Abstract:
:The sciatic nerve of adult mice was transected and proximal and distal nerve stumps were sutured into a nontoxic bioresorbable nerve guide. Nerve guide lumens were either empty or filled with a gel containing 80% laminin and additional extracellular matrix components. Two weeks later cells in the L3 through L5 dorsal root ganglia and the ventral horn of the spinal cord were retrogradely filled with horseradish peroxidase. All animals with the laminin-containing gel but none with empty nerve guides displayed labeled cells. This suggests that the laminin-containing gel significantly hastened axonal regeneration in vivo.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Madison R,da Silva CF,Dikkes P,Chiu TH,Sidman RLdoi
10.1016/0014-4886(85)90087-1subject
Has Abstractpub_date
1985-06-01 00:00:00pages
767-72issue
3eissn
0014-4886issn
1090-2430journal_volume
88pub_type
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