Muscle-conditioned media and cAMP promote survival and neurite outgrowth of adult spinal cord motor neurons.

abstract：:Previously injured dorsal roots were electrically stimulated to determine if regenerating sensory axons can form physiologically active synaptic contacts with neurons within fetal spinal cord tissue transplants. Dorsal rootlets, sectioned at their spinal cord entry zone, were apposed to intraspinal transplants of feta...

journal_title：Experimental neurology

authors： Houle JD,Skinner RD,Garcia-Rill E,Turner KL

更新日期：1996-06-01 00:00:00

abstract：:Rats with precollicular transections leaving the brain stem intact were subjected to electroshock or pentylenetetrazol-induced convulsions. Animals with transections failed to display the face and forelimb clonus (with or without rearing) typically seen in sham-operated rats subjected to pentylenetetrazol- or minimal ...

journal_title：Experimental neurology

authors： Browning RA,Nelson DK

更新日期：1986-09-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is an adult-onset, fatal neurodegenerative syndrome characterized by the systemic loss of motor neurons with prominent astrocytosis and microgliosis in the spinal cord and brain. Astrocytes play an essential role in maintaining extracellular microenvironments that surround motor neu...

journal_title：Experimental neurology

authors： Shijo T,Warita H,Suzuki N,Ikeda K,Mitsuzawa S,Akiyama T,Ono H,Nishiyama A,Izumi R,Kitajima Y,Aoki M

更新日期：2018-09-01 00:00:00

abstract：:Peripheral nerves have the unique capability to regenerate after injury. Insights into regeneration of peripheral nerves after injury may have implications for neurodegenerative diseases of the nervous system. In this study, we analyzed the expression and function of desmoplakin in peripheral nerve regeneration. Desmo...

journal_title：Experimental neurology

authors： Gess B,Röhr D,Lange E,Halfter H,Young P

更新日期：2015-02-01 00:00:00

abstract：:Rats were treated with single subcutaneous injections of the irreversible AChE inhibitors, sarin (90 to 100 micrograms/kg) or soman (55 micrograms/kg), and with chronic doses of the reversible carbamate inhibitor, pyridostigmine. In surviving animals with severe behavioral symptoms, we examined the end-plate regions o...

journal_title：Experimental neurology

authors： Meshul CK,Boyne AF,Deshpande SS,Albuquerque EX

更新日期：1985-07-01 00:00:00

abstract：:As part of a wider investigation on brain structure and function in young rats with inherited hydrocephalus, this study was undertaken to develop a technique to monitor, and quantify, progressive changes in ventricle and cortical dimensions in hydrocephalic rats in vivo. Magnetic resonance images were obtained with a ...

journal_title：Experimental neurology

authors： Harris NG,Jones HC,Williams SC

更新日期：1992-10-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) plays an essential role in sensory neuronal activation in response to visceral inflammation. Here we report that BDNF up-regulation in the primary afferent neurons in the dorsal root ganglia (DRG) in a rat model of colitis is mediated by the activation of endogenous extracellul...

journal_title：Experimental neurology

authors： Yu SJ,Grider JR,Gulick MA,Xia CM,Shen S,Qiao LY

更新日期：2012-12-01 00:00:00

abstract：:Hamsters were inoculated intracerebrally with the agent of transmissible mink encephalopathy and developed clerical signs of encephalopathy. Photoreceptor degeneration occurred in all animals examined histologically. The changes were similar to those in scrapie, although less extensive. The findings suggest that eithe...

journal_title：Experimental neurology

authors： Buyukmihci NC,Goehring-Harmon F,Marsh RF

更新日期：1987-06-01 00:00:00

abstract：:Systemic administration of kainic acid (12 mg/kg, i.p.), causing the established epileptic syndrome and the associated specific pattern of limbic nerve cell loss, led to substantial time-dependent increases in the brain metabolism of the endogenous excitotoxin, quinolinic acid. These changes preferentially affected bi...

journal_title：Experimental neurology

authors： Speciale C,Schwarcz R

更新日期：1988-01-01 00:00:00

abstract：:Long-term levodopa or dopamine agonist treatment in the MPTP-lesioned primate model of Parkinson's disease elicits dyskinesia, which is phenotypically similar to levodopa-induced dyskinesia in patients with Parkinson's disease. AMPA receptor antagonists have previously been shown to have both anti-parkinsonian and ant...

journal_title：Experimental neurology

authors： Silverdale MA,Crossman AR,Brotchie JM

更新日期：2002-03-01 00:00:00

abstract：:Mice genetically deficient in growth hormone were compared with normal littermates for evidence of altered neuronal development. In the lit/lit motor cortex, area 6 of Caviness, cell number, stratification of neurons, and the proportionate layer widths were identical to those of the controls (lit/+). Examined by the G...

journal_title：Experimental neurology

authors： Noguchi T,Sugisaki T

更新日期：1985-07-01 00:00:00

abstract：:The ST14A cell line was previously derived from embryonic day 14 rat striatal primordia by retroviral transduction of the temperature-sensitive SV40 large T antigen. We showed that cell division and expression of nestin persists at 33 degrees C, the permissive temperature, whereas cell division ceases, nestin expressi...

journal_title：Experimental neurology

authors： Ehrlich ME,Conti L,Toselli M,Taglietti L,Fiorillo E,Taglietti V,Ivkovic S,Guinea B,Tranberg A,Sipione S,Rigamonti D,Cattaneo E

更新日期：2001-02-01 00:00:00

abstract：:Stroke causes CNS injury associated with strong fast microglial activation as part of the inflammatory response. In rat models of stroke, sulphonylurea receptor blockade with glibenclamide reduced cerebral edema and infarct volume. We postulated that glibenclamide administered during the early stages of stroke might f...

journal_title：Experimental neurology

authors： Ortega FJ,Gimeno-Bayon J,Espinosa-Parrilla JF,Carrasco JL,Batlle M,Pugliese M,Mahy N,Rodríguez MJ

更新日期：2012-05-01 00:00:00

abstract：:We compared mitochondrial respiratory chain function, mitochondrial DNA (mtDNA) integrity, and oxidative stress levels in muscle, myoblasts, fibroblasts and cybrids, from 12 amyotrophic lateral sclerosis (ALS) patients with 28 control samples. Mitochondrial respiratory chain enzyme activities were normal in muscle, my...

journal_title：Experimental neurology

authors： Bradley LJ,Taanman JW,Kallis C,Orrell RW

更新日期：2009-07-01 00:00:00

abstract：:Our primary aim was to determine if there exists a preferential involvement of the fast-twitch or slow-twitch skeletal muscle fibers in the dy2J/dy2J strain of murine dystrophy. The changes in the contractile properties of the slow-twitch soleus (SOL) and the fast-twitch extensor digitorum longus (EDL) muscles of norm...

journal_title：Experimental neurology

authors： Bressler BH,Jasch LG,Ovalle WK,Slonecker CE

更新日期：1983-05-01 00:00:00

abstract：:The members of the tenascin family are involved in a number of developmental processes, mainly by their ability to regulate cell adhesion. We have here studied the distribution of mRNAs for tenascin-X, -C, and -R and the closely related molecule tenascin/J1 in the olfactory system and spinal cord. The olfactory bulb a...

journal_title：Experimental neurology

authors： Deckner M,Lindholm T,Cullheim S,Risling M

更新日期：2000-12-01 00:00:00

abstract：:Astrocytes are relatively resistant to injury compared to neurons and oligodendrocytes. Here, we report transient region-specific loss of astrocytes in mice early after pilocarpine-induced status epilepticus (SE). In the dentate hilus, immunoreactivity for glial acidic fibrillary protein (GFAP) was decreased, and the ...

journal_title：Experimental neurology

authors： Borges K,McDermott D,Irier H,Smith Y,Dingledine R

更新日期：2006-10-01 00:00:00

abstract：:The success of peripheral nerve regeneration depends on intrinsic properties of neurons and a favorable environment, although the mechanisms underlying the molecular events during degeneration and regeneration are still not elucidated. Schwann cells are considered one of the best candidates to be closely involved in t...

journal_title：Experimental neurology

authors： Narciso MS,Mietto Bde S,Marques SA,Soares CP,Mermelstein Cdos S,El-Cheikh MC,Martinez AM

更新日期：2009-05-01 00:00:00

abstract：:Altered activity in one of the output nuclei of the basal ganglia, the internal segment of the globus pallidus, is known to play an important role in the generation of parkinsonism. These inactivation studies tested the hypothesis that altered activity in the second major output nucleus of the basal ganglia, the subst...

journal_title：Experimental neurology

authors： Wichmann T,Kliem MA,DeLong MR

更新日期：2001-02-01 00:00:00

abstract：:The tendency of a rat to approach the wall of an open-field and to travel along the perimeter of the field (termed as "peritaxis" or "wall-facing") is affected by unilateral removal of the vibrissae. Peritaxis is lateralized by hemivibrissotomy. The finding that the dopamine agonist apomorphine reversed the direction ...

journal_title：Experimental neurology

authors： Steiner H,Bonatz AE,Huston JP,Schwarting R

更新日期：1988-03-01 00:00:00

abstract：:We provide evidence for apoptosis in Alzheimer's disease using the in situ labeling technique TUNEL (terminal transferase-mediated dUTP-biotin nick end labeling). The technique specifically detects apoptotic cells by utilizing terminal transferase to incorporate biotinylated nucleotides into the fragmented DNA of apop...

journal_title：Experimental neurology

authors： Smale G,Nichols NR,Brady DR,Finch CE,Horton WE Jr

更新日期：1995-06-01 00:00:00

abstract：:Ischemic stroke is a devastating brain injury and an important cause of neurologic disability worldwide and across the lifespan. Despite the physical, social, and economic burdens of this disease there is only a single approved medicine for the treatment of acute stroke, and its use is unfortunately limited to the sma...

journal_title：Experimental neurology

authors： Felling RJ,Song H

更新日期：2015-06-01 00:00:00

abstract：:Blood flow in the feline thoracic spinal cord was measured, using a laser-Doppler flowmetry. Rhythmic changes in the spinal cord blood flow were repeatedly observed with a frequency of about three to eight cycles per minute, unrelated to the respiratory or cardiac cycles. These changes were unaffected by hypertension ...

journal_title：Experimental neurology

authors： Mizutani M,Yamamuro T,Shikata J

更新日期：1988-08-01 00:00:00

abstract：:Purkinje neurons are a sensitive and specialised cell type important for fine motor movement and coordination. Purkinje cell damage manifests as motor incoordination and ataxia - a prominent feature of many human disorders including spinocerebellar ataxia and Huntington's disease. A correlation between Purkinje degene...

journal_title：Experimental neurology

authors： Cops EJ,Sashindranath M,Daglas M,Short KM,da Fonseca Pereira C,Pang TY,Lijnen RH,Smyth IM,Hannan AJ,Samson AL,Medcalf RL

更新日期：2013-11-01 00:00:00

abstract：:Adult cats were subjected to subarachnoid hemorrhage by three repeated intracisternal injections of autogenous nonheparinized blood (2 ml/injection) at weekly intervals. Histological studies (light and electron microscope) were made of the basilar artery and the middle cerebral arteries of all animals. In the subarach...

journal_title：Experimental neurology

authors： Clower BR,Kapp JP,Moore NA,Smith RR,Haining JL

更新日期：1986-11-01 00:00:00

abstract：:The regional cerebral blood flow of 27 young (mean age 24 years) schizophrenic patients was measured using the intravenous 133Xe method. The results were compared with those obtained from a group of age- and sex-matched control subjects. The main findings of the study were as follows: (a) the gray matter mean values o...

journal_title：Experimental neurology

authors： Dousse M,Mamo H,Ponsin JC,Tran Dinh Y

更新日期：1988-04-01 00:00:00

abstract：:delta-Aminolevulinic acid (ALA), a toxic precursor of porphyrin, when injected i.v. failed to enter most brain structures, such as the cortex, thalamus, midbrain, and others, as determined by the autoradiographic technique. However, the choroid plexus, median eminence, and a narrow strip of the periventricular zone, w...

journal_title：Experimental neurology

authors： Terr L,Weiner LP

更新日期：1983-02-01 00:00:00

abstract：:It has been reported that the severe cerebral edema produced in experimental animals by Clostridium perfringens (Cl p) type D epsilon toxin can be prevented by prior treatment with its precursor prototoxin due to competitive binding to endothelial cells (ECs) at the blood-brain barrier (BBB). In this study we investig...

journal_title：Experimental neurology

authors： Zhu C,Ghabriel MN,Blumbergs PC,Reilly PL,Manavis J,Youssef J,Hatami S,Finnie JW

更新日期：2001-05-01 00:00:00

abstract：:Rats typically display self-mutilation (autotomy) of a paw that has been denervated by transection of the sciatic and saphenous nerves. The cause of autotomy, however, is not known. It may be due to hyperesthesia (comparable to that seen in humans after peripheral nerve injury) or anesthesia (as an attempt to shed an ...

journal_title：Experimental neurology

authors： Coderre TJ,Melzack R

更新日期：1986-06-01 00:00:00

abstract：:Oxaliplatin (OXA) is the common and extremely potent anti-advanced colorectal cancer chemotherapeutic. Accumulating evidence reveals that OXA evokes mechanical and cold hypersensitivity. However, the mechanism underlying these bothersome and dose-limiting adverse effects is poorly understood. It is well known that cyc...

journal_title：Experimental neurology

authors： Jiang SP,Zhang ZD,Kang LM,Wang QH,Zhang L,Chen HP

更新日期：2016-01-01 00:00:00