Abstract：
:Ghrelin has been shown to regulate neurogenesis in the hippocampus. The aim of this study was to investigate the possible influence of ghrelin on cell proliferation and neuroblast formation in the subventricular zone (SVZ) and rostral migratory system (RMS) and generation of interneurons in the olfactory bulb (OB). We found that ghrelin receptors were expressed in the SVZ-RMS-OB system. Ghrelin knockout (GKO) mice have fewer proliferating neural progenitor cells and neuroblasts in the SVZ, while ghrelin administration attenuated these changes. We also found that not only the number of BrdU-labeled cells but also the fraction of migratory neuroblasts in the RMS was decreased in the GKO mice compared with controls. Treatment of GKO mice with ghrelin restored these numbers to the wild-type control values. Far fewer BrdU/NeuN double-labeled cells were found in the OB of GKO mice than in wild-type mice 4 weeks after labeling, which were increased by ghrelin replacement. GKO mice showed less numbers of BrdU/calbindin, BrdU/calretinin and BrdU/tyrosine hydroxylase double-labeled cells in the periglomerular layer of the OB. However, these numbers were increased to wild-type values after ghrelin administration. Finally, in the GH-deficient spontaneous dwarf rats, ghrelin increased the number of progenitor cells and neuroblasts in the SVZ, without significant effect on the differentiation in the OB. These findings suggest that ghrelin is involved in the regulation of proliferation of progenitor cells in the SVZ, the number of migratory neuroblasts in the SVZ, and the differentiation of interneurons in the OB.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Li E,Kim Y,Kim S,Sato T,Kojima M,Park Sdoi
10.1016/j.expneurol.2013.11.021subject
Has Abstractpub_date
2014-02-01 00:00:00pages
75-84eissn
0014-4886issn
1090-2430pii
S0014-4886(13)00354-3journal_volume
252pub_type
杂志文章abstract：:Ascending and descending spinal cord potentials were recorded during conduction block produced by compression and ischemia to the spinal cord of cats. Dorsally and ventrally applied compression produced proportional changes in both ascending and descending potentials. Results for induced ischemia were much more variab...
journal_title：Experimental neurology
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journal_title：Experimental neurology
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doi：10.1016/j.expneurol.2006.12.020
更新日期：2007-04-01 00:00:00
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journal_title：Experimental neurology
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journal_title：Experimental neurology
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2004.12.011
更新日期：2005-05-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1996.0169
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journal_title：Experimental neurology
pub_type： 杂志文章
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2012.07.016
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journal_title：Experimental neurology
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doi：10.1016/j.expneurol.2008.05.019
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2005.07.009
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journal_title：Experimental neurology
pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1016/j.expneurol.2009.03.011
更新日期：2009-06-01 00:00:00
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journal_title：Experimental neurology
pub_type： 临床试验,杂志文章
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更新日期：2012-01-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1995.1028
更新日期：1995-06-01 00:00:00
abstract：:The regulation of perinatal glia limitans (GL) reformation by interleukin-1beta (IL-1beta) following prenatal neural trauma in the mouse was studied in lesioned fetal mice by immunocytochemistry and computer-assisted image analysis for presence and distribution of astrocytes and IL-1beta immunoreactivity (ir). Astrocy...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1997.6470
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1999.7163
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journal_title：Experimental neurology
pub_type： 杂志文章
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journal_title：Experimental neurology
pub_type： 杂志文章
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1993.1086
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2008.05.007
更新日期：2008-09-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
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更新日期：1997-06-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
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更新日期：2012-02-01 00:00:00
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journal_title：Experimental neurology
pub_type： 评论,杂志文章,评审
doi：10.1016/j.expneurol.2011.06.002
更新日期：2011-09-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(90)90034-p
更新日期：1990-11-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
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