Abstract：
:Overexpression of nerve growth factor (NGF) using adenoviruses (Adts) after spinal cord injury induces extensive regeneration and sprouting of calcitonin-gene-related peptide immunoreactive (CGRP-IR) fibers, whereas overexpression of cell adhesion molecules (CAMs) has no effect on the normal distribution of these fibers. Interestingly, co-expression of cell adhesion molecule L1 and NGF significantly decreases (p<0.0001) CGRP-IR fiber sprouting within the spinal cord, when compared to NGF alone. Co-expression of cell adhesion molecules NCAM or N-cadherin had no effect on NGF-induced CGRP-IR fiber sprouting. These data demonstrate that reduced sprouting is specific to L1 co-expression and not other cell adhesion molecules. In vitro studies carried out to address potential mechanisms show that neurite outgrowth over astrocytes overexpressing L1 in the presence of NGF is comparable to controls, indicating that other factors present in vivo might be involved in the L1-mediated reduction in sprouting. One potential factor is semaphorin 3A (sema3A), which mediates growth cone collapse of CGRP-positive axons. Recent studies have shown that L1 is important in sema3A receptor signaling for cortical neurons. In our study, co-expression of sema3A indeed reduces neurite outgrowth from DRG neurons by about 40% on L1-expressing astrocytes. Based on these results, we hypothesize that overexpression of L1 potentiates sema3A signaling resulting in reduced sprouting.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Chaudhry N,de Silva U,Smith GMdoi
10.1016/j.expneurol.2006.06.001subject
Has Abstractpub_date
2006-11-01 00:00:00pages
238-49issue
1eissn
0014-4886issn
1090-2430pii
S0014-4886(06)00363-3journal_volume
202pub_type
杂志文章abstract：:Spinal lamina II, where nociceptive C-fibers terminate, expresses high amounts of the polysialylated form of neural cell adhesion molecule (PSA-NCAM). While enzymatic removal of the PSA moiety from NCAM did not affect normal sensitivity to thermal stimuli, it exacerbated nerve injury-induced neuropathic hyperalgesia. ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2011.12.017
更新日期：2012-02-01 00:00:00
abstract：:Nerve growth factor (NGF) is well known to be involved in the development, survival, and maintenance of sympathetic and neural crest-derived sensory neurons in the peripheral nervous system. Over the last 10-15 years, however, the role of NGF as a necessary trophic substrate for magnocellular cholinergic neurons in th...
journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1016/0014-4886(88)90231-2
更新日期：1988-12-01 00:00:00
abstract：:An electron microscope study of 2- and 8-week-old normal and dystrophic chickens compared sarcomere lengths in relaxed and passively extended Patagialis (PAT) muscles. Sarcomeres were measured in dystrophic muscles only in fibers which exhibited no morphological signs of degeneration. Sarcomere lengths were not differ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(88)90005-2
更新日期：1988-08-01 00:00:00
abstract：:We have analyzed the effects of environmental enrichment (EE) in a seizure-prone mouse model in which the genetic disruption of the presynaptic protein Bassoon leads to structural and functional alterations in the hippocampus and causes early spontaneous seizures mimicking human neurodevelopmental disorders. One-month...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2014.05.010
更新日期：2014-11-01 00:00:00
abstract：:Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by a progressive and extensive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) and their terminals in the striatum, which results in debilitating movement disorders. This devastating disease affects over 1 m...
journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1016/j.expneurol.2013.03.016
更新日期：2013-09-01 00:00:00
abstract：:Cerebral edema is a clinical problem that frequently follows ischemic infarcts. Sulfonylurea receptor 1 (SUR1) is an inducible protein that can form a heteromultimeric complex with aquaporin 4 (AQP4) that mediate the ion/water transport involved in brain tissue swelling. Transcription of the Abcc8 gene coding for SUR1...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2020.113353
更新日期：2020-08-01 00:00:00
abstract：:The effects of unilateral intrahippocampal injection of kainic acid, a potent neuroexcitant and neurotoxin, on subsequent susceptibility to kindling of the contralateral hippocampus or contralateral amygdala were investigated in albino rats. At the chosen doses (0.20 to 1.25 micrograms dissolved in physiologic saline)...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(87)90087-2
更新日期：1987-08-01 00:00:00
abstract：:Both alpha- and beta-adrenergic receptors (ARs) are involved in the facilitation of the monosynaptic jaw-closing reflex in the trigeminal motor nucleus (MoV) caused by norepinephrine (NE). The amplitude of muscle spindle afferent-evoked EPSPs in masseter motor neurons is 65% greater when noradrenergic axons to the mot...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(91)90038-e
更新日期：1991-11-01 00:00:00
abstract：:Injections of horseradish peroxidase were made into surgically exposed superior cervical ganglia of Sprague-Dawley rats weighing 250 to 320 g. Anterogradely labeled postganglionic fibers were observed in the nervus conarii, pineal gland, pineal stalk, and the choroid plexus. Terminal fields were identified in lamina i...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(87)90101-4
更新日期：1987-08-01 00:00:00
abstract：:The effects of superior cervical ganglion stimulation and the local application of norepinephrine or its antagonist propranolol were studied in 18 pineal cells. In 61% of the pineal cells, stimulation elicited excitation; the same cells also responded by excitation to norepinephrine ejection. When stimulation and nore...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(85)90149-9
更新日期：1985-12-01 00:00:00
abstract：:Contusive spinal cord injury (SCI) results in the formation of a chronic lesion cavity surrounded by a rim of spared fibers. Tissue bridges containing axons extend from the spared rim into the cavity dividing it into chambers. Whether descending axons can grow into these trabeculae or whether fibers within the trabecu...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2001.7734
更新日期：2001-09-01 00:00:00
abstract：:Previous studies have shown that traumatic brain injury (TBI) produces progressive degradation of cytoskeletal proteins including neurofilaments (e.g., neurofilament 68 [NF68] and neurofilament 200 [NF200]) within the first 24 h after injury. Thus, we employed immunofluorescence (light and confocal microscopy) to stud...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1999.7244
更新日期：2000-01-01 00:00:00
abstract：:Multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), an animal model of MS, are inflammatory demyelinating diseases of the central nervous system. The inflammatory attacks lead to glial dysfunction and death, axonal damage, and neurological deficits. Numerous studies in rat suggest that extrace...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2004.05.023
更新日期：2004-09-01 00:00:00
abstract：:Two neutral alpha-glucosidase isoenzymes were isolated from the muscle of Japanese quails with late-onset acid maltase deficiency. One isoenzyme is predominantly expressed in embryonic muscle and the other in adult muscle. The time of switching from one to the other of these two neutral alpha-glucosidases was the same...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(88)90117-3
更新日期：1988-05-01 00:00:00
abstract：:Using an approach that combines gene therapy with aromatic l-amino acid decarboxylase (AADC) gene and a pro-drug (l-dopa), dopamine, the neurotransmitter involved in Parkinson's disease, can be synthesized and regulated. Striatal neurons infected with the AADC gene by an adeno-associated viral vector can convert perip...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2000.7408
更新日期：2000-07-01 00:00:00
abstract：:Twenty-eight-day-old (juvenile) rats were kindled with hourly stimulations to partial or fully kindled status. Adult rats were stimulated with hourly or daily stimulations. Alterations in [3H]dihydroalprenolol binding were determined 3 weeks after the last stimulation. We found that partially kindled, hourly stimulate...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(87)90006-9
更新日期：1987-01-01 00:00:00
abstract：:The effects of neonatal 6-hydroxydopamine (6-OHDA) treatment on the projection of locus coeruleus (LC) neurons to the dorsal part of the lateral geniculate nucleus (dLGN) were examined using histofluorescence and electrophysiological methods. Histofluorescence studies confirmed the previous results of Gustafson and Mo...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(91)90128-y
更新日期：1991-06-01 00:00:00
abstract：:Interactions between neurotrophic factors and neurotransmitters participate in the formation and maintenance of appropriate connections, as well as in neurodegenerative processes. Here we have measured changes in the developmental expression pattern of BDNF and NT-3 in the striatum, cortex, and substantia nigra induce...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2000.7451
更新日期：2000-09-01 00:00:00
abstract：:The aim of the present study is to determine whether the expansion and mobilization of circulating bone marrow (BM) stem cells by in vivo treatment with granulocyte-colony stimulating factor (G-CSF) and stem cell factor (SCF) increase the amount of BM-derived neuronal cells in mouse brain. The presence of BM-derived c...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2002.8004
更新日期：2002-10-01 00:00:00
abstract：:Exogenously added gangliosides enhance sprouting, neurite outgrowth, and other neuronal activities; this effect may be initiated when a ganglioside binds to a membrane protein or when a ganglioside intercalates into the plasma membrane. To test whether binding to membrane proteins is sufficient for ganglioside-mediate...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1997.6459
更新日期：1997-05-01 00:00:00
abstract：:Adaptive responses in glutamate and opioid receptor systems in limbic circuits are emerging as a critical component of the neural plasticity induced by chronic use of abused substances. The present commentary reviews findings from neuroanatomical studies, with superior spatial resolution, that support a cellular basis...
journal_title：Experimental neurology
pub_type： 评论,杂志文章
doi：10.1016/j.expneurol.2011.03.016
更新日期：2011-06-01 00:00:00
abstract：:The success of peripheral nerve regeneration depends on intrinsic properties of neurons and a favorable environment, although the mechanisms underlying the molecular events during degeneration and regeneration are still not elucidated. Schwann cells are considered one of the best candidates to be closely involved in t...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2009.01.008
更新日期：2009-05-01 00:00:00
abstract：:Dorsal root ganglia (DRG) neuronopathy was induced in rats by chronic treatment (2 mg/kg twice a week for nine injections) with the antineoplastic drug cisplatin. Morphological alterations and changes in peptide [calcitonin gene-related peptide (CGRP), substance P, galanin (Gal), and somatostatin] concentration were s...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1996.0050
更新日期：1996-03-01 00:00:00
abstract：:The cortical reorganization after spinal cord injury (SCI) involves a series of physiological changes that drive the expansion of the intact cortical area to the deafferented cortical area. These changes have always been studied under a stimulus-response paradigm, which demonstrates that the deafferented cortex become...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2019.113035
更新日期：2019-12-01 00:00:00
abstract：:Phenytoin is known to reduce neural overactivity (pseudomyotonia) affecting the hind limb musculature in C57B1/6J dystrophic (dy2J/dy2J) mice. This study reports a change in the metabolic profile of superficial gastrocnemius muscle fibers from dy2J/dy2J animals after chronic phenytoin treatment. The superficial gastro...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(84)90011-6
更新日期：1984-04-01 00:00:00
abstract：:Several mutations in transthyretin (TTR) are related to familial amyloidotic polyneuropathy (FAP), a neurodegenerative disorder caused by extracellular deposition of TTR fibrils, particularly in the peripheral nervous system (PNS). TTR is mainly synthesized by the liver and choroid plexus of the brain that contribute ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2008.08.019
更新日期：2008-12-01 00:00:00
abstract：:Triggering receptor expressed on myeloid cells-2 (TREM2) was a newly identified receptor expressed on microglia. Several observations support the hypothesis that TREM2 variation may confer susceptibility to Parkinson's disease (PD). Therefore, in this paper, we explored the role of TREM2 in the 1-methyl-4-phenyl-1,2,3...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2018.01.016
更新日期：2018-04-01 00:00:00
abstract：:Spasticity is a condition that can include increased muscle tone, clonus, spasms, and hyperreflexia. In this study, we report the effect of manually stimulating the dorsal lumbosacral skin on spontaneous locomotor-like activity and on a variety of reflex responses in 5 decerebrate chronic spinal cats treated with clon...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2012.03.013
更新日期：2012-06-01 00:00:00
abstract：:Previously injured dorsal roots were electrically stimulated to determine if regenerating sensory axons can form physiologically active synaptic contacts with neurons within fetal spinal cord tissue transplants. Dorsal rootlets, sectioned at their spinal cord entry zone, were apposed to intraspinal transplants of feta...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1996.0101
更新日期：1996-06-01 00:00:00
abstract：:Urethane-induced cortical slow wave activity (SWA) spreads into the basal ganglia in dopamine (DA)-depleted rat models of Parkinson's disease (PD). During physiological sleep, SWA is powerfully expressed at the beginning of night and progressively reduced during sleep-time reflecting the sleep need. However, its under...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2017.12.004
更新日期：2018-03-01 00:00:00
