Abstract：
:Ghrelin, a 28-amino acid peptide, is an endogenous ligand for the growth hormone secretagogue (GHS) receptor. Our previous data showed that ghrelin could inhibit apoptosis in Parkinson's disease (PD) models both in vitro and in vivo. There is now growing evidence that oxidative stress has a critical role in the etiology of PD. And ghrelin was reported to possess anti-inflammatory, antioxidant effects. Dose ghrelin protect dopaminergic neurons by its antioxidant effect? In the present study, 1-methyl-4-phenylpyridinium (MPP(+)) was used to evaluate the possible antioxidant effects of ghrelin on MPP(+)-induced neurotoxicity in MES23.5 cells and the underlying mechanisms. Our results showed that MPP(+) significantly increased malonaldehyde (MDA) level and Bax/Bcl2 ratio, reduced the level of Cu-Zn superoxide dismutase (SOD) and catalase (CAT). Ghrelin protected MES23.5 cells against MPP(+)-induced neurotoxicity by reversing these changes. Furthermore, ghrelin pretreatment significantly inhibited MPP(+)-induced nuclear factor-kappaB translocation. These results suggest that the protective effects of ghrelin on MPP(+)-induced cytotoxicity may be ascribed to its antioxidative properties, and the modulation of nuclear factor-kappaB.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Liu L,Xu H,Jiang H,Wang J,Song N,Xie Jdoi
10.1016/j.expneurol.2009.11.009subject
Has Abstractpub_date
2010-03-01 00:00:00pages
25-9issue
1eissn
0014-4886issn
1090-2430pii
S0014-4886(09)00467-1journal_volume
222pub_type
杂志文章abstract：:We evaluated the effects of allogeneic bone marrow stromal cell treatment of stroke on functional outcome, glial-axonal architecture, and immune reaction. Female Wistar rats were subjected to 2 h of middle cerebral artery occlusion. Rats were injected intravenously with PBS, male allogeneic ACI--or syngeneic Wistar--b...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2005.11.029
更新日期：2006-04-01 00:00:00
abstract：:An autoradiographic method is described for detecting changes in ornithine decarboxylase in axotomized superior cervical ganglion neurons of rats using [3H]difluoromethylornithine. An increase in binding to neurons was seen at 12 h and 1 day after crushing the postganglionic nerves. Binding returned to control values ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(86)90097-x
更新日期：1986-05-01 00:00:00
abstract：:A cerebrospinal fluid (CSF) to brain exchange has been postulated for lipid-soluble and small molecular substances and has led to nearly 100 attempts per year to produce central effects via intrathecal injections. With few exceptions, however, modern neurological practice has avoided this approach because of its demon...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(84)90192-4
更新日期：1984-11-01 00:00:00
abstract：:Radiosurgery is an important non-invasive procedure for the treatment of tumors and vascular malformations. However, in addition to killing target tissues, cranial irradiation induces damage to adjacent healthy tissues leading to neurological deterioration in both pediatric and adult patients, which is poorly understo...
journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1016/j.expneurol.2012.03.011
更新日期：2012-06-01 00:00:00
abstract：:We have previously demonstrated an opioid link in nucleus accumbens (NAc) that mediates antinociception produced by a novel ascending pain modulation pathway. For example, noxious stimulation induces heterosegmental antinociception that is mediated by both mu- and delta-opioid receptors in NAc. However, spinal intrath...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2011.03.021
更新日期：2011-06-01 00:00:00
abstract：BACKGROUND AND PURPOSE:N,N-dimethyltryptamine (DMT) is an endogenous ligand of the Sigma 1 receptor (Sig-1R) with documented in vitro cytoprotective properties against hypoxia. Our aim was to demonstrate the in vivo neuroprotective effect of DMT following ischemia-reperfusion injury in the rat brain. METHODS:Transient...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2020.113245
更新日期：2020-05-01 00:00:00
abstract：:The effects of delta-9-tetrahydrocannabinol on sensory activity in the thalamic intralaminar nuclei, centralis lateralis and the mesencephalic reticular formation were compared with the effects on cortical association or heterosensory systems in alpha-chloralose-anesthetized cats. The drug depressed the anterior margi...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(87)90121-x
更新日期：1987-09-01 00:00:00
abstract：:Electrical stimulation of the trigeminal ganglion has been widely used as a model of nociception, characterizing migraine. This treatment is known to evoke release of neuropeptides and neurotransmitters from nerve fibers of the dura mater. On the basis of immunocytochemical investigations, we found that under normal c...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2003.12.001
更新日期：2004-04-01 00:00:00
abstract：:The present study was carried out to determine if augmentation of phrenic nerve activity during the crossed phrenic phenomenon temporally coincides with the morphological changes in the phrenic nucleus that we have observed in previous studies. This investigation consisted of two experiments in spinal cord hemisected ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(91)90012-2
更新日期：1991-02-01 00:00:00
abstract：:We demonstrated previously that the hypothalamic supraoptic nucleus (SON) undergoes a robust axonal sprouting response following unilateral transection of the hypothalamo-neurohypophysial tract. Concomitant with this response is an increase in ciliary neurotrophic factor (CNTF) and CNTF receptor alpha (CNTFRα) express...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2011.10.009
更新日期：2012-01-01 00:00:00
abstract：:In the cerebellum of adult-aging Ts65Dn mice, a murine model of Down syndrome, Purkinje cells undergo degeneration. Searching for the cause of Purkinje cell degeneration, we have studied the ubiquitin-proteasome system (UPS) in the cerebellum of aging Ts65Dn mice. Inhibition of UPS is sufficient to induce neuron degen...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2011.08.009
更新日期：2011-12-01 00:00:00
abstract：:An inherited deficiency of β-galactosylceramidase (GALC) causes the lysosomal storage disease globoid cell leukodystrophy (GLD). The disease is characterized by the accumulation of the cytotoxic metabolite psychosine (galactosylsphingosine), causing rapid degeneration of myelinating cells. Most patients suffer from th...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2015.04.020
更新日期：2015-09-01 00:00:00
abstract：:There is evidence to suggest that the reticular activating system may have an influence on the neurons of the preoptic area (POA). We studied the responses of POA neurons and their relation to the cortical EEG, on stimulation of the midbrain reticular formation (MRF) at various frequencies, in unanesthetized, encéphal...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(84)90065-7
更新日期：1984-10-01 00:00:00
abstract：:The anticonvulsant long-term efficacy of diazepam was studied in amygdala-kindled rats. The drug was administered three times daily at doses of 5 mg/kg i.p. for 2 weeks in fully kindled animals. The severity of the kindled seizures was markedly reduced throughout the period of treatment, while tolerance developed to t...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(85)90026-3
更新日期：1985-11-01 00:00:00
abstract：:Epidermal growth factor responsive (EGFr) neural progenitor (NP) cells have been shown to be a potential alternative tissue source for neural transplantation and for developmental study. We have shown that nonpassaged EGFr NP cells can self-renew for 2 years in neurospheres and can robustly differentiate into glia and...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2000.7425
更新日期：2000-07-01 00:00:00
abstract：BACKGROUND:Intracerebral hemorrhage (ICH) is the common brain diseases in middle-aged and elderly people, with high disability and/or mortality rate, and is a serious public health concern. Both WNK3 kinase and the WNK3/SPAK/NKCC1 signaling pathway play an integral role in maintaining normal cell homeostasis. However, ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2020.113386
更新日期：2020-10-01 00:00:00
abstract：:In a model of Parkinson's disease (PD), amphetamine, a dopamine (DA)-releasing drug, fails to induce ipsilateral drug rotations in a proportion of rats with complete unilateral 6-hydroxydopamine (6-OHDA) lesions of the medial forebrain bundle and DA neurons of the substantia nigra. To investigate this phenomenon, indi...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2001.7823
更新日期：2001-12-01 00:00:00
abstract：:We have treated spinal cord injured rats with demyelination plus Schwann cell transplantation and assessed neurite outgrowth in a quantifiable model of axonal regeneration. Axonal injuries of differing severity were induced in the dorsal funiculus of adult rats using a micromanipulator-controlled Scouten knife. Demyel...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1999.7100
更新日期：1999-09-01 00:00:00
abstract：:Genetic and protein studies have indicated abnormalities in alpha-synuclein in neurodegenerative diseases. However, the developmental localization and cellular role of synuclein isoforms is contentious. We investigated the cellular localization of alpha-, beta-, and gamma-synuclein in developing cultured rat neurons a...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/s0014-4886(03)00108-0
更新日期：2003-07-01 00:00:00
abstract：:Experimental autoimmune neuritis (EAN) is an animal model of the human disease Guillain-Barré syndrome. In this autoimmune inflammatory disease, CD4(+) T cells mediate demyelination in the peripheral nervous system (PNS). Infiltrating macrophages and T cells as well as cytokines like interferon (IFN)-gamma are intimat...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2001.7662
更新日期：2001-06-01 00:00:00
abstract：:Overt behavioral symptoms of Parkinson's disease (PD) do not occur until over 80% of the striatal dopamine content has been lost. Diagnosis of the disorder relies on identifying clinical symptoms including akinesia, resting tremor, and rigidity. In retrospect, behavioral deficits are observed several years prior to di...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2002.8021
更新日期：2002-11-01 00:00:00
abstract：:Injections of horseradish peroxidase were made into surgically exposed superior cervical ganglia of Sprague-Dawley rats weighing 250 to 320 g. Anterogradely labeled postganglionic fibers were observed in the nervus conarii, pineal gland, pineal stalk, and the choroid plexus. Terminal fields were identified in lamina i...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(87)90101-4
更新日期：1987-08-01 00:00:00
abstract：:Amyotrophic lateral sclerosis [ALS] is a rapidly progressive neurodegenerative disorder of motor neurons, heralded by the development of cortical hyperexcitability. Reduction of short interval intracortical inhibition [SICI] in ALS, a feature linked to the development of cortical hyperexcitability, may be mediated by ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2009.08.017
更新日期：2009-11-01 00:00:00
abstract：:Alzheimer's disease is associated with an age-related accumulation of Abeta and inflammation. The inflammatory mediator, TNFalpha activates a signaling cascade involving NFkappaB translocation to the nucleus and a beneficial or detrimental transcriptional response, depending on the age of the neurons and the type of s...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2008.05.007
更新日期：2008-09-01 00:00:00
abstract：:The subchronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridin (MPTP) paradigm is one of the most widely used in vivo models of Parkinson's disease (PD). However, particularly in the mouse model it has remained difficult to reliably detect behavioural correlates for PD. In the present study we apply a novel murine motor t...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2007.01.030
更新日期：2007-05-01 00:00:00
abstract：:Pompe disease is an inherited disorder due to a mutation in the gene that encodes acid α-glucosidase (GAA). Children with infantile-onset Pompe disease develop progressive hypotonic weakness and cardiopulmonary insufficiency that may eventually require mechanical ventilation (MV). Our team conducted a first in human t...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2016.07.013
更新日期：2017-01-01 00:00:00
abstract：:Progesterone and its metabolite, allopregnanolone, are neurosteroids that are present at high concentrations in fetal brains that decrease right after birth. Allopregnanolone is a potent positive modulator of γ-aminobutyric acid A (GABA(A)) receptor function. We examined the effect of exogenous administration of these...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2011.10.004
更新日期：2012-01-01 00:00:00
abstract：:This paper reports that endolymphatic hydrops causes a significant reduction of retrogradely labeled cell bodies of the ipsilateral trigeminal ganglion following application of horseradish peroxidase in the cochlea. We previously showed that the trigeminal ganglion is a source of primary sensory innervation to the coc...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1998.6813
更新日期：1998-06-01 00:00:00
abstract：:Grafting fetal striatal cells into the brain of Huntington's disease (HD) patients has raised certain expectations in the past decade as an effective cell-based-therapy for this devastating condition. We argue that the first requirement for successful transplantation is defining the window of plasticity for the striat...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2014.04.021
更新日期：2014-07-01 00:00:00
abstract：:Experimental tumors of the central nervous system were investigated with antibodies to quinolinate to assess the cellular distribution of this endogenous neurotoxin. In advanced F98 and RG-2 glioblastomas and E367 neuroblastomas in the striatum of rats, variable numbers of quinolinate immunoreactive cells were observe...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1996.6365
更新日期：1997-04-01 00:00:00
