Autosomal dominant spinocerebellar ataxia (SCA) in a Siberian founder population: assignment to the SCA1 locus.

abstract：:Vasoactive intestinal peptide (VIP) and neuropeptide Y (NPY) in dorsal root ganglia (DRGs) are known to be upregulated and to contribute to the mechanisms of neuropathic pain following peripheral nerve injury. Moreover, transcription factor c-Jun regulates the expressions of both VIP and NPY in cultured DRG neurons. T...

journal_title：Experimental neurology

authors： Son SJ,Lee KM,Jeon SM,Park ES,Park KM,Cho HJ

更新日期：2007-03-01 00:00:00

abstract：:Respiratory motor output after cervical spinal cord injury (cSCI) is profoundly influenced by spinal serotonin. We hypothesized that intraspinal transplantation of embryonic midline brainstem (MB) cells rich in serotonergic raphé neurons would improve respiratory outcomes after cSCI. One week after hemisection of the ...

journal_title：Experimental neurology

authors： Dougherty BJ,Gonzalez-Rothi EJ,Lee KZ,Ross HH,Reier PJ,Fuller DD

更新日期：2016-04-01 00:00:00

abstract：:Oxidative stress has been implicated in several neurodegenerative diseases affecting both neuronal and glial cells. The aim of this study was to investigate the involvement of reactive oxygen species in glutamate-evoked activation of NF-kappaB in primary astrocytes. A prolonged exposure to glutamate (24 h) caused a de...

journal_title：Experimental neurology

authors： Caccamo D,Campisi A,Marini H,Adamo EB,Li Volti G,Squadrito F,Ientile R

更新日期：2005-06-01 00:00:00

abstract：:This paper focuses on transient boundaries of glia and glycoconjugates during development of the mouse central nervous system (CNS). Lectin-bound glycoconjugates, glial fibrillary acidic protein, and the J1/tenascin glycoprotein are distributed coextensively within boundaries around developing substructural arrangemen...

journal_title：Experimental neurology

authors： Steindler DA,O'Brien TF,Laywell E,Harrington K,Faissner A,Schachner M

更新日期：1990-07-01 00:00:00

abstract：:The activity of 2',3'-cyclic nucleotide 3'-phosphohydrolase (CNPase), as a marker for myelinogenesis, was measured in different parts of the nervous system of dilute-lethal mutant mice (d1/d1). The activity in terms of micromoles of 2'-AMP formed per milligram of protein of homogenate per minute was found to be exceed...

journal_title：Experimental neurology

authors： Noguchi T,Sugisaki T,Tsukada Y

更新日期：1983-01-01 00:00:00

abstract：:The present study was carried out to determine if augmentation of phrenic nerve activity during the crossed phrenic phenomenon temporally coincides with the morphological changes in the phrenic nucleus that we have observed in previous studies. This investigation consisted of two experiments in spinal cord hemisected ...

journal_title：Experimental neurology

authors： O'Hara TE Jr,Goshgarian HG

更新日期：1991-02-01 00:00:00

abstract：:Dravet syndrome is a severe, early-onset epileptic encephalopathy frequently resulting from de novo mutations of SCN1A. Mice with heterozygous deletion of Scn1a (Scn1a+/-) model many features of Dravet syndrome, including spontaneous seizures and premature lethality. Scn1a+/- mice exhibit variable phenotype penetrance...

journal_title：Experimental neurology

authors： Hawkins NA,Calhoun JD,Huffman AM,Kearney JA

更新日期：2019-01-01 00:00:00

abstract：:In this study we investigated whether the link between mitochondrial dysfunction and deregulation of Ca(2+) homeostasis preceding excitotoxic cell death is mediated by cellular deenergization. Glycolytic and/or mitochondrial ATP synthesis was inhibited with 2-deoxy-D-glucose (2DG) and oligomycin, respectively. Changes...

journal_title：Experimental neurology

authors： Vergun O,Han YY,Reynolds IJ

更新日期：2003-10-01 00:00:00

abstract：:The present study evaluates the temporal relationships between increases in glial fibrillary acidic protein (GFAP) mRNA, GFA protein levels, and GFAP immunostaining in the hippocampus of adult rats following unilateral lesions of the entorhinal cortex (EC). GFAP mRNA levels were assessed at 12 h, 1, 2, 4, 6, 8, 10, 12...

journal_title：Experimental neurology

authors： Steward O,Kelley MS,Torre ER

更新日期：1993-12-01 00:00:00

abstract：:Ocular movements of alert cats were recorded by classical electronystagmography techniques during (a) vestibular stimulation (sinusoidal rotation of the cat in complete darkness), (b) optokinetic stimulation (sinusoidal rotation of the visual surroundings around the stationary cat), (c) additive visual-vestibular stim...

journal_title：Experimental neurology

authors： Godaux E,Gobert C,Halleux J

更新日期：1983-04-01 00:00:00

abstract：:In the human embryo, from approximately 6 weeks gestational age (GA), dopaminergic (DA) neurons can be found in the ventral mesencephalon (VM). More specifically, the post-mitotic neurons are located in the ventral part of the tegmentum (VT), whereas no mature DA neurons are found in the neighboring dorsal part. We us...

journal_title：Experimental neurology

authors： Jørgensen JR,Juliusson B,Henriksen KF,Hansen C,Knudsen S,Petersen TN,Blom N,Seiger A,Wahlberg LU

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:Medial forebrain bundle (MFB) deep brain stimulation (DBS) has anti-depressant effects clinically and in depression models. Currently, therapeutic mechanisms of MFB DBS or how stimulation parameters acutely impact neurotransmitter release, particularly dopamine, are unknown. Experimentally, MFB DBS has been ...

journal_title：Experimental neurology

authors： Ashouri Vajari D,Ramanathan C,Tong Y,Stieglitz T,Coenen VA,Döbrössy MD

更新日期：2020-05-01 00:00:00

abstract：:Hypernatremic dehydration was induced in rabbits during a 3- to 5-day period resulting in mean plasma sodium concentrations of 187 meq/liter. The animals were then rehydrated during a 4-h period by intravenous administration of a 2.5% glucose or fructose solution. The water content of four regions of brain sample show...

journal_title：Experimental neurology

authors： Hogan GR,Pickering LK,Dodge PR,Shepard JB,Master S

更新日期：1985-02-01 00:00:00

abstract：:Breathing is a vital homeostatic behavior and must be precisely regulated throughout life. Clinical conditions commonly associated with inflammation, undermine respiratory function may involve plasticity in respiratory control circuits to compensate and maintain adequate ventilation. Alternatively, other clinical cond...

journal_title：Experimental neurology

authors： Hocker AD,Stokes JA,Powell FL,Huxtable AG

更新日期：2017-01-01 00:00:00

abstract：:It has been >20 years since studies first revealed that the brain is insulin sensitive, highlighted by the expression of insulin receptors in neurons and glia, the presence of circulating brain insulin, and even localized insulin production. Following these discoveries, evidence of decreased brain insulin receptor num...

journal_title：Experimental neurology

authors： Frazier HN,Ghoweri AO,Anderson KL,Lin RL,Porter NM,Thibault O

更新日期：2019-03-01 00:00:00

abstract：:The effect of frequency potentiation on the postsynaptic potential in granule cells was studied stimulating the perforant path in curarized and urethanized rats. At stimulation frequencies between 2.0-5.0 Hz, synaptic efficacy in eliciting an orthodromic action potential increased despite the hyperpolarization of the ...

journal_title：Experimental neurology

authors： Muñoz MD,Núñez A,García-Austt E

更新日期：1991-07-01 00:00:00

abstract：:In order to test the functional implication of herpes simplex virus (HSV) vector-mediated gene transfer after axonal injury, we injected replication-incompetent HSV vectors coding for the anti-apoptotic peptide Bcl-2 and the glial cell-derived neurotrophic factor (GDNF), separately or in combination into ventral spina...

journal_title：Experimental neurology

authors： Natsume A,Wolfe D,Hu J,Huang S,Puskovic V,Glorioso JC,Fink DJ,Mata M

更新日期：2003-12-01 00:00:00

abstract：:Morphologic alterations of the hippocampal mossy fiber pathway after postnatal lead exposure have been observed in rats. It is hypothesized that lead might perturb zinc pools found in this pathway. To test this hypothesis, rat pups were exposed to lead indirectly by administering 0.2% lead acetate to dams via the drin...

journal_title：Experimental neurology

authors： Sato SM,Frazier JM,Goldberg AM

更新日期：1984-09-01 00:00:00

abstract：:Huntington's disease (HD) is an autosomal dominant neurodegenerative disease associated with a CAG trinucleotide repeat expansion in a large gene on chromosome 4. The gene encodes the protein huntingtin with a polyglutamine tract encoded by the CAG repeat at the N-terminus. The number of CAG repeats in HD are signific...

journal_title：Experimental neurology

authors： Singhrao SK,Thomas P,Wood JD,MacMillan JC,Neal JW,Harper PS,Jones AL

更新日期：1998-04-01 00:00:00

abstract：:Many neurological and psychiatric disorders exhibit gender disparities, and sex differences in the brain likely explain some of these effects. Recent work in rodents points to a role for epigenetics in the development or maintenance of neural sex differences, although genome-wide studies have so far been lacking. Here...

journal_title：Experimental neurology

authors： Shen EY,Ahern TH,Cheung I,Straubhaar J,Dincer A,Houston I,de Vries GJ,Akbarian S,Forger NG

更新日期：2015-06-01 00:00:00

abstract：:The contribution of chondroitin sulfate proteoglycan (CSPG) in the suppression of axonal growth in rat spinal cord has been examined by means of an in vitro bioassay in which regenerating neurons are grown on tissue section substrata. Dissociated embryonic chick dorsal root ganglionic neurons were grown on normal and ...

journal_title：Experimental neurology

authors： Zuo J,Neubauer D,Dyess K,Ferguson TA,Muir D

更新日期：1998-12-01 00:00:00

abstract：:Fetal spinal cord from embryonic day 14 (E14/FSC) has been used for numerous transplantation studies of injured spinal cord. E14/FSC consists primarily of neuronal (NRP)- and glial (GRP)-restricted precursors. Therefore, we reasoned that comparing the fate of E14/FSC with defined populations of lineage-restricted prec...

journal_title：Experimental neurology

authors： Lepore AC,Fischer I

更新日期：2005-07-01 00:00:00

abstract：:We present here an example case of neuropathic pain with heat allodynia as a major symptom to illustrate how the functional imaging of pain may provide new insights into the pathophysiology of painful sensory disorders. Tissue injury of almost any kind, but especially peripheral or central neural tissue injury, can le...

journal_title：Experimental neurology

authors： Casey KL,Lorenz J,Minoshima S

更新日期：2003-11-01 00:00:00

abstract：:The aim of this study was to elucidate whether oligodendrocytes die in fiber tracts that are spared by a spinal cord injury but are in close vicinity of inflammatory cells. Adult rat spinal cords were studied histologically 1 day to 2 weeks after a contusion lesion that left the ventral white matter largely intact. Ma...

journal_title：Experimental neurology

authors： Frei E,Klusman I,Schnell L,Schwab ME

更新日期：2000-06-01 00:00:00

abstract：:In recent years, it has become evident that Parkinson's disease is associated with a self-sustaining cycle of neuroinflammation and neurodegeneration, with dying neurons activating microglia, which, once activated, can release several factors that kill further neurons. One emerging pharmacological target that has the ...

journal_title：Experimental neurology

authors： Concannon RM,Okine BN,Finn DP,Dowd E

更新日期：2016-09-01 00:00:00

abstract：:A "neuroplastic" hypothesis proposes that changes in neuronal structural plasticity may underlie the aetiology of depression and the action of antidepressants. The medial prefrontal cortex (mPFC) is affected by this disorder and shows an intense expression of the polysialylated form of the neural cell adhesion molecul...

journal_title：Experimental neurology

authors： Castillo-Gómez E,Gómez-Climent MA,Varea E,Guirado R,Blasco-Ibáñez JM,Crespo C,Martínez-Guijarro FJ,Nácher J

更新日期：2008-11-01 00:00:00

abstract：:Chronically axotomized motoneurons progressively fail to regenerate their axons. Since axonal regeneration is associated with the increased expression of tubulin, actin and GAP-43, we examined whether the regenerative failure is due to failure of chronically axotomized motoneurons to express and sustain the expression...

journal_title：Experimental neurology

authors： Gordon T,You S,Cassar SL,Tetzlaff W

更新日期：2015-02-01 00:00:00

abstract：:Caffeinol has been proposed as a neuroprotectant for human trials. This review covers a variety of animal models used and various attempts to take animal protocols to human trials. The accompanying paper discusses the rabbit model that was used to identify the efficacy of tissue plasminogen activator (tPA) treatment. ...

journal_title：Experimental neurology

authors： Hoyte L,Kaur J,Buchan AM

更新日期：2004-08-01 00:00:00

abstract：:Cerebrospinal fluid (CSF) is produced by the choroid plexus and moved by multi-ciliated ependymal cells through the ventricular system of the vertebrate brain. Defects in the ependymal layer functionality are a common cause of hydrocephalus. N-WASP (Neural-Wiskott Aldrich Syndrome Protein) is a brain-enriched regulato...

journal_title：Experimental neurology

authors： Jain N,Lim LW,Tan WT,George B,Makeyev E,Thanabalu T

更新日期：2014-04-01 00:00:00

abstract：:Locally generating new proteins in subcellular regions provide means to spatially and temporally modify protein content in polarized cells. Recent years have seen resurgence of the concept that axonal processes of neurons can locally synthesize proteins. Experiments from a number of groups have now shown that axonal p...

journal_title：Experimental neurology

authors： Yoo S,van Niekerk EA,Merianda TT,Twiss JL

更新日期：2010-05-01 00:00:00