Abstract:
:Serotonergic neurons were recorded in the nucleus centralis superior (NCS) in freely moving cats and were initially identified on-line by their slow and regular spontaneous activity (mean 2.55 +/- 0.21 spikes/s). Discharge rates of NCS serotonergic neurons were highest during active waking (AW) (mean 2.94 +/- 0.28 spikes/s), decreased during slow-wave sleep (middle of SWS: mean 1.38 +/- 0.18 spikes/s), and were lowest during REM sleep (mean 0.46 +/- 0.13 spikes/s). The activity of serotonergic NCS neurons did not significantly increase during transient elevations of the EMG during AW but did significantly decrease immediately preceding, and during the occurrence of, SWS spindles. These neurons were responsive to phasic auditory and visual stimuli, with most neurons showing excitatory responses. In response to a small dose of the serotonin-specific agonist 5-methoxy-N,N-dimethyltryptamine (50 micrograms/kg, i.m.), NCS serotonergic neurons responded with a mean decrease in unit activity of 43.9 +/- 6.1%. Among the NCS serotonergic neurons a subpopulation differed from the remaining serotonergic neurons in that they showed a much smaller decrease in unit activity across the sleep-wake cycle and responded with an inhibition of activity to phasic auditory and visual stimuli. The results of this study are compared with those previously reported for serotonergic neurons in the dorsal raphe nucleus, nucleus raphe pallidus, and nucleus raphe magnus of freely moving cats.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Rasmussen K,Heym J,Jacobs BLdoi
10.1016/S0014-4886(84)90100-6subject
Has Abstractpub_date
1984-02-01 00:00:00pages
302-17issue
2eissn
0014-4886issn
1090-2430pii
S0014-4886(84)90100-6journal_volume
83pub_type
杂志文章abstract::The electromyographic (EMG) activity of the gastrocnemius and tibialis anterior muscles was recorded from normal geriatric subjects and from hemiplegic patients subjected to a continuous back-and-forth movement of the platform on which they stood. The platform oscillated at a fixed frequency of 0.5 Hz. Movement amplit...
journal_title:Experimental neurology
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journal_title:Experimental neurology
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journal_title:Experimental neurology
pub_type: 杂志文章
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journal_title:Experimental neurology
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journal_title:Experimental neurology
pub_type: 杂志文章
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journal_title:Experimental neurology
pub_type: 杂志文章
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journal_title:Experimental neurology
pub_type: 杂志文章
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journal_title:Experimental neurology
pub_type: 杂志文章,评审
doi:10.1006/exnr.1994.1017
更新日期:1994-01-01 00:00:00
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journal_title:Experimental neurology
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