Evidence that central nicotinic-acetylcholine receptors are involved in the modulation of basal and stress-induced adrenocortical responses.

abstract：:Biochemical, physiological, and anatomical studies over the past 30 years have firmly established glutamate (Glu) as the major neurotransmitter of those cortical neurons which give rise to corticofugal pathways. In the present study we utilized immunohistochemistry, with an antibody directed against Glu, in conjunctio...

journal_title：Experimental neurology

authors： Dinopoulos A,Dori I,Davies SW,Parnavelas JG

更新日期：1989-07-01 00:00:00

abstract：:Falls are a major source of hospitalization, long-term institutionalization, and death in older adults and patients with Parkinson's disease (PD). Limited attentional resources are a major risk factor for falls. In this review, we specify cognitive-behavioral mechanisms that produce falls and map these mechanisms onto...

journal_title：Experimental neurology

authors： Sarter M,Albin RL,Kucinski A,Lustig C

更新日期：2014-07-01 00:00:00

abstract：:Both alpha- and beta-adrenergic receptors (ARs) are involved in the facilitation of the monosynaptic jaw-closing reflex in the trigeminal motor nucleus (MoV) caused by norepinephrine (NE). The amplitude of muscle spindle afferent-evoked EPSPs in masseter motor neurons is 65% greater when noradrenergic axons to the mot...

journal_title：Experimental neurology

authors： Shao YP,Sutin J

更新日期：1991-11-01 00:00:00

abstract：:Cinnamophilin (CINN, (8R, 8'S)-4, 4'-dihydroxy-3, 3'-dimethoxy-7-oxo-8, 8'-neolignan) protects against ischemic stroke in mice. While some anti-oxidative effects of CINN have been characterized, its therapeutic window and molecular basis for neuroprotection remain unclear. We evaluated antioxidant and anti-inflammator...

journal_title：Experimental neurology

authors： Lee EJ,Chen HY,Hung YC,Chen TY,Lee MY,Yu SC,Chen YH,Chuang IC,Wu TS

更新日期：2009-05-01 00:00:00

abstract：:The claim that AlCl3 could produce 100% inhibition of cerebrospinal fluid secretion was investigated using ventriculocisternal perfusion in the rabbit, and it was shown that a large part of this inhibition was an artefact due to a pH sensitivity of Blue Dextran, used as an indiffusible marker, caused by AlCl3. Thus th...

journal_title：Experimental neurology

authors： Zlokovic BV,Davson H,Preston JE,Segal MB

更新日期：1987-11-01 00:00:00

abstract：:Ventral root avulsion (VRA) triggers a strong glial reaction which contributes to neuronal loss, as well as to synaptic detachment. To overcome the degenerative effects of VRA, treatments with neurotrophic factors and stem cells have been proposed. Thus, we investigated neuroprotection elicited by human embryonic stem...

journal_title：Experimental neurology

authors： Araújo MR,Kyrylenko S,Spejo AB,Castro MV,Ferreira Junior RS,Barraviera B,Oliveira ALR

更新日期：2017-08-01 00:00:00

abstract：:Blood brain barrier (BBB) hyperpermeability and brain edema contribute to increased seizure susceptibility and brain injury in status epilepticus (SE). The endothelial glycocalyx is the coating on luminal side of the endothelium and can be considered as the first barrier of BBB. Currently, little is known about the ef...

journal_title：Experimental neurology

authors： Li X,Zhu J,Liu K,Hu Y,Huang K,Pan S

更新日期：2020-08-01 00:00:00

abstract：:Serial diffusion tensor imaging scans were collected at baseline and 1 year follow-up to investigate the neurodegenerative profile of white matter (WM) in seven individuals with the Huntington's Disease (HD) gene mutation and seven control subjects matched on age and gender. In the HD subjects, but not controls, a sig...

journal_title：Experimental neurology

authors： Weaver KE,Richards TL,Liang O,Laurino MY,Samii A,Aylward EH

更新日期：2009-04-01 00:00:00

abstract：:Oxidative stress can contribute to many neurological disease processes. Because many events known to involve oxidative stress (infection, hemorrhage, brain trauma) are accompanied by hydrocephalus, the present study sought to evaluate the relationship between oxidative stress and the progression of hydrocephalus. Assa...

journal_title：Experimental neurology

authors： Socci DJ,Bjugstad KB,Jones HC,Pattisapu JV,Arendash GW

更新日期：1999-01-01 00:00:00

abstract：:An inherited deficiency of β-galactosylceramidase (GALC) causes the lysosomal storage disease globoid cell leukodystrophy (GLD). The disease is characterized by the accumulation of the cytotoxic metabolite psychosine (galactosylsphingosine), causing rapid degeneration of myelinating cells. Most patients suffer from th...

journal_title：Experimental neurology

authors： Matthes F,Andersson C,Stein A,Eistrup C,Fogh J,Gieselmann V,Wenger DA,Matzner U

更新日期：2015-09-01 00:00:00

abstract：:The effect of sinusoidal magnetic field stimulation on regeneration of the rat sciatic nerve was studied. Rats were exposed, after crush lesioning of the nerve, between a pair of Helmholtz coils to a 50 Hz magnetic field of 0.2 mT or 0.4 mT, respectively. Regeneration of the sciatic nerve was measured by the "pinch te...

journal_title：Experimental neurology

authors： Rusovan A,Kanje M

更新日期：1991-06-01 00:00:00

abstract：:Based on previous studies demonstrating the potential of growth factors to enhance peripheral nerve regeneration, we developed a novel growth factor delivery system to provide sustained delivery of nerve growth factor (NGF). This delivery system uses heparin to immobilize NGF and slow its diffusion from a fibrin matri...

journal_title：Experimental neurology

authors： Lee AC,Yu VM,Lowe JB 3rd,Brenner MJ,Hunter DA,Mackinnon SE,Sakiyama-Elbert SE

更新日期：2003-11-01 00:00:00

abstract：:Inherited neurological diseases in animals are of interest to a wide range of scientific disciplines, particularly because such animals may be suited as genetic animal models for respective human disorders. Because the pig has a number of anatomic and physiologic features similar to those of human beings, this species...

journal_title：Experimental neurology

authors： Richter A,Wissel J,Harlizius B,Simon D,Schelosky L,Scholz U,Poewe W,Löscher W

更新日期：1995-08-01 00:00:00

abstract：:We assessed the potential of different MRI measures to detect and quantify skeletal muscle changes with denervation in two mouse models of denervation/neurogenic atrophy. Acute complete denervation and chronic partial denervation were examined in calf muscles after sciatic nerve axotomy and in transgenic SOD1(G93A) mi...

journal_title：Experimental neurology

authors： Zhang J,Zhang G,Morrison B,Mori S,Sheikh KA

更新日期：2008-08-01 00:00:00

abstract：:The blood-brain barrier function and the vasomotor response in rat microcirculation was studied using a closed cranial window technique and an intravital fluorescence microscope with an attempt to reduce both the light intensity and the amount of 2% Na(+)-fluorescein to as little as possible. The light intensities in ...

journal_title：Experimental neurology

authors： Kawamura S,Yasui N

更新日期：1992-09-01 00:00:00

abstract：:Frequency information of the environment is an important feature for sensory perception. It has been demonstrated that cortical and thalamic neurons exhibited frequency-specific responses to peripheral stimulation. In the present study, we investigated the effects of 1-100 Hz peripheral electrical stimulations on vari...

journal_title：Experimental neurology

authors： Yang H,Chang JY,Woodward DJ,Baccalá LA,Han JS,Luo F

更新日期：2005-11-01 00:00:00

abstract：:Urinary bladder and urethral sphincter responses evoked by bladder distention, ventral root stimulation, or microstimulation of S2 segment of the sacral spinal cord were investigated under alpha-chloralose anesthesia in cats with an intact spinal cord and in chronic spinal cord injured (SCI) cats 6-8 weeks after spina...

journal_title：Experimental neurology

authors： Tai C,Booth AM,de Groat WC,Roppolo JR

更新日期：2004-11-01 00:00:00

abstract：:An autoradiographic method is described for detecting changes in ornithine decarboxylase in axotomized superior cervical ganglion neurons of rats using [3H]difluoromethylornithine. An increase in binding to neurons was seen at 12 h and 1 day after crushing the postganglionic nerves. Binding returned to control values ...

journal_title：Experimental neurology

authors： Wells MR

更新日期：1986-05-01 00:00:00

abstract：:Whereas quite a number of previous reports have shown that the developing brain is vulnerable to protein deprivation, the mature CNS is usually considered resistant to this condition. To explore this assumption the present experimental model was built on groups of 2-month-old rats fed with a low-protein diet (8% casei...

journal_title：Experimental neurology

authors： Paula-Barbosa MM,Andrade JP,Castedo JL,Azevedo FP,Camões I,Volk B,Tavares MA

更新日期：1989-02-01 00:00:00

abstract：:We have studied the functional involvement of J1-160 and J1-180 in the interaction between oligodendrocytes and neurons, astrocytes, or L cells in short- and long-term adhesion assays using monoclonal antibodies directed against topographically distinct epitopes on the molecules. Whereas antibodies to mouse liver memb...

journal_title：Experimental neurology

authors： Morganti MC,Taylor J,Pesheva P,Schachner M

更新日期：1990-07-01 00:00:00

abstract：:The gastrointestinal tract of vertebrates is a heterogeneous organ system innervated to varying degrees by a local enteric neural network as well as extrinsic parasympathetic and sympathetic neural circuits located along the brainstem and spinal axis. This diverse organ system serves to regulate the secretory and prop...

journal_title：Experimental neurology

authors： Holmes GM,Blanke EN

更新日期：2019-10-01 00:00:00

abstract：:Convection-enhanced delivery (CED) distributes macromolecules in the brain in a homogeneous, targeted fashion in clinically useful volumes. However, the binding of growth factors to heparin-binding sites in the extracellular matrix may limit the volume of distribution (V(d)). To overcome this limitation, we examined t...

journal_title：Experimental neurology

authors： Hamilton JF,Morrison PF,Chen MY,Harvey-White J,Pernaute RS,Phillips H,Oldfield E,Bankiewicz KS

更新日期：2001-03-01 00:00:00

abstract：:The electromyographic (EMG) activity of the gastrocnemius and tibialis anterior muscles was recorded from normal geriatric subjects and from hemiplegic patients subjected to a continuous back-and-forth movement of the platform on which they stood. The platform oscillated at a fixed frequency of 0.5 Hz. Movement amplit...

journal_title：Experimental neurology

authors： Hocherman S,Dickstein R,Hirschbiene A,Pillar T

更新日期：1988-02-01 00:00:00

abstract：:Previous studies have suggested that defective high-affinity glutamate uptake, due mainly to a major loss of the astroglial-specific GLT-1 glutamate transporter, underlies the selective motoneuron degeneration observed in sporadic ALS (24, 28). If a defect in glutamate transport underlies the pathogenesis of sporadic ...

journal_title：Experimental neurology

authors： Medina L,Figueredo-Cardenas G,Rothstein JD,Reiner A

更新日期：1996-12-01 00:00:00

abstract：:Transforming growth factor-alpha (TGF-alpha), previously identified as a major member of the epidermal growth factor (EGF) family of growth factors, plays a role in proliferation, differentiation, and survival of neuronal and glial precursors and is implicated in development of the nervous system. However, its roles i...

journal_title：Experimental neurology

authors： Xian CJ,Li L,Deng YS,Zhao SP,Zhou XF

更新日期：2001-11-01 00:00:00

abstract：:It has been suggested that the increased transient expression of immediate-early gene transcription factors seen in nerve cells following an afterdischarge may initiate longer lasting or permanent changes in gene expression which underly the development of kindling. Since the development of kindling is sensitive to ph...

journal_title：Experimental neurology

authors： Hughes P,Singleton K,Dragunow M

更新日期：1994-08-01 00:00:00

abstract：:The aim of this study was to compare the physiological properties of single neurons in the glabrous (G) and heterogeneous (H) subdivisions of primary somatosensory digit 3 cortex of adult raccoons. Extracellular recordings were obtained from 50 G neurons whose receptive fields (RFs) were confined to the glabrous skin ...

journal_title：Experimental neurology

authors： Doetsch GS,Stoney SD Jr,Hauge DH

更新日期：1992-02-01 00:00:00

abstract：:Opening of the mitochondrial permeability transition pore has increasingly been implicated in excitotoxic, ischemic, and apoptotic cell death, as well as in several neurodegenerative disease processes. However, much of the work directly characterizing properties of the transition pore has been performed in isolated li...

journal_title：Experimental neurology

authors： Berman SB,Watkins SC,Hastings TG

更新日期：2000-08-01 00:00:00

abstract：:Blood flow in the feline thoracic spinal cord was measured, using a laser-Doppler flowmetry. Rhythmic changes in the spinal cord blood flow were repeatedly observed with a frequency of about three to eight cycles per minute, unrelated to the respiratory or cardiac cycles. These changes were unaffected by hypertension ...

journal_title：Experimental neurology

authors： Mizutani M,Yamamuro T,Shikata J

更新日期：1988-08-01 00:00:00

abstract：:Ibuprofen is commonly used as an anti-inflammatory analgesic drug, although it is not amongst the first-line treatments for neuropathic pain. Its main effects are mediated by non-specific inhibition of COX enzymes, but it also exerts some COX-independent effects, such as the inhibition of RhoA signaling and the modula...

journal_title：Experimental neurology

authors： Redondo-Castro E,Navarro X

更新日期：2014-02-01 00:00:00