Interaction of norepinephrine and superior cervical ganglion input in the rat pineal body.


:The effects of superior cervical ganglion stimulation and the local application of norepinephrine or its antagonist propranolol were studied in 18 pineal cells. In 61% of the pineal cells, stimulation elicited excitation; the same cells also responded by excitation to norepinephrine ejection. When stimulation and norepinephrine ejection were applied together, summation (of the excitation) was observed in these cells. Several cells that failed to respond to stimulation did respond to norepinephrine ejection, but with the opposite pattern, i.e., decrease of firing rates. Propranolol prevented the norepinephrine-induced excitation and inhibition, as well as the excitation produced by stimulation. We suggest that norepinephrine regulates pineal activity by two routes: activation of the sympathetic neuronal input and inhibition by way of the circulation.


Exp Neurol


Experimental neurology


Reyes-Vazquez C,Dafny N




Has Abstract


1985-12-01 00:00:00












  • An example of neural plasticity evoked by putative behavioral demand and early use of vibrissal hairs after facial nerve transection.

    abstract::Abnormally associated movements inevitably occur after surgical repair of the facial nerve. The reason for this postparalytic syndrome is poor navigation of regrowing axons. Despite the valuable functional advantage provided by the easily detected movement of vibrissae in rats, the major investigative tools for establ...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Tomov TL,Guntinas-Lichius O,Grosheva M,Streppel M,Schraermeyer U,Neiss WF,Angelov DN

    更新日期:2002-12-01 00:00:00

  • Ca2+ capacity and uptake rate in skinned fibers of myodystrophic muscle.

    abstract::Parameters related to the capacity and the rate of uptake of calcium ions by the sarcoplasmic reticulum were measured in skinned extensor digitorum longus fibers of control and myodystrophic mice. Single fibers were isolated and skinned in a relaxing solution and mounted on a force transducer and apparatus for changin...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Mobley BA

    更新日期:1985-01-01 00:00:00

  • Primary afferent plasticity following deafferentation of the trigeminal brainstem nuclei in the adult rat.

    abstract::Alpha-tyrosinated tubulin is a cytoskeletal protein that is involved in axonal growth and is considered a marker of neuronal plasticity in adult mammals. In adult rats, unilateral ablation of the left facial sensorimotor cortical areas induces degeneration of corticotrigeminal projections and marked denervation of the...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: De Riu PL,Russo A,Pellitteri R,Stanzani S,Tringali G,Roccazzello AM,De Riu G,Marongiu P,Mameli O

    更新日期:2008-09-01 00:00:00

  • Quantitative assessment of phrenic nerve functional recovery mediated by the crossed phrenic reflex at various time intervals after spinal cord injury.

    abstract::The present study was carried out to determine if augmentation of phrenic nerve activity during the crossed phrenic phenomenon temporally coincides with the morphological changes in the phrenic nucleus that we have observed in previous studies. This investigation consisted of two experiments in spinal cord hemisected ...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: O'Hara TE Jr,Goshgarian HG

    更新日期:1991-02-01 00:00:00

  • Spatial diversity of blood-brain barrier alteration and macrophage invasion in experimental autoimmune encephalomyelitis: a comparative MRI study.

    abstract::Inflammation plays a central role in the development of numerous disorders of the central nervous system (CNS) such as multiple sclerosis (MS). For a long time it was assumed that recruitment of macrophages into the CNS and breakdown of the blood-brain barrier (BBB) are closely linked. In the present study we challeng...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Ladewig G,Jestaedt L,Misselwitz B,Solymosi L,Toyka K,Bendszus M,Stoll G

    更新日期:2009-11-01 00:00:00

  • Nerve injury-induced mechanical but not thermal hyperalgesia is attenuated in neurokinin-1 receptor knockout mice.

    abstract::Mice lacking the gene encoding for substance P and neurokinin A, or the NK-1 receptor, exhibit alterations in behavior to various acute nociceptive stimuli. However, behavioral responses of NK-1 mutant animals have not been well characterized in models of chronic pain. We studied the behavioral responses of NK-1 knock...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Mansikka H,Sheth RN,DeVries C,Lee H,Winchurch R,Raja SN

    更新日期:2000-04-01 00:00:00

  • Gene expression profiling in a mouse model of Dravet syndrome.

    abstract::Dravet syndrome is a severe, early-onset epileptic encephalopathy frequently resulting from de novo mutations of SCN1A. Mice with heterozygous deletion of Scn1a (Scn1a+/-) model many features of Dravet syndrome, including spontaneous seizures and premature lethality. Scn1a+/- mice exhibit variable phenotype penetrance...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Hawkins NA,Calhoun JD,Huffman AM,Kearney JA

    更新日期:2019-01-01 00:00:00

  • The effects of sympathetic outflow on upregulation of vanilloid receptors TRPV(1) in primary afferent neurons evoked by intradermal capsaicin.

    abstract::The vanilloid receptor TRPV(1) is a key nociceptive molecule located in primary afferent nociceptive neurons in dorsal root ganglia (DRG) for initiating neurogenic inflammation and pain. Our recent study demonstrates that up-regulation of TRPV(1) receptors by intradermal injection of capsaicin is modulated by activati...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Xu X,Wang P,Zou X,Li D,Fang L,Gong K,Lin Q

    更新日期:2010-03-01 00:00:00

  • A search for brain damage in a rat model of alcoholic sleep apnea.

    abstract::To determine whether or not brain damage is likely to occur in the repeated apneic episodes experienced by some alcoholics during intoxicated sleep, rats were anesthetized with alcohol and subjected to repeated episodes to asphyxia. Each episode lasted 90 s, arterial PO2 was less than 50 mm Hg for 60 s, and 30 episode...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Cragg B,Phillips S

    更新日期:1984-04-01 00:00:00

  • Activation of GABAA receptors controls mesiotemporal lobe epilepsy despite changes in chloride transporters expression: In vivo and in silico approach.

    abstract::Mesiotemporal lobe Epilepsy (MTLE), the most frequent form of focal epilepsy, is often drug-resistant. Enriching the epileptic focus with GABA-releasing engineered cells has been proposed as a strategy to prevent seizures. However, ex vivo data from animal models and MTLE patients suggest that, due to changes in chlor...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Stamboulian-Platel S,Legendre A,Chabrol T,Platel JC,Pernot F,Duveau V,Roucard C,Baudry M,Depaulis A

    更新日期:2016-10-01 00:00:00

  • Bilateral effects of unilateral GDNF administration on dopamine- and GABA-regulating proteins in the rat nigrostriatal system.

    abstract::Dopamine (DA) affects GABA neuronal function in the striatum and together these neurotransmitters play a large role in locomotor function. We recently reported that unilateral striatal administration of GDNF, a growth factor that has neurotrophic effects on DA neurons and enhances DA release, bilaterally increased str...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Salvatore MF,Gerhardt GA,Dayton RD,Klein RL,Stanford JA

    更新日期:2009-09-01 00:00:00

  • Motor and somatosensory deficits following uni- and bilateral lesions of the cortex induced by aspiration or thermocoagulation in the adult rat.

    abstract::We have previously shown that lesions of the sensorimotor cortex induced by either thermocoagulation or aspiration produce different effects on axonal plasticity. We have now investigated whether these methods of lesion also influence the behavioral outcome. The behavioral effects of unilateral and bilateral lesions o...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Napieralski JA,Banks RJ,Chesselet MF

    更新日期:1998-11-01 00:00:00

  • Peripheral nerve pathology following sciatic cryoneurolysis: relationship to neuropathic behaviors in the rat.

    abstract::Sciatic cryoneurolysis (SCN) is an experimental rat mononeuropathy model that produces neuropathic behavioral sequelae distinct from other neuropathy models. Following SCN, there is limited autotomy peaking in severity and incidence at 7-14 days and delayed but sustained allodynia appearing at about 21 days, with no e...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Wagner R,DeLeo JA,Heckman HM,Myers RR

    更新日期:1995-06-01 00:00:00

  • Plasma alpha-synuclein is decreased in subjects with Parkinson's disease.

    abstract::Alpha-synuclein (alphaSN) is implicated in Parkinson's disease (PD) and is the major component of Lewy bodies (LBs). Although alphaSN is mainly expressed in neuronal cells and exists as a cytoplasmic protein, it has been found in body fluids including cerebrospinal fluid and blood. This study explored plasma alphaSN a...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Li QX,Mok SS,Laughton KM,McLean CA,Cappai R,Masters CL,Culvenor JG,Horne MK

    更新日期:2007-04-01 00:00:00

  • C-type natriuretic peptide functions as an innate neuroprotectant in neonatal hypoxic-ischemic brain injury in mouse via natriuretic peptide receptor 2.

    abstract::Neonatal hypoxia-ischemia (HI) is the most common cause of brain injury in neonates, which leads to high neonatal mortality and severe neurological morbidity in later life (Vannucci, 2000; Volpe, 2001). Yet the molecular mechanisms of neuronal death and brain damage induced by neonatal HI remain largely elusive. Herei...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Ma Q,Zhang L

    更新日期:2018-06-01 00:00:00

  • Enhanced axonal regeneration following combined demyelination plus schwann cell transplantation therapy in the injured adult spinal cord.

    abstract::We have treated spinal cord injured rats with demyelination plus Schwann cell transplantation and assessed neurite outgrowth in a quantifiable model of axonal regeneration. Axonal injuries of differing severity were induced in the dorsal funiculus of adult rats using a micromanipulator-controlled Scouten knife. Demyel...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Keirstead HS,Morgan SV,Wilby MJ,Fawcett JW

    更新日期:1999-09-01 00:00:00

  • Acute excitotoxic injury induces expression of monocyte chemoattractant protein-1 and its receptor, CCR2, in neonatal rat brain.

    abstract::Chemokines are a family of structurally related cytokines that activate and recruit leukocytes into areas of inflammation. The "CC" chemokine, monocyte chemoattractant protein (MCP)-1 may regulate the microglia/monocyte response to acute brain injury. Recent studies have documented increased expression of MCP-1 in div...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Galasso JM,Miller MJ,Cowell RM,Harrison JK,Warren JS,Silverstein FS

    更新日期:2000-10-01 00:00:00

  • Using routine MRI data of depressed patients to predict individual responses to electroconvulsive therapy.

    abstract::Electroconvulsive therapy (ECT) is one of the most effective treatments in cases of severe and treatment resistant major depression. 60-80% of patients respond to ECT, but the procedure is demanding and robust prediction of ECT responses would be of great clinical value. Predictions based on neuroimaging data have rec...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Gärtner M,Ghisu E,Herrera-Melendez AL,Koslowski M,Aust S,Asbach P,Otte C,Regen F,Heuser I,Borgwardt K,Grimm S,Bajbouj M

    更新日期:2021-01-01 00:00:00

  • Expression of the type 1 and type 2 receptors for tumor necrosis factor after traumatic spinal cord injury in adult rats.

    abstract::Posttraumatic inflammation has been implicated in secondary tissue damage after spinal cord injury (SCI). Tumor necrosis factor-alpha (TNF-alpha) is a key inflammatory mediator that is increasingly expressed after SCI. The effect of TNF-alpha is mediated through its receptors TNFR1 (p55) and TNFR2 (p75). However, whet...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Yan P,Liu N,Kim GM,Xu J,Xu J,Li Q,Hsu CY,Xu XM

    更新日期:2003-10-01 00:00:00

  • The antidepressant sertraline improves the phenotype, promotes neurogenesis and increases BDNF levels in the R6/2 Huntington's disease mouse model.

    abstract::Huntington's disease (HD) is an inherited progressive neurodegenerative disorder characterized by progressive movement, psychiatric and cognitive disturbances. Previous studies have indicated that HD pathogenesis may be mediated in part by loss of brain derived neurotrophic factor (BDNF). Antidepressants selectively b...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Peng Q,Masuda N,Jiang M,Li Q,Zhao M,Ross CA,Duan W

    更新日期:2008-03-01 00:00:00

  • Identification of novel genes regulated in the developing human ventral mesencephalon.

    abstract::In the human embryo, from approximately 6 weeks gestational age (GA), dopaminergic (DA) neurons can be found in the ventral mesencephalon (VM). More specifically, the post-mitotic neurons are located in the ventral part of the tegmentum (VT), whereas no mature DA neurons are found in the neighboring dorsal part. We us...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Jørgensen JR,Juliusson B,Henriksen KF,Hansen C,Knudsen S,Petersen TN,Blom N,Seiger A,Wahlberg LU

    更新日期:2006-04-01 00:00:00

  • Nerve regeneration through biodegradable polyester tubes.

    abstract::One approach to repair of transected nerves is to attempt extrinsic guidance of axons across the gaps. We inserted the proximal and distal stumps of severed mouse sciatic nerves into opposite ends of biodegradable polyester tubes. The nerves and ensheathing tubes were examined after postoperative survival times of as ...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Henry EW,Chiu TH,Nyilas E,Brushart TM,Dikkes P,Sidman RL

    更新日期:1985-12-01 00:00:00

  • Influence of early life status epilepticus on the developmental expression profile of the GluA2 subunit of AMPA receptors.

    abstract::AMPA receptors (AMPARs) are responsible for fast excitatory neurotransmission, and their prolonged activation can result in the generation and spread of epileptic seizures. At early stages of postnatal development, the majority of AMPARs are permeable to both Na(+) and Ca(2+) ions. This permeability, which increases n...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Szczurowska E,Ergang P,Kubová H,Druga R,Salaj M,Mareš P

    更新日期:2016-09-01 00:00:00

  • Positively reinforcing effects of the neurokinin substance P in the basal forebrain: mediation by its C-terminal sequence.

    abstract::The conditioned corral preference paradigm was used to assess reinforcing effects of substance P (SP) and its N- and C-terminal fragments injected unilaterally into the region of the nucleus basalis magnocellularis (NBM) in rats. Behavioral testing was carried out in a circular open field, consisting of 4 quadrants eq...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Hasenöhrl RU,Gerhardt P,Huston JP

    更新日期:1992-02-01 00:00:00

  • Evidence that oxidative stress is associated with the pathophysiology of inherited hydrocephalus in the H-Tx rat model.

    abstract::Oxidative stress can contribute to many neurological disease processes. Because many events known to involve oxidative stress (infection, hemorrhage, brain trauma) are accompanied by hydrocephalus, the present study sought to evaluate the relationship between oxidative stress and the progression of hydrocephalus. Assa...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Socci DJ,Bjugstad KB,Jones HC,Pattisapu JV,Arendash GW

    更新日期:1999-01-01 00:00:00

  • ATP receptors gate microglia signaling in neuropathic pain.

    abstract::Microglia were described by Pio del Rio-Hortega (1932) as being the 'third element' distinct from neurons and astrocytes. Decades after this observation, the function and even the very existence of microglia as a distinct cell type were topics of intense debate and conjecture. However, considerable advances have been ...

    journal_title:Experimental neurology

    pub_type: 杂志文章,评审


    authors: Trang T,Beggs S,Salter MW

    更新日期:2012-04-01 00:00:00

  • Dopamine release rather than content in the caudate putamen is associated with behavioral changes in the iron rat model of Parkinson's disease.

    abstract::The effects of intranigral iron injection on dopamine (DA) release and content in the caudate putamen (CPu) and their relationship to DA-related behavioral response were investigated in rats. Different concentrations of FeCl(3) (10, 20, and 40 microg) and saline were injected separately into the left substantia nigra....

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Junxia X,Hong J,Wenfang C,Ming Q

    更新日期:2003-08-01 00:00:00

  • Drug/nutrition interaction in the developing brain: dipyrone enhances spreading depression in rats.

    abstract::The abuse of pharmaceutical drugs and the inadequate ingestion of nutrients constitute external factors that can alter brain development, both individually and in combination. We used cortical spreading depression (CSD) as a neurophysiological parameter to investigate the combined effects of the antipyretic/analgesic/...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: do Amaral AP,Barbosa MS,de Souza VC,Ramos IL,Guedes RC

    更新日期:2009-10-01 00:00:00

  • Human nasal olfactory epithelium as a dynamic marker for CNS therapy development.

    abstract::Discovery of new central nervous system (CNS) acting therapeutics has been slowed down by the lack of useful applicable biomarkers of disease or drug action often due to inaccessibility of relevant human CNS tissue and cell types. In recent years, non-neuronal cells, such as astrocytes, have been reported to play a hi...

    journal_title:Experimental neurology

    pub_type: 临床试验,杂志文章


    authors: Sattler R,Ayukawa Y,Coddington L,Sawa A,Block D,Chipkin R,Rothstein JD

    更新日期:2011-12-01 00:00:00

  • Characterization of histaminergic H3 receptors in intraocular tuberomammillary transplants containing histaminergic neurons.

    abstract::This study was performed to investigate the physicological properties of histaminergic neurons in intraocular hypothalamic transplants. Pieces of posterolateral hypothalamus containing the tuberomammillary nucleus were dissected from Embryonic Day 17 rat fetuses and transplanted into the anterior chamber of the eye of...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Bergman H,Prell GD,Lupica CR,Granholm AC

    更新日期:1995-11-01 00:00:00