Abstract:
:Ibuprofen is commonly used as an anti-inflammatory analgesic drug, although it is not amongst the first-line treatments for neuropathic pain. Its main effects are mediated by non-specific inhibition of COX enzymes, but it also exerts some COX-independent effects, such as the inhibition of RhoA signaling and the modulation of glial activity. These effects have boosted the use of ibuprofen as a tool to promote axonal regeneration and to increase functional recovery after neural injuries, although with controversial results showing positive and negative outcomes of ibuprofen treatment in several experimental models. We have evaluated the effects of ibuprofen administered at 60 mg/kg twice a day to rats subjected to a mild spinal cord contusion. Our results indicate that ibuprofen ameliorates mechanical hyperalgesia in rats by reducing central hyperexcitability, but failed to produce improvements in the recovery of locomotion. Despite an early effect on reducing microglial reactivity, the ibuprofen treatment did not provide histological evidence of neuroprotection; indeed the volume of cord tissue spared rostral to the lesion was decreased in ibuprofen treated rats. In summary, the early modulation of neuroinflammation produced by the administration of ibuprofen seems to eventually lead to a worse resolution of detrimental events occurring in the secondary injury phase, but also to reduce the development of neuropathic pain.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Redondo-Castro E,Navarro Xdoi
10.1016/j.expneurol.2013.11.008subject
Has Abstractpub_date
2014-02-01 00:00:00pages
95-103eissn
0014-4886issn
1090-2430pii
S0014-4886(13)00332-4journal_volume
252pub_type
杂志文章abstract::Dopaminergic loss is known to be one of the major hallmarks of Parkinson disease (PD). In addition to its function as a neurotransmitter, dopamine plays significant roles in developmental and adult neurogenesis. Both dopaminergic deafferentation and stimulation modulate proliferation in the subventricular zone (SVZ)/o...
journal_title:Experimental neurology
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doi:10.1016/0014-4886(90)90126-d
更新日期:1990-06-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
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journal_title:Experimental neurology
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doi:10.1016/j.expneurol.2004.06.008
更新日期:2004-10-01 00:00:00
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journal_title:Experimental neurology
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journal_title:Experimental neurology
pub_type: 杂志文章
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2017.05.004
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90290-1
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journal_title:Experimental neurology
pub_type: 杂志文章
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更新日期:1984-12-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.1016/0014-4886(92)90160-r
更新日期:1992-05-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2017.10.013
更新日期:2018-01-01 00:00:00
abstract::Bilateral lesions of the ventromedial nucleus of the hypothalamus (VMN) significantly attentuated lordosis behavior in the female rat. The degree of this deficit was significantly correlated with the amount of damage to the VMN. There was no improvement in lordosis performance even after an extended recovery period. ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(83)90035-3
更新日期:1983-03-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2011.02.013
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journal_title:Experimental neurology
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1999.7247
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(91)90092-q
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1993.1069
更新日期:1993-05-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2017.06.016
更新日期:2017-09-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2005.02.020
更新日期:2005-07-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2012.04.006
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journal_title:Experimental neurology
pub_type: 杂志文章
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更新日期:1997-07-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2018.02.016
更新日期:2018-06-01 00:00:00
abstract::Previously, our lab reported the isolation of patient-specific neurosphere-forming progenitor lines from human adult olfactory epithelium from cadavers as well as patients undergoing nasal sinus surgery. RT-PCR and ELISA demonstrated that the neurosphere-forming cells (NSFCs) produced BDNF. Since rubrospinal tract (RS...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2005.01.021
更新日期:2005-07-01 00:00:00