Abstract:
:We evaluated the effects of allogeneic bone marrow stromal cell treatment of stroke on functional outcome, glial-axonal architecture, and immune reaction. Female Wistar rats were subjected to 2 h of middle cerebral artery occlusion. Rats were injected intravenously with PBS, male allogeneic ACI--or syngeneic Wistar--bone marrow stromal cells at 24 h after ischemia and sacrificed at 28 days. Significant functional recovery was found in both cell-treated groups compared to stroke rats that did not receive BMSCs, but no difference was detected between allogeneic and syngeneic cell-treated rats. No evidence of T cell priming or humoral antibody production to marrow stromal cells was found in recipient rats after treatment with allogeneic cells. Similar numbers of Y-chromosome+ cells were detected in the female rat brains in both groups. Significantly increased thickness of individual axons and myelin, and areas of the corpus callosum and the numbers of white matter bundles in the striatum were detected in the ischemic boundary zone of cell-treated rats compared to stroked rats. The areas of the contralateral corpus callosum significantly increased after cell treatment compared to normal rats. Processes of astrocytes remodeled from hypertrophic star-like to tadpole-like shape and oriented parallel to the ischemic regions after cell treatment. Axonal projections emanating from individual parenchymal neurons exhibited an overall orientation parallel to elongated radial processes of reactive astrocytes of the cell-treated rats. Allogeneic and syngeneic bone marrow stromal cell treatment after stroke in rats improved neurological recovery and enhanced reactive oligodendrocyte and astrocyte related axonal remodeling with no indication of immunologic sensitization in adult rat brain.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Li Y,McIntosh K,Chen J,Zhang C,Gao Q,Borneman J,Raginski K,Mitchell J,Shen L,Zhang J,Lu D,Chopp Mdoi
10.1016/j.expneurol.2005.11.029keywords:
subject
Has Abstractpub_date
2006-04-01 00:00:00pages
313-25issue
2eissn
0014-4886issn
1090-2430pii
S0014-4886(05)00430-9journal_volume
198pub_type
杂志文章abstract::The cascade of events leading to post-traumatic epilepsy (PTE) after traumatic brain injury (TBI) remains unclear. Altered inhibition in the hippocampal formation and dentate gyrus is a hallmark of several neurological disorders, including TBI and PTE. Inhibitory synaptic signaling in the hippocampus is predominately ...
journal_title:Experimental neurology
pub_type: 杂志文章
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abstract::Acute exposure of peripheral axons to the free radical Nitric Oxide (NO) may trigger conduction block and, if prolonged, Wallerian degeneration. It was hypothesized that this neurotoxic effect of NO may be due primarily to energy restriction by inhibition of mitochondrial respiration. We compared the neurotoxic effect...
journal_title:Experimental neurology
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abstract::Increasing evidence indicates that the cytokines, tumor necrosis factor (TNF), interleukin-1, and/or interferon-gamma, may play a crucial role in the pathogenesis of multiple sclerosis. Several reports demonstrated that inhibition of TNF is highly protective in experimental allergic encephalomyelitis (EAE) when sensit...
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journal_title:Experimental neurology
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doi:10.1006/exnr.2000.7543
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journal_title:Experimental neurology
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doi:10.1006/exnr.1998.6857
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2003.12.012
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journal_title:Experimental neurology
pub_type: 杂志文章
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2012.04.006
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1998.6832
更新日期:1998-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0014-4886(83)90229-7
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1993.1021
更新日期:1993-02-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2008.09.018
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journal_title:Experimental neurology
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abstract::The beta-Amyloid peptide (A beta) is hypothesized to mediate the neurodegeneration seen in Alzheimer's disease. Recently, we proposed a new hypothesis to explain the toxicity of A beta based on the free-radical generating capacity of A beta. We have recently demonstrated using electron paramagnetic resonance (EPR) spe...
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journal_title:Experimental neurology
pub_type: 杂志文章
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更新日期:2018-04-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
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更新日期:2012-10-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2004.09.009
更新日期:2005-01-01 00:00:00
abstract::Electrical stimulation of the midbrain tegmentum can produce differential modulation of quiet biting attack and affective defense behavior elicited from the hypothalamus of the cat. Stimulation of the lateral half of the tegmentum facilitated quiet biting attack and suppressed affective defense. Conversely, stimulatio...
journal_title:Experimental neurology
pub_type: 杂志文章
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更新日期:1984-02-01 00:00:00
abstract::We previously reported that 1 month following unilateral loss (>95%) of striatal dopamine, there is an increase in striatal glutamate function as measured by in vivo microdialysis and quantitative immuno-gold electron microscopy, Neuroscience 88, 1-16). The goal of this study was to determine the effect of bilateral l...
journal_title:Experimental neurology
pub_type: 杂志文章
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更新日期:2003-03-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章,评审
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更新日期:2018-01-01 00:00:00
abstract::RNA interference appears to have a great potential not only as an in vitro target validation, but also as a novel therapeutic strategy based on the highly specific and efficient silencing of a target gene. We hypothesize that MMP-9 siRNA can be effective as an MMP-9 protein inhibitor in a rat focal ischemia model. Mal...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2008.11.007
更新日期:2009-03-01 00:00:00
abstract::Nitrosative stress contributes to nerve conduction slowing, thermal hypoalgesia, and impaired nitrergic innervation in animal models of Type 1 diabetes. The role for reactive nitrogen species in Type 2 diabetes-associated neuropathy remains unexplored. This study evaluated the role for nitrosative stress in functional...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2007.03.019
更新日期:2007-06-01 00:00:00