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Intranasal cotinine improves memory, and reduces depressive-like behavior, and GFAP+ cells loss induced by restraint stress in mice.

Abstract：

:Posttraumatic stress disorder (PTSD), chronic psychological stress, and major depressive disorder have been found to be associated with a significant decrease in glial fibrillary acidic protein (GFAP) immunoreactivity in the hippocampus of rodents. Cotinine is an alkaloid that prevents memory impairment, depressive-like behavior and synaptic loss when co-administered during restraint stress, a model of PTSD and stress-induced depression, in mice. Here, we investigated the effects of post-treatment with intranasal cotinine on depressive- and anxiety-like behaviors, visual recognition memory as well as the number and morphology of GFAP+ immunoreactive cells, in the hippocampus and frontal cortex of mice subjected to prolonged restraint stress. The results revealed that in addition to the mood and cognitive impairments, restraint stress induced a significant decrease in the number and arborization of GFAP+ cells in the brain of mice. Intranasal cotinine prevented these stress-derived symptoms and the morphological abnormalities GFAP+ cells in both of these brain regions which are critical to resilience to stress. The significance of these findings for the therapy of PTSD and depression is discussed.

journal_name

Exp Neurol

journal_title

Experimental neurology

authors

Perez-Urrutia N,Mendoza C,Alvarez-Ricartes N,Oliveros-Matus P,Echeverria F,Grizzell JA,Barreto GE,Iarkov A,Echeverria V

doi

10.1016/j.expneurol.2017.06.016

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

211-221

eissn

0014-4886

issn

1090-2430

pii

S0014-4886(17)30155-3

journal_volume

295

pub_type

杂志文章

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