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Degeneration of granule cells following chronic phenytoin administration: an electron microscopic investigation of the mouse cerebellum.

Abstract：

:Fifteen male mice (C57/Bl6J) were fed the liquid diet "Stardit" supplemented with vitamins together with phenytoin for 8 weeks; experimental animals and controls were pair-fed. After 8 weeks of treatment, the anesthetized animals were perfused with 3.5% glutaraldehyde. Tissue samples of the cerebral cortex (area 3), cerebellum (vermis), thalamus, hypothalamus, and liver were embedded in Araldite. All phenytoin-treated animals displayed a hepatomegaly. Semithin sections and ultrastructural investigations of the cerebellar vermis showed pyknoses of granule cells and an enlargement and swelling of parallel fibers in presynaptic areas in the molecular layer. The swollen axons showed an accumulation of tubular structures which represented proliferated smooth endoplasmic reticulum. Similar tubular structures were observed in hepatocytes of experimental animals. It is proposed that phenytoin caused an induction of the microsomal system of hepatocytes and granule cells which led to a proliferation of the smooth endoplasmic reticulum. The transport of these organelles to the axon terminals of parallel fibers via the axoplasmic flow is assumed to cause a swelling of the presynaptic area. A dying-back process may then lead to pyknosis of granule cells. Chronic phenytoin administration to mice is a new experimental model of neuroaxonal dystrophy.

journal_name

Exp Neurol

journal_title

Experimental neurology

authors

Volk B,Kirchgässner N,Detmar M

doi

10.1016/0014-4886(86)90026-9

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

60-70

issue

1

eissn

0014-4886

issn

1090-2430

pii

0014-4886(86)90026-9

journal_volume

91

pub_type

杂志文章

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