.28 spi...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/S0014-4886(84)90100-6
更新日期：1984-02-01 00:00:00
abstract：:We examined c-Fos and FosB staining in the central nervous system 8 and 24 h following acute volume expansion in unanesthetized rats. Male rats were instrumented with a femoral artery catheter for measurement of blood pressure and heart rate (HR), a jugular venous catheter for measurement of central venous pressure (C...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2004.01.020
更新日期：2004-05-01 00:00:00
abstract：:Spinal cord injury (SCI) results in chronic pain states in which the underlying mechanism is poorly understood. To begin to explore possible mechanisms, calcitonin gene-related peptide (CGRP), a neuropeptide confined to fine primary afferent terminals in laminae I and II in the dorsal horn of the spinal cord and impli...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1997.6608
更新日期：1997-10-01 00:00:00
abstract：:Osteopontin (OPN) is a glycosylated phosphoprotein that regulates both oxidative stress and inflammatory processes. OPN is present in the rat substantia nigra (SN) and both protein and mRNA levels are up-regulated following a pro-inflammatory insult produced by lipopolysaccharide. We now report on the effects of lesio...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2007.05.030
更新日期：2007-09-01 00:00:00
abstract：:Functional regeneration of brainstem-spinal pathways occurs in the developing chick when the spinal cord is severed prior to embryonic day (E) 13. Functional spinal cord regeneration is not observed in animals injured after E13. This developmental transition from a permissive to a restrictive repair period may be due ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2000.7496
更新日期：2000-11-01 00:00:00
abstract：:Impaired olfaction is an early symptom of Alzheimer disease (AD). This likely to reflect neurodegenerative processes taking place in basal telencephalic structures that mediate olfactory processing, including the anterior olfactory nucleus. Betaeta-amyloid (Abeta) accumulation in AD brain may relate to decline in soma...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2009.06.010
更新日期：2010-06-01 00:00:00
abstract：:c-fos expression in response to noxious mechanical stimulation of the peripheral receptive field was used to study the somatotopic representation of the oral mucous membrane and trigeminal cutaneous receptive fields in the trigeminal subnucleus caudalis and the cervical spinal dorsal horn. Fos-neurons (neurons with c-...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1994.1167
更新日期：1994-10-01 00:00:00
abstract：:Activity-dependent alteration in synaptic efficacy is referred to as synaptic plasticity and is the believed hallmark of any learning process. Here we employed a recently validated complex maze for spatial training and investigated the impact of repeated and extensive training on basal synaptic transmission of the hip...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2006.08.025
更新日期：2007-02-01 00:00:00
abstract：:MicroRNAs (miRs) are powerful regulators of CNS development and diseases. Plasma and cerebrospinal fluid (CSF) miRs have recently been implicated as potential new sources for biomarker development. Previously we showed that miR-124-3p, an essential miR for neuronal identity, is highly abundant in neuronal exosomes and...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2020.113414
更新日期：2020-11-01 00:00:00
abstract：:Neurons from cerebral neocortex and hippocampus exhibit a striking difference in vulnerability to transient global ischemia. In order to study the contribution of neuronal connections and neuron-glia interactions to this variation in neuronal vulnerability, we used hippocampal and neocortical cultures submitted to var...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1997.6728
更新日期：1998-03-01 00:00:00
abstract：:Fish optic nerve sections were recently shown to be nonpermissive to growth of adult retinal axons. In addition, fish optic nerve myelin was found to inhibit growth of adult retinal axons and this inhibition was neutralized by IN-1 antibodies (known to block rat myelin-associated inhibitors). In this study we examined...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1994.1221
更新日期：1994-12-01 00:00:00
abstract：:Ethanol exposure profoundly affects learning and memory and neural plasticity. Key players underlying these functions are neurotrophins. The present study explored the effects of ethanol on the distribution of neurotrophins in the cerebral cortex of the adult rat. Age- and weight-matched pairs of adult male, Long-Evan...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2006.12.022
更新日期：2007-04-01 00:00:00
abstract：:The ST14A cell line was previously derived from embryonic day 14 rat striatal primordia by retroviral transduction of the temperature-sensitive SV40 large T antigen. We showed that cell division and expression of nestin persists at 33 degrees C, the permissive temperature, whereas cell division ceases, nestin expressi...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2000.7551
更新日期：2001-02-01 00:00:00
abstract：:Ghrelin, a 28-amino acid peptide, is an endogenous ligand for the growth hormone secretagogue (GHS) receptor. Our previous data showed that ghrelin could inhibit apoptosis in Parkinson's disease (PD) models both in vitro and in vivo. There is now growing evidence that oxidative stress has a critical role in the etiolo...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2009.11.009
更新日期：2010-03-01 00:00:00
abstract：:Traumatic CNS injury triggers a systemic inflammatory response syndrome (SIRS), in which circulating inflammatory cells invade body organs causing local inflammation and tissue damage. We have shown that the SIRS caused by spinal cord injury is greatly reduced by acute intravenous treatment with an antibody against th...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2015.07.003
更新日期：2015-09-01 00:00:00
