Activity dependent therapies modulate the spinal changes that motoneurons suffer after a peripheral nerve injury.

abstract：:We have previously demonstrated an opioid link in nucleus accumbens (NAc) that mediates antinociception produced by a novel ascending pain modulation pathway. For example, noxious stimulation induces heterosegmental antinociception that is mediated by both mu- and delta-opioid receptors in NAc. However, spinal intrath...

journal_title：Experimental neurology

authors： Gear RW,Levine JD

更新日期：2011-06-01 00:00:00

abstract：:The beta-Amyloid peptide (A beta) is hypothesized to mediate the neurodegeneration seen in Alzheimer's disease. Recently, we proposed a new hypothesis to explain the toxicity of A beta based on the free-radical generating capacity of A beta. We have recently demonstrated using electron paramagnetic resonance (EPR) spe...

journal_title：Experimental neurology

authors： Harris ME,Hensley K,Butterfield DA,Leedle RA,Carney JM

更新日期：1995-02-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is an adult-onset, fatal neurodegenerative syndrome characterized by the systemic loss of motor neurons with prominent astrocytosis and microgliosis in the spinal cord and brain. Astrocytes play an essential role in maintaining extracellular microenvironments that surround motor neu...

journal_title：Experimental neurology

authors： Shijo T,Warita H,Suzuki N,Ikeda K,Mitsuzawa S,Akiyama T,Ono H,Nishiyama A,Izumi R,Kitajima Y,Aoki M

更新日期：2018-09-01 00:00:00

abstract：:Bone marrow stromal cells (BMSC) have been shown to generate neural cells under experimental conditions in vitro and following transplantation into animal models of stroke and traumatic CNS injury. Hastened recovery from the neurological deficit has not correlated with structural repair of the lesion in the stroke mod...

journal_title：Experimental neurology

authors： Song S,Kamath S,Mosquera D,Zigova T,Sanberg P,Vesely DL,Sanchez-Ramos J

更新日期：2004-01-01 00:00:00

abstract：:We have studied the functional involvement of J1-160 and J1-180 in the interaction between oligodendrocytes and neurons, astrocytes, or L cells in short- and long-term adhesion assays using monoclonal antibodies directed against topographically distinct epitopes on the molecules. Whereas antibodies to mouse liver memb...

journal_title：Experimental neurology

authors： Morganti MC,Taylor J,Pesheva P,Schachner M

更新日期：1990-07-01 00:00:00

abstract：:Huntingtin is a cytoplasmic protein that is found in neurons and somatic cells. In patients with Huntington's disease (HD), the NH2-terminal region of huntingtin has an expanded polyglutamine tract. An abnormal protein interaction by mutant huntingtin has been proposed as a mechanism for HD pathogenesis. Huntingtin as...

journal_title：Experimental neurology

authors： Velier J,Kim M,Schwarz C,Kim TW,Sapp E,Chase K,Aronin N,DiFiglia M

更新日期：1998-07-01 00:00:00

abstract：:Activation of N-methyl-d-aspartate (NMDA) receptors in the spinal dorsal horn has been shown to be essential for the initiation of central sensitization and the hyperexcitability of dorsal horn neurons in chronic pain. However, whether the spinal NR2B-containing NMDA (NMDA-2B) receptors are involved still remains larg...

journal_title：Experimental neurology

authors： Qu XX,Cai J,Li MJ,Chi YN,Liao FF,Liu FY,Wan Y,Han JS,Xing GG

更新日期：2009-02-01 00:00:00

abstract：:Axonal lesions to the optic nerve (ON) induce c-Jun expression in retinal ganglion cells (RGCs) of the rat in vivo. Detailed investigations using retrograde tracers, and double labeling studies for c-Jun and regeneration-associated factors, such as the growth-associated protein GAP-43, have suggested that this upregul...

journal_title：Experimental neurology

authors： Isenmann S,Bähr M

更新日期：1997-09-01 00:00:00

abstract：:Both fresh and cryopreserved-thawed human fetal ventral mesencephalon have been used for preclinical research and implantation into the brains of patients with Parkinson's disease. Further characterization and an evaluation of the effects of cryopreservation on immunocytochemical and neurochemical markers of monoamine...

journal_title：Experimental neurology

authors： Kontur PJ,Leranth C,Redmond DE Jr,Roth RH,Robbins RJ

更新日期：1993-06-01 00:00:00

abstract：:We investigated the involvement of central nervous system nicotinic-acetylcholine receptors in the secretory activity of the hypothalamic-hypophyseal-adrenal axis. Antiacetylcholine receptor antibodies derived from rabbits immunized with purified Torpedo-acetylcholine receptor or from myasthenia gravis patients were i...

journal_title：Experimental neurology

authors： Brenner T,Mizrachi R,Bodoff M,Weidenfeld J

更新日期：1986-12-01 00:00:00

abstract：:The sub-thalamic nucleus (STN) is relevant to the preparation of movement ignition but its role in movement termination is uncertain. Fourteen patients with Parkinson's disease (PD) received local field potentials (LFPs) recording at the left STN on the fourth day after deep brain stimulation surgery. They performed p...

journal_title：Experimental neurology

authors： Hsu YT,Lai HY,Chang YC,Chiou SM,Lu MK,Lin YC,Liu YL,Chen CC,Huang HC,Chien TF,Lin SZ,Chen YY,Tsai CH

更新日期：2012-01-01 00:00:00

abstract：:We have recently shown that tanycytes present in the median eminence (ME) constitute a preferential support for the regeneration of lesioned neurohypophysial oxytocinergic and vasopressinergic axons. However, although tanycytes are particularly abundant in the ME, they are also present along the third ventricle wall. ...

journal_title：Experimental neurology

authors： Chauvet N,Prieto M,Alonso G

更新日期：1998-05-01 00:00:00

abstract：:Administration of endogenous corticosterone to intact animals induces calbindin-D28k protein in the hippocampal CA1-CA2 subfields. The fact that this effect on calbindin-D28k was shown to be specific for the hippocampus argues for a receptor-mediated effect on gene expression. In addition, chronic pretreatment with co...

journal_title：Experimental neurology

authors： Rami A,Rabié A,Winckler J

更新日期：1998-02-01 00:00:00

abstract：:The EEG of 20 Wistar rats inbred for audiogenic seizures was recorded during 40 daily auditory stimuli 90 s long. The first stimuli provoked wild running, with no cortical EEG abnormality, and then a tonic phase with a characteristic EEG of a brief flat trace 2 to 3 s long followed by low-amplitude regular activity, 1...

journal_title：Experimental neurology

authors： Marescaux C,Vergnes M,Kiesmann M,Depaulis A,Micheletti G,Warter JM

更新日期：1987-07-01 00:00:00

abstract：:It is widely accepted that the immune system plays important functional roles in regeneration after injury to the spinal cord. Immune response towards injury involves a complex interplay of immune system cells, such as neutrophils, macrophages and microglia, T- and B-lymphocytes. We investigated the influence of the l...

journal_title：Experimental neurology

authors： Wu B,Matic D,Djogo N,Szpotowicz E,Schachner M,Jakovcevski I

更新日期：2012-10-01 00:00:00

abstract：:The majority of human spinal cord injuries involve gray matter loss from the cervical or lumbar enlargements. However, the deficits that arise from gray matter damage are largely masked by the severe deficits due to associated white matter damage. We have developed a model to examine gray matter-specific deficits and ...

journal_title：Experimental neurology

authors： Magnuson DS,Trinder TC,Zhang YP,Burke D,Morassutti DJ,Shields CB

更新日期：1999-03-01 00:00:00

abstract：:Outcome following stroke is difficult to measure because the behavioral response to infarction is variable. We hypothesized that cognitive function, such as spatial learning, may be a reproducible and sensitive outcome variable. We developed an animal model of multifocal cerebral ischemia in order to study the effects...

journal_title：Experimental neurology

authors： Lyden PD,Zivin JA,Chabolla DR,Jacobs MA,Gage FH

更新日期：1992-05-01 00:00:00

abstract：:The members of the tenascin family are involved in a number of developmental processes, mainly by their ability to regulate cell adhesion. We have here studied the distribution of mRNAs for tenascin-X, -C, and -R and the closely related molecule tenascin/J1 in the olfactory system and spinal cord. The olfactory bulb a...

journal_title：Experimental neurology

authors： Deckner M,Lindholm T,Cullheim S,Risling M

更新日期：2000-12-01 00:00:00

abstract：:The astrocyte-endothelial cell interaction is crucial for normal brain homeostasis and blood-brain barrier (BBB) disruption in pathological conditions. However, the mechanism by which astrocytes control BBB integrity, especially after traumatic brain injury (TBI), remains unclear. Here, we present evidence that astroc...

journal_title：Experimental neurology

authors： Rui Q,Ni H,Lin X,Zhu X,Li D,Liu H,Chen G

更新日期：2019-12-01 00:00:00

abstract：:Intracranial collaterals provide residual blood flow to penumbral tissue in acute ischemic stroke and contribute to infarct size variability in humans. In the present study, hemodynamic monitoring of the borderzone territory between the leptomeningeal branches of middle cerebral artery and anterior cerebral artery was...

journal_title：Experimental neurology

authors： Riva M,Pappadà GB,Papadakis M,Cuccione E,Carone D,Menendez VR,Sganzerla EP,Beretta S

更新日期：2012-02-01 00:00:00

abstract：:Chemokines are a family of structurally related cytokines that activate and recruit leukocytes into areas of inflammation. The "CC" chemokine, monocyte chemoattractant protein (MCP)-1 may regulate the microglia/monocyte response to acute brain injury. Recent studies have documented increased expression of MCP-1 in div...

journal_title：Experimental neurology

authors： Galasso JM,Miller MJ,Cowell RM,Harrison JK,Warren JS,Silverstein FS

更新日期：2000-10-01 00:00:00

abstract：:SCI is followed by dramatic upregulation of chondroitin sulfate proteoglycans (CSPGs) which limit axonal regeneration, oligodendrocyte replacement and remyelination. The recent discovery of the specific CSPGs signaling receptor protein tyrosine phosphatase sigma (RPTPσ) provided an opportunity to refine the therapeuti...

journal_title：Experimental neurology

authors： Rink S,Arnold D,Wöhler A,Bendella H,Meyer C,Manthou M,Papamitsou T,Sarikcioglu L,Angelov DN

更新日期：2018-11-01 00:00:00

abstract：:The distribution and relative intrafascicular contribution of myelin fibers derived from spinal segments L-4 to L-6 were analyzed in adult rat sciatic nerve and its main branches, using 200-kDa neurofilament subunit immunodetection in previously injured nerve sections in the L-4 or L-5 spinal branch or both. These bra...

journal_title：Experimental neurology

authors： Montoya G JV,Ariza J,Sutachán JJ,Hurtado H

更新日期：2002-02-01 00:00:00

abstract：:Peripheral nerve regeneration following injury occurs spontaneously, but many of the processes require metabolic energy. The mechanism of energy supply to axons has not previously been determined. In the central nervous system, monocarboxylate transporter 1 (MCT1), expressed in oligodendroglia, is critical for supplyi...

journal_title：Experimental neurology

authors： Morrison BM,Tsingalia A,Vidensky S,Lee Y,Jin L,Farah MH,Lengacher S,Magistretti PJ,Pellerin L,Rothstein JD

更新日期：2015-01-01 00:00:00

abstract：:The conditioned corral preference paradigm was used to assess reinforcing effects of substance P (SP) and its N- and C-terminal fragments injected unilaterally into the region of the nucleus basalis magnocellularis (NBM) in rats. Behavioral testing was carried out in a circular open field, consisting of 4 quadrants eq...

journal_title：Experimental neurology

authors： Hasenöhrl RU,Gerhardt P,Huston JP

更新日期：1992-02-01 00:00:00

abstract：:Minocycline is neuroprotective in many experimental models of neurodegenerative diseases and central nervous system (CNS) injury but has not previously been tested in a model of viral encephalitis. Experimental infection of neonatal mice with neurotropic reoviruses is a classic model for studying the pathogenesis of v...

journal_title：Experimental neurology

authors： Richardson-Burns SM,Tyler KL

更新日期：2005-04-01 00:00:00

abstract：:Fluoxetine is one of the most promising drugs for improving clinical outcome in patients with ischemic stroke. This in vivo study investigated the hypothesis that fluoxetine may affect HIF-1α-Netrin/VEGF cascade, angiogenesis and neuroprotection using a rat model of transient middle cerebral artery occlusion (tMCAO). ...

journal_title：Experimental neurology

authors： Hu Q,Liu L,Zhou L,Lu H,Wang J,Chen X,Wang Q

更新日期：2020-07-01 00:00:00

abstract：:Progesterone and its metabolite, allopregnanolone, are neurosteroids that are present at high concentrations in fetal brains that decrease right after birth. Allopregnanolone is a potent positive modulator of γ-aminobutyric acid A (GABA(A)) receptor function. We examined the effect of exogenous administration of these...

journal_title：Experimental neurology

authors： Tsuji M,Taguchi A,Ohshima M,Kasahara Y,Ikeda T

更新日期：2012-01-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) patients treated with nucleoside reverse transcriptase inhibitors (NRTIs), have been known to develop neuropathic pain. While there has been a major shift away from some neurotoxic NRTIs in current antiretroviral therapy, a large number of HIV patients alive today have previously rec...

journal_title：Experimental neurology

authors： Iida T,Yi H,Liu S,Huang W,Kanda H,Lubarsky DA,Hao S

更新日期：2016-07-01 00:00:00

abstract：:The age-dependent effects of sympathetic superior cervical ganglionectomy on smooth muscle alpha-adrenoceptor contractile responses were investigated in Müller's muscle in the superior eyelid of the Sprague-Dawley rat. Ganglionectomies in juvenile (32 days) and adult (70 days) rats produced sustained sympathetic dener...

journal_title：Experimental neurology

authors： Smith PG

更新日期：1986-01-01 00:00:00