Depletion of serotonin using p-chlorophenylalanine (PCPA) and reserpine protects against the neurotoxic effects of p-chloroamphetamine (PCA) in the brain.

abstract：:In vivo imaging of patients with Alzheimer's disease using positron emission tomography (PET) demonstrates progressive reductions in brain glucose metabolism and blood flow in relation to dementia severity, more so in association than primary cortical regions. These reductions likely follow regional synaptic loss or d...

journal_title：Experimental neurology

authors： Chandrasekaran K,Hatanpää K,Brady DR,Rapoport SI

更新日期：1996-11-01 00:00:00

abstract：:Peripheral inflammation induces sensitization of nociceptive spinal cord neurons. Both spinal tumor necrosis factor (TNF) and neuronal membrane insertion of Ca2+ permeable AMPA receptor (AMPAr) contribute to spinal sensitization and resultant pain behavior, molecular mechanisms connecting these two events have not bee...

journal_title：Experimental neurology

authors： Wigerblad G,Huie JR,Yin HZ,Leinders M,Pritchard RA,Koehrn FJ,Xiao WH,Bennett GJ,Huganir RL,Ferguson AR,Weiss JH,Svensson CI,Sorkin LS

更新日期：2017-07-01 00:00:00

abstract：:Thalamocortical spike-and-wave discharges characterize the nonconvulsive absence seizures that occur spontaneously in genetic absence epilepsy rats from Strasbourg (GAERS), a selected strain of Wistar rats. GABA is crucial in the generation of absence seizures. The susceptibility to convulsions induced by threshold do...

journal_title：Experimental neurology

authors： Vergnes M,Boehrer A,Reibel S,Simler S,Marescaux C

更新日期：2000-02-01 00:00:00

abstract：:We recently revealed a unique glycan on the Fc domain of IgG antibodies in ALS patients that mediates antibody-dependent cell cytotoxicity (ADCC). This glycan has a bi-antennary structure that lacks the core fucose and sialic acid residues but contains a bisecting GlcNAc (A2BG2). Little is known, however, about the in...

journal_title：Experimental neurology

authors： Edri-Brami M,Sharoni H,Hayoun D,Skutelsky L,Nemirovsky A,Porgador A,Lichtenstein RG

更新日期：2015-05-01 00:00:00

abstract：:Abnormal corticostriatal plasticity is a key mechanism of L-DOPA-induced dyskinesia (LID) in Parkinson's disease (PD). Antagonists at glutamatergic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, such as IEM 1460, reduce induction and expression of dyskinesia in rat and non-human primate models ...

journal_title：Experimental neurology

authors： Kobylecki C,Crossman AR,Ravenscroft P

更新日期：2013-09-01 00:00:00

abstract：:The depressant effects of iontophoretically applied dopamine and noradrenaline on glutamate-induced neuronal firing in the amygdaloid complex of cats were significantly reduced 1 and 2 h after induction of a local epileptiform afterdischarge of the kind used in kindling. Neuronal excitation by glutamate and depression...

journal_title：Experimental neurology

authors： Spehlmann R,Norcross K

更新日期：1984-01-01 00:00:00

abstract：:Osteogenic protein-1 (OP-1), a member of the transforming growth factor-beta (TGF-beta) superfamily, has been demonstrated to stimulate dendrite growth from sympathetic neurons in culture. However, it is not known whether OP-1 affects dendrite growth from central nervous system neurons. Therefore we quantified axon an...

journal_title：Experimental neurology

authors： Le Roux P,Behar S,Higgins D,Charette M

更新日期：1999-11-01 00:00:00

abstract：:It is difficult to assess cerebral function in comatose patients. Because earlier functional neuroimaging studies demonstrate associations between cerebral metabolism and levels of consciousness, fMRI in comatose survivors of cardiac arrest could provide further insight into cerebral function during coma. Using fMRI, ...

journal_title：Experimental neurology

authors： Gofton TE,Chouinard PA,Young GB,Bihari F,Nicolle MW,Lee DH,Sharpe MD,Yen YF,Takahashi AM,Mirsattari SM

更新日期：2009-06-01 00:00:00

abstract：:Second-order neurons in trigeminal subnucleus caudalis (Vc) and upper cervical spinal cord (C1) are critical for craniofacial pain processing and project rostrally to terminate in: ventral posteromedial thalamic nucleus (VPM), medial thalamic nuclei (MTN) and parabrachial nuclei (PBN). The contribution of each region ...

journal_title：Experimental neurology

authors： Saito H,Katagiri A,Okada S,Mikuzuki L,Kubo A,Suzuki T,Ohara K,Lee J,Gionhaku N,Iinuma T,Bereiter DA,Iwata K

更新日期：2017-07-01 00:00:00

abstract：:Fifteen male mice (C57/Bl6J) were fed the liquid diet "Stardit" supplemented with vitamins together with phenytoin for 8 weeks; experimental animals and controls were pair-fed. After 8 weeks of treatment, the anesthetized animals were perfused with 3.5% glutaraldehyde. Tissue samples of the cerebral cortex (area 3), c...

journal_title：Experimental neurology

authors： Volk B,Kirchgässner N,Detmar M

更新日期：1986-01-01 00:00:00

abstract：:We have previously shown that lesions of the sensorimotor cortex induced by either thermocoagulation or aspiration produce different effects on axonal plasticity. We have now investigated whether these methods of lesion also influence the behavioral outcome. The behavioral effects of unilateral and bilateral lesions o...

journal_title：Experimental neurology

authors： Napieralski JA,Banks RJ,Chesselet MF

更新日期：1998-11-01 00:00:00

abstract：:Administration of endogenous corticosterone to intact animals induces calbindin-D28k protein in the hippocampal CA1-CA2 subfields. The fact that this effect on calbindin-D28k was shown to be specific for the hippocampus argues for a receptor-mediated effect on gene expression. In addition, chronic pretreatment with co...

journal_title：Experimental neurology

authors： Rami A,Rabié A,Winckler J

更新日期：1998-02-01 00:00:00

abstract：:Previously injured dorsal roots were electrically stimulated to determine if regenerating sensory axons can form physiologically active synaptic contacts with neurons within fetal spinal cord tissue transplants. Dorsal rootlets, sectioned at their spinal cord entry zone, were apposed to intraspinal transplants of feta...

journal_title：Experimental neurology

authors： Houle JD,Skinner RD,Garcia-Rill E,Turner KL

更新日期：1996-06-01 00:00:00

abstract：:Nitrosative stress contributes to nerve conduction slowing, thermal hypoalgesia, and impaired nitrergic innervation in animal models of Type 1 diabetes. The role for reactive nitrogen species in Type 2 diabetes-associated neuropathy remains unexplored. This study evaluated the role for nitrosative stress in functional...

journal_title：Experimental neurology

authors： Vareniuk I,Pavlov IA,Drel VR,Lyzogubov VV,Ilnytska O,Bell SR,Tibrewala J,Groves JT,Obrosova IG

更新日期：2007-06-01 00:00:00

abstract：:Idiopathic inflammatory myopathies (IIMs), comprising of polymyositis, dermatomyositis, and inclusion-body myositis, are characterized by muscle weakness and various types of inflammatory changes in muscle cells. They also show non-inflammatory changes, including perifascicular atrophy, mitochondrial changes, and amyl...

journal_title：Experimental neurology

authors： Nozaki K,Das A,Ray SK,Banik NL

更新日期：2010-10-01 00:00:00

abstract：:The regional, cellular, and subcellular localization of phosphorylated p38 MAPK (pp38) was examined by immunocytochemistry, immuofluorescent multiple labeling, and immunoblotting of extracts as well as immunoprecipitates of human postmortem tissue from control and Alzheimer's disease (AD) cases at different Braak stag...

journal_title：Experimental neurology

authors： Sun A,Liu M,Nguyen XV,Bing G

更新日期：2003-10-01 00:00:00

abstract：:In the present study homonymous and heteronymous projections of muscle spindle afferent fibers in the human jaw-closing system were investigated. Stretch reflex responses were elicited with percutaneous displacement stimuli applied to the belly of the anterior superficial divisions of temporalis and masseter muscles. ...

journal_title：Experimental neurology

authors： Smith A,Moore CA,Pratt CA

更新日期：1985-06-01 00:00:00

abstract：:In this study, we examined modulations in phosphatase and tensin homolog (PTEN) and mammalian target of rapamycin (mTOR) protein expression after a lateral C2 hemisection and subsequent intermittent hypoxia (IH) exposure and training, which initiates respiratory motor plasticity and recovery. PTEN and mTOR are signifi...

journal_title：Experimental neurology

authors： Gutierrez DV,Clark M,Nwanna O,Alilain WJ

更新日期：2013-10-01 00:00:00

abstract：:Nerve growth factor (NGF) enhances neuronal survival during injury to the mature central and peripheral nervous systems, but its potential as a neuroprotective factor in the enteric nervous system (ENS) has not been examined. We used the trinitrobenzene sulfonic acid (TNBS)-induced model of colitis to examine if NGF-s...

journal_title：Experimental neurology

authors： Lin A,Lourenssen S,Stanzel RD,Blennerhassett MG

更新日期：2005-02-01 00:00:00

abstract：:Infection with human immunodeficiency virus-1 (HIV-1) is associated with dysfunctions of the central nervous system (CNS). HIV-1 induces its effects on the CNS by a variety of mechanisms, including by shedding the neurotoxic viral proteins such as gp120 and Tat. Both HIV-1 and gp120 have been shown to cross the blood-...

journal_title：Experimental neurology

authors： Banks WA,Robinson SM,Nath A

更新日期：2005-05-01 00:00:00

abstract：:The alpha-secretase-derived form of the amyloid precursor protein (sAPPalpha), which is released from neurons in an activity-dependent manner, has been shown to promote long-term survival of hippocampal and cortical neurons in culture and can protect those neurons against excitotoxic and ischemic injury in culture and...

journal_title：Experimental neurology

authors： Cheng G,Yu Z,Zhou D,Mattson MP

更新日期：2002-06-01 00:00:00

abstract：:Oxidative stress can contribute to many neurological disease processes. Because many events known to involve oxidative stress (infection, hemorrhage, brain trauma) are accompanied by hydrocephalus, the present study sought to evaluate the relationship between oxidative stress and the progression of hydrocephalus. Assa...

journal_title：Experimental neurology

authors： Socci DJ,Bjugstad KB,Jones HC,Pattisapu JV,Arendash GW

更新日期：1999-01-01 00:00:00

abstract：:Intrastriatal injection of excitatory amino acids, particularly quinolinic acid, has been proposed as an animal model of Huntington's disease. Such neurotoxic lesions of caudate-putamen result in marked dopamine type-1 (D1) receptor losses in the injected nuclei as well as in the ipsilateral substantia nigra pars reti...

journal_title：Experimental neurology

authors： Filloux F,Wagster MV,Folstein S,Price DL,Hedreen JC,Dawson TM,Wamsley JK

更新日期：1990-11-01 00:00:00

abstract：:Systematic protein expression studies in the brain of exercising and sedentary animals have not been carried out so far and it was therefore decided to determine differences in metabolic protein levels in rat hippocampus of sedentary, voluntary and involuntary exercising rats by a proteomic approach. Aged, male Spragu...

journal_title：Experimental neurology

authors： Kirchner L,Chen WQ,Afjehi-Sadat L,Viidik A,Skalicky M,Höger H,Lubec G

更新日期：2008-07-01 00:00:00

abstract：:The present study demonstrates that the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes significantly greater reductions in striatal dopamine levels in C57/bl mice than in CD-1 mice, thus confirming a greater sensitivity of the C57/bl mice to MPTP. To determine the possible reasons for this diffe...

journal_title：Experimental neurology

authors： Muthane U,Ramsay KA,Jiang H,Jackson-Lewis V,Donaldson D,Fernando S,Ferreira M,Przedborski S

更新日期：1994-04-01 00:00:00

abstract：:Estetrol (E4) is a recently described natural estrogen with four hydroxyl-groups that is synthesized exclusively during pregnancy by the human fetal liver. It has important antioxidative activity. The aim of the present study was to define the importance of E4 in the attenuation of neonatal hypoxic-ischemic encephalop...

journal_title：Experimental neurology

authors： Tskitishvili E,Nisolle M,Munaut C,Pequeux C,Gerard C,Noel A,Foidart JM

更新日期：2014-11-01 00:00:00

abstract：:A new procedure was developed for ablating the mammillary nuclei in nonhuman primates via direct visual exposure. Using this technique, monkeys receiving lesions of the mammillary nuclei were compared to control animals after surgery to assess the retention of preoperatively acquired visuospatial discriminations and s...

journal_title：Experimental neurology

authors： Holmes EJ,Jacobson S,Stein BM,Butters N

更新日期：1983-07-01 00:00:00

abstract：:The nontoxic C fragment of tetanus toxin (TC) can transport other proteins from the circulation to central nervous system (CNS) motor neurons. Increased levels of CuZn superoxide dismutase (SOD) are protective in experimental models of stroke and Parkinson's disease, whereas mutations in SOD can cause motor neuron dis...

journal_title：Experimental neurology

authors： Figueiredo DM,Hallewell RA,Chen LL,Fairweather NF,Dougan G,Savitt JM,Parks DA,Fishman PS

更新日期：1997-06-01 00:00:00

abstract：:Our previous studies showed that Insulin-like Growth Factor (IGF)-1 reduced blood brain barrier permeability and decreased infarct volume caused by middle cerebral artery occlusion (MCAo) in middle aged female rats. Similarly, cultures of primary brain microvessel endothelial cells from middle-aged female rats and exp...

journal_title：Experimental neurology

authors： Bake S,Okoreeh A,Khosravian H,Sohrabji F

更新日期：2019-01-01 00:00:00

abstract：:Purkinje neurons are a sensitive and specialised cell type important for fine motor movement and coordination. Purkinje cell damage manifests as motor incoordination and ataxia - a prominent feature of many human disorders including spinocerebellar ataxia and Huntington's disease. A correlation between Purkinje degene...

journal_title：Experimental neurology

authors： Cops EJ,Sashindranath M,Daglas M,Short KM,da Fonseca Pereira C,Pang TY,Lijnen RH,Smyth IM,Hannan AJ,Samson AL,Medcalf RL

更新日期：2013-11-01 00:00:00